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https://read.qxmd.com/read/30877754/pzr-promotes-metastasis-of-colorectal-cancer-through-increasing-fak-and-src-phosphorylation
#1
Dan Tan, Wenpeng Zhang, Yu Tao, Yesseyeva Galiya, Mingliang Wang
Metastasis is the main cause of death in patients with colorectal cancer (CRC), but the molecular mechanism is not yet fully understood. Previous studies have shown that P zero-related protein (PZR), a member of the immunoglobulin family, can promote fibronectin-dependent migration of mouse embryonic fibroblasts as well as invasion and metastasis of hepatic carcinoma cells. However, the role of PZR in CRC remains unclear. In this study, we determined the ectopic expression of PZR in CRC tissues, and results showed that PZR expression was increased not only in tumors with higher pathological stage, but also in tumors with distant metastasis...
March 16, 2019: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/30877623/leptin-induced-signaling-pathways-in-cancer-cell-migration-and-invasion
#2
REVIEW
Ahmad Ghasemi, Jafar Saeidi, Mohsen Azimi-Nejad, Seyed Isaac Hashemy
BACKGROUND: Increasing evidence indicates that obesity is associated with tumor development and progression. Leptin is an adipocyte-related hormone with a key role in energy metabolism and whose circulating levels are elevated in obesity. The effect of leptin on cancer progression and metastasis and its underlying mechanisms are still unclear. Leptin can impact various steps in tumor metastasis, including epithelial-mesenchymal transition, cell adhesion to the extracellular matrix (ECM), and proteolysis of ECM components...
March 15, 2019: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/30877498/diagnostic-accuracy-and-usefulness-of-intraoperative-margin-assessment-by-frozen-section-in-gastric-cancer
#3
Koki Nakanishi, Shinji Morita, Hirokazu Taniguchi, Sho Otsuki, Takeo Fukagawa, Hitoshi Katai
BACKGROUND: Intraoperative frozen examination is clinically important for negative margin confirmation in cancer surgery. We investigated the diagnostic accuracy of frozen-section assessment and risk factors for positive resection margins by studying gastric cancer specimens from 1115 patients treated at our hospital. METHODS: The results of gastric cancer patients who had undergone intraoperative margin assessment, employing frozen examination, with curative intent in our unit between 2000 and 2017 were retrospectively analyzed...
March 14, 2019: Annals of Surgical Oncology
https://read.qxmd.com/read/30877475/fluorescence-imaging-of-meningioma-cells-with-somatostatin-receptor-ligands-an-in-vitro-study
#4
Stefan Linsler, Ralf Ketter, Joachim Oertel, Steffi Urbschat
BACKGROUND: The use of five-aminolevulinic acid (5-ALA) in the staining of malignant glioma cells has significantly improved intraoperative radicality in the resection of gliomas in the last decade. Currently, there is no comparable selective fluorescent substance available for meningiomas. There is however a demand for intraoperative fluorescent identification of, e.g., invasive skull base meningiomas to help improve safe radical resection. Meningiomas show high expression of the somatostatin receptor type 2, offering the possibility of receptor-targeted imaging...
March 15, 2019: Acta Neurochirurgica
https://read.qxmd.com/read/30877471/cerebral-metastases-do-size-peritumoral-edema-or-multiplicity-predict-infiltration-into-brain-parenchyma
#5
Ingo Fiss, Abdelhalim Hussein, Alonso Barrantes-Freer, Swetlana Sperling, Silvia Hernandez-Duran, Christina Wolfert, Tobias Pukrop, Milena Ninkovic, Annalen Bleckmann, Veit Rohde, Dorothee Mielke, Bawarjan Schatlo
BACKGROUND: Brain metastases (BMs) are the most frequent malignancy of the central nervous system. Previous research suggested that some metastases show infiltrative behavior rather than sharp demarcation. We hypothesized that three magnetic resonance (MR) imaging parameters-(a) tumor size, (b) extent of peritumoral edema, and (c) presence of multiple BMs-are predictors of cellular invasion beyond the surgically identifiable tumor margins. METHODS: We performed a post hoc analysis on prospectively collected data of patients with BMs...
