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JOURNAL ARTICLE
Jason Betz, Hannah Behrens, Brooke M Harkness, Richard Stutzman, Winston Chamberlain, Marie Perez Blanco, Deborah M Hegarty, Sue A Aicher, Anat Galor
PURPOSE: To examine the frequency and risk factors for ocular pain after laser assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). METHODS: Prospective study of individuals undergoing refractive surgery at two different centers. Participants rated their ocular pain on a 0 - 10 Numerical Rating Scale (NRS) pre-surgery and 1 day, 3 months, and 6 months post-surgery. A clinical examination focused on ocular surface health was performed 3- and 6-months post-surgery...
February 19, 2023: Ophthalmology
#22
JOURNAL ARTICLE
Ahmed Mamai, Anh M Chau, Brian J Wilson, Iain D Watson, Babu B Joseph, Pandiaraju R Subramanian, Monzur M Morshed, Justin A Morin, Michael A Prakesch, Tianbao Lu, Pete Connolly, Douglas A Kuntz, Neil C Pomroy, Gennady Poda, Kong Nguyen, Richard Marcellus, Graig Strathdee, Brigitte Theriault, Ratheesh Subramaniam, Mohammed Mohammed, Ayome Abibi, Manuel Chan, Jeffrey Winston, Taira Kiyota, Elijus Undzys, Ahmed Aman, Nigel Austin, Marc Du Jardin, Kathryn Packman, Ulrike Phillippar, Riccardo Attar, James Edwards, Jeff O'Meara, David E Uehling, Rima Al-Awar, Gilbert G Privé, Methvin B Isaac
B cell lymphoma 6 (BCL6), a highly regulated transcriptional repressor, is deregulated in several forms of non-Hodgkin lymphoma (NHL), most notably in diffuse large B-cell lymphoma (DLBCL). The activities of BCL6 are dependent on protein-protein interactions with transcriptional co-repressors. To find new therapeutic interventions addressing the needs of patients with DLBCL, we initiated a program to identify BCL6 inhibitors that interfere with co-repressor binding. A virtual screen hit with binding activity in the high micromolar range was optimized by structure-guided methods, resulting in a novel and highly potent inhibitor series...
February 9, 2023: ACS Medicinal Chemistry Letters
#23
JOURNAL ARTICLE
Charles Blatti, Jesús de la Fuente Cedeño, Huanyao Gao, Irene Marín-Goñi, Zikun Chen, Sihai D Zhao, Winston Tan, Richard Weinshilboum, Krishna R Kalari, Liewei Wang, Mikel Hernaez
Survival rates of patients with metastatic castration-resistant prostate cancer (mCRPC) are low due to lack of response or acquired resistance to available therapies, such as abiraterone (Abi). A better understanding of the underlying molecular mechanisms is needed to identify effective targets to overcome resistance. Given the complexity of the transcriptional dynamics in cells, differential gene expression analysis of bulk transcriptomics data cannot provide sufficient detailed insights into resistance mechanisms...
February 13, 2023: Cancer Research
#24
JOURNAL ARTICLE
Brooke M Harkness, Deborah M Hegarty, Julie A Saugstad, Hannah Behrens, Jason Betz, Larry L David, Jodi A Lapidus, Siting Chen, Richard Stutzman, Winston Chamberlain, Maricarmen Perez-Blanco, Anat Galor, Sue A Aicher
PURPOSE: Human tears contain abundant, diverse sets of proteins that may serve as biomarkers of ocular surface health. There is a need for reproducible methods that consider multiple factors influencing the tear proteome, in addition to the variable of interest. Here we examined a workflow for proteomic analysis of tear proteins without the need to pool tear samples from multiple individuals, thus allowing for analyses based on individual factors, and increasing opportunities for protein biomarker discovery...
