keyword
https://read.qxmd.com/read/35312839/sodium-retention-in-nephrotic-syndrome-is-independent-of-the-activation-of-the-membrane-anchored-serine-protease-prostasin-cap1-prss8-and-its-enzymatic-activity
#21
JOURNAL ARTICLE
Daniel Essigke, Bernhard N Bohnert, Andrea Janessa, Matthias Wörn, Kingsley Omage, Hubert Kalbacher, Andreas L Birkenfeld, Thomas H Bugge, Roman Szabo, Ferruh Artunc
Experimental nephrotic syndrome leads to activation of the epithelial sodium channel (ENaC) by proteolysis and promotes renal sodium retention. The membrane-anchored serine protease prostasin (CAP1/PRSS8) is expressed in the distal nephron and participates in proteolytic ENaC regulation by serving as a scaffold for other serine proteases. However, it is unknown whether prostasin is also involved in ENaC-mediated sodium retention of experimental nephrotic syndrome. In this study, we used genetically modified knock-in mice with Prss8 mutations abolishing its proteolytic activity (Prss8-S238A) or prostasin activation (Prss8-R44Q) to investigate the development of sodium retention in doxorubicin-induced nephrotic syndrome...
June 2022: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/34714852/drug-repositioning-of-clopidogrel-or-triamterene-to-inhibit-influenza-virus-replication-in-vitro
#22
JOURNAL ARTICLE
Nichole Orr-Burks, Jackelyn Murray, Kyle V Todd, Abhijeet Bakre, Ralph A Tripp
Influenza viruses cause respiratory tract infections and substantial health concerns. Infection may result in mild to severe respiratory disease associated with morbidity and some mortality. Several anti-influenza drugs are available, but these agents target viral components and are susceptible to drug resistance. There is a need for new antiviral drug strategies that include repurposing of clinically approved drugs. Drugs that target cellular machinery necessary for influenza virus replication can provide a means for inhibiting influenza virus replication...
2021: PloS One
https://read.qxmd.com/read/34667853/trends-and-patterns-of-neurotology-drug-prescriptions-on-a-nationwide-insurance-database
#23
JOURNAL ARTICLE
Khodayar Goshtasbi, Mehdi Abouzari, Arash Abiri, Kasra Ziai, Brandon M Lehrich, Adwight Risbud, Soha Bayginejad, Harrison W Lin, Hamid R Djalilian
OBJECTIVE: To examine neurotologists' 2013 to 2016 Medicare Part-D data and evaluate commonly prescribed medications, longitudinal changes in prescribing patterns, presumed associated pathologies, and cost distribution across United States. METHODS: Comprehensive prescription data of Part-D-participating neurotologists was quiered from the 2013 to 2016 Medicare Part-D database. Outcome variables consisted of the 25 most commonly prescribed + refilled medications, cost distribution per medication, presumed associated pathologies, and standardized prescription cost across United States...
October 2021: Laryngoscope Investigative Otolaryngology
https://read.qxmd.com/read/34628642/pharmacotherapy-for-hypertension-induced-left-ventricular-hypertrophy
#24
REVIEW
Leire Leache, Marta Gutiérrez-Valencia, Rosa M Finizola, Elizabeth Infante, Bartolome Finizola, Jordi Pardo Pardo, Yris Flores, Ricardo Granero, Kaduo J Arai
BACKGROUND: Hypertension is the leading preventable risk factor for cardiovascular disease and premature death worldwide. One of the clinical effects of hypertension is left ventricular hypertrophy (LVH), a process of cardiac remodelling. It is estimated that over 30% of people with hypertension also suffer from LVH, although the prevalence rates vary according to the LVH diagnostic criteria. Severity of LVH is associated with a higher prevalence of cardiovascular disease and an increased risk of death...
October 10, 2021: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/34436582/ultra-performance-liquid-chromatographic-and-densitometric-methods-for-sensitive-determination-of-xipamide-and-triamterene-in-pure-and-pharmaceutical-dosage-forms
#25
JOURNAL ARTICLE
N V Fares, Haitham A El Fiky, Amr M Badawey, Maha F Abd El Ghany
BACKGROUND: Validated UPLC method and TLC densitometric method were prescribed for determination of antihypertensive components. Objectives: To establish and validate rapid and accurate Ultra performance liquid chromatographic (UPLC) and TLC densitometric methods for determination of Xipamide and Triamterene in pure and dosage forms. METHODS: The first method; UPLC method, depended on using Agilent Zorbax Eclipse Plus C8 (50 mm × 2.1 mm, 1.8 μm), as the column, mobile phase composed of (acetonitrile-water) (70 + 30, v/v) adjusted by acetic acid to obtain (pH 3), 0...
August 26, 2021: Journal of AOAC International
https://read.qxmd.com/read/34352275/enhanced-purification-protocol-for-the-angiotensin-converting-enzyme-from-bovine-systems-and-investigation-of-the-in-vitro-effect-of-some-active-substances
#26
JOURNAL ARTICLE
Fatih Karahan, Vedat Turkoglu
Angiotensin-converting enzyme (ACE, EC 3.4.15.1) synthesized by endothelial cells and responsible for the regulation of blood pressure was purified from the bovine lung with affinity chromatography method. The purification rate of the ACE of the bovine lung was calculated as 1748- fold. Optimum pH and optimum temperature for the purified ACE were found to be 7.6 and 35-40 °C, respectively. The purity and molecular weight of the ACE were designated with SDS-PAGE. The ACE was found to have three subunits with molecular weights of 57 kDa, 66 kDa, and 190 kDa...
