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Filiz Eksi Haydardedeoglu, Gulay Simsek Bagir, Bulent Haydardedeoglu, Emre Bozkirli, Okan Bakiner, Kerem Metin, Melek Eda Ertorer
Betatrophin is defined as a new marker in glucose homeostasis and lipid metabolism. We aimed to investigate the role of serum betatrophin in full-blown polycystic ovary syndrome (PCOS) patients and 47-aged healthy women, 51 full-blown PCOS patients were included in this cross-sectional study. Betatrophin concentrations were significantly lower in PCOS group and displayed a positive correlation only with serum tryglyceride in control group (p < .05). A cutoff level (464.5 ng/L) was determined for betatrophin according to Receiver Operating Characteristic curve...
September 21, 2018: Gynecological Endocrinology
Yu Gao, Ruilian She, Wenqiong Sha
Peroxisome proliferator-activated receptors γ (PPARγ) is a member of nuclear receptor superfamily, and studies have demonstrated that dysregulation of PPARγ was associated with gestational diabetes mellitus (GDM), which is one of the most common metabolic abnormalities occurring during pregnancy. However, the results regarding the associations between PPARγ and GDM were conflicting among different studies. The present study aimed to determine the expression of PPARγ in adipose and placenta from GDM women in a Chinese population and to further explore the role of PPARγ in GDM women...
December 26, 2017: Oncotarget
Murat Dursun, Huseyin Besiroglu, Suleyman Sami Cakir, Alper Otunctemur, Emin Ozbek
OBJECTIVE: Visceral adipose index (VAI) is a novel parameter for the evaluation of visceral obesity. As we know that obesity is a risk factor for erectile dysfunction (ED). So, in this study, we compared the VAI levels between the men with ED and without ED. MATERIALS AND METHOD: A total of 177 men were included in the study. Ninety-five men with ED and 82 men without ED (control). All men were evaluated for ED by Index of Erectile Function-5 items (IIEF-5). VAI levels were calculated using body mass index, high density lipoprotein and tryglyceride levels...
September 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Andres Roman-Urrestarazu, Faleh Mohamed Hussain Ali, Husein Reka, Matthew J Renwick, Gabriela D Roman, Elias Mossialos
AIMS: Understanding type 2 diabetes mellitus is critical for designing effective diabetes prevention policies in Qatar and the Middle East. METHODS: Using the Qatar 2012 WHO STEPwise approach to surveillance survey, a subsample of 1224 Qatari participants aged 18-64 years was selected. Subjects had their fasting blood glucose levels tested, had not been diagnosed with or treated for diabetes, had a fasting time >12 hours and were not pregnant. We applied a hypothesized structural equation model (SEM) to assess sociodemographic, behavioral, anthropometric and metabolic variables affecting persons with type 2 diabetes mellitus...
2016: BMJ Open Diabetes Research & Care
Teresa Balbi, Caterina Ciacci, Elena Grasselli, Arianna Smerilli, Adriana Voci, Laura Canesi
In vertebrate systems, many endocrine disruptors (EDs) can also interfere with energy and lipid metabolism, thus acting as metabolic disruptors. At the cellular level, these effects are mainly mediated by interactions with nuclear receptors/transcription factors, leading to the modulation of genes involved in lipid homeostasis, as well as by rapid, receptor-independent pathways. Several potential metabolic disruptors are found in aquatic environments. In fish, different EDs have been shown to affect hepatic lipid homeostasis both in vivo and in vitro...
January 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
V K Spiridonov, Z S Tolochko, M V Ovcjukova, N E Kostina, T A Obut
The effects of the stimulation of capsaicin-sensitive nerves (capsaicin, 1 mg/kg, s/c) and their eafferentation (capsaicin, 150 mg/kg, s/c) on the blood content of dehydroepiandrosterone sulfate (DHEAS) was investigated in normal rats and rats with fructose-induced metabolic syndrome (12.5% fructose solution, 10 weeks). An increase in blood of tryglyceride, lipid peroxidation, glucose (fasting and after loading glucose, 2 mg/kg, i/p) was considered as symptoms of metabolic syndrome. It was shown that in normal rats drinking tap water the stimulation of capsaicin-sensitive nerves resulted in the increase of DHEAS content while their deafferentation reduced the concentration of this hormone in the blood...
August 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
Isabel A Pérez-Hernández, Rosario Palacios, Marisa Mayorga, Carmen M González-Doménech, Manuel Castaño, Antonio Rivero, Alfonso Del Arco, Fernando Lozano, Jesús Santos
INTRODUCTION: Rilpivirine (RPV) has a better lipid profile than efavirenz (EFV) in naïve patients (1). Switching to RPV may be convenient for many patients, while maintaining a good immunovirological control (2). The aim of this study was to analyze lipid changes in HIV-patients at 24 weeks after switching to Eviplera® (emtricitabine/RPV/tenofovir disoproxil fumarate [FTC/RPV/TDF]). MATERIALS AND METHODS: Retrospective, multicentre study of a cohort of asymptomatic HIV-patients who switched from a regimen based on 2 nucleoside reverse transcriptase inhibitors (NRTI)+protease inhibitor (PI)/non nucleoside reverse transcriptase inhibitor (NNRTI) or ritonavir boosted PI monotherapy to Eviplera® during February-December, 2013; all had undetectable HIV viral load for ≥3 months prior to switching...