February 9, 2023: Ocular Surface
#25
JOURNAL ARTICLE
Ogul E Uner, Donald C Hubbard, Carlos Torres-Quinones, Roma Pegany, Lingling Huang, Momoko K Ponsetto, Miles Fletcher, Monica K Sikka, Afshan Nanji, Travis K Redd, Richard D Stutzman, Winston Chamberlain, Donna H Kim
PURPOSE: The aim of this study was to describe a case of corneal involvement as an early manifestation of ocular disease in the 2022 human mpox (monkeypox) virus outbreak. METHODS: This is a single case report with longitudinal care. RESULTS: A 47-year-old immunocompetent man presented with viral conjunctivitis before development of skin lesions or systemic symptoms. Subsequently, he developed membranous keratoconjunctivitis and a corneal epithelial defect...
January 11, 2023: Cornea
#26
JOURNAL ARTICLE
David N Sattler, James M Graham, Albert Whippy, Richard Atienza, James Johnson
BACKGROUND: This two-study paper developed a climate change risk perception model that considers the role of posttraumatic growth (i.e., a reappraisal of life priorities and deeper appreciation of life), resource loss, posttraumatic stress, coping, and social support. METHOD: In Study 1, participants were 332 persons in the Philippines who experienced Super Typhoon Haiyan. In Study 2, participants were 709 persons in Fiji who experienced Cyclone Winston. Climate change can increase the size and destructive potential of cyclones and typhoons as a result of warming ocean temperatures, which provides fuel for these storms...
January 13, 2023: International Journal of Environmental Research and Public Health
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JOURNAL ARTICLE
Maria Jose Lista, Helena Winstone, Harry D Wilson, Adam Dyer, Suzanne Pickering, Rui Pedro Galao, Giuditta De Lorenzo, Vanessa M Cowton, Wilhelm Furnon, Nicolas Suarez, Richard Orton, Massimo Palmarini, Arvind H Patel, Luke Snell, Gaia Nebbia, Chad Swanson, Stuart J D Neil
The appearance of new dominant variants of concern (VOC) of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) threatens the global response to the coronavirus disease 2019 (COVID-19) pandemic. Of these, the alpha variant (also known as B.1.1.7), which appeared initially in the United Kingdom, became the dominant variant in much of Europe and North America in the first half of 2021. The spike (S) glycoprotein of alpha acquired seven mutations and two deletions compared to the ancestral virus, including the P681H mutation adjacent to the polybasic cleavage site, which has been suggested to enhance S cleavage...
November 9, 2022: Journal of Virology
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JOURNAL ARTICLE
Petroula Laiou, Andrea Biondi, Elisa Bruno, Pedro F Viana, Joel S Winston, Zulqarnain Rashid, Yatharth Ranjan, Pauline Conde, Callum Stewart, Shaoxiong Sun, Yuezhou Zhang, Amos Folarin, Richard J B Dobson, Andreas Schulze-Bonhage, Matthias Dümpelmann, Mark P Richardson, Radar-Cns Consortium
Epilepsy is one of the most common neurological disorders, characterized by the occurrence of repeated seizures. Given that epilepsy is considered a network disorder, tools derived from network neuroscience may confer the valuable ability to quantify the properties of epileptic brain networks. In this study, we use well-established brain network metrics (i.e., mean strength, variance of strength, eigenvector centrality, betweenness centrality) to characterize the temporal evolution of epileptic functional networks over several days prior to seizure occurrence...
October 21, 2022: Biomedicines
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JOURNAL ARTICLE
Hugues Sicotte, Krishna R Kalari, Sisi Qin, Scott M Dehm, Vipul Bhargava, Michael Gormley, Winston Tan, Jason P Sinnwell, David W Hillman, Ying Li, Peter T Vedell, Rachel E Carlson, Alan H Bryce, Raphael E Jimenez, Richard M Weinshilboum, Manish Kohli, Liewei Wang
We identified resistance mechanisms to abiraterone acetate/prednisone (AA/P) in patients with metastatic castration-resistant prostate cancer (mCRPC) in the PROMOTE (Prostate Cancer Medically Optimized Genome-Enhanced Therapy) study. We analyzed whole-exome sequencing (WES) and RNA-seq data from 83 patients with metastatic biopsies pre (V1) and after 12 weeks of AA/P treatment (V2). Resistance was determined by time to treatment change (TTTC). At V2, 18 and 11 out of 58 patients had either short (median 3.6 months; range 1...
