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Mayara Lourencetti, Marida Morgado de Abreu
OBJECTIVE: The objective of this study was to analyse the existing bibliographic production on clinical trials related to the use of vitamin D for oral treatment of psoriasis. METHOD: A literature review of clinical trials related to the use of vitamin D for oral treatment of psoriasis, published in the LILACS, Scielo, Medline, PubMed and Cochrane Library from 1986 to 2013. The search included the following terms: "Psoriasis and oral Vitamin D"; "psoríase e vitamina D oral"...
July 2018: Revista da Associação Médica Brasileira
Rongna A, Pei Yu, Siyu Hao, Yuzhen Li
Psoriasis is an autoimmune disease characterized by abnormal differentiation and hyper-proliferation of epidermal keratinocytes. The object of the study is to investigate the role of miRNA-876-5p in psoriasis. It reported that MicroRNAs (miRNAs) played roles in the malignant progression in psoriasis development. The expression of miR-876-5p was found to be down-regulated in psoriasic tissue and blood of patients. The luciferase assay verified the targeting role of miR-876-5p to 3'UTR of Angiopoietin-1 (Ang-1)...
July 2018: Biomedicine & Pharmacotherapy
J J González-López, Á M García-Aparicio, D Sánchez-Ponce, N Muñoz-Sanz, N Fernandez-Ledo, P Beneyto, M C Westcott
PurposeTo develop and validate a Bayesian belief network algorithm for the differential diagnosis of anterior uveitis.Patients and methodsThe 11 most common etiologies were included (idiopathic, ankylosing spondylitis, psoriasic arthritis, reactive arthritis, inflammatory bowel diseases, sarcoidosis, tuberculosis, Behçet, Posner-Schlossman syndrome, juvenile idiopathic arthritis (JIA), and Fuchs' heterochromic cyclitis). Frequencies of association between factors and etiologies were retrieved from a systematic review of the literature...
June 2016: Eye
S Zürcher, W-H Boehncke, S Boehncke
Psoriatic arthritis occurs almost exclusively together with psoriasis of the skin. It seems useful therefore for the practitioner to consider the two of them as manifestations of one "psoriatic disease". This pragmatic approach is more contemporary, particularly since it is increasingly clear that the "psoriatic disease" goes beyond damage to the skin and joints. The most important "comorbidities" associated with psoriatic disease are presented here; especially the cardiovascular diseases as well as their risk factors, namely smoking, obesity, and the metabolic syndrome...
April 2, 2014: Revue Médicale Suisse
A Balato, L Di Costanzo, C Patruno, F Ayala, M Megna, N Balato
No abstract text is available yet for this article.
December 2013: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Kulveer Singh Ahlawat, Bhupender Singh Khatkar
Aloe vera is used for vigor, wellness and medicinal purposes since rigvedic times. Health benefits of aloe vera include its application in wound healing, treating burns, minimizing frost bite damage, protection against skin damage from x-rays, lung cancer, intestinal problems, increasing high density lipoprotein (HDL), reducing low density lipoprotein (LDL), reducing blood sugar in diabetics, fighting acquired immune deficiency syndrome (AIDS), allergies and improving immune system. Phytochemistry of aloe vera gel has revealed the presence of more than 200 bioactive chemicals...
October 2011: Journal of Food Science and Technology
Elizabeth Soto-Cabrera, Alejandro Hernández-Martínez, Hiram Yáñez, Raúl Carrera
BACKGROUND: adalimumab, a human recombinant monoclonal antibody against tumoral necrosis factor alpha (TNFα), has been associated with central nervous system demyelinating diseases and peripheral neuropathic syndrome. The Guillain-Barré Syndrome (GBS) is one of them. CLINICAL CASE: we presented the case of a 65 year old woman, with diabetes mellitus and psoriasic arthritis, treated with adalimumab; after the fourth infusion, she developed paresthesia and mild weakness in lower limbs, these symptoms persisted three days after each infusion and each time remitted spontaneously; following the eight dose, presented a characteristic clinical picture of the GBS, confirmed with neurophysiological studies that showed an axonal motor-sensitive polyneuropathy...
