Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Yuwen Tian, Tunyu Jian, Jin Li, Lushi Huang, Shen Li, Hao Lu, Guanting Niu, Xiuhua Meng, Bingru Ren, Huarong Liao, Xiaoqin Ding, Jian Chen
BACKGROUND: Inflammatory bowel disease (IBD) is a type of immune-mediated condition associated with intestinal homeostasis. Our preliminary studies disclosed that Cichorium intybus L., a traditional medicinal plant, also known as Chicory in Western countries, contained substantial phenolic acids displaying significant anti-inflammatory activities. We recognized the potential of harnessing Chicory for the treatment of IBD, prompting a need for in-depth investigation into the underlying mechanisms...
January 18, 2024: Phytomedicine
#2
JOURNAL ARTICLE
Xin Liu, Xiaoyu Guo, Xiaomin Su, Bingru Ji, Yawei Chang, Qichao Huang, Yuan Zhang, Xiaobing Wang, Pan Wang
The colonizing microbiota on the body surface play a crucial role in barrier function. Staphylococcus aureus ( S. aureus ) is a significant contributor to skin infection, and the utilization of colonization resistance of skin commensal microorganisms to counteract the invasion of pathogens is a viable approach. However, most studies on colonization resistance have focused on skin bacteria, with limited research on the resistance of skin fungal communities to pathogenic bacteria. Extracellular vehicles (EVs) play an important role in the colonization of microbial niches and the interaction between distinct strains...
January 31, 2024: ACS Infectious Diseases
#3
JOURNAL ARTICLE
Jinyan Teng, Yahui Gao, Hongwei Yin, Zhonghao Bai, Shuli Liu, Haonan Zeng, Lijing Bai, Zexi Cai, Bingru Zhao, Xiujin Li, Zhiting Xu, Qing Lin, Zhangyuan Pan, Wenjing Yang, Xiaoshan Yu, Dailu Guan, Yali Hou, Brittney N Keel, Gary A Rohrer, Amanda K Lindholm-Perry, William T Oliver, Maria Ballester, Daniel Crespo-Piazuelo, Raquel Quintanilla, Oriol Canela-Xandri, Konrad Rawlik, Charley Xia, Yuelin Yao, Qianyi Zhao, Wenye Yao, Liu Yang, Houcheng Li, Huicong Zhang, Wang Liao, Tianshuo Chen, Peter Karlskov-Mortensen, Merete Fredholm, Marcel Amills, Alex Clop, Elisabetta Giuffra, Jun Wu, Xiaodian Cai, Shuqi Diao, Xiangchun Pan, Chen Wei, Jinghui Li, Hao Cheng, Sheng Wang, Guosheng Su, Goutam Sahana, Mogens Sandø Lund, Jack C M Dekkers, Luke Kramer, Christopher K Tuggle, Ryan Corbett, Martien A M Groenen, Ole Madsen, Marta Gòdia, Dominique Rocha, Mathieu Charles, Cong-Jun Li, Hubert Pausch, Xiaoxiang Hu, Laurent Frantz, Yonglun Luo, Lin Lin, Zhongyin Zhou, Zhe Zhang, Zitao Chen, Leilei Cui, Ruidong Xiang, Xia Shen, Pinghua Li, Ruihua Huang, Guoqing Tang, Mingzhou Li, Yunxiang Zhao, Guoqiang Yi, Zhonglin Tang, Jicai Jiang, Fuping Zhao, Xiaolong Yuan, Xiaohong Liu, Yaosheng Chen, Xuewen Xu, Shuhong Zhao, Pengju Zhao, Chris Haley, Huaijun Zhou, Qishan Wang, Yuchun Pan, Xiangdong Ding, Li Ma, Jiaqi Li, Pau Navarro, Qin Zhang, Bingjie Li, Albert Tenesa, Kui Li, George E Liu, Zhe Zhang, Lingzhao Fang
The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues...
January 2024: Nature Genetics
#4
JOURNAL ARTICLE
William Errickson, Bingru Huang
Rhizobacteria that produce 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase (ACCd) that inhibits ethylene production may mitigate stress damages. The objectives of this study were to examine whether a novel strain of ACCd-producing bacteria, Paraburkholderia aspalathi "WSF23," promotes plant tolerance to drought stress and post-stress recovery and determine changes in metabolic profiles in leaves and roots associated with the positive ACCd-bacteria effects in cool-season perennial grass species. Creeping bentgrass (Agrostis Stolonifera L...
