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https://read.qxmd.com/read/30758150/-a-child-with-severe-growth-delay-and-renal-cysts
#1
Gianluca Vergine, Elisa Ravaioli, Viviana Palazzo, Giovanni Gambaro, Sabrina Giglio
We describe the case of a 5-year-old who came to our attention for a growth delay. Among the investigations planned because of the child's short stature, we performed an abdominal ultrasound showing normal-sized kidneys with signs of cortico-medullar de-differentiation, diffuse medullary hyperechogenicity with reduction of cortical thickness and cortical-medullary cysts. The ultrasound findings, also confirmed in MRI, led us to suspect a genetically determined cystic nephropathy of the nephronophthisis or medullary cystic disease type...
February 2019: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://read.qxmd.com/read/30753611/phase-i-ii-trial-testing-safety-and-immunogenicity-of-the-multipeptide-ima950-poly-iclc-vaccine-in-newly-diagnosed-adult-malignant-astrocytoma-patients
#2
Denis Migliorini, Valérie Dutoit, Mathilde Allard, Nicole Grandjean Hallez, Eliana Marinari, Valérie Widmer, Géraldine Philippin, Francesca Corlazzoli, Robin Gustave, Mario Kreutzfeldt, Nathalie Blazek, Joëlle Wasem, Andreas Hottinger, Avinash Koka, Shahan Momjian, Alexander Lobrinus, Doron Merkler, Maria-Isabel Vargas, Paul R Walker, Anna Patrikidou, Pierre-Yves Dietrich
Background: Peptide vaccines offer the opportunity to elicit glioma-specific T cells with tumor killing ability. Using antigens eluted from the surface of glioblastoma samples, we designed a phase I/II study to test safety and immunogenicity of the IMA950 multipeptide vaccine adjuvanted with poly-ICLC in HLA-A2 + glioma patients. Methods: Adult patients with newly diagnosed glioblastoma (n=16) and grade III astrocytoma (n=3) were treated with radiochemotherapy followed by IMA950/poly-ICLC vaccination...
February 12, 2019: Neuro-oncology
https://read.qxmd.com/read/30735958/comparison-of-short-term-dosing-ferrous-ion-and-nanoscale-zero-valent-iron-for-rapid-recovery-of-anammox-activity-from-dissolved-oxygen-inhibition
#3
Yuan Yan, Yayi Wang, Weigang Wang, Shuai Zhou, Junjie Wang, Jianhua Guo
As obligate anaerobes, anammox bacteria are sensitive to oxygen, which might hinder the maximization of anammox activity. However, there are very few effective strategies to rapidly recover anammox activity after its deterioration under exposure of oxygen. In this study, the activity recovery of anammox bacteria encountering dissolved oxygen (DO) exposure (0.2 and 2.0 mg L-1 ) were compared by three strategies in short-term experiments, nZVI, Fe(II) dosing, and N2 purging. nZVI is more effective in recovering anammox activity with a high DO exposure (2 mg L-1 ), compared to a low DO exposure (0...
January 30, 2019: Water Research
https://read.qxmd.com/read/30734104/what-are-the-best-isometric-exercises-of-muscle-potentiation
#4
Albertas Skurvydas, Giedre Jurgelaitiene, Sigitas Kamandulis, Dalia Mickeviciene, Marius Brazaitis, Dovile Valanciene, Diana Karanauskiene, Mantas Mickevicius, Gediminas Mamkus
PURPOSE: The aim of this study was to follow post-activation potentiation (PAP), low-frequency fatigue (LFF), metabolic-induced fatigue and post-contractile depression (PCD) in response to different isometric muscle contraction modalities. METHODS: Young healthy men (N = 120) were randomly assigned to one of ten exercise modality groups which differed in contraction duration (5-60 s), activation pattern (intermittent or continuous contractions), activation mode (voluntary or stimulated), and intensity [maximal or submaximal (50%)]...
February 7, 2019: European Journal of Applied Physiology
https://read.qxmd.com/read/30733232/recovery-from-acidosis-is-a-robust-trigger-for-loss-of-force-in-murine-hypokalemic-periodic-paralysis
#5
Wentao Mi, Fenfen Wu, Marbella Quinonez, Marino DiFranco, Stephen C Cannon
Periodic paralysis is an ion channelopathy of skeletal muscle in which recurrent episodes of weakness or paralysis are caused by sustained depolarization of the resting potential and thus reduction of fiber excitability. Episodes are often triggered by environmental stresses, such as changes in extracellular K+ , cooling, or exercise. Rest after vigorous exercise is the most common trigger for weakness in periodic paralysis, but the mechanism is unknown. Here, we use knock-in mutant mouse models of hypokalemic periodic paralysis (HypoKPP; NaV 1...