September 22, 2022: Molecular Cancer Research: MCR
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JOURNAL ARTICLE
David Winston Hamilton, Benjamin Heaven, Richard Thomson, Janet Wilson, Catherine Exley
OBJECTIVES: To describe how patients are engaged with cancer decisions in the context of multidisciplinary team (MDT) and how MDT recommendations are operationalised in the context of a shared decision. DESIGN: Ethnographic qualitative study. SETTING: Four head and neck cancer centres in the north of England. PARTICIPANTS: Patients with a diagnosis of new or recurrent head and neck cancer; non-participant observation of 35 MDT meetings and 37 MDT clinics, informal interviews, and formal, semistructured interviews with 20 patients and 9 MDT staff members...
August 24, 2022: BMJ Open
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JOURNAL ARTICLE
Devinder Singh, Nick J Levell, Lawrence Charles Parish, Leonard J Hoenig
Following the 1898 Battle of Omdurman in Sudan, Winston Churchill, then a second lieutenant in the British army, donated a skin graft to Richard Molyneux, a wounded fellow officer. This contribution tells the story of Churchill's skin graft donation within the context of the development of skin grafting as a viable treatment for serious wounds and burns.
July 28, 2022: Clinics in Dermatology
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JOURNAL ARTICLE
Richard K Koech, Yusuf A Olanrewaju, Reisya Ichwani, Moses Kigozi, Deborah O Oyewole, Omolara V Oyelade, Dahiru M Sanni, Sharafadeen A Adeniji, Erika Colin-Ulloa, Lyubov V Titova, Julia L Martin, Ronald L Grimm, Abdulhakeem Bello, Oluwaseun K Oyewole, Esidor Ntsoenzok, Winston O Soboyejo
In this paper, we use Polyethylene Oxide (PEO) particles to control the morphology of Formamidinium (FA)-rich perovskite films and achieve large grains with improved optoelectronic properties. Consequently, a planar perovskite solar cell (PSC) is fabricated with additions of 5 wt% of PEO, and the highest PCE of 18.03% was obtained. This solar cell is also shown to retain up to 80% of its initial PCE after about 140 h of storage under the ambient conditions (average relative humidity of 62.5 ± 3.25%) in an unencapsulated state...
July 27, 2022: Scientific Reports
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JOURNAL ARTICLE
Courtney Weber, Janelle Cheri Millen, Huazhi Liu, Jason Clark, Lawrence Ferber, Winston Richards, Darwin Ang
INTRODUCTION: Elderly undertriage rates are estimated up to 55% in the United States. This study examined risk factors for undertriage among hospitalized trauma patients in a state with high volumes of geriatric trauma patients. MATERIALS AND METHODS: This is a population-based retrospective cohort study of 62,557 patients admitted to Florida hospitals between 2016 and 2018 from the Agency for Healthcare Administration database. Severely injured trauma patients were defined by American College of Surgeons definitions and an International Classification of Disease Injury Severity Score <0...
November 2022: Journal of Surgical Research
#34
JOURNAL ARTICLE
Denise R Purdie, Myke Federman, Alan Chin, Diana Winston, Brenda Bursch, Richard Olmstead, Yonca Bulut, Michael R Irwin
Physicians are experiencing epidemic levels of work-related stress and burnout. Determine efficacy of mindfulness meditation delivered as a hybrid (in-person and digital) format to reduce perceived stress in pediatric residents. Pediatric residents (n = 66) were block randomized to a hybrid Mindful Awareness Practices (MAPs) intervention, comprised of one in-person 60-min session and 6-week access to a digitally delivered MAPs curriculum (n = 27) or wait-list control (n = 39). Perceived Stress Scale (PSS) was administered at baseline and post-intervention as the primary outcome measure...
