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Upper gastrointestinal cancer

Masuyo Miyake, Akimitsu Yamada, Kentaro Miyake, Itaru Endo
BACKGROUND: The esophageal metastasis of breast cancer is rare. Moreover, it is extremely unusual for patients to experience the symptoms of esophageal metastasis during their lifetimes. We present a case of dysphagia caused by esophageal metastasis after a long interval following a primary mastectomy. CASE PRESENTATION: A 77-year-old woman with a history of heterochronous bilateral breast cancer and under treatment for pleural dissemination recurrence originating from right breast cancer complained of dysphagia...
February 15, 2019: Surgical Case Reports
Hiroki Kudo, Yasuji Seyama, Hiroyuki Kanomata, Masamichi Takahashi, Tachen Chang, Yujiro Matsuoka, Tomoyo Machida, Yohei Furumoto, Masahiro Warabi, Tooru Tanizawa, Ikuo Wada, Tsuyoshi Maeshiro, Sachio Miyamoto, Nobutaka Umekita
A 72-year-old man with general fatigue was referred, and CT and MRI revealed a pancreatic mass with necrosis that was suspected of invading the stomach, splenic artery, celiac artery, liver, and portal vein. Upper gastrointestinal endoscopy showed an extrinsic mass with ulcer formation in the posterior wall of the upper gastric corpus and irregular mucosa in the lower esophagus incidentally. Biopsy showed squamous cell carcinoma from both lesions, leading to the diagnosis of pancreatic adenosquamous carcinoma and early esophageal cancer...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Takashi Katsumori, Hisami Ohshima, Hiromitsu Hamaguchi, Shinichi Yamamoto, Yukika Tsukamoto, Tomohiro Iwanaga, Susumu Ohkawara
A 70s male was referred to our hospital with anemia that was detected during a medical checkup. Upper gastrointestinal endoscopy showed advanced cardia gastric cancer. A diagnosis of pernicious anemia was made due to the macrocytic hyperchromic anemia and detection of intrinsic factor antibody. A CT scan showed fundic wall thickening and regional lymph node metastasis. After anemia improved following vitamin B12 injection, total gastrectomy with lymphadenectomy was performed. The histopathological findings showed adenocarcinoma(tub1>tub2), Type2 , pT3(SS), pN1(2/24), Stage ⅡB, INF b, ly1, v2, PM0, DM0, EW(+), pR1...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Takashi Ajiki, Junichiro Yamauchi, Keiichi Shirasaki, Shota Fujita, Mamoru Sato, Tomoya Ikeda, Tomoya Miura, Katsuo Tsuchihara
Case 1: A 52-year-old man underwent laparoscopic total gastrectomy for gastric cancer. After 2 years, a follow-up computed tomography(CT)scan showed a large, solid 10 cm-sized mass in his left upper abdomen. Under the diagnosis of a suspected mesenchymal tumor, a tumor resection with a partial resection of the upper jejunum and transverse colon was performed. Case 2: A 61-year-old man underwent laparoscopic pylorus-preserving gastrectomy for gastric cancer. After 1.5 years, follow-up CT showed a tumor of 2 cm in diameter near the greater curvature side of the upper stomach...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Kojiro Ono, Takuo Takehana, Kazuhiro Yamamoto, Shunsuke Kawai, Michitaka Nagase
A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Contrast computed tomography(CT)showed upper gastric wall thickening, and #1, #3, #7, #8a, and #11p enlarged lymph nodes but no distant metastasis. We diagnosed gastric cancer, UM, Less, Type 3, gastric neuroendocrine carcinoma, cT4aN3M0P0CY0, Stage ⅢC...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Jessica M Molkentine, Tara N Fujimoto, Thomas D Horvath, Aaron J Grossberg, Carolina J Garcia Garcia, Amit Deorukhkar, Marimar de la Cruz Bonilla, Daniel Lin, Errol L G Samuel, Wai Kin Chan, Philip L Lorenzi, Helen Piwnica-Worms, Robert Dantzer, James M Tour, Kathryn A Mason, Cullen M Taniguchi
Unresectable pancreatic cancer is almost universally lethal because chemotherapy and radiation cannot completely stop the growth of the cancer. The major problem with using radiation to approximate surgery in unresectable disease is that the radiation dose required to ablate pancreatic cancer exceeds the tolerance of the nearby duodenum. WR-2721, also known as amifostine, is a well-known radioprotector, but has significant clinical toxicities when given systemically. WR-2721 is a prodrug and is converted to its active metabolite, WR-1065, by alkaline phosphatases in normal tissues...