February 7, 2019: Journal of General Physiology
https://read.qxmd.com/read/30713776/the-role-of-additional-k-wires-on-ao-type-c-distal-radius-fracture-treatment-with-external-fixator-in-young-population
#6
Ivan Micic, Erica Kholinne, Yucheng Sun, Jae-Man Kwak, In-Ho Jeon
Objectives: Several methods have been proposed to treat AO type C distal radius fracture. External fixator has gained popularity for its simple procedure and rapid recovery. Some surgeons suggested that additional K-wires may play a critical role in the outcome. The purpose of study is to evaluate the role of additional K wires in treating distal radial fracture with external fixator regarding its outcome. Material and Methods: From January 2006 to January 2010, 40 patients with AO type C distal radius fracture were treated with external fixator, with (EF) or without additional K wires (EFK)...
2019: Advances in Orthopedics
https://read.qxmd.com/read/30713772/mouse-model-for-assessing-the-subchronic-toxicity-of-organophosphate-pesticides
#7
V A Palikov, S S Terekhov, Yu A Palikova, O N Khokhlova, V A Kazakov, I A Dyachenko, S V Panteleev, Yu A Mokrushina, V D Knorre, O G Shamborant, I V Smirnov, A G Gabibov
The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. The study showed a high activity of BChE as a protective agent for subchronic anticholinesterase poisoning in an in vivo model...
October 2018: Acta Naturae
https://read.qxmd.com/read/30684620/endovascular-treatment-of-ruptured-pancreaticoduodenal-artery-aneurysm-with-celiac-axis-stenosis
#8
Xiaoyu Zhang, Wenwen Zhang, Weimin Zhou, Wei Zhou
BACKGROUND: Splanchnic artery aneurysms are relatively rare diseases. Pancreaticoduodenal arterial (PDA) aneurysms are especially uncommon and account for approximately 2% of all visceral aneurysms. However, rupture of a PDA aneurysm often results in fatal consequences. Intervention therapy has evolved as a mainstream method due to its low risk and rapid recovery. Previous studies have demonstrated that PDA aneurysms are often associated with occlusion or stenosis of the celiac artery, but management of the celiac artery lesion remains controversial...
January 23, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30669800/-clinical-analysis-of-transumbilical-single-incision-laparoscopic-cholecystectomy-with-totally-free-umbilical-ring-by-conventional-instruments
#9
C Zhou, Q S Guo, C C Ling, P Wang
Objective: To summarize the clinical experience of transumbilical single-port laparoscopic cholecystectomy, and evaluate its clinical utility and the feasibility of widely usage. Methods: Between April 2012 and June 2017, 500 cases who underwent transumbilical single-port laparoscopic cholecystectomy with totally free umbilical ring by conventional instruments were enrolled. The clinical data were retrospectively analyzed. Results: A total of 487 patients were successfully completed the operation. In addition, 3 cases were converted to open cholecystectomy, 10 cases were converted to multi-port laparoscopy and drainage tubes were placed in 5 cases...
December 25, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/30668593/anaesthetic-efficacy-of-aqui-s-benzoak-and-ms-222-on-lumpfish-cyclopterus-lumpus-fries-impact-from-temperature-salinity-and-fasting
#10
Julianne Valla Jacobsen, Klemet Steen, Kjell J Nilssen
Large numbers of lumpfish are produced for the Norwegian salmon industry and are used to combat sea lice infestations. Periodically high mortality of farmed lumpfish demonstrates the need to improve farming conditions and animal welfare. As part of such efforts, the present work tested the efficacy of three anaesthetic chemicals on lumpfish fries (average weight of 0.97 g). The anaesthetic impact from salinity (15 ppt-18 ppt), temperature (12°C versus 7 and 18°C), and fasting conditions (three days) was also examined...
