keyword
https://read.qxmd.com/read/38545126/crispr-car-t-and-nk-current-applications-and-future-perspectives
#1
REVIEW
Mohadeseh Khoshandam, Hossein Soltaninejad, Amir Ali Hamidieh, Saman Hosseinkhani
Chimeric antigen receptor T (CAR-T) cell therapy represents a breakthrough in personalized cancer treatments. In this regard, synthetic receptors comprised of antigen recognition domains, signaling, and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy them. Despite the success of this approach in refractory B-cell malignancies, the optimal potency of CAR T-cell therapy for many other cancers, particularly solid tumors, has not been validated. Natural killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity cells...
July 2024: Genes & Diseases
https://read.qxmd.com/read/38544346/dual-activity-of-type-iii-pi3k-kinase-vps34-is-critical-for-nk-cell-development-and-senescence
#2
JOURNAL ARTICLE
Shasha Chen, Zehua Li, Jin Feng, Yuhe Quan, Junming He, Jiqing Hao, Zhongjun Dong
Vps34 is the unique member of the class III phosphoinositide 3-kinase family that performs both vesicular transport and autophagy. Its role in natural killer (NK) cells remains uncertain. In this study, a model without Vps34 (Vps34fl/fl /CD122Cre/+ ) is generated, deleting Vps34 during and after NK-cell commitment. These mice exhibit a nearly 90% decrease in NK cell count and impaired differentiation. A mechanistic study reveals that the absence of Vps34 disrupts the transport of IL-15 receptor subunit alpha CD122 to the cell membrane, resulting in reduced responsiveness of NK cells to IL-15...
March 27, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38543837/an-evaluation-of-type-1-interferon-related-genes-in-male-and-female-matched-sars-cov-2-infected-individuals-early-in-the-covid-19-pandemic
#3
JOURNAL ARTICLE
Tom P Huecksteadt, Elizabeth J Myers, Samuel E Aamodt, Shubhanshi Trivedi, Kristi J Warren
SARS-CoV-2 infection has claimed just over 1.1 million lives in the US since 2020. Globally, the SARS-CoV-2 respiratory infection spread to 771 million people and caused mortality in 6.9 million individuals to date. Much of the early literature showed that SARS-CoV-2 immunity was defective in the early stages of the pandemic, leading to heightened and, sometimes, chronic inflammatory responses in the lungs. This lung-associated 'cytokine storm' or 'cytokine release syndrome' led to the need for oxygen supplementation, respiratory distress syndrome, and mechanical ventilation in a relatively high number of people...
March 20, 2024: Viruses
https://read.qxmd.com/read/38540262/the-htert-and-icasp9-transgenes-affect-eomes-and-t-bet-levels-in-nk-cells-and-the-introduction-of-both-genes-improves-nk-cell-proliferation-in-response-to-il2-and-il15-stimulation
#4
JOURNAL ARTICLE
Anastasia I Palamarchuk, Elena I Kovalenko, Maria A Streltsova
The NK cell exhaustion state evolving during extensive and prolonged cultivation is still one of the limitations of NK cell approaches. In this research, we transduced NK cells with the hTERT and iCasp9 genes. hTERT overexpression can prevent the functional exhaustion of NK cells during long-term cultivation, but, still, the therapeutic use of such cells is unsafe without irradiation. To overcome this obstacle, we additionally transduced NK cells with the iCasp9 transgene that enables the rapid elimination of modified cells...