2023: Physiologia Plantarum
#5
JOURNAL ARTICLE
Xiaoqin Ding, Yuwen Tian, Lushi Huang, Yanan Gai, Han Lyu, Mimi Li, Bingru Ren, Yan Liu, Weilin Li, Xiuhua Meng, Jian Chen
Type 2 diabetes mellitus (T2DM) has been the most prevalent disease and has become a serious public health threat worldwide. Gynura bicolor (Willd.) DC. (GB) contains a variety of nutrients and possesses numerous activities, which might benefit those with diabetes. The current study aimed to confirm the improvement of metabolic disorders and explore the potential mechanism of GB in high fat diet-fed (HFD) and streptozotocin (STZ)-induced T2DM mice. The aboveground sample of GB was extracted with alcohol, and identified by highperformance liquid chromatography (HPLC) and liquid chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) analysis...
November 30, 2023: Journal of Pharmaceutical and Biomedical Analysis
#6
JOURNAL ARTICLE
Bingru Huang, Haidong Yan, Min Sun, Yarong Jin
Global warming adversely affects crop production worldwide. Massive efforts have been undertaken to study mechanisms regulating heat tolerance in plants. However, the roles of structural variations (SVs) in heat stress tolerance remain unclear. In a recent article, Yan et al. (Nat Genet 1-12, 2023) constructed the first pan-genome of pearl millet (Pennisetum glaucum) and identified key SVs linked to genes involved in regulating plant tolerance to heat stress for an important crop with a superior ability to thrive in extremely hot and arid climates...
May 15, 2023: Stress Biol
#7
JOURNAL ARTICLE
Bingru Nan, Xia Sun, Shijing Yang, Qingyu Huang, Heqing Shen
Chronic exposure to very low ambient PM2.5 has been linked to cardiovascular risks in epidemiological observation, which also brought doubts on its safety threshold. In this study, we approached this question by chronic exposure of AC16 to the non-observable acute effect level (NOAEL) PM2.5 5 μg/mL and its positive reference 50 μg/mL, respectively. The doses were respectively defined on the cell viabilities >95% (p = 0.354) and >90% (p = 0.004) when treated acutely (24 h)...
June 5, 2023: Journal of Applied Toxicology: JAT
#8
JOURNAL ARTICLE
Tian Chen, Qibing Chen, Fen Li, Manli Zeng, Bingru Wang, Shiyong Huang, Shiming Chen, Zezhang Tao
Objectives: We investigated the effects of macrophage migration inhibitory factor (MIF) knockdown or overexpression combined with ultraviolet radiation B (UVB) irradiation on cell proliferation and apoptosis of oral squamous cell carcinoma (OSCC). Methods: MIF expression in OSCC and adjacent tissues was detected by immunohistochemistry. MIF expression in human immortalized oral epithelial cells (HIOEC) and OSCC cells was detected by western blotting. MIF was knocked down or overexpressed in OSCC cell lines (SCC-25 and CAL-27)...
2023: Technology in Cancer Research & Treatment
#9
JOURNAL ARTICLE
Ying Wan, Elise Slevin, Sachiko Koyama, Chiung-Kuei Huang, Ashok K Shetty, Xuedong Li, Kelly Harrison, Tian Li, Bingru Zhou, Sugeily Ramos Lorenzo, Yudian Zhang, Jennifer Mata Salinas, Wenjuan Xu, James E Klaunig, Chaodong Wu, Hidekazu Tsukamoto, Fanyin Meng
BACKGROUND: Alcohol-associated liver disease (ALD) is a syndrome of progressive inflammatory liver injury and vascular remodeling associated with long-term heavy intake of ethanol. Elevated miR-34a expression, macrophage activation, and liver angiogenesis in ALD and their correlation with the degree of inflammation and fibrosis have been reported. The current study aims to characterize the functional role of miR-34a-regulated macrophage- associated angiogenesis during ALD. METHODS RESULTS: We identified that knockout of miR-34a in 5 weeks of ethanol-fed mice significantly decreased the total liver histopathology score and miR-34a expression, along with the inhibited liver inflammation and angiogenesis by reduced macrophage infiltration and CD31/VEGF-A expression...
