keyword
https://read.qxmd.com/read/38458796/association-between-long-term-use-of-calcium-channel-blockers-ccb-and-the-risk-of-breast-cancer-a-retrospective-longitudinal-observational-study-protocol
#21
JOURNAL ARTICLE
Chau Ho, Ninh Thi Ha, David Youens, Walter P Abhayaratna, Max K Bulsara, Jeffery David Hughes, Gita Mishra, Sallie-Anne Pearson, David B Preen, Christopher M Reid, Rikje Ruiter, Christobel M Saunders, Bruno H Stricker, Frank J A van Rooij, Cameron Wright, Rachael Moorin
INTRODUCTION: Calcium channel blockers (CCB), a commonly prescribed antihypertensive (AHT) medicine, may be associated with increased risk of breast cancer. The proposed study aims to examine whether long-term CCB use is associated with the development of breast cancer and to characterise the dose-response nature of any identified association, to inform future hypertension management. METHODS AND ANALYSIS: The study will use data from 2 of Australia's largest cohort studies; the Australian Longitudinal Study on Women's Health, and the 45 and Up Study, combined with the Rotterdam Study...
March 8, 2024: BMJ Open
https://read.qxmd.com/read/38454466/how-does-weight-gain-since-the-age-of-18-years-affect-breast-cancer-risk-in-later-life-a-meta-analysis
#22
JOURNAL ARTICLE
Yunan Han, Ebunoluwa E Otegbeye, Carrie Stoll, Angela Hardi, Graham A Colditz, Adetunji T Toriola
Early life factors are important risk factors for breast cancer. The association between weight gain after age 18 and breast cancer risk is inconsistent across previous epidemiologic studies. To evaluate this association, we conducted a meta-analysis according to PRISMA guidelines and the established inclusion criteria. We performed a comprehensive literature search using Medline (Ovid), Embase, Scopus, Cochrane Library, and ClinicalTrials.gov to identify relevant studies published before June 3, 2022. Two reviewers independently reviewed the articles for final inclusion...
March 7, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38454442/the-fbxw7-binding-sites-on-fam83d-are-potential-targets-for-cancer-therapy
#23
JOURNAL ARTICLE
Xiaoyu Jiang, Yuli Wang, Lulu Guo, Yige Wang, Tianshu Miao, Lijuan Ma, Qin Wei, Xiaoyan Lin, Jian-Hua Mao, Pengju Zhang
Increasing evidence shows the oncogenic function of FAM83D in human cancer, but how FAM83D exerts its oncogenic function remains largely unclear. Here, we investigated the importance of FAM83D/FBXW7 interaction in breast cancer (BC). We systematically mapped the FBXW7-binding sites on FAM83D through a comprehensive mutational analysis together with co-immunoprecipitation assay. Mutations at the FBXW7-binding sites on FAM83D led to that FAM83D lost its capability to promote the ubiquitination and proteasomal degradation of FBXW7; cell proliferation, migration, and invasion in vitro; and tumor growth and metastasis in vivo, indicating that the FBXW7-binding sites on FAM83D are essential for its oncogenic functions...
March 7, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38453587/-effects-of-extended-aromatase-inhibitors-in-women-with-hormone-dependent-breast-cancer-who-have-already-received-five-years-of-adjuvant-hormone-therapy-a-systematic-review-and-meta-analysis
#24
JOURNAL ARTICLE
Kossi Clément Trenou, Miceline Mésidor, Caroline Diorio, Aida Eslami, Denis Talbot
INTRODUCTION: Evaluating the benefits and risks of prolonged hormonal treatment with aromatase inhibitors (AIs) for treating hormone-dependent breast cancer. METHODS: A systematic review and meta-analysis was conducted. Studies reporting on randomized clinical trials concerning prolongating hormonal therapy with AIs as compared to a placebo or no prolongation, after an initial five years of hormonal therapy, were eligible. RESULTS: Seven clinical trials were included...