March 14, 2024: Biomedicines
https://read.qxmd.com/read/38538093/safety-and-efficacy-of-snk01-autologous-natural-killer-cells-in-combination-with-cytotoxic-chemotherapy-and-or-cetuximab-after-failure-of-prior-tyrosine-kinase-inhibitor-in-non-small-cell-lung-cancer-non-clinical-mouse-model-and-phase-i-iia-clinical-study
#5
JOURNAL ARTICLE
Myeong Geun Choi, Gun Woo Son, Mi Young Choi, Jae Seob Jung, Jin Kyung Rho, Wonjun Ji, Byeong Gon Yoon, Jong-Min Jo, Yong Man Kim, Dae-Hyun Ko, Jae Cheol Lee, Chang-Min Choi
BACKGROUND: Choosing treatments for epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) patients with osimertinib resistance is challenging. We evaluated the safety and efficacy of SNK01 (autologous natural killer (NK) cells) in combination with cytotoxic chemotherapy and/or cetuximab (an anti-EGFR monoclonal antibody) in treating EGFR-mutated NSCLC in this non-clinical and phase I/IIa clinical trial. METHODS: We developed a cell line-derived xenograft-humanized mouse model with an osimertinib-resistant lung cancer cell line...
March 27, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38536662/natural-killer-group%C3%A2-2d-major-histocompatibility-complex-class%C3%A2-i-polypeptide-related-sequence%C3%A2-a-activation-enhances-natural-killer-cell-mediated-immunity-against-hepatocellular-carcinoma-a-review
#6
REVIEW
Jun Arai, Akinori Okumura, Naoya Kato, Kiyoaki Ito
The recent clinical introduction of immune checkpoint inhibitors has improved therapeutic outcomes in patients with advanced hepatocellular carcinoma. However, these therapies targeting CD8+ T lymphocytes have a response rate of approximately 30%. In addition to CD8+ T lymphocytes, natural killer (NK) cells represent promising therapeutic targets for hepatocellular carcinoma, because they comprise 30%-50% of all lymphocytes in the liver and contribute to antitumor immunity. A recent meta-analysis revealed that the percentage of infiltrating NK cells in hepatocellular carcinoma correlates with a better patient outcome...
March 27, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38536635/the-acetic-acid-produced-by-lactobacillus-species-regulates-immune-function-to-alleviate-pedv-infection-in-piglets
#7
JOURNAL ARTICLE
Ming-Jie Sun, Jun Hong Xing, Qing-Song Yan, Bo-Shi Zou, Ying-Jie Wang, Tian-Ming Niu, Tong Yu, Hai-Bin Huang, Di Zhang, Shu-Min Zhang, Wu-Sheng Sun, Ruo-Nan Zou, Chun-Feng Wang, Chun-Wei Shi
Porcine epidemic diarrhea virus (PEDV) infection results in significant mortality among newborn piglets, leading to substantial economic setbacks in the pig industry. Short-chain fatty acids (SCFA), the metabolites of intestinal probiotics, play pivotal roles in modulating intestinal function, enhancing the intestinal barrier, and bolstering immune responses through diverse mechanisms. The protective potential of Lactobacillus delbrueckii, Lactobacillus johnsonii, and Lactococcus lactis was first noted when administered to PEDV-infected piglets...
March 27, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38534424/the-impact-of-cytomegalovirus-infection-on-natural-killer-and-cd8-t-cell-phenotype-in-multiple-sclerosis
#8
JOURNAL ARTICLE
Valentina Perri, Maria Antonella Zingaropoli, Patrizia Pasculli, Federica Ciccone, Matteo Tartaglia, Viola Baione, Leonardo Malimpensa, Gina Ferrazzano, Claudio Maria Mastroianni, Antonella Conte, Maria Rosa Ciardi
Multiple sclerosis (MS) is a debilitating neurological disease that has been classified as an immune-mediated attack on myelin, the protective sheath of nerves. Some aspects of its pathogenesis are still unclear; nevertheless, it is generally established that viral infections influence the course of the disease. Cytomegalovirus (CMV) is a major pathogen involved in alterations of the immune system, including the expansion of highly differentiated cytotoxic CD8+ T cells and the accumulation of adaptive natural killer (NK) cells expressing high levels of the NKG2C receptor...