April 1, 2023: Hepatology Communications
#10
JOURNAL ARTICLE
Bingru Liu, Xiaoyu Zhao, Ziyin Wang, Huili Liu, Xueshuang Huang, Peng Yang
Tetraena mongolica is an endangered xerophytic shrub with high ecological value for the restoration of desert vegetation because of its high tolerance to drought and heat stress. Here, we generated a high-quality chromosome-level reference genome of T. mongolica by combining PacBio HiFi data and Hi-C sequencing technologies, which was approximately 1.12 Gb (contig N50 of 25.5 Mb) in size and contained 61,888 protein-coding genes; repetitive sequences comprised 44.8% of the genome. This genome of T. mongolica is the first published genome sequence of a member of the order Zygophyllales...
March 31, 2023: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
#11
JOURNAL ARTICLE
Yanfang Guan, Xiaoliang Wang, Qilong Wang, Bingru Kong, Maosen Yuan, Shukai Zhang, Jiangchao Huang, Ran Wang, Zaihui Wu, Zongcai Wang, Yimo Zhao, Wujie Li, Guangyu Liu
Harmful particles such as heavy metal particles in the human body can cause many problems such as kidney stones, gallstones, and cerebrovascular diseases. Therefore, it is critical to separate them from the blood and perform a systematic analysis as early as possible. Here, we apply eutectic gallium indium (EGaIn) microparticles as a model to study the separation of particles from blood, thanks to their properties of low toxicity, excellent degradability, and negligible vapor pressure. In particular, the dielectrophoresis (DEP) separation method is employed to separate EGaIn of different sizes and characteristics in blood...
February 15, 2023: Langmuir: the ACS Journal of Surfaces and Colloids
#12
JOURNAL ARTICLE
Ningli Fan, Qian Xu, Zhimin Yang, Lili Zhuang, Jingjin Yu, Bingru Huang
Expansins are cell-wall loosening proteins involved in plant cell expansion and elongation. Objectives of this study were to identify expansins related to leaf elongation in a perennial grass species and determine the relationship between the expression of expansin genes and leaf elongation. A total of 20 expansin genes were identified in tall fescue (Festuca arundinacea), out of which 9 genes belonged to the EXPA- and 11 to the EXPB subfamily. Two genotypes ('TF007' and 'TF116') with different growth rates were used to determine the correlation between expansins and leaf growth...
January 23, 2023: Physiologia Plantarum
#13
JOURNAL ARTICLE
Ying Wan, Tianhao Zhou, Elise Slevin, Sachiko Koyama, Xuedong Li, Kelly Harrison, Tian Li, Bingru Zhou, Sugeily Ramos Lorenzo, Yudian Zhang, Wenjuan Xu, James E Klaunig, Chaodong Wu, Ashok K Shetty, Chiung-Kuei Huang, Fanyin Meng
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by inflammatory responses and fibrotic scar formation leading to cholestasis. Ductular reaction and liver fibrosis are typical liver changes seen in human PSC and cholestasis patients. The current study aimed to clarify the role of liver-specific microRNA-34a in the cholestasis-associated ductular reaction and liver fibrosis. We demonstrated that miR-34a expression was significantly increased in human PSC livers along with the enhanced ductular reaction, cellular senescence, and liver fibrosis...
February 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
#14
JOURNAL ARTICLE
Junmin He, Xixia Huang, Bingru Zhao, Guifen Liu, Yuezhen Tian, Guoping Zhang, Chen Wei, Jingyi Mao, Kechuan Tian
BACKGROUND: Merino sheep exhibit high wool production and excellent wool quality. The fleece of Merino sheep is predominantly composed of wool fibers grown from hair follicles (HFs). The HF is a complex biological system involved in a dynamic process governed by gene regulation, and gene expression is regulated by microRNAs (miRNAs). miRNA inhibits posttranscriptional gene expression by specifically binding to target messenger RNA (mRNA) and plays an important role in regulating gene expression, the cell cycle and biological development sequences...