July 1, 2022: Journal of Clinical Psychology in Medical Settings
#35
JOURNAL ARTICLE
Husna Begum, Ary S Neto, Patricia Alliegro, Tessa Broadley, Tony Trapani, Lewis T Campbell, Allen C Cheng, Winston Cheung, D James Cooper, Simon J Erickson, Craig J French, Edward Litton, Richard McAllister, Alistair Nichol, Annamaria Palermo, Mark P Plummer, Hannah Rotherham, Mahesh Ramanan, Benjamin Reddi, Claire Reynolds, Steven Ar Webb, Andrew A Udy, Aidan Burrell
OBJECTIVE: To compare the demographic and clinical features, management, and outcomes for patients admitted with COVID-19 to intensive care units (ICUs) during the first, second, and third waves of the pandemic in Australia. DESIGN, SETTING, AND PARTICIPANTS: People aged 16 years or more admitted with polymerase chain reaction-confirmed COVID-19 to the 78 Australian ICUs participating in the Short Period Incidence Study of Severe Acute Respiratory Infection (SPRINT-SARI) Australia project during the first (27 February - 30 June 2020), second (1 July 2020 - 25 June 2021), and third COVID-19 waves (26 June - 1 November 2021)...
October 3, 2022: Medical Journal of Australia
#36
JOURNAL ARTICLE
Irmina A Elliott, Mark F Berry, Winston Trope, Natalie S Lui, Brandon A Guenthart, Douglas Z Liou, Richard I Whyte, Leah M Backhus, Joseph B Shrager
BACKGROUND: The sensitivity of fluoroscopic esophagography with oral administration of contrast material to exclude anastomotic leak after esophagectomy is not well documented, and the consequences of missing a leak in this setting have not been previously described. METHODS: We performed a retrospective cohort study of a prospectively maintained institutional database of patients undergoing esophagectomy with esophagogastric anastomosis from 2008 to 2020. Relevant details of leaks, management, and outcomes were obtained from the database and formal chart review...
May 23, 2022: Annals of Thoracic Surgery
#37
RANDOMIZED CONTROLLED TRIAL
John E Pachankis, Audrey Harkness, Kaitlin R Maciejewski, Kriti Behari, Kirsty A Clark, Erin McConocha, Roxanne Winston, Oluwaseyi Adeyinka, Jesse Reynolds, Richard Bränström, Denise A Esserman, Mark L Hatzenbuehler, Steven A Safren
OBJECTIVE: Effective Skills to Empower Effective Men (ESTEEM) represents the first intervention to address the psychological pathways through which minority stress undermines young sexual minority men's (SMM's) mental and sexual health using transdiagnostic cognitive-behavioral therapy. This study compared the efficacy of ESTEEM against two existing interventions. METHOD: Participants were young HIV-negative SMM ( N = 254; ages = 18-35; 67.2% racial/ethnic minority) experiencing a depression, anxiety, and/or stress-/trauma-related disorder and past-90-day HIV transmission risk behavior...
June 2022: Journal of Consulting and Clinical Psychology
#38
JOURNAL ARTICLE
Kostandinos Sideras, David W Hillman, Karthik Giridhar, Brenda F Ginos, Richard C Tenglin, Heshan Liu, Beiyun Chen, Winston Tan, Gerald G Gross, Rex B Mowat, Amylou C Dueck, Edith A Perez, Alvaro Moreno-Aspitia
BACKGROUND: Anthracycline use in metastatic breast cancer (MBC) is hindered by cumulative exposure limits and risk of cardiotoxicity. Pixantrone, a novel aza-anthracenedione with structural similarities to mitoxantrone and anthracyclines, is theorized to exhibit less cardiotoxicity, mainly due to lack of iron binding. We conducted a randomized phase II study to evaluate the efficacy and safety of 2 dosing schedules of pixantrone in patients with refractory HER2-negative MBC. METHODS: Intravenous pixantrone was administered at 180 mg/m2 every 3 weeks (group A) versus 85 mg/m2 on days 1, 8, and 15 of a 28-day cycle (group B)...