February 13, 2019: Scientific Reports
Benjamin Walter, Simone Schmidbaur, Yannick Krieger, Alexander Meining
Background  En-bloc resection of large, flat lesions or early stages of cancer is challenging. No bimanual tasks are possible using standard endoscopes. Dual-channel endoscopes are not available everywhere and have a small distance between the channels. Patients and methods  A new external additional working channel (AWC) (Ovesco, Tuebingen, Germany) was designed and developed potentially enabling bimanual tasks. Fixed to the tip of a standard gastroscope or pediatric colonoscope, a second endoscopic tool can be inserted through the AWC and used for tissue retraction during endoscopic resection...
February 2019: Endoscopy International Open
L A D Busweiler, M Jeremiasen, B P L Wijnhoven, M Lindblad, L Lundell, C J H van de Velde, R A E M Tollenaar, M W J M Wouters, J W van Sandick, J Johansson, J L Dikken
Background: Benchmarking on an international level might lead to improved outcomes at a national level. The aim of this study was to compare treatment and surgical outcome data from the Swedish National Register for Oesophageal and Gastric Cancer (NREV) and the Dutch Upper Gastrointestinal Cancer Audit (DUCA). Methods: All patients with primary oesophageal or gastric cancer who underwent a resection and were registered in NREV or DUCA between 2012 and 2014 were included...
February 2019: BJS open
Germán Calderillo-Ruiz, Roberto Herrera-Goepfert, Marytere Herrera Martínez, Elizabeth Trejo Durán, Berenice Carbajal-López
Gastric squamous cell carcinoma (SCC) is a rare type of cancer. We report three patients with the tumor. A 65 years old male presenting with weight los and heartburn. An upper gastrointestinal endoscopy revealed an ulcerated tumor whose biopsy disclosed a gastric epidermoid carcinoma. The patient was operated and chemotherapy was attempted, but he died five months later. A 39 years old male with an antral tumor corresponding to an epidermoid carcinoma. He was operated and received chemotherapy and radiotherapy and died one year later...
December 2018: Revista Médica de Chile
Philipp Jurmeister, Anne Schöler, Alexander Arnold, Frederick Klauschen, Dido Lenze, Michael Hummel, Leonille Schweizer, Hendrik Bläker, Berit Maria Pfitzner, Soulafa Mamlouk, Christine Sers, Carsten Denkert, Damian Stichel, Nikolaj Frost, David Horst, Maximilian von Laffert, David Capper
Pulmonary enteric adenocarcinoma is a rare non-small cell lung cancer subtype. It is poorly characterized and cannot be distinguished from metastatic colorectal or upper gastrointestinal adenocarcinomas by means of routine pathological methods. As DNA methylation patterns are known to be highly tissue specific, we aimed to develop a methylation-based algorithm to differentiate these entities. To this end, genome-wide methylation profiles of 600 primary pulmonary, colorectal, and upper gastrointestinal adenocarcinomas obtained from The Cancer Genome Atlas and the Gene Expression Omnibus database were used as a reference cohort to train a machine learning algorithm...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
David See, Brian Le, Alexandra Gorelik, Peter Eastman
BACKGROUND: There is increasing recognition that patients with non-malignant diseases have comparable physical and psychosocial symptom burden to patients with cancer. There is currently limited data directly comparing symptom burden between these patient groups. OBJECTIVE: To investigate differences in symptom burden between patients with malignant and non-malignant conditions admitted to a palliative care unit (PCU). METHOD: A cross-sectional study involving 186 patients admitted to a PCU was undertaken...