2014: Journal of the International AIDS Society
J F Aller, S S Callejas, R H Alberio
The objectives of the current study were to (i) define the changes in size and number of follicles populations, (ii) determine the follicular fluid (FF) biochemical and steroid concentrations collected from different-sized follicles (5-9 and ≥ 10 mm) and (iii) compare between biochemical and hormonal concentrations of FF with those in blood plasma in relation to the first two follicular waves of the estrous cycle (days 4 and 13) from normal and cows primed for superovulation. After estrus, cows (n=20) were assigned randomly to each of four treatment groups...
November 30, 2013: Animal Reproduction Science
Tatjana Pavlica, Milena Mikalacki, Radenko Matić, Darinka Korovljev, Nebojsa Cokorilo, Sandra Vujkov, Biljana Srdić, Dejan Sakac
Studies conducted on children and adults have pointed to the correlation of BMI (kg/m2) with risk factors for certain diseases. Other studies have stressed a more intense correlation between the risk factors and indicators of subcutaneous fat obtained in other ways. The aim Of the study was to compare the intensity of correlation between the risk factors and triceps and subscapular skinfold thickness in relation to BMI. The study included 53 postmenopausal and 107 premenopausal women, the risk factors were assessed upon systolic and diastolic blood pressure, glucose concentration, triglyceride and cholesterol levels...
May 2013: Collegium Antropologicum
Seema Taprial, Deepak Kashyap, Vineet Mehta, Sunil Kumar, Dinesh Kumar
ETHNOPHARMACOLOGICAL RELEVANCE: Michelia champaca L. (family: Magnoliaceae), commonly known as Champa [Hindi], is traditionally used for fertility regulation by the women of Chhattisgarh state in India. No scientific evidence regarding the antifertility effect of this plant is available till date. AIM OF THE STUDY: To study the anti-fertility effect of hydroalcoholic leaf extract of Michelia champaca Linn. in female rats. MATERIALS AND METHODS: The antifertility activity of the extract (HAEMC) administered at dose levels (100 and 200mg/kg body weight, p...
June 3, 2013: Journal of Ethnopharmacology
Belén Vaz, Ángel R de Lera
INTRODUCTION: Retinoid X receptors (subtypes RXRα or NR2B1, RXRβ or NR2B2 and RXRγ or NR2B3, which originate from three distinct genes) are promiscuous partners with heterodimeric associations to other members of the Nuclear Receptor (NR) superfamily. Some of the heterodimers are "permissive" and transcriptionally active in the presence of either an RXR ligand ("rexinoid") or a NR partner ligand, whereas others are "non-permissive" and unresponsive to rexinoids alone. In rodent models, rexinoids and partner agonists (mainly PPARγ, LXR, FXR) produce beneficial effects on insulin sensitization, diabetes and obesity, but secondary effects have also been noted, such as a raise in tryglyceride levels, supression of the thyroid hormone axis and induction of hepatomegaly...
November 2012: Expert Opinion on Drug Discovery
(no author information available yet)
The effect of an extract from tunic of the sea hydrobiont purple ascidium (Halocynthia aurantium) on the lipid metabolism in the liver of mice has been studied under the acute stress conditions modeled by fixing animals for 22 h at the dorsal neck fold. The extract from purple ascidium tunic is superior to essentiale (well-known commercial hepatoprotector) in the efficacy of restoring lipid fraction content (tryglycerides, cholesterol, free fat acids, lysophospholipids) disturbed by stress action. In addition, the extract normalizes the esterification function of the liver...
2012: Eksperimental'naia i Klinicheskaia Farmakologiia
Atsushi Gabe, Masahiro Seki, Naohiro Taira, Morihiro Katsura, Tomoki Ishida, Yukijya Kang, Tadao Kubota, Toshimitsu Yamashiro, Tetsuo Uehara, Tohru Sunagawa, Kazuaki Ohkubo
A 77-year-old male with chronic hepatitis and liver cirrhosis underwent a right middle-lower lobectomy and lymph node dissection because of non-small cell carcinoma of the lung. On the 1st post-operative day (POD1), a large quantity of chylous pleural effusion was recognized after he initiated oral intake. The diagnosis was postoperative chylothorax. Conservative therapy including a medium chain tryglyceride diet and total parental nutrition were not effective. Considering of the patient's past history, we decided to continue conservative therapy using octreotide acetate on POD7...
