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Byung Kook Lee, Chun Song Youn, Youn-Jung Kim, Seung Mok Ryoo, Kyung Soo Lim, Gi-Byoung Nam, Su Jin Kim, Won Young Kim
Amiodarone is recommended for shock-refractory ventricular arrhythmia during resuscitation; however, it is unknown whether amiodarone is effective for preventing ventricular arrhythmia recurrence in out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management (TTM). We investigated the effectiveness of prophylactic amiodarone in preventing ventricular arrhythmia recurrence in OHCA survivors. Data of consecutive adult non-traumatic OHCA survivors treated with TTM between 2010 and 2016 were extracted from prospective cardiac arrest registries of four tertiary care hospitals...
February 13, 2019: Journal of Clinical Medicine
Hoang-Nam Nguyen, Tan-Y Nguyen, Ke Van Tran, Thanh Trung Tran, Truong-Thinh Nguyen, Van-Duc Phan, Thom Van Do
Triple-layered composite plates are created by joining three composite layers using shear connectors. These layers, which are assumed to be always in contact and able to move relatively to each other during deformation, could be the same or different in geometric dimensions and material. They are applied in various engineering fields such as ship-building, aircraft wing manufacturing, etc. However, there are only a few publications regarding the calculation of this kind of plate. This paper proposes novel equations, which utilize Mindlin's theory and finite element modelling to simulate the forced vibration of triple-layered composite plates with layers connected by shear connectors subjected to a moving load...
February 16, 2019: Materials
Jin Young Nam, Sang Gyu Lee, Chung Mo Nam, Sohee Park, Sung In Jang, Eun-Cheol Park
BACKGROUND: Severe maternal morbidity is an indicator for quality of maternal care. Recently, there has been growing interest in identifying which provision factors affect the quality of maternity care. The extent to off-hour delivery on SMM rates contributes to individual or provision factor in Korea has not been studied. This study aimed to determine the relationship between off-hour delivery and SMM during childbirth hospitalization. METHODS: This is a population-based retrospective cohort study...
February 18, 2019: European Journal of Public Health
Gustav Emilsson, Evelyn Röder, Bita Malekian, Kunli Xiong, John Manzi, Feng-Ching Tsai, Nam-Joon Cho, Marta Bally, Andreas Dahlin
Biosensors based on plasmonic nanostructures are widely used in various applications and benefit from numerous operational advantages. One type of application where nanostructured sensors provide unique value in comparison with, for instance, conventional surface plasmon resonance, is investigations of the influence of nanoscale geometry on biomolecular binding events. In this study, we show that plasmonic "nanowells" conformally coated with a continuous lipid bilayer can be used to detect the preferential binding of the insulin receptor tyrosine kinase substrate protein (IRSp53) I-BAR domain to regions of negative surface curvature, i...
2019: Frontiers in Chemistry
Una Amelia Yoon, Yong Chul Kim, Hyewon Lee, Soie Kwon, Jung Nam An, Dong Ki Kim, Yon Su Kim, Chun Soo Lim, Jung Pyo Lee, Ho Kim
Recent data suggest that reduced sunlight exposure is associated with increased mortality in the general population. To date, the association between sunlight exposure and mortality in dialysis patients has not been examined. Among 134,478 dialysis patients in the Korean end-stage renal disease (ESRD) cohort from 2001 to 2014, 31,291 patients were enrolled from seven metropolitan cities, and data were analyzed using bi-directional case-crossover design. We examined the association between short-term sunlight exposure and mortality in ESRD patients...
February 18, 2019: Scientific Reports
Young Hee Nam, Warren B Bilker, Charles E Leonard, Michelle L Bell, Sean Hennessy
OBJECTIVE: Heat is associated with elevated all-cause mortality, and furosemide-induced potassium depletion might be worsened by heat-induced sweating. Because empiric potassium is associated with a marked survival benefit in users of furosemide at a dose of ≥40 mg/day, we hypothesised that this empiric potassium's survival benefit would increase with higher temperature (≥24°C). DESIGN: Cohort study. SETTING: Outpatient setting, captured by Medicaid claims, supplemented with Medicare claims for dual enrollees, from 5 US states from 1999 to 2010, linked to meteorological data...