February 4, 2019: BMJ Supportive & Palliative Care
Daniela Oliveira, Cheryl Latimer, Pier Parpot, Chris I R Gill, Rui Oliveira
PURPOSE: The recognized biological properties of Ginkgo biloba extracts potentiate their utilization as an ingredient for functional foods. However, the digestive conditions can affect the chemical composition of the extracts and consequently their biological properties, which can lead to food safety problems. Thus, the impact of in vitro-simulated upper gastrointestinal tract digestion on the chemical composition and bioactivity of Ginkgo biloba leaf extract (GBE) was evaluated. METHODS: Physicochemical conditions of human digestion were simulated in vitro, and its impact on the chemical composition of GBE was investigated by electrospray ionization-mass spectrometry...
February 5, 2019: European Journal of Nutrition
Loretta J Nastoupil, Matthew A Lunning, Julie M Vose, Marshall T Schreeder, Tanya Siddiqi, Christopher R Flowers, Jonathon B Cohen, Jan A Burger, William G Wierda, Susan O'Brien, Peter Sportelli, Hari P Miskin, Michelle A Purdom, Michael S Weiss, Nathan H Fowler
BACKGROUND: Therapeutic approaches for B-cell malignancies continue to evolve, especially with regard to combination approaches. We assessed the safety and efficacy of the triplet ublituximab, umbralisib, and ibrutinib in patients with advanced B-cell malignancies. METHODS: We did an open-label, phase 1 study with dose-escalation and dose-expansion phases, at five centres in the USA. Eligible patients were aged 18 years or older with histologically confirmed lymphocytic leukaemia or relapsed or refractory B-cell non-Hodgkin lymphoma, had measurable disease, adequate organ function, and an Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less...
February 2019: Lancet Haematology
Rohan Fuladi, Rajnish Nagarkar, Sirshendu Roy
BACKGROUND Anaplastic thyroid carcinoma (ATC) is an uncommon and aggressive form of human cancer. Despite advancement in multimodal therapy for patients with ATC, the prognosis remains poor. Most patients presenting with ATC have metastasis to the lungs and regional lymph nodes. Gastrointestinal tract metastasis is a rare entity observed among patients with ATC. We report a case of ATC with gastrointestinal metastasis. CASE REPORT A 72-year-old euthyroid female with hypertension presented to the clinic with swelling of the neck and breathlessness...
February 1, 2019: American Journal of Case Reports
Yankang Feng, Ming Cui, Yun He, Xilong Zhao
OBJECTIVE: To establish a modified endoscopic Freka Trelumina placement (mEFTP) for modifying or substituting the traditional endoscopic Freka Trelumina placement (EFTP) and to explore the safety and feasibility of mEFTP in patients requiring enteral nutrition and gastrointestinal decompression in general surgery. METHODS: A retrospective cohort study was conducted to analyze the clinical data of patients undergoing EFTP or mEFTP at General Surgery Department of 920 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from January 2016 to January 2018...
January 25, 2019: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Mina E Adam, Matyas Fehervari, Piers R Boshier, Sung-Tong Chin, Geng-Ping Lin, Andrea Romano, Sacheen Kumar, George B Hanna
A non-invasive breath test has the potential to improve survival from oesophagogastric cancer by facilitating earlier detection. This study aimed to investigate production of target volatile fatty acids (VFAs) in oesophagogastric cancer through analysis of ex vivo headspace above un-derivatised tissues and in vivo analysis within defined anatomical compartments including mixed breath, isolated bronchial breath and gastric endoluminal air. VFAs were measured by PTR-ToF-MS and GC-MS. Levels of VFAs (acetic-, butyric-, pentanoic- and hexanoic-acid) and acetone were elevated in ex-vivo experiments in the headspace above oesophagogastric cancer compared to samples from control subjects with morphologically normal and benign conditions of the upper gastrointestinal tract...