February 28, 2024: Biology
https://read.qxmd.com/read/38534423/research-progress-of-nanomaterials-acting-on-nk-cells-in-tumor-immunotherapy-and-imaging
#9
REVIEW
Yachan Feng, Haojie Zhang, Jiangtao Shao, Chao Du, Xiaolei Zhou, Xueling Guo, Yingze Wang
The prognosis for cancer patients has declined dramatically in recent years due to the challenges in treating malignant tumors. Tumor immunotherapy, which includes immune target inhibition and chimeric antigen receptor cell treatment, is currently evolving quickly. Among them, natural killer (NK) cells are gradually becoming another preferred cell immunotherapy after T cell immunotherapy due to their unique killing effects in innate and adaptive immunity. NK cell therapy has shown encouraging outcomes in clinical studies; however, there are still some problems, including limited efficacy in solid tumors, inadequate NK cell penetration, and expensive treatment expenses...
February 27, 2024: Biology
https://read.qxmd.com/read/38533505/ozanimod-mediated-remission-in-experimental-autoimmune-encephalomyelitis-is-associated-with-enhanced-activity-of-cns-cd27-low-nk-cell-subset
#10
JOURNAL ARTICLE
Doua Kamyan, Maya Hassane, Alanood Alnaqbi, Abdul-Kader Souid, Zakeya Al Rasbi, Abeer Al Tahrawi, Mariam Al Shamsi
BACKGROUND: Ozanimod (RPC1063) is an immunomodulator that has been recently approved by the FDA (2020) for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is a selective agonist of the sphingosine-1-phophate receptors 1 and 5, expressed on naïve and central memory T and B cells, as well as natural killer (NK) cells, and is involved in lymphocyte trafficking. Oral administration of ozanimod was reported to result in rapid and reversible reduction in circulating lymphocytes in multiple sclerosis (MS) patients, however, only minimal effect on NK cells was observed...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532383/single-cell-rna-sequencing-reveals-the-immune-features-and-viral-tropism-in-the-central-nervous-system-of-mice-infected-with-japanese-encephalitis-virus
#11
JOURNAL ARTICLE
Ling'en Yang, Junyao Xiong, Yixin Liu, Yinguang Liu, Xugang Wang, Youhui Si, Bibo Zhu, Huanchun Chen, Shengbo Cao, Jing Ye
Japanese encephalitis virus (JEV) is a neurotropic pathogen that causes lethal encephalitis. The high susceptibility and massive proliferation of JEV in neurons lead to extensive neuronal damage and inflammation within the central nervous system. Despite extensive research on JEV pathogenesis, the effect of JEV on the cellular composition and viral tropism towards distinct neuronal subtypes in the brain is still not well comprehended. To address these issues, we performed single-cell RNA sequencing (scRNA-seq) on cells isolated from the JEV-highly infected regions of mouse brain...
March 26, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38532017/a-cd25-biased-interleukin-2-for-autoimmune-therapy-engineered-via-a-semi-synthetic-organism
#12
JOURNAL ARTICLE
Jerod L Ptacin, Lina Ma, Carolina E Caffaro, Nicole V Acuff, Kristine Germar, Peter Severy, Yanyan Qu, Jose-Luis Vela, Xinming Cai, Kristine M San Jose, Hans R Aerni, David B Chen, Ean Esche, Taylor K Ismaili, Rob Herman, Yelena Pavlova, Michael J Pena, Jasmine Nguyen, Lilia K Koriazova, Laura K Shawver, Ingrid B Joseph, Jill Mooney, Mark Peakman, Marcos E Milla
BACKGROUND: Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise for treatment of autoimmune (AI) disorders yet exhibits short systemic half-life and opposing immune responses that negate an appropriate therapeutic index. METHODS: A semi-synthetic microbial technology platform was used to engineer a site-specifically pegylated form of rhIL-2 with enhanced PK, specificity for induction of immune-suppressive regulatory CD4 + T cells (Tregs), and reduced stimulation of off-target effector T and NK cells...