March 6, 2024: Bulletin du Cancer
https://read.qxmd.com/read/38452109/awareness-regarding-breast-cancer-amongst-women-in-pakistan-a-systematic-review-and-meta-analysis
#25
JOURNAL ARTICLE
Muhammad Abdul Rehman, Erfa Tahir, Huzaifa Ghulam Hussain, Ayesha Khalid, Syed Mohammad Taqi, Eilaf Ahmed Meenai
BACKGROUND: Breast cancer (BCa) is the most common cause of cancer death in Pakistan. In 2019, Pakistan saw the highest global BCa-associated death rate. But do Pakistani women know about the various aspects of BCa? And how prevalent are BCa screening methods amongst Pakistani females? These questions formed the basis for our study. METHODS: We conducted this review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
2024: PloS One
https://read.qxmd.com/read/38451419/differences-in-preferences-for-drug-therapy-between-patients-with-metastatic-versus-early-stage-breast-cancer-a-systematic-literature-review
#26
Lilly Sophia Brandstetter, Steffi Jírů-Hillmann, Stefan Störk, Peter Ulrich Heuschmann, Achim Wöckel, Jens-Peter Reese
INTRODUCTION: Compared with early stages (eBC) metastatic BC (mBC) is incurable. In mBC, aggressive treatment may increase the duration of survival but may also cause severe treatment side effects. A better understanding how patients with BC value different aspects of drug therapy might improve treatment effectiveness, satisfaction and adherence. This systematic review aims to identify and summarise studies evaluating patient preferences for drug therapy of BC and to compare preferences of patients with eBC and mBC...
March 7, 2024: Patient
https://read.qxmd.com/read/38449400/-timing-of-administration-of-pegfilgrastim-and-prophylaxis-for-febrile-neutropenia-for-patients-with-early-breast-cancer-receiving-chemotherapy
#27
JOURNAL ARTICLE
Chihiro Toyoda, Yutaka Mizuno
Febrile neutropenia(FN)causes a prolonged treatment schedule and decreased relative dose intensity(RDI)during cancer chemotherapy, which adversely affects prognosis. In recent years, dose-dense(dd)chemotherapy has been used as adjuvant chemotherapy for patients with breast cancer based on the results of improved disease-free survival according to meta-analysis data. Regarding neoadjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer, taxanes and trastuzumab with the addition of pertuzumab have shown higher pathological complete response rates and elevated incidences of FN...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38447357/corrigendum-to-safety-and-feasibility-of-cdk4-6-inhibitors-treatment-combined-with-radiotherapy-in-patients-with-hr-positive-her2-negative-breast-cancer-a-systematic-review-and-meta-analysis-radiother-oncol-187-2023-109839
#28
Marcin Kubeczko, Michał Jarząb, Dorota Gabryś, Aleksandra Krzywon, Alexander J Cortez, Amy J Xu
No abstract text is available yet for this article.
March 5, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38445713/the-unique-risk-factor-profile-of-triple-negative-breast-cancer-a-comprehensive-meta-analysis
#29
JOURNAL ARTICLE
Nitya Kumar, Sarah Ehsan, Shahana Banerjee, Claudia Fernandez Perez, Isabelle Lhuilier, Jillian Neuner, Tara Friebel-Klinger, Oluwadamilola M Fayanju, Bindhu Nair, Sara Anjum Niinuma, Shivangi Nampoothiri, Anne Marie McCarthy
BACKGROUND: Triple-negative breast cancer (TNBC) has a poor prognosis compared to other breast cancer subtypes. This systematic review and meta-analysis examines whether known risk factors for breast cancer are also associated with TNBC in adult females. METHODS: EMBASE, Medline, SCOPUS, and grey literature were queried with no limit on the date or language of publication. The exposures of interest included parity, breastfeeding, duration of breastfeeding, age at menarche, age at first live birth, oral contraceptive (OC) use, duration of OC use, use of menopausal hormone therapy (MHT), family history, body mass index (BMI), alcohol use, smoking and breast density...
March 5, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38443227/bcar4-expression-as-a-predictive-biomarker-for-endocrine-therapy-resistance-in-breast-cancer
#30
JOURNAL ARTICLE
Muheng Liao, Jace Webster, Emily M Coonrod, Katherine N Weilbaecher, Christopher A Maher, Nicole M White
BACKGROUND: Breast cancer, particularly the estrogen receptor positive (ER+) subtype, remains a leading cause of cancer-related death among women. Endocrine therapy is the most effective treatment for ER+ breast cancer; however, the development of resistance presents a significant challenge. This study explored the role of the breast cancer antiestrogen resistance 4 (BCAR4) gene as a potential driver of resistance and a pivotal biomarker in breast cancer. PATIENTS AND METHODS: The researchers undertook a comprehensive analysis of 1743 patients spanning 6 independent cohorts...