September 2012: Revista Médica del Instituto Mexicano del Seguro Social
S Madonna, C Scarponi, S Pallotta, A Cavani, C Albanesi
Because of their genetically determined capacity to respond to pro-inflammatory stimuli, keratinocytes have a crucial role in the pathogenesis of psoriasis. Upon IFN-γ and TNF-α exposure, psoriatic keratinocytes express exaggerated levels of inflammatory mediators, and show aberrant hyperproliferation and terminal differentiation. The thickening of psoriasic skin also results from a peculiar resistance of keratinocytes to cytokine-induced apoptosis. In this study, we investigated on the molecular mechanisms concurring to the resistance of psoriatic keratinocytes to cell death, focusing on the role having suppressor of cytokine signaling (SOCS)1 and SOCS3, two molecules abundantly expressed in IFN-γ/TNF-α-activated psoriatic keratinocytes, in sustaining anti-apoptotic pathways...
June 28, 2012: Cell Death & Disease
Bianca Marasini, Luca Cozzaglio, Laura Belloli, Marco Massarotti, Nicola Ughi, Paolo Pedrazzoli
INTRODUCTION: The risk of cancer with the use of biologic agents in rheumatic diseases is still a matter of debate. Published data suggest that the extent of cancer risk might differ according to the type of cancer, and there is recent clinical evidence for a significant increased risk for skin cancer, including melanoma. In contrast with the extensive literature on cancer risk in rheumatoid arthritis, little has been reported on the development of malignancies in spondyloarthroparthies...
September 1, 2011: Current Drug Safety
Maiwand Nazary, H H van der Zee, E P Prens, Gert Folkerts, Jurr Boer
The focus of this review is to discuss the pathogenesis and the pharmacotherapy of Hidradenitis suppurativa (HS). HS is a distressing chronic skin disorder characterized by abscesses, boils, fistulas and scarring, generally affecting the groins, anogenital area and axillae. It is a common disease with an estimated prevalence of 1%. The etiology is unknown. HS was thought to be a disease of the apocrine sweat glands, but histological findings indicate that HS is a disease arising from the hair follicles. Several pathogenic factors seem important including genetic predisposition, smoking, obesity and an aberrant immune response to commensal flora...
December 15, 2011: European Journal of Pharmacology
T Gambichler, S Kobus, A Kobus, C Tigges, N Scola, P Altmeyer, A Kreuter, F G Bechara, M Skrygan
Recent papers highlight the role of dysregulated expression of antimicrobial peptides and proteins (AMPs) in the pathogenesis of psoriasis. Etanercept, a blocker of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α), is effective in the treatment of psoriasis. We aimed to evaluate the expression profiles of AMPs in psoriatic skin before and after a 6-week course of etanercept therapy. We included 12 psoriasis patients who underwent medium-dose etanercept treatment for 6weeks. At baseline and at the end of therapy immunohistochemistry from lesional skin was performed for psoriasin, LL-37, and human ß-defensin 2 (hBD-2)...
April 11, 2011: Regulatory Peptides
Mathieu Sacquépée, Vincent Rouleau, Jean-François Cantin, Nicolas Quirin, Yves Doussy, Jean-Claude Valéry, Cristina Picu, Jean-Michel Tivollier
INTRODUCTION: Drug-induced lupus nephritis in patients treated with TNF α inhibitor is a rare adverse effect. Anti-TNF α therapies are commonly associated with the induction of auto-antibodies, whereas anti-TNF α-induced lupus is rare, most frequently involving arthritis and cutaneous lesions. However, several renal involvement has been reported. OBSERVATION: A 26-year old woman with a history of psoriasic arthritis treated with TNF α inhibitor (etanercept) presented with a biopsy-proved class IV lupus nephritis...
November 2010: Néphrologie & Thérapeutique
A Chatzikyriakidou, P V Voulgari, I Georgiou, A A Drosos
MicroRNAs have shown different expression patterns in immune diseases. The present study explores the association of miRNA-146a variant rs2910164 and of two IRAK1 (target of miR-146a) polymorphisms rs3027898 and rs1059703 with psoriasic arthritis (PsA). Twenty-nine PsA and 66 controls were enrolled in the study. To study if the statistical significant differences between patients with PsA and controls are independent to psoriasis, we expanded the study in 49 patients with ankylosing spondylitis (AS). Strong statistical significant difference was observed in IRAK1 rs3027898 polymorphism distribution between patients with PsA and controls (P = 0...