April 21, 2022: Oncologist
#39
JOURNAL ARTICLE
Sergey Nurk, Sergey Koren, Arang Rhie, Mikko Rautiainen, Andrey V Bzikadze, Alla Mikheenko, Mitchell R Vollger, Nicolas Altemose, Lev Uralsky, Ariel Gershman, Sergey Aganezov, Savannah J Hoyt, Mark Diekhans, Glennis A Logsdon, Michael Alonge, Stylianos E Antonarakis, Matthew Borchers, Gerard G Bouffard, Shelise Y Brooks, Gina V Caldas, Nae-Chyun Chen, Haoyu Cheng, Chen-Shan Chin, William Chow, Leonardo G de Lima, Philip C Dishuck, Richard Durbin, Tatiana Dvorkina, Ian T Fiddes, Giulio Formenti, Robert S Fulton, Arkarachai Fungtammasan, Erik Garrison, Patrick G S Grady, Tina A Graves-Lindsay, Ira M Hall, Nancy F Hansen, Gabrielle A Hartley, Marina Haukness, Kerstin Howe, Michael W Hunkapiller, Chirag Jain, Miten Jain, Erich D Jarvis, Peter Kerpedjiev, Melanie Kirsche, Mikhail Kolmogorov, Jonas Korlach, Milinn Kremitzki, Heng Li, Valerie V Maduro, Tobias Marschall, Ann M McCartney, Jennifer McDaniel, Danny E Miller, James C Mullikin, Eugene W Myers, Nathan D Olson, Benedict Paten, Paul Peluso, Pavel A Pevzner, David Porubsky, Tamara Potapova, Evgeny I Rogaev, Jeffrey A Rosenfeld, Steven L Salzberg, Valerie A Schneider, Fritz J Sedlazeck, Kishwar Shafin, Colin J Shew, Alaina Shumate, Ying Sims, Arian F A Smit, Daniela C Soto, Ivan Sović, Jessica M Storer, Aaron Streets, Beth A Sullivan, Françoise Thibaud-Nissen, James Torrance, Justin Wagner, Brian P Walenz, Aaron Wenger, Jonathan M D Wood, Chunlin Xiao, Stephanie M Yan, Alice C Young, Samantha Zarate, Urvashi Surti, Rajiv C McCoy, Megan Y Dennis, Ivan A Alexandrov, Jennifer L Gerton, Rachel J O'Neill, Winston Timp, Justin M Zook, Michael C Schatz, Evan E Eichler, Karen H Miga, Adam M Phillippy
Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addressing the remaining 8% of the genome, the Telomere-to-Telomere (T2T) Consortium presents a complete 3.055 billion-base pair sequence of a human genome, T2T-CHM13, that includes gapless assemblies for all chromosomes except Y, corrects errors in the prior references, and introduces nearly 200 million base pairs of sequence containing 1956 gene predictions, 99 of which are predicted to be protein coding...
April 2022: Science
#40
JOURNAL ARTICLE
Richard J McLaughlin, Anastasia J Whitson, Anna Panebianco, Winston J Warme, Frederick A Matsen, Jason E Hsu
BACKGROUND: Preoperative and postoperative patient self-reported measures are the key to understanding the benefit of shoulder arthroplasty for patients with different diagnoses and having different surgical approaches. The minimal clinically important difference (MCID) for patient-reported outcomes such as the Simple Shoulder Test (SST) is often used to document the amount of improvement that is of importance to the patient; however, the MCID may differ for different types of shoulder arthroplasty...
August 2022: Journal of Shoulder and Elbow Surgery
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