February 18, 2019: BMJ Open
Ji Yeong Soh, Se Uk Lee, Inpyo Lee, Ki Sang Yoon, Changho Song, Nam Hun Kim, Tae Sung Sohn, Jae Moon Bae, Dong Kyung Chang, Won Chul Cha
BACKGROUND: An incentive spirometer (IS) is a medical device used to help patients improve the functioning of their lungs. It is provided to patients who have had any surgery that might jeopardize respiratory function. An incentive spirometer plays a key role in the prevention of postoperative complications, and the appropriate use of an IS is especially well known for the prevention of respiratory complications. However, IS utilization depends on the patient's engagement, and information and communication technology (ICT) can help in this area...
February 19, 2019: JMIR MHealth and UHealth
Jake Hemingway, Davidson Emanuels, Shahram Aarabi, Elina Quiroga, Nam Tran, Benjamin Starnes, Niten Singh
OBJECTIVE: The primary objective was to evaluate the safety of transfer, type of procedure, and factors associated with limb salvage in patients with acute limb ischemia (ALI) treated at a quaternary referral center. METHODS: A retrospective review of all patients with ALI secondary to thrombotic or embolic occlusion at a quaternary referral hospital from 2013 to 2016 was conducted. Patients were transferred from throughout Washington and Alaska by ambulance, helicopter, or fixed-wing modes of transportation...
February 15, 2019: Journal of Vascular Surgery
Hyo Song Kim, Chung Mo Nam, Suk-Yong Jang, Sun Kyu Choi, Minkyung Han, Seonmin Kim, Maria Victoria Moneta, Sae Young Lee, Jae Min Cho, Diego Novick, Sun Young Rha
Purpose: A soft tissue sarcoma (STS) is a rare type of cancer, accounting for 1% of adult solid cancers. The aim of the present study is to determine the incidence of localized and advanced STS in Korean patients, their treatment patterns, and the survival of patients by disease status. Materials and Methods: The STS patient cohort was defined using National Health Insurance Service medical data from 2002 to 2015. Incidence, distribution, anatomical location of tumors, survival rates (Kaplan-Meyer survival function) and treatment patterns were analyzed by applying different algorithms to the STS cohort containing localized and advanced STS cases...
February 18, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Chye Ling Tan, Toby Chin, Christina Yan Ru Tan, Holly A Rovito, Ling Shih Quek, John E Oblong, Sophie Bellanger
Nicotinamide (NAM) is the main precursor of NAD+ , a co-enzyme essential for DNA repair, glycolysis and oxidative phosphorylation (OXPHOS). NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3D organotypic skin models, we show that NAM inhibits differentiation of the upper epidermal layers and maintains proliferation in the basal layer. In 2D culture, NAM reduces the expression of early and late epidermal differentiation markers and increases the proliferative capacity of human primary keratinocytes (HPKs)...
February 15, 2019: Journal of Investigative Dermatology
Jun Yong Choi, Jin Ok Oh, Jin Young Ahn, Heun Choi, Jung Ho Kim, Hye Seong, Su Jin Jeong, Nam Su Ku, Joon-Sup Yeom, Jae-Phil Choi
We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection...
January 2019: Clinical and Experimental Vaccine Research
In Seok Moon, Dongchul Cha, Sung-Il Nam, Hyun-Jin Lee, Jae Young Choi
Objective  We evaluated the feasibility of an exclusive endoscopic transcanal transpromontorial approach (EETTA) for the treatment of small vestibular schwannomas (VSs) limited to the internal auditory canal (IAC), and introduced a modification without external auditory canal closure. Methods  Between June 2016 and June 2017, seven patients with VS underwent surgery using a modified EETTA. Treatment outcomes, including efficacy of tumor resection, preservation of function, operation time, and quality of life (QOL), were evaluated...
February 2019: Journal of Neurological Surgery. Part B, Skull Base
Jun S Kim, Kevin Phan, Zoe B Cheung, Nam Lee, Luilly Vargas, Varun Arvind, Robert K Merrill, Sunder Gidumal, John Di Capua, Samuel Overley, James Dowdell, Samuel K Cho
Study Design: Meta-analysis. Objective: Proximal junctional kyphosis (PJK) is a complication of surgical management for adult spinal deformity with a multifactorial etiology. Many risk factors are controversial and their relative importance are not fully understood. We aimed to identify the surgical, radiographic, and patient-related risk factors associated with PJK and proximal junctional failure (PJF). Methods: A systematic literature search was performed using PubMed, Cochrane Database of Systematic Reviews, and EMBASE...