January 30, 2019: Analytical Chemistry
Yoshinori Kajiwara, Katsuyuki Aoyama, Yu Mikane, Ryohei Shoji, Megumi Watanabe, Tomohiro Nogami, Hitoshi Nishikawa, Susumu Shinoura, Kaori Shigemitsu, Yasuyuki Nonaka, Dofu Hayashi, Naohiko Tokuda, Takayoshi Miyake
A 71-year-old man visited our hospital because ofepigastralgia and anorexia. Upper gastrointestinal endoscopy revealed type 1 gastric cancer. Contrast-enhanced abdominal CT revealed gastric wall thickening in the midgastric region and direct invasion ofthe transverse colon. CT findings also revealed a suspicion ofdissemination on the omentum and para-aortic lymph node swelling. We diagnosed gastric cancer with transverse colon invasion. Therefore, we performed distal gastrectomy with transverse colectomy and D2+No...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Kaoru Fukuyama, Atsushi Takeno, Kohei Murakami, Kenji Kawai, Takuya Sakamoto, Junichi Inatome, Atsushi Naito, Yoshiteru Katsura, Yoshiaki Ohmura, Yoshinori Kagawa, Toru Masuzawa, Chiyomi Egawa, Yutaka Takeda, Kohei Murata
A 78-year-old man complained of dysphagia. Gastrointestinal endoscopy showed a Type 2 tumor in the lower esophagus and a Type 0-Ⅱa lesion in the posterior wall of the upper gastric body. An enhanced CT scan showed several swollen abdominal and cervical lymph nodes as well as bilateral lung multiple nodules, suggesting distant metastasis. We diagnosed the patient with double cancers consisting of an unresectable advanced esophageal squamous cell carcinoma with multiple lymph nodes and lung metastases(Lt, cT3N4M1, cStage Ⅳb)and early gastric cancer(U, post, cType 0-Ⅱa, cT1N0M0, cStageⅠ)...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Hideyuki Yokokawa, Kentaro Yamaguchi, Tomoko Mizuguchi, Yukio Shimojima, Miki Miyazawa, Shinichi Asaka, Takefumi Usui, Hajime Yokomizo, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
We report a case of sigmoid colon cancer that was incidentally found using CT that was performed for upper abdominal pain. An 83-year-old man with a long history of lung tuberculosis and idiopathic pulmonary fibrosis presented with upper abdominal pain. CT findings revealed free gas around the stomach. He was diagnosed with upper gastrointestinal perforation and his condition improved after undergoing conservative treatment. Upper endoscopy revealed an irregular ulcer at the angular incisure of the stomach with thickened folds, but biopsy resulted in a Group 1 classification...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Shigeta Hagino, Takashi Fujimura, Toru Kurata, Yasuhiro Shoji, Shozo Sasaki, Itsuro Terada, Akemi Yoshikawa, Hirohisa Kitagawa, Ryohei Izumi, Katsuhiko Saito
We encountered a case of type 4 gastric cancer with esophageal invasion that responded to neoadjuvant chemotherapy containing S-1 and oxaliplatin(SOX)followed by surgery, which could be curative resection. A 46-year-old man was referred to our hospital because of abnormal upper gastrointestinal series findings. He was diagnosed with type 4 advanced gastric cancer with esophageal invasion, cT4b(diaphragm)N2M0, Stage ⅢC, and 3 courses of neoadjuvant SOX therapy were administered. Adverse events were minor. After NAC, the primary lesion and lymph nodes showed marked reductions on CT; total gastrectomy and subtotal thoracic esophagectomy were performed...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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