February 16, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38442809/efficacy-and-safety-of-trastuzumab-deruxtecan-in-treating-human-epidermal-growth-factor-receptor-2-low-positive-advanced-breast-cancer-a-meta-analysis-of-randomized-controlled-trials
#31
REVIEW
Rui Ma, Yixun Shi, Ruijuan Yan, Shiqing Yin, Huanen Bu, Jie Huang
BACKGROUND: A novel antibody-drug conjugate, trastuzumab deruxtecan is a combination of a human epidermal growth factor receptor 2 (HER2)-targeting antibody and DNA topoisomerase I inhibitor used to treat HER2-low/positive advanced breast cancer. To determine its safety and efficacy in treating HER2-low/positive advanced breast cancer, we performed a meta-analysis of several randomized clinical trials (RCTs) including DESTINY-Breast02 (NCT03523585), DESTINY-Breast03 (NCT03529110), and DESTINY-Breast04 (NCT03734029)...
March 3, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38442453/body-mass-index-weight-change-and-cancer-prognosis-a-meta-analysis-and-systematic-review-of-73-cohort-studies
#32
REVIEW
H Wen, G Deng, X Shi, Z Liu, A Lin, Q Cheng, J Zhang, P Luo
BACKGROUND: Identifying the association between body mass index (BMI) or weight change and cancer prognosis is essential for the development of effective cancer treatments. We aimed to assess the strength and validity of the evidence of the association between BMI or weight change and cancer prognosis by a systematic evaluation and meta-analysis of relevant cohort studies. METHODS: We systematically searched the PubMed, Web of Science, EconLit, Embase, Food Sciences and Technology Abstracts, PsycINFO, and Cochrane databases for literature published up to July 2023...
March 4, 2024: ESMO Open
https://read.qxmd.com/read/38436219/the-association-between-circulating-carotenoids-and-risk-of-breast-cancer-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#33
REVIEW
Maryam Karim Dehnavi, Soraiya Ebrahimpour-Koujan, Keyhan Lotfi, Leila Azadbakht
Carotenoids appear to have anticancer effects. Prospective evidence for the relation between serum carotenoids and breast cancer is controversial. The present systematic review and meta-analysis aimed to investigate the link between circulating carotenoids and the risk of breast cancer. We performed a systematic search of PubMed, Scopus, and Web of Science up to 30 November, 2022. Prospective studies on adults aged ≥18 y that have reported risk estimates for the association between circulating carotenoids and breast cancer risk were considered...
January 2024: Advances in Nutrition
https://read.qxmd.com/read/38428110/autoimmune-diseases-and-female-specific-cancer-risk-a-systematic-review-and-meta-analysis
#34
JOURNAL ARTICLE
Simone Fischer, Christa Meisinger, Dennis Freuer
OBJECTIVES: Among the over 80 different autoimmune diseases, psoriasis (PsO), rheumatoid arthritis (RA), and ankylosing spondylitis (AS) are common representatives. Previous studies indicated a potential link with cancer risk, but suffered often from low statistical power. Thus, we aimed to synthesize the evidence and quantify the association to different female-specific cancer sites. METHODS: The systematic review was performed according to PRISMA guidelines. A search string was developed for the databases PubMed, Web of Science, Cochrane Library and Embase...
February 29, 2024: Journal of Autoimmunity
https://read.qxmd.com/read/38423376/clinical-characteristics-associated-with-efficacy-and-prognosis-among-patients-treated-with-pd-1-pd-l1-inhibitors-for-early-stage-triple-negative-breast-cancers-a-meta-analysis
#35
REVIEW
Yuhan Wei, Yun Wu, Yang Luo, Fei Ma
OBJECTIVE: To assess the efficacy of PD-1/PD-L1 inhibitors combined with chemotherapy for early-stage triple-negative breast cancer (TNBC) patients with different clinical characteristics. METHODS: Randomized clinical trials for PD-1/PD-L1 inhibitors and chemotherapy combination were included. Pooled analysis of odds ratio (OR) for pathological complete response (pCR) and hazard ratio (HR) for event-free survival (EFS) was conducted overall and for predefined subgroups...