March 15, 2019: Acta Neurochirurgica
https://read.qxmd.com/read/30877465/ivim-improves-preoperative-assessment-of-microvascular-invasion-in-hcc
#6
Yi Wei, Zixing Huang, Hehan Tang, Liping Deng, Yuan Yuan, Jiaxing Li, Dongbo Wu, Xiaocheng Wei, Bin Song
PURPOSE: To prospectively evaluate the potential role of intravoxel incoherent motion (IVIM) and conventional radiologic features for preoperative prediction of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). METHODS: Institutional review board approval and written informed consent were obtained for this study. A cohort comprising 115 patients with 135 newly diagnosed HCCs between January 2016 and April 2017 were evaluated. Two radiologists independently reviewed the radiologic features and the apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*), and pseudodiffusion component fraction (f) were also measured...
March 15, 2019: European Radiology
https://read.qxmd.com/read/30877339/review-of-paraneoplastic-syndromes-in-children
#7
REVIEW
Grace My Ma, Jeanne S Chow, George A Taylor
Paraneoplastic syndromes are defined as clinical syndromes that are not related to direct tumor invasion or compression but are secondary to tumor secretion of functional peptides/hormones or related to immune cross-reactivity with normal host tissue. Paraneoplastic syndromes have a wide range of presentations and can present before the primary malignancy or tumor recurrence is diagnosed. They can mimic non-neoplastic processes, making detection, diagnosis and treatment difficult. However, they can also provide clues to the presence of an underlying malignancy...
March 16, 2019: Pediatric Radiology
https://read.qxmd.com/read/30877181/a-dual-modality-linker-enables-site-specific-conjugation-of-antibody-fragments-for-18-f-immunopet-and-fluorescence-imaging
#8
Kirstin A Zettlitz, Christopher M Waldmann, Wen-Ting K Tsai, Richard Tavaré, Jeffrey Collins, Jennifer M Murphy, Anna M Wu
Rationale: Antibody-based dual-modality (PET/fluorescence) imaging enables both pre-surgery antigen-specific immunoPET for non-invasive whole-body evaluation and intra-operative fluorescence for visualization of superficial tissue layers for image guided surgery. Methods: We developed a universal dual-modality linker (DML) that facilitates 1) site-specific conjugation to a cysteine residue bearing antibody fragment; 2) introduction of a commercially available fluorescent dye (via amine-reactive prosthetic group); 3) rapid and efficient radiolabeling via click chemistry with 18 F-labeled trans-cyclooctene (18 F-TCO)...
March 15, 2019: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://read.qxmd.com/read/30877107/mri-imaging-of-the-hemodynamic-vasculature-of-neuroblastoma-predicts-response-to-anti-angiogenic-treatment
#9
Konstantinos Zormpas-Petridis, Neil P Jerome, Matthew David Blackledge, Fernando Carceller, Evon Poon, Matthew Clarke, Ciara M McErlean, Giuseppe Barone, Alexander Koers, Sucheta J Vaidya, Lynley V Marshall, Andrew D J Pearson, Lucas Moreno, John Anderson, Neil Sebire, Kieran McHugh, Dow-Mu Koh, Yinyin Yuan, Louis Chesler, Simon P Robinson, Yann Jamin
Childhood neuroblastoma is a hypervascular tumor of neural origin for which antiangiogenic drugs are currently being evaluated; however, predictive biomarkers of treatment response, crucial for successful delivery of precision therapeutics, are lacking. We describe a MRI-pathological cross-correlative approach using intrinsic susceptibility (IS-) and susceptibility contrast (SC-) MRI to non-invasively map the vascular phenotype in neuroblastoma Th-MYCN transgenic mice treated with the vascular endothelial growth factor receptor inhibitor cediranib...
March 15, 2019: Cancer Research
https://read.qxmd.com/read/30877104/aqp4-aggregation-state-is-a-determinant-for-glioma-cell-fate
#10
Laura Simone, Francesco Pisani, Maria Grazia Mola, Manuela De Bellis, Giuseppe Merla, Lucia Micale, Antonio Frigeri, Angelo Luigi Vescovi, Maria Svelto, Grazia P Nicchia
The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms. The isoform ratio controls AQP4 aggregation into supramolecular structures called orthogonal arrays of particles (AQP4-OAP). The role of AQP4 aggregation into OAP in malignant gliomas is still unclear. In this study, we demonstrate that AQP4 aggregation/disaggregation into OAP influences the biology of glioma cells. Selective expression of the OAP-forming isoform M23-AQP4 (AQP4-OAP) triggered cell shape changes in glioma cells associated with alterations to the F-actin cytoskeleton that affected apoptosis...