2019: PloS One
https://read.qxmd.com/read/30664526/the-development-of-chronic-critical-illness-determines-physical-function-quality-of-life-and-long-term-survival-among-early-survivors-of-sepsis-in-surgical-icus
#11
Anna K Gardner, Gabriela L Ghita, Zhongkai Wang, Tezcan Ozrazgat-Baslanti, Steven L Raymond, Robert T Mankowski, Babette A Brumback, Philip A Efron, Azra Bihorac, Frederick A Moore, Stephen D Anton, Scott C Brakenridge
OBJECTIVES: This study sought to examine mortality, health-related quality of life, and physical function among sepsis survivors who developed chronic critical illness. DESIGN: Single-institution, prospective, longitudinal, observational cohort study assessing 12-month outcomes. SETTING: Two surgical/trauma ICUs at an academic tertiary medical and level 1 trauma center. PATIENTS: Adult critically ill patients that survived 14 days or longer after sepsis onset...
January 18, 2019: Critical Care Medicine
https://read.qxmd.com/read/30662121/comparison-of-the-efficacy-of-intrathecal-isobaric-ropivacaine-and-bupivacaine-in-day-care-knee-arthroscopy-a-randomized-controlled-trial
#12
S Suresh Kumar, Vandana Talwar, Poonam Gupta, Anoop Raj Gogia
Background: The primary goal of ambulatory anesthesia is a rapid recovery with minimal side effects. Ropivacaine, due to its property of sensory-motor dissociation, maybe a useful agent when equivalent spinal anesthesia and quicker recovery of motor function is desirable. Aim: The aim of this study is to compare the efficacy of intrathecal isobaric ropivacaine with bupivacaine and to assess their postoperative recovery profile in patients undergoing arthroscopic knee surgery...
October 2018: Anesthesia, Essays and Researches
https://read.qxmd.com/read/30658476/the-effect-of-the-thermosensitive-biodegradable-plga%C3%A2-peg%C3%A2-plga-copolymer-on-the-rheological-structural-and-mechanical-properties-of-thixotropic-self-hardening-tricalcium-phosphate-cement
#13
Lucy Vojtova, Lenka Michlovska, Kristyna Valova, Marek Zboncak, Martin Trunec, Klara Castkova, Milan Krticka, Veronika Pavlinakova, Petr Polacek, Matej Dzurov, Vera Lukasova, Michala Rampichova, Tomas Suchy, Radek Sedlacek, Maria-Pau Ginebra, Edgar B Montufar
The current limitations of calcium phosphate cements (CPCs) used in the field of bone regeneration consist of their brittleness, low injectability, disintegration in body fluids and low biodegradability. Moreover, no method is currently available to measure the setting time of CPCs in correlation with the evolution of the setting reaction. The study proposes that it is possible to improve and tune the properties of CPCs via the addition of a thermosensitive, biodegradable, thixotropic copolymer based on poly(lactic acid), poly(glycolic acid) and poly(ethylene glycol) (PLGA⁻PEG⁻PLGA) which undergoes gelation under physiological conditions...
January 17, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30657114/apophyseal-avulsion-fractures-of-the-pelvis-a-review
#14
Filippo Calderazzi, Alessandro Nosenzo, Cristina Galavotti, Francesco Pogliacomi, Francesco Ceccarelli
BACKGROUND AND AIM OF THE WORK: Fractures of the pelvis classically occur in adolescent during sports activities with forceful and repetitive contractions or passive lengthening acting on not yet ossified growth plates. Their misdiagnosis lead to disability, chronic pain and decrease of performances. Evidence based treatment guidelines do not exist; aim of this paper is to point out clinical outcomes, return to sport rates and complications of surgical and conservative approach. METHODS: A systematic search based on MEDLINE database was performed in August 2017 to identify all published articles from 2010 to 2017 reporting outcomes, return to sport and complications rates after surgical and non-operative treatment of avulsion fractures of the pelvis...
November 15, 2018: Acta Bio-medica: Atenei Parmensis
https://read.qxmd.com/read/30649398/two-annexin-genes-zmann33-and-zmann35-encode-proteins-that-function-in-cell-membrane-recovery-during-the-germination-of-maize-zea-mays-l-seeds
#15
Fei He, Canhong Gao, Genyuan Guo, Jun Liu, Yue Gao, Ronghui Pan, Yajing Guan, Jin Hu
Plasma membrane (PM) recovery from impaired dry state is essential for seed germination, but its underlying mechanism remains yet unclear. In this study, we found that ZmANN33 and ZmANN35, two annexin genes in maize, encode proteins that participate in PM recovery during seed germination. The expression of both genes was up-regulated during seed germination and strongly repressed by chilling (either 15ºC or 5ºC) as compared with the normal temperature (25ºC). In addition, the increased membrane damage caused by chilling imbibition was correlated with suppressed ZmANN33/35 expression, while rapid recovery of their expression levels accompanied the rescue of the damaged membrane...