February 27, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38422624/breast-conserving-surgery-is-not-associated-with-increased-local-recurrence-in-patients-with-early-stage-node-negative-triple-negative-breast-cancer-treated-with-neoadjuvant-chemotherapy
#36
JOURNAL ARTICLE
David Krug, Valentina Vladimirova, Michael Untch, Thorsten Kühn, Andreas Schneeweiss, Carsten Denkert, Beyhan Ataseven, Christine Solbach, Bernd Gerber, Hans Tesch, Michael Golatta, Sabine Seiler, Jörg Heil, Valentina Nekljudova, Johannes Holtschmidt, Sibylle Loibl
BACKGROUND: Neoadjuvant chemotherapy (NACT) is routinely used for patients with triple-negative breast cancer (TNBC). Upfront breast-conserving therapy (BCT) consisting of breast-conserving surgery (BCS) and adjuvant radiotherapy (RT) has been shown to be associated with improved outcome in patients with early TNBC as compared to mastectomy. METHODS: We identified 2632 patients with early TNBC from the German Breast Group meta-database. Patients with cT1-2 cN0 and ypN0, available surgery and follow-up data were enrolled...
February 24, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38417232/stakeholders-experiences-and-perceptions-of-male-breast-cancer-a-qualitative-evidence-synthesis
#37
REVIEW
Maodie Ye, Lin Qiu, Yongmei Jin, Yingying Huang
BACKGROUND: The experiences, physical and mental health and needs of women with breast cancer have been studied in some detail, but there is a lack of discussion of the experiences of stakeholder groups such as men with breast cancer, partners and carers and healthcare professionals. The aim of this study was to explore and understand the experiences and perceptions of male breast cancer stakeholders from diagnosis through to survivorship. METHODS: We conducted a thematic review of qualitative studies included in a large published scoping review on male breast cancer (reported under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews extension)...
February 20, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38410801/the-relationship-between-cancer-associated-fibroblasts-biomarkers-and-prognosis-of-breast-cancer-a-systematic-review-and-meta-analysis
#38
JOURNAL ARTICLE
Meimei Cui, Hao Dong, Wanli Duan, Xuejie Wang, Yongping Liu, Lihong Shi, Baogang Zhang
BACKGROUND: To elucidate the relationship between cancer-associated fibroblast (CAFs) biomarkers and the prognosis of breast cancer patients for individualized CAFs-targeting treatment. METHODOLOGY: PubMed, Web of Science, Cochrane, and Embase databases were searched for CAFs-related studies of breast cancer patients from their inception to September, 2023. Meta-analysis was performed using R 4.2.2 software. Sensitivity analyses were performed to explore the sources of heterogeneity...
2024: PeerJ
https://read.qxmd.com/read/38407013/meta-analysis-of-diagnostic-efficacy-of-digital-radiography-and-color-doppler-ultrasound-for-breast-cancer
#39
JOURNAL ARTICLE
Qian Wang, Ling Wang, Xiaojun Li
No abstract text is available yet for this article.
February 26, 2024: Panminerva Medica
https://read.qxmd.com/read/38406816/various-interventions-for-cancer-related-fatigue-in-patients-with-breast-cancer-a-systematic-review-and-network-meta-analysis
#40
Ying Li, Lei Gao, Yaqing Chao, Tianhao Lan, Jie Zhang, Ruoqi Li, Zerui Zhang, Shuming Li, Jing Lian, Zhaofeng Wang, Xiaoan Chen
PURPOSE: To investigate the effects of various intervention approaches on cancer-related fatigue (CRF) in patients with breast cancer. METHOD: Computer searches were conducted on PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and Wanfang databases from their establishment to June 2023. Selection was made using inclusion and exclusion criteria, and 77 articles were included to compare the effects of 12 interventions on patients with breast cancer...
2024: Frontiers in Oncology
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