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https://read.qxmd.com/read/30781686/identification-and-evaluation-of-inhibitors-of-lipase-from-malassezia-restricta-using-virtual-high-throughput-screening-and-molecular-dynamics-studies
#1
Shahid Ali, Faez Iqbal Khan, Taj Mohammad, Dongming Lan, Md Imtaiyaz Hassan, Yonghua Wang
Recent studies revealed the role of lipase in the pathogenicity of Malassezia restricta in dandruff and seborrheic dermatitis (D/SD). The lipase from M. restricta (Mrlip1) is considered a potential target for dandruff therapy. In this work, we performed structure-based virtual screening in Zinc database to find the natural bioactive inhibitors of Mrlip1. We identified three compounds bearing superior affinity and specificity from the Traditional Chinese Medicine database (~60,000 compounds), and their binding patterns with Mrlip1 were analyzed in detail...
February 18, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30774406/clinical-and-instrumental-evaluation-of-a-new-topical-non-corticosteroid-antifungal-anti-inflammatory-antiseborrheic-combination-cream-for-the-treatment-of-mild-to-moderate-facial-seborrheic-dermatitis
#2
Federica Dall'Oglio, Francesco Lacarrubba, Maria Luca, Simona Boscaglia, Corinne Granger, Giuseppe Micali
Purpose: Topical agents play a key role in the management of facial seborrheic dermatitis (SD) by reducing inflammation and scale production. The aim of this open-label trial was to assess the efficacy and tolerability of a new non-corticosteroid, antifungal/anti-inflammatory/antiseborrheic cream containing piroctone olamine, stearyl glycyrrhetinate, and zinc PCA in the treatment of facial SD using clinical and instrumental evaluation. Patients and methods: Twenty adult subjects affected by mild-to-moderate inflamed facial SD were enrolled and instructed to apply the study cream twice daily for 60 days...
2019: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/30762251/acanthosis-nigricans-hypochondroplasia-and-fgfr3-mutations-findings-with-five-new-patients-and-a-review-of-the-literature
#3
Louise Muguet Guenot, Helene Aubert, Bertrand Isidor, Annick Toutain, Juliette Mazereeuw-Hautier, Corinne Collet, Emmanuelle Bourrat, Marie Denis Musquer, Sébastien Barbarot
Early development of extensive acanthosis nigricans (AN) is a key feature in some patients who have hypochondroplasia (HCH) in association with FGFR3 mutations. We here report regarding five new patients with HCH who exhibited AN, and we compare their characteristics to the eight patients previously described in the literature. In these patients, the AN lesions began in childhood, and they were extensive. These lesions were located on the torso, the abdomen, and the face, in addition to the typical skin fold sites...
February 14, 2019: Pediatric Dermatology
https://read.qxmd.com/read/30758335/pityriasis-amiantacea-following-bone-marrow-transplant
#4
Omar Bari, Phillip R Cohen
Pityriasis amiantacea (PA) is a hair disorder characterized by matting of multiple hair shafts, typically occurring as an idiopathic condition. A 67-year-old woman with multiple myeloma who developed PA following a bone marrow transplant with melphalan conditioning is described.She noted initial changes in scalp hair regrowth 4 weeks posttransplant. During the next 4 months she developed multiple lesions of PA that rapidly responded to management, including mineral oil under occlusion in the evening followed by daily shampooing with alternating coal tar, salicylic acid, and ketoconazole shampoos...
January 2019: Cutis; Cutaneous Medicine for the Practitioner
https://read.qxmd.com/read/30746521/complete-genome-sequence-of-malassezia-restricta-cbs-7877-an-opportunist-pathogen-involved-in-dandruff-and-seborrheic-dermatitis
#5
Stanislas C Morand, Morgane Bertignac, Agnes Iltis, Iris C R M Kolder, Walter Pirovano, Roland Jourdain, Cécile Clavaud
Malassezia restricta, one of the predominant basidiomycetous yeasts present on human skin, is involved in scalp disorders. Here, we report the complete genome sequence of the lipophilic Malassezia restricta CBS 7877 strain, which will facilitate the study of the mechanisms underlying its commensal and pathogenic roles within the skin microbiome.
February 2019: Microbiology resource announcements
https://read.qxmd.com/read/30745965/efficacy-of-oral-itraconazole-in-the-treatment-of-seborrheic-dermatitis-in-vietnamese-adults-patients
#6
Thuong Nguyen Van, Ngo Hoang Thi, Tam Hoang Van, Hung Le Van, Nghi Dinh Huu, Phuong Pham Thi Minh, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: This longitudinal study aims to evaluate the efficacy of oral itraconazole in the treatment of seborrheic dermatitis in Vietnamese patients. METHODS: Thirty patients were enrolled at National Hospital of Dermatology and Venereology, Hanoi, Vietnam and were treated with oral itraconazole (200 mg daily in 14 days followed by 200 mg weekly in 4 weeks). The clinical severity was assessed by a four-parameter scoring system. All patients completed the six-week regimen with good adherence...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30712317/variable-response-to-low-dose-naltrexone-in-patients-with-darier-disease-a-case-series
#7
D Boehmer, K Eyerich, U Darsow, T Biedermann, A Zink
BACKGROUND: Darier disease is a rare autosomal-dominant genodermatosis with a loss of function of a Ca2+ -ATPase pump (SERCA2-pump). Clinically, the disease is characterized by red-brown keratotic papules mainly in seborrheic areas and has only limited and unsatisfactory treatment options. Previously, low-dose naltrexone was described as a successful treatment option in Hailey-Hailey-disease, a genodermatosis with a genetic mutation coding for a similar loss of function of a Ca2+ -ATPase pump (hSPCA1-pump)...