January 10, 2019: Journal of Experimental Botany
https://read.qxmd.com/read/30644254/-analysis-of-medial-unicompartmental-knee-arthroplasty-for-patients-with-spontaneous-osteonecrosis-of-the-knee
#16
Deqing Hu, Zida Huang, Wenming Zhang, Jianhua Lin, Wenbo Li
Objective: To analyse the effectiveness of unicompartmental knee arthroplasty (UKA) for the patients with spontaneous osteonecrosis of the knee (SONK). Methods: Between January 2012 and December 2016, 31 patients with SONK was admitted and treated with medial UKA. All patients were examined by both plain radiography and magnetic resonance images. The patients were composed of 5 men and 26 women with an average age of 64.3 years (range, 48-79 years), and with 16 left joints and 15 right joints...
January 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/30622679/pancreaticoduodenectomy-complicated-by-budd-chiari-syndrome-a-case-report-and-review-of-literature
#17
Damien Dousse, Eric Bloom, Bertrand Suc
BACKGROUND: Pancreaticoduodenectomy (PD)-induced morbidity, consisting mainly of the pancreatic fistula and its hemorrhagic and infectious consequences, is well described in the literature, in terms of its definition, risk factors, preventive measures, and standardized management of complications. However, some life-threatening complications remain atypical and undescribed. CASE SUMMARY: We report here the case of a 69-year-old patient with Budd-Chiari syndrome that occurred after arterial embolization of postpancreatectomy hemorrhage...
December 27, 2018: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/30620950/japanese-encephalitis-virus-induced-anti-n-methyl-d-aspartate-receptor-encephalitis-a-case-report-and-review-of-literature
#18
Maoqiang Tian, Juan Li, Wenting Lei, Xiaomei Shu
Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARe) was originally described as a paraneoplastic disease with more than 50% cases involving a tumor. However, tumor incidence in anti-NMDARe in children is much lower. Herpes simplex virus-induced anti-NMDARe has been well-described; however, findings on Japanese encephalitis virus (JEV)-induced anti-NMDARe are scarce. Here, we describe a 7-year-old boy who presented with fever and headache that progressed to seizures and disturbance of consciousness...
January 8, 2019: Neuropediatrics
https://read.qxmd.com/read/30616406/benefits-of-direct-patient-discharge-to-outpatient-physical-therapy-after-total-knee-arthroplasty
#19
Jesse C Christensen, Roger J Paxton, Carol Baym, Jeri E Forster, Michael R Dayton, Craig A Hogan, Jennifer E Stevens-Lapsley
PURPOSE: To investigate the effectiveness of home health physical therapy followed by outpatient physical therapy as compared to patients discharged directly to outpatient physical therapy in improving functional performance, strength/activation and residual knee pain outcomes among patients who received a total knee arthroplasty. MATERIALS AND METHODS: A secondary analysis of longitudinal data in which patients with total knee arthroplasty underwent home health physical therapy or were discharged directly to outpatient physical therapy...
January 7, 2019: Disability and Rehabilitation
https://read.qxmd.com/read/30605715/protective-and-adaptogenic-role-of-peroxiredoxin-2-prx2-in-neutralization-of-oxidative-stress-induced-by-ionizing-radiation
#20
M G Sharapov, V I Novoselov, N V Penkov, E E Fesenko, M V Vedunova, V I Bruskov, S V Gudkov
A radioprotective effect of exogenous recombinant peroxiredoxin 2 (Prx2) was revealed and characterized using an animal model of whole body X-ray irradiation at sublethal and lethal doses. Prx2 belongs to an evolutionarily ancient family of peroxidases that are involved in enzymatic degradation of a wide variety of organic and inorganic hydroperoxides. Apart from that, the oxidized form of Prx2 also exhibits chaperone activity, thereby preventing protein misfolding and aggregation under oxidative stress. Intravenous administration of Prx2 in animals at a concentration of 20 µg/g 15 min before exposure to ionizing radiation contributes to a significantly higher survival rate, suppresses the development of leucopenia and thrombocytopenia, as well as protects the bone marrow cells from genome DNA damage...
December 31, 2018: Free Radical Biology & Medicine
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