May 2010: Scandinavian Journal of Immunology
R Manna, E Verrecchia, C Fonnesu, M Giovinale, G De Socio, V Curigliano, C Cerquaglia, A Soriano, M Granata, A Migliore, U Massafra, G Gasbarrini
INTRODUCTION: In autoimmune disorders (ADs), if Hepatitis C Virus (HCV) is present, immunosuppressive treatment could increase virus replication. Cyclosporine A (CsA), in standard therapeutic doses, has been proven able to inhibit HCV cyclophilin in vitro. Therefore CsA could improve the therapy of HCV patients with ADs. AIM: In these patients, we started an open pilot study to evaluate the safety of 3 mg/kg CsA and the ability to reduce steroid therapy. PATIENTS AND METHODS: Five females and 1 male were recruited; mean age 66 +/- 8 years, mean disease duration 13 +/- 5 years...
March 2009: European Review for Medical and Pharmacological Sciences
L Daoud, M R Dhaoui, S Youssef, K Jaber, Néjib Doss
BACKGROUND: With its varied clinical presentation, psoriasis is actually considered as a public health care problem. Severe psoriasis remains difficult to treat. METHODS: Our study was retrospective involving 50 patient with severe psoriasis treated in the dermatology unit of military hospital of Tunis from January 1990 to December 2003. Aim of our study was to evaluate actual different therapeutic attitudes and new treatments in case of severe psoriasis. RESULTS: During the 14 years studied the frequency of severe psoriasis was about 19...
October 2007: La Tunisie Médicale
Virendra N Sehgal
Twenty nail dystrophy (TND) trachyonychia, a fascinating clinical condition, was brought to focus 25 years ago. Ever since, it has been sparingly reported. Nonetheless, the condition is well-recognized and its diagnosis is made on the basis of clinical features characterized by onset in infancy/childhood, and occasionally in adults. The lesions are fairly representative, and are characterized by the alternating elevation and depression (ridging) and/or pitting, lack of luster, roughening likened to sandpaper, splitting, and change to a muddy grayish-white color...
June 2007: Journal of Dermatology
A Pouye, S Fall, S Diallo, S Ndongo, Y Leye, S M Seck, A Leye, M M Ka, A Niang, T Moreira Diop
Juvenile chronic gout in its polyarticular deformative form has rarely been described in medical literature. We report a rare case of destructive polyarticular tophaceous gout in a 31-year-old Senegalese man. He consulted for bilateral asymmetric polyarthritis with deformities of the hands and feet that had been ongoing in recurrent episodes since the age of 18 years in association with tophus. He had received no previous medication. All laboratory investigations were normal except hyperuricemia 104 mg/l. Radiographs of affected joints demonstrated evidence of destructive polyarthritis, i...
June 2006: Médecine Tropicale: Revue du Corps de Santé Colonial
Silvano Menni, Lorenzo Gualandri, Daniela Boccardi, Carlo Agostoni, Marco Sala, Enrica Riva
We report a case of a 3-month-old female baby showing clinical and hematological signs compatible with Kawasaki disease. A few days after the beginning of the specific therapy, the young patient developed asymptomatic erythematous plaques appearing on the trunk. The histology disclosed a psoriasic pattern. To the best of our knowledge, we describe the youngest baby in the published work developing a psoriasis during the course of Kawasaki disease.
August 2006: Journal of Dermatology
A Sparsa
Etanercept (Enbrel, Wyeth Pharmaceuticals) is a fusion protein composed of a soluble TNF alpha receptor issued from bio-technology. It is a member of TNF alpha's family with two others marked infliximab (Remicade, Scheringh Plough Laboratory), chimeric monoclonal antibody (25 p. 100 mouse) and adalimumab (Humira, Abbott France Laboratory), humanized monoclonal antibody (100 p. 100 human). In United States, etanercept is approved by Food and Drug Administration, since 1998, to treat rheumatoid arthritis showing an inadequate response to prior therapy with other disease-modifying antirheumatic drugs (DMARDS)...
November 2005: Annales de Dermatologie et de Vénéréologie
Laura Mahiques Santos, Teresa Martínez-Menchón, José Luis Sánchez Carazo, Amparo Pérez-Ferriols, Carlos Joaquín Soriano Navarro, José Miguel Fortea Baixauli
BACKGROUND AND OBJECTIVES: Etanercept is a dimeric fusion protein that binds to tumor necrosis factor and blocks inflammatory response. The purpose of this study was to assess the effects of etanercept and its maintenance in patients with severe and refractory psoriasis. PATIENTS AND METHOD: Twenty two patients with severe and refractory psoriasis in an open-label clinical trial were studied. Patients received etanercept 50 mg/week subcutaneously during 6 months...
September 24, 2005: Medicina Clínica
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