March 2012: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Darshan S Kelley, Yuriko Adkins, Leslie R Woodhouse, Arthur Swislocki, Bruce E Mackey, David Siegel
BACKGROUND: Increase in obesity and metabolic syndrome are associated with increases in insulin resistance (IR) and type 2 diabetes mellitus. Results from animal intervention studies and human epidemiological studies suggest that n-3 polyunsaturated fatty acids can prevent and reverse IR, but results from human intervention studies have varied. Results from some human and animal studies suggest that docosahexaenoic acid (22:6n-3; DHA) may be more effective than eicosapentaenoic acid (20:5n-3; EPA) in the prevention of IR...
February 2012: Metabolic Syndrome and related Disorders
S Sahin, A Gürkan, M Uyar, H Dheir, V Turunç, C Varilsuha, S Kaçar
BACKGROUND: Despite significant advances in kidney transplantation, long-term graft survival has not dramatically improved leading to strategies to change immunosuppression during the posttransplantation period. Proliferation signal inhibitors (PSI) sirolimus or everolimus possess immunosuppressive and antiproliferative properties. METHODS: We evaluated 62 kidney transplant recipients who underwent conversion from a calcineurin inhibitors (CNI)- to a PSI-based regimen for various reasons...
April 2011: Transplantation Proceedings
Zehra Karatas, Sultan Durmus Aydogdu, Ener Cagri Dinleyici, Omer Colak, Nesrin Dogruel
The aim of this study was to evaluate the changes in the ghrelin, leptin, and fat levels in the foremilk and hindmilk and the possible relationship between these levels with the age and growth of term healthy infants. Sixty-two babies were subdivided (according to their nutrition) into breastfed (BF), formula-fed (FF), and BF plus FF (BF + FF) groups. The total and active ghrelin and tryglyceride levels and the total cholesterol levels in the foremilk and hindmilk were studied at the first and second visits (mean of the second and fifth months, respectively)...
October 2011: European Journal of Pediatrics
Elena Larrieta, Fidel Velasco, Paz Vital, Teresita López-Aceves, María Luisa Lazo-de-la-Vega-Monroy, Alberto Rojas, Cristina Fernandez-Mejia
Besides its role as a carboxylase prosthetic group, biotin regulates gene expression and has a wide repertoire of effects on systemic processes. Several studies have shown that pharmacological concentrations of biotin reduce hypertriglyceridemia. The molecular mechanisms by which pharmacological concentrations of biotin affect lipid metabolism are largely unknown. The present study analyzed the effects of pharmacological doses of biotin on triglyceridemia, insulin sensitivity and on mRNA expression of various lipogenic genes...
October 10, 2010: European Journal of Pharmacology
Attilio Giacosa, Mariangela Rondanelli
The metabolic syndrome (MS) is a clustering of hyperglycemia/insulin resistance, dyslipidemia, overweight and hypertension. MS identifies patients who are at high risk of developing atherosclerotic cardiovascular disease (CVD) and type 2 diabetes (T2D). Based on current data dietary fibre intake from whole foods or supplements may lower blood pressure, may improve serum lipid levels, may reduce indicators of inflammations,may lower serum glucose levels and favour body weight loss. US Food and Drug Administration in 2006 authorized a health claim that psyllium husk, beta glucan in oats and beta glucan in barley can reduce the risk of heart disease...
September 2010: Journal of Clinical Gastroenterology
Takako Miyamae, Fumie Sano, Remi Ozawa, Tomoyuki Imagawa, Yoshiaki Inayama, Shumpei Yokota
We report a 14-year-old girl with juvenile dermatomyositis (JDM) complicated by severe inflammatory calcinosis successfully treated with thalidomide. She was diagnosed as JDM when she was 4 years old after a few months of increasing lethargy, muscle pain, muscle weakness, and rash. During three months, clinical manifestations and abnormal laboratory findings were effectively treated with oral prednisolone. However, calcinosis was recognized 18 months after disease onset. Generalized calcinosis rapidly progressed with high fever, multiple skin/subcutaneous inflammatory lesions, and increased level of CRP...
February 4, 2010: Pediatric Rheumatology Online Journal
Arzu Atalay Akan, Neriman Sengül, Serife Simşek, Seher Demirer
PURPOSE: Atherosclerosis observations after splenectomy for trauma and hypersplenism suggests a possible role for the spleen in lipid metabolism. The authors examined the effects of splenectomy on serum lipids in rats and also cholesterol-fed rats with experimental atherosclerosis. METHODS: This study was designed on rats. The rats were divided into five groups: splenectomy, normal diet (SP-N, n: 8), splenectomy, cholesterol-fed groups (SP-C, n: 8), splenic autotransplantation after splenectomy, normal diet (SA-N, n: 8), splenic autotransplantation after splenectomy, cholesterol-fed groups (SA-C, n: 8) and sham groups (n: 8)...
November 2008: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
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