March 15, 2019: Cancer Research
https://read.qxmd.com/read/30877012/endoscopic-keyhole-retromastoid-approach-in-neurosurgical-practice-ant-man-s-view-of-the-neurosurgical-marvel
#11
Abhijit Parab, Deepak Khatri, Suyash Singh, Jaskaran S Gosal, Harsh Deora, Kuntal Kanti Das, Dr Pawan Verma, Anant Mehrotra, Arun Kumar Srivastava, Sanjay Behari, Sushila Jasiwal, Awadhesh K Jaiswal
BACKGROUND: Endoscopy is now a staple of any neurosurgical practice. The versatility of this approach and gratifying results has resulted in its increased popularity. AIMS AND OBJECTIVES: To report our experience of managing various cerebello-pontine angle (CPA) pathologies by endoscopic keyhole retro-mastoid sub-occipital (RMSO) approach. MATERIAL AND METHODS: A retrospective review of the medical records of patients operated in our department by endoscopic keyhole RMSO approach was done along with a collection of relevant patient particulars...
March 12, 2019: World Neurosurgery
https://read.qxmd.com/read/30876945/radiomic-analysis-of-contrast-enhanced-ct-predicts-microvascular-invasion-and-outcome-in-hepatocellular-carcinoma
#12
Xun Xu, Hai-Long Zhang, Qiu-Ping Liu, Shu-Wen Sun, Jing Zhang, Fei-Peng Zhu, Guang Yang, Xu Yan, Yu-Dong Zhang, Xi-Sheng Liu
BACKGROUND & AIMS: Microvascular invasion (MVI) impairs surgical outcomes in hepatocellular carcinoma (HCC) patients. As a single highly reliable factor to preoperatively predict MVI is lacking, we developed a computational approach integrating large-scale clinical and imaging modalities, especially radiomic features from contrast-enhanced CT, to predict MVI and clinical outcomes in HCC patients. METHODS: In total, 495 surgically resected patients were retrospectively included...
March 12, 2019: Journal of Hepatology
https://read.qxmd.com/read/30876939/microrna-424-5p-acts-as-a-potential-biomarker-and-inhibits-proliferation-and-invasion-in-hepatocellular-carcinoma-by-targeting-trim29
#13
Huimin Du, Qing Xu, Sheng Xiao, Zhenru Wu, Jianping Gong, Changan Liu, Guosheng Ren, Hao Wu
BACKGROUND: miRNA-424-5p (miR-424-5p) has been implicated in the development and progression of various tumors. However, the functional mechanisms of miR-424-5p in hepatocellular carcinoma (HCC) are unclear. In this study, we investigated the specific biological functions of miRNA in HCC. METHODS: The expression of miR-424-5p was measured by qRT-PCR in HCC tissues and cell lines. Western blot and immunohistochemistry were used to detect the protein expression level of TRIM29...
March 12, 2019: Life Sciences
https://read.qxmd.com/read/30876934/retrospective-review-of-a-venous-sparing-approach-to-resection-of-parasagittal-meningiomas
#14
Stephan A Munich, Daniel Eddelman, Richard W Byrne
Parasagittal meningiomas make up 20-30% of intracranial meningiomas. Their proximity to, and often invasion of, the superior sagittal sinus (SSS) may preclude complete surgical resection. Repair and reconstruction of the SSS in pursuit of Simpson grade I resection is associated with increased morbidity. We retrospectively reviewed 76 parasagittal meningiomas. Our surgical technique emphasized preservation of bridging cortical veins and the SSS. In cases where the SSS was already occluded by tumor, this portion of the sinus and adjacent falx were resected...
March 12, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/30876788/radiological-features-and-outcomes-of-combined-hepatocellular-cholangiocarcinoma-in-patients-undergoing-surgical-resection
#15
Chen-Ta Chi, Gar-Yang Chau, Rheun-Chuan Lee, Yen-Ying Chen, Hao-Jan Lei, Ming-Chih Hou, Yee Chao, Yi-Hsiang Huang
BACKGROUND/PURPOSE: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer. Preoperative diagnosis of cHCC-CCA is difficult, and outcome of cHCC-CCA is obscured. Our study aimed to investigate the clinicopathological and radiological features of cHCC-CCA and compare their outcomes with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). METHODS: From August 2010 to December 2017, 891 patients undergoing liver tumor resection in Taipei Veterans General Hospital, including 30 patients with pathology-proven cHCC-CCA, 819 HCC, and 42 ICC were retrospectively reviewed...