March 26, 2024: Commun Med (Lond)
https://read.qxmd.com/read/38530897/innate-like-t-cell-subset-commitment-in-the-murine-thymus-is-independent-of-tcr-characteristics-and-occurs-during-proliferation
#13
JOURNAL ARTICLE
Vadim K Karnaukhov, Anne-Laure Le Gac, Linda Bilonda Mutala, Aurélie Darbois, Laetitia Perrin, Francois Legoux, Aleksandra M Walczak, Thierry Mora, Olivier Lantz
How T-cell receptor (TCR) characteristics determine subset commitment during T-cell development is still unclear. Here, we addressed this question for innate-like T cells, mucosal-associated invariant T (MAIT) cells, and invariant natural killer T (iNKT) cells. MAIT and iNKT cells have similar developmental paths, leading in mice to two effector subsets, cytotoxic (MAIT1/iNKT1) and IL17-secreting (MAIT17/iNKT17). For iNKT1 vs iNKT17 fate choice, an instructive role for TCR affinity was proposed but recent data argue against this model...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38529413/synergistic-integration-of-histone-deacetylase-inhibitors-apparently-enhances-the-cytokine-induced-killer-cell-efficiency-in-multiple-myeloma-via-the-nkg2d-pathway
#14
JOURNAL ARTICLE
Jingjing Pu, Amit Sharma, Ting Liu, Jian Hou, Ingo Gh Schmidt-Wolf
OBJECTIVES: The rapid recognition of epigenetic manipulation's potential in restricting cancer cell capabilities spurred translational initiatives, including histone deacetylase inhibitors (HDACis). Clinical trials on multiple myeloma (MM) demonstrated substantial benefits of HDACis, coupled with promising outcomes from cytokine-induced killer cell (CIK) immunotherapy. Intriguingly, the unexplored synergy of HDACis and CIK cell immunotherapy in MM prompted our study. METHODS: We examined clinically relevant HDACis (panobinostat/LBH589 and romidepsin) alongside CIK cells derived from peripheral blood mononuclear cells across diverse MM cell lines (U266, RPMI8226, OPM-2 and NCI-H929)...
2024: Clinical & Translational Immunology
https://read.qxmd.com/read/38529307/comprehensive-analysis-of-peroxisome-proliferator-activated-receptors-to-predict-the-drug-resistance-immune-microenvironment-and-prognosis-in-stomach-adenocarcinomas
#15
JOURNAL ARTICLE
Qing Jia, Baozhen Li, Xiulian Wang, Yongfen Ma, Gaozhong Li
BACKGROUND: Peroxisome proliferator-activated receptors (PPARs) exert multiple functions in the initiation and progression of stomach adenocarcinomas (STAD). This study analyzed the relationship between PPARs and the immune status, molecular mutations, and drug therapy in STAD. METHODS: The expression profiles of three PPAR genes (PPARA, PPARD and PPARG) were downloaded from The Cancer Genome Atlas (TCGA) dataset to analyze their expression patterns across pan-cancer...