February 3, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30697928/efficacy-and-possible-mechanisms-of-botulinum-toxin-treatment-of-oily-skin
#8
REVIEW
Liu Shuo, Yang Ting, Wu KeLun, Zhao Rui, Zhao Rui, Wang Hang
BACKGROUND: Oily skin is one of the most common dermatological complaints. Oily skin may be accompanied by enlarged pores, acne, and seborrheic dermatitis. Moreover, oily skin has negative effects on self-perception. Most therapeutic approaches used to treat oily skin have had varying degrees of efficacy and include topical treatments, such as photodynamic therapy and lasers. However, certain of these therapies for oily skin may lead to severe side effects. With the expanding use and high safety profile of botulinum toxin type A (BoNT-A), its use in the treatment of oily skin has caused significant concerns; moreover, relevant reports have gradually accumulated to address the efficacy of BoNT-A and explore its mechanisms of action...
January 29, 2019: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/30681789/seborrheic-dermatitis-in-skin-of-color-clinical-considerations
#9
May Elgash, Ncoza Dlova, Temitayo Ogunleye, Susan C. Taylor
Seborrheic dermatitis is a common, relapsing, inflammatory skin condition of unclear etiology. The Malassezia yeast genus are believed to play a role. Seborrheic dermatitis commonly affects areas of the skin with high sebum production, including the scalp, nasolabial folds, glabella, eyebrows, beard, ears, retroauricular skin, sternum, and other skin folds. Seborrheic dermatitis may present differently in individuals with skin of color. Darker-skinned individuals may present with scaly, hypopigmented macules and patches in typical areas of involvement...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30668185/topical-ketoconazole-a-systematic-review-of-current-dermatological-applications-and-future-developments
#10
Franchesca D Choi, Margit Lw Juhasz, Natasha Atanaskova Mesinkovska
INTRODUCTION: Although labelling changes and market withdrawal have been implemented for oral ketoconazole (KTZ) due to serious adverse effects, topical KTZ is generally thought to be effective and safe for the treatment of superficial fungal infections. New dermatologic indications for the use of topical KTZ have arisen such as onychomycosis, blepharitis and hair loss. This article aims to review the literature on topical KTZ's efficacy and adverse effects, as well as provide an overview on current insights regarding its mechanism of action and upcoming developments...
January 22, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30653638/common-neonatal-rashes
#11
REVIEW
Angad Chadha, Marla Jahnke
Skin eruptions are commonly encountered in the neonatal and infant period and can be a source of concern for providers and parents alike. We present a brief, clinically focused discussion on topics commonly encountered by the pediatrician with a focus on pearls of knowledge to help distinguish diseases from one another and from more serious conditions. We review miliaria, transient neonatal pustular melanosis, neonatal cephalic pustulosis, erythema toxicum neonatorum, diaper dermatitis, seborrheic dermatitis, and atopic dermatitis...
January 1, 2019: Pediatric Annals
https://read.qxmd.com/read/30632124/endoscopic-submucosal-dissection-of-seborrheic-keratosis-like-lesion-of-the-esophagus-a-new-entity
#12
Nese Ekinci, Eylül Gün, Fatih Aslan
Seborrheic keratosis, one of the most common lesions of the epidermis, is rarely seen on mucosal surfaces. We report a case of a distinctive epithelial neoplasm of the esophagus showing close resemblance to seborrheic keratosis that was resected with endoscopic submucosal dissection. A 65-year-old patient's previous esophageal biopsy showed suspicious low grade dysplasia and the patient was referred for endoscopic submucosal dissection of a flat lesion in the mid-esophagus. Macroscopic examination revealed a well circumscribed, pigmented and elevated lesion with a diameter of 20 mm...
January 11, 2019: Türk Patoloji Dergisi
https://read.qxmd.com/read/30627524/perianal-infectious-dermatitis-an-underdiagnosed-unremitting-and-stubborn-condition
#13
REVIEW
Elena Daniela Serban
Perianal infectious dermatitis (PID) represents a superficial inflammation of the perianal skin, which is of bacterial origin (classically, group A beta-hemolytic streptococci ). This narrative review aims to critically review and summarize the available scientific literature regarding pediatric PID, being the first of its kind, to the best of the author's knowledge. It also reports the first cases of Romanian children with PID. Multiple databases were subjected to systematic literature search (from 1966 to April 30, 2018) to identify studies and case reports of children with PID...