March 12, 2019: Journal of the Formosan Medical Association
https://read.qxmd.com/read/30876486/national-trends-outcomes-and-costs-of-radiation-therapy-in-the-management-of-low-and-high-intermediate-risk-endometrial-cancer
#16
Rudy S Suidan, Weiguo He, Charlotte C Sun, Hui Zhao, Grace L Smith, Ann H Klopp, Nicole D Fleming, Karen H Lu, Sharon H Giordano, Larissa A Meyer
OBJECTIVE: To assess treatment patterns, outcomes, and costs for women with low-(LIR) and high-intermediate risk endometrial cancer (HIR) who are treated with and without adjuvant radiotherapy. METHODS: All patients with stage I endometrioid endometrial cancer who underwent surgery from 2000 to 2011 were identified from the SEER-Medicare database. LIR was defined as G1-2 tumors with <50% myometrial invasion or G3 with no invasion. HIR was defined as G1-2 tumors with ≥50% or G3 with <50% invasion...
March 2019: Gynecologic Oncology
https://read.qxmd.com/read/30876473/nomogram-based-on-homogeneous-and-heterogeneous-associated-factors-for-predicting-bone-metastases-in-patients-with-different-histological-types-of-lung-cancer
#17
Chao Zhang, Min Mao, Xu Guo, Ping Cui, Lianmin Zhang, Yao Xu, Lili Li, Xiuxin Han, Karl Peltzer, Shunbin Xiong, Vladimir P Baklaushev, Xin Wang, Guowen Wang
BACKGROUND: The purpose of the present study was to characterize the prevalence, associated factors, and to construct a nomogram for predicting bone metastasis (BM) with different histological types of lung cancer. PATIENTS AND METHODS: This study was a descriptive study that basing on the invasive lung cancer patients diagnosed between 2010 and 2014 in Surveillance, Epidemiology, and End Results program. A total of 125,652 adult patients were retrieved. Logistic regression analysis was conducted to investigate homogeneous and heterogeneous factors for BM occurrence...
March 15, 2019: BMC Cancer
https://read.qxmd.com/read/30876468/stromal-integrin-%C3%AE-11-deficiency-reduces-interstitial-fluid-pressure-and-perturbs-collagen-structure-in-triple-negative-breast-xenograft-tumors
#18
Hilde Ytre-Hauge Smeland, Ning Lu, Tine V Karlsen, Gerd Salvesen, Rolf K Reed, Linda Stuhr
BACKGROUND: Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the interstitial fluid pressure (PIF) in most solid tumors. An increased tumor PIF is a barrier to the transport of interstitial fluid into and within the tumor. Therefore, understanding the mechanisms that regulate pressure homeostasis can lead to new insight into breast tumor progression, invasion and response to therapy...
March 15, 2019: BMC Cancer
https://read.qxmd.com/read/30876464/tm4sf1-is-a-potential-target-for-anti-invasion-and-metastasis-in-ovarian-cancer
#19
Caiyun Gao, Hongyu Yao, Huimin Liu, Yanying Feng, Zhijun Yang
BACKGROUND: Patients with ovarian cancer commonly have a poor prognosis, owing to its invasiveness and distant metastasis. Studies have found TM4SF1 participates in regulating tumor cell invasion and migration. Therefore, it is expected to become a target for anti-invasion and metastasis in ovarian cancer. METHODS: The expression of TM4SF1 in normal ovarian epithelial tissues, benign ovarian tumor tissues, primary foci of epithelial ovarian cancer and the matched lymph mode metastatic foci was detected using immunohistochemistry to analyze its association with prognosis...
March 15, 2019: BMC Cancer
https://read.qxmd.com/read/30875975/synergistic-action-of-gefitinib-and-gsk41364a-simultaneously-loaded-in-ratiometrically-engineered-polymeric-nanoparticles-for-glioblastoma-multiforme
#20
Praveena Velpurisiva, Prakash Rai
Glioblastoma Multiforme is a deadly cancer of glial cells with very low survival rates. Current treatment options are invasive and have serious side effects. Single drug treatments make the tumor refractory after a certain period. Combination therapies have shown improvements in treatment responses against aggressive forms of cancer and are becoming a mainstay in the management of cancer. The purpose of this study is to design a combinatorial treatment regimen by engineering desired ratios of two different small molecule drugs (gefitinib and GSK461364A) in a single carrier that can reduce off-target effects and increase their bioavailability...
March 15, 2019: Journal of Clinical Medicine
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