February 2019: Global Spine Journal
Seon Woo A An, Eun-Seok Choi, Wooseon Hwang, Heehwa G Son, Jae-Seong Yang, Keunhee Seo, Hyun-Jun Nam, Nhung T H Nguyen, Eun Ji E Kim, Bo Kyoung Suh, Youngran Kim, Shunji Nakano, Youngjae Ryu, Chang Man Ha, Ikue Mori, Sang Ki Park, Joo-Yeon Yoo, Sanguk Kim, Seung-Jae V Lee
PDZ domain-containing proteins (PDZ proteins) act as scaffolds for protein-protein interactions and are crucial for a variety of signal transduction processes. However, the role of PDZ proteins in organismal lifespan and aging remains poorly understood. Here, we demonstrate that KIN-4, a PDZ domain-containing microtubule-associated serine-threonine (MAST) protein kinase, is a key longevity factor acting through binding PTEN phosphatase in Caenorhabditis elegans. Through a targeted genetic screen for PDZ proteins, we find that kin-4 is required for the long lifespan of daf-2/insulin/IGF-1 receptor mutants...
February 17, 2019: Aging Cell
Dong-Ho Kang, Nam-Gyu Park
Current-density-voltage (J-V) hysteresis in perovskite solar cells (PSCs) is a critical issue because it is related to power conversion efficiency and stability. Although parameters affecting the hysteresis have been already reported and reviewed, little investigation is reported on scan-direction-dependent J-V curves depending on perovskite composition. This review investigates J-V hysteric behaviors depending on perovskite composition in normal mesoscopic and planar structure. In addition, methodologies toward hysteresis-free PSCs are proposed...
February 18, 2019: Advanced Materials
Kyungmi Yang, Sang Won Jung, Hyemi Shin, Do Hoon Lim, Jung-Il Lee, Doo-Sik Kong, Ho Jun Seol, Sung Tae Kim, Do-Hyun Nam
BACKGROUND AND PURPOSE: To find genetic markers associated with response to radiotherapy (RT) in glioblastoma (GB) patients. MATERIALS AND METHODS: From Jan 2009 to Dec 2016, 161 patients with newly diagnosed IDH-wild type GB were treated with surgery and adjuvant concurrent chemoradiotherapy with the Stupp's regimen, and then genomic research proceeded with their surgical specimens. Among the 161 patients, 49 with clinically measurable disease on postoperative MRI were analyzed...
February 2019: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Yen Dao Hai, Thanh-Thien Tran-Lam, Trung Quang Nguyen, Nam Duc Vu, Kim Hoi Ma, Giang Truong Le
Acrylamide, a colourless and odourless crystalline solid, formed via the Maillard reaction in food, has been reported with harmful properties for humans, such as toxicity and carcinogenicity. Three hundred and four processed food samples from 17 product types, collected in Hanoi, Vietnam, were analyzed by LC-MS/MS to measure the acrylamide concentration. The limit of detection (LOD) and the limit of quantification (LOQ) of acrylamide were 1 µg Kg-1 and 3 µg Kg-1 , respectively. Effectively, the highest acrylamide content is usually found in processed food, which is one of the primary reasons of increased acrylamide content in food...
February 18, 2019: Food Additives & Contaminants. Part B, Surveillance
Yoon Suk Jung, Nam Hee Kim, Mi Yeon Lee, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND & AIMS: Previous assessments of colorectal neoplasia (CRN) recurrence after polypectomy used self-report to determine smoking status. We evaluated the association between change in smoking status and metachronous CRN risk after polypectomy using cotinine level in urine to determine tobacco exposure. METHODS: We performed a retrospective study of participants in the Kangbuk Samsung Health Study, in Korea, who underwent a screening colonoscopy examination and measurement of cotinine in urine samples...
February 14, 2019: Clinical Gastroenterology and Hepatology
Jeonghun Nam, Jung Yoon, Jeeyong Kim, Woong Sik Jang, Chae Seung Lim
The removal of erythrocytes from whole blood is an essential step during sample preparations intended for biomedical analyses and clinical diagnoses. To address the limitations of present methods, such as centrifugation and chemical lysis, we propose a novel microfluidic device for erythrocyte removal with high-efficiency and leukocyte separation from bulk flows of highly concentrated erythrocytes using a viscoelastic non-Newtonian fluid. The proposed device is designed based on the principle of viscoelasticity-induced particle migration toward the center of the microchannel...
February 10, 2019: Journal of Chromatography. A
Eun Jung Jung, Hwa Jin Cho, Jung Mi Byun, Dae Hoon Jeong, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim, Young Nam Kim
No abstract text is available yet for this article.
February 13, 2019: Placenta
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