October 22, 2022: BMC Genomics
#15
JOURNAL ARTICLE
Shuhan Lei, Bingru Huang
α-Ketoglutarate (AKG) is a key intermediate metabolite in the tricarboxylic acid cycle of respiration and a precursor for glutamate, playing important roles in regulating plant growth and stress tolerance. The objectives of this study were to examine effects of AKG on heat tolerance characterized by leaf senescence in a cool-season grass species by foliar application and to determine major metabolites and associated metabolic pathways regulated by AKG for its effects on heat tolerance. Perennial ryegrass (Lolium perenne L...
November 1, 2022: Plant Physiology and Biochemistry: PPB
#16
JOURNAL ARTICLE
Wei Chen, Bingru Huang
Heat stress is a major abiotic stress for temperate plant species with characteristic symptoms of premature leaf senescence. The objectives of this study were to evaluate the physiological effects of cytokinins (CK) and an ethylene inhibitor, aminoethoxyvinylglycine (AVG) on heat-induced leaf senescence in the temperate perennial grass species, perennial ryegrass (Lolium perenne), and to investigate whether WRKY transcriptional factors (TFs) could be associated with CK- or ethylene-mediated regulation of heat-induced leaf senescence by exogenously applying CK or AVG to perennial ryegrass...
August 20, 2022: Physiologia Plantarum
#17
JOURNAL ARTICLE
Junmin He, Bingru Zhao, Xixia Huang, Xuefeng Fu, Guifen Liu, Yuezhen Tian, Cuiling Wu, Jingyi Mao, Jing Liu, Shuangbao Gun, Kechuan Tian
BACKGROUND: Merino sheep are the most famous fine wool sheep in the world. They have high wool production and excellent wool quality and have attracted worldwide attention. The fleece of the Merino sheep is composed predominantly of wool fibers grown from secondary wool follicles. Therefore, it is necessary to study the development of hair follicles to understand the mechanism of wool production. The hair follicle is a complex biological system involved in a dynamic process governed by gene regulation...
June 8, 2022: BMC Genomics
#18
JOURNAL ARTICLE
Shan Liu, Qingyu Huang, Chen Chen, Yi Song, Xi Zhang, Wei Dong, Wenlou Zhang, Bin Zhao, Bingru Nan, Jie Zhang, Heqing Shen, Xinbiao Guo, Furong Deng
Indoor particulate matter (PM) and black carbon (BC) are associated with adverse cardiopulmonary effect. However, the cumulative and interactive effects of the mixture of size-fractioned PMs and BC on cardiopulmonary function are not well understood, and the underlying biological mechanisms remain unclear. This repeated-measure study was conducted to assess the joint cardiopulmonary effect and metabolic mechanisms of multiple-size particles and BC among 46 children. PM0.5 , PM1 , PM2.5 , PM5 , PM10 and BC were monitored for 5 weekdays...
August 15, 2022: Environmental Pollution
#19
JOURNAL ARTICLE
Xin Guo, Rui Pu, Zhimin Zhu, Shuqian Qiao, Yusen Liang, Bingru Huang, Haichun Liu, Lucía Labrador-Páez, Uliana Kostiv, Pu Zhao, Qiusheng Wu, Jerker Widengren, Qiuqiang Zhan
Stimulated emission depletion (STED) microscopy is a powerful diffraction-unlimited technique for fluorescence imaging. Despite its rapid evolution, STED fundamentally suffers from high-intensity light illumination, sophisticated probe-defined laser schemes, and limited photon budget of the probes. Here, we demonstrate a versatile strategy, stimulated-emission induced excitation depletion (STExD), to deplete the emission of multi-chromatic probes using a single pair of low-power, near-infrared (NIR), continuous-wave (CW) lasers with fixed wavelengths...
May 23, 2022: Nature Communications
#20
JOURNAL ARTICLE
Bingru Nan, Xia Sun, Jie Zhang, Qingyu Huang, Xi Zhang, Yanbo Li, Junchao Duan, Rui Chen, Zhiwei Sun, Heqing Shen
Few studies have reported the accumulation of non-observable acute effect (NOAE) of PM2.5 , especially exposure to the NOAE doses (NOAEDs) of PM2.5 in chronic way. To address this issue, HUVECs were cultured from the 1st to 30th generations (G1 to G30) and treated by the NOAED PM2.5 once every three passages. The generational changes of oxidative damage markers, inflammatory factors, and cell adhesion molecules (CAMs) were monitored in HUVECs at G6, G12, G18, G24, and G30, and proteomes at G18 and G30, respectively...
May 9, 2022: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