2024: PeerJ
https://read.qxmd.com/read/38529047/identification-and-validation-of-the-pyroptosis-related-hub-gene-signature-and-the-associated-regulation-axis-in-diabetic-keratopathy
#16
JOURNAL ARTICLE
Yi Cui, Li Wang, Wentao Liang, Li Huang, Shuting Zhuang, Hong Shi, Nuo Xu, Jianzhang Hu
BACKGROUND: Diabetic keratopathy (DK) poses a significant challenge in diabetes mellitus, yet its molecular pathways and effective treatments remain elusive. The aim of our research was to explore the pyroptosis-related genes in the corneal epithelium of the streptozocin-induced diabetic rats. METHODS: After sixteen weeks of streptozocin intraperitoneal injection, corneal epithelium from three diabetic rats and three normal groups underwent whole-transcriptome sequencing...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38527290/the-kir2dl-family-serves-as-prognostic-biomarkers-and-correlates-with-immune-infiltrates-in-acute-myeloid-leukaemia
#17
JOURNAL ARTICLE
Wenling Liu, Mingming Zhu, Ganggang Li, Yaming Xi
Acute myeloid leukaemia (AML) is a prevalent haematological malignancy in which various immune and stromal cells in the bone marrow microenvironment have instrumental roles and substantially influence its progression. KIR2DL is a member of the immunoglobulin-like receptor family and a natural killer (NK) cell surface-specific receptor. However, its impact on immune infiltration regarding AML has not been addressed. We aimed to explore molecular markers associated with the immune microenvironment and prognosis of AML with a particular focus on KIR2DL family members...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38526128/the-%C3%AF-3-polyunsaturated-fatty-acid-docosahexaenoic-acid-enhances-nk-cell-antitumor-effector-functions
#18
JOURNAL ARTICLE
Shuting Wu, Hongyan Peng, Songyang Li, Lanlan Huang, Xiangyu Wang, Yana Li, Yongjie Liu, Peiwen Xiong, Qinglan Yang, Kunpeng Tian, Weiru Wu, Rongxi Pu, Xiulan Lu, Zhenghui Xiao, Jian Yang, Zhaoyang Zhong, Yuan Gao, Yafei Deng, Youcai Deng
ω-3 polyunsaturated fatty acids (PUFAs) are known to directly repress tumour development and progression. In this study, we explored whether docosahexaenoic acid (DHA), a type of ω-3 PUFA, had an immunomodulatory role in promoting tumour growth in immunocompetent mice. The number of natural killer (NK) cells but not the number of T or B cells was decreased by DHA supplementation in various tissues under physiological conditions. Although the frequency and number of NK cells were comparable, IFN-γ production by NK cells in both the spleen and lung was increased in DHA-supplemented mice in the mouse B16F10 melanoma tumour model...
March 25, 2024: Cancer Immunology Research
https://read.qxmd.com/read/38525441/the-role-of-tim3-nk-and-tim3-nk-cells-in-the-immune-pathogenesis-of-severe-aplastic-anemia
#19
JOURNAL ARTICLE
Shaoxue Ding, Tian Zhang, Yingying Lei, Chunyan Liu, Zhaoyun Liu, Rong Fu
BACKGROUND: Natural killer (NK) cells play important immunoregulatory roles in the immune pathogenesis of severe aplastic anemia (SAA). Our previous research showed that SAA caused a decrease in T cell immunoglobulin mucin-3 (TIM3) expression on NK cells. Here we investigated the expression of surface receptors, and the cytotoxicity of peripheral TIM3+ NK and TIM3- NK cells in patients with SAA. METHODS: The expressions of surface receptors and cytoplasmic protein of TIM3+ NK and TIM3- NK cells from peripheral blood were detected by FCM...
February 2024: Journal of Translational Internal Medicine
https://read.qxmd.com/read/38525380/exploring-nk-cell-receptor-dynamics-in-paediatric-leukaemias-implications-for-immunotherapy-and-prognosis
#20
JOURNAL ARTICLE
Cui Tu, Irina Buckle, Ingrid Leal Rojas, Gustavo Rodrigues Rossi, David P Sester, Andrew S Moore, Kristen Radford, Camille Guillerey, Fernando Souza-Fonseca-Guimaraes
OBJECTIVES: Immunotherapies targeting natural killer (NK) cell receptors have shown promise against leukaemia. Unfortunately, cancer immunosuppressive mechanisms that alter NK cell phenotype prevent such approaches from being successful. The study utilises advanced cytometry to examine how cancer immunosuppressive pathways affect NK cell phenotypic changes in clinical samples. METHODS: In this study, we conducted a high-dimensional examination of the cell surface expression of 16 NK cell receptors in paediatric patients with acute myeloid leukaemia and acute lymphoblastic leukaemia, as well as in samples of non-age matched adult peripheral blood (APB) and umbilical cord blood (UCB)...
2024: Clinical & Translational Immunology
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