October 25, 2018: World Journal of Clinical Pediatrics
https://read.qxmd.com/read/30620369/hydrogen-peroxide-40-eskata-for-seborrheic-keratoses
#14
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2019: JAMA: the Journal of the American Medical Association
https://read.qxmd.com/read/30559899/seborrheic-keratoses-the-most-common-benign-skin-tumor-of-humans-clinical-presentation-and-an-update-on-pathogenesis-and-treatment-options
#15
REVIEW
Uwe Wollina
Seborrheic keratoses (SK) are the most common skin tumour of humanity. The incidence of this purely benign epithelial proliferation is increasing with age and exposure to ultraviolet light. It has a remarkable variability in its clinical presentation raising some differential diagnoses. Recently, oncogenic mutations have been detected involved in the development of SK, which, however, do not bear the risk of malignant transformation. SK may also develop with the use of modern targeted drugs for the treatment of malignancies...
November 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30529706/reflectance-confocal-microscopy-terminology-glossary-for-non-melanocytic-skin-lesions-a-systematic-review
#16
REVIEW
Cristian Navarrete-Dechent, Antonio P DeRosa, Caterina Longo, Konstantinos Liopyris, Margaret Oliviero, Harold Rabinovitz, Ashfaq A Marghoob, Allan C Halpern, Giovanni Pellacani, Alon Scope, Manu Jain
BACKGROUND: There is lack of uniformity in reflectance confocal microscopy (RCM) terminology for non-melanocytic lesions (NMLs). OBJECTIVE: To review published RCM terms for NMLs and identify likely-synonymous terms. METHODS: Systematic review of original research articles adhering to PRISMA guidelines was conducted until August 19, 2017. Two investigators gathered all published RCM terms used to describe basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and seborrheic keratosis/solar lentigo/lichen planus-like keratosis (SK/SL/LPLK)...
December 7, 2018: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30488271/labial-adhesions-in-postmenopausal-women-presentation-and-management
#17
Priyanka Singh, How Chuan Han
Labial adhesion is defined as complete or partial fusion of the labia minora in the midline through flimsy or dense adhesions. It may be congenital or acquired. Acquired cases are mainly seen in oestrogen deficiency states in prepubertal girls and postmenopausal women. Aggravating factors include chronic inflammation due to poor hygiene, eczema, lichen planus or sclerosus, seborrhic dermatitis, eczema, local trauma and recurrent urinary tract infections. Patients may be asymptomatic or present with urinary or vulval symptoms...
November 28, 2018: International Urogynecology Journal
https://read.qxmd.com/read/30487459/whole-fruits-and-fruit-fiber-emerging-health-effects
#18
REVIEW
Mark L Dreher
Less than 10% of most Western populations consume adequate levels of whole fruits and dietary fiber with typical intake being about half of the recommended levels. Evidence of the beneficial health effects of consuming adequate levels of whole fruits has been steadily growing, especially regarding their bioactive fiber prebiotic effects and role in improved weight control, wellness and healthy aging. The primary aim of this narrative review article is to examine the increasing number of health benefits which are associated with the adequate intake of whole fruits, especially fruit fiber, throughout the human lifecycle...
November 28, 2018: Nutrients
https://read.qxmd.com/read/30458984/male-genital-dermatology-a-primer-for-the-sexual-medicine-physician
#19
REVIEW
Andrew T Gabrielson, Tan V Le, Christopher Fontenot, Mustafa Usta, Wayne J G Hellstrom
INTRODUCTION: The dermatologic conditions affecting the male genitalia are diverse and range from normal variants and benign growths to overt malignancy. Unfortunately, there is a dearth of urologic dermatology training in most residency programs, and many dermatologic lesions with a classic appearance on other areas of the body may have atypical presentations on the genitalia. Patients may present to a variety of physicians without receiving a definitive diagnosis, which can be highly distressing to the afflicted individual...
January 2019: Sexual Medicine Reviews
https://read.qxmd.com/read/30458354/fusing-fine-tuned-deep-features-for-skin-lesion-classification
#20
Amirreza Mahbod, Gerald Schaefer, Isabella Ellinger, Rupert Ecker, Alain Pitiot, Chunliang Wang
Malignant melanoma is one of the most aggressive forms of skin cancer. Early detection is important as it significantly improves survival rates. Consequently, accurate discrimination of malignant skin lesions from benign lesions such as seborrheic keratoses or benign nevi is crucial, while accurate computerised classification of skin lesion images is of great interest to support diagnosis. In this paper, we propose a fully automatic computerised method to classify skin lesions from dermoscopic images. Our approach is based on a novel ensemble scheme for convolutional neural networks (CNNs) that combines intra-architecture and inter-architecture network fusion...
November 3, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
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