September 25, 2021: Chemico-biological Interactions
https://read.qxmd.com/read/34303885/cofe-alloy-embedded-in-n-doped-carbon-nanotubes-derived-from-triamterene-as-a-highly-efficient-and-durable-electrocatalyst-beyond-commercial-pt-c-for-oxygen-reduction
#27
JOURNAL ARTICLE
Hong-Ling Meng, Shi-Yi Lin, Ying Cao, Ai-Jun Wang, Lu Zhang, Jiu-Ju Feng
For development of green and sustainable energy, it is of importance to search highly efficient and low-cost electrocatalysts of oxygen reduction reaction (ORR) in energy conversion devices. Herein, CoFe alloyed nanocrystals embedded in N-doped bamboo-like carbon nanotubes (CoFe@NCNTs) were facilely synthetized by one-step co-pyrolysis with the mixture of triamterene, metal chlorides and graphitic carbon nitride (g-C3 N4 ). The resultant CoFe@NCNTs exhibited excellent ORR activity with the positive shifts in the onset potential (Eonset  = 0...
July 16, 2021: Journal of Colloid and Interface Science
https://read.qxmd.com/read/34233330/the-forgotten-antiproteinuric-properties-of-diuretics
#28
REVIEW
Hernando Trujillo, Fernando Caravaca-Fontán, Jara Caro, Enrique Morales, Manuel Praga
BACKGROUND: Although diuretics are one of the most widely used drugs by nephrologists, their antiproteinuric properties are not generally taken into consideration. SUMMARY: Thiazide diuretics have been shown to reduce proteinuria by >35% in several prospective controlled studies, and these values are markedly increased when combined with a low-salt diet. Thiazide-like diuretics (indapamide and chlorthalidone) have shown similar effectiveness. The antiproteinuric effect of mineralocorticoid receptor antagonists (spironolactone, eplerenone, and finerenone) has been clearly established through prospective and controlled studies, and treatment with finerenone reduces the risk of chronic kidney disease progression in type-2 diabetic patients...
2021: American Journal of Nephrology
https://read.qxmd.com/read/34128052/hptlc-method-for-the-ultrasensitive-detection-of-triamterene-in-plasma
#29
JOURNAL ARTICLE
Ahmed A Khorshed, Mohamed M Elsutohy, Abobakr A Mohamed, Mohamed Oraby
A high-performance thin-layer chromatographic (HPTLC) method has developed for the selective detection of a diuretic drug, triamterene (TRIAM), in pure form, tablets and human plasma. The method was based on chromatographic separation of TRIAM using HPTLC plates, precoated with silica gel, and a mobile phase consisted of ethyl acetate: dimethylformamide: ammonia (7.0: 2.7: 0.3, by volume). The native fluorescence signal of TRIAM was detected at 440 nm and used to quantify TRIAM using the proposed method, improving the method sensitivity to ~250-folds in comparison to that reported in previous HPTLC studies...
June 14, 2021: Journal of Chromatographic Science
https://read.qxmd.com/read/34100261/triamterene-induces-autophagic-degradation-of-lysosome-by-exacerbating-lysosomal-integrity
#30
JOURNAL ARTICLE
Na Yeon Park, Doo Sin Jo, Yong Hwan Kim, Ji-Eun Bae, Joon Bum Kim, Hyun Jun Park, Ji Yeon Choi, Ha Jung Lee, Jeong Ho Chang, Heeyoun Bunch, Hong Bae Jeon, Yong-Keun Jung, Dong-Hyung Cho
The maintenance of lysosomal integrity is essential for lysosome function and cell fate. Damaged lysosomes are degraded by lysosomal autophagy, lysophagy. The mechanism underlying lysophagy remains largely unknown; this study aimed to contribute to the understanding of this topic. A cell-based screening system was used to identify novel lysophagy modulators. Triamterene (6-phenylpteridine-2,4,7-triamine) was identified as one of the most potent lysophagy inducers from the screening process. We found that triamterene causes lysosomal rupture without affecting other cellular organelles and increases autophagy flux in HepG2 cells...
June 7, 2021: Archives of Pharmacal Research
https://read.qxmd.com/read/33957621/the-effect-of-amiloride-on-proteinuria-in-patients-with-proteinuric-kidney-disease
#31
RANDOMIZED CONTROLLED TRIAL
Wen Shen, Mohammed Alshehri, Sameer Desale, Christopher Wilcox
INTRODUCTION: Proteinuric kidney diseases share an aggressive clinical course of developing end-stage renal disease. However, the treatment is limited. Amiloride, an epithelial sodium channel (ENaC) inhibitor, was reported to reduce proteinuria in animal studies and case reports independent of ENaC inhibition. We hypothesized that amiloride not triamterene (an analog of amiloride) would reduce proteinuria in the patients with proteinuric kidney disease. METHODS: Patients with proteinuria >1...
2021: American Journal of Nephrology
https://read.qxmd.com/read/33883016/synthesis-spectroscopic-electrochemical-and-photophysical-properties-of-high-band-gap-polymers-for-potential-applications-in-semi-transparent-solar-cells
#32
JOURNAL ARTICLE
Peshawa O Amin, Kamal Aziz Ketuly, Salah Raza Saeed, Fahmi F Muhammadsharif, Mark D Symes, Avishek Paul, Khaulah Sulaiman
BACKGROUND: The design of new polymers able to filter the electromagnetic spectrum and absorb distinctly in the UV and high-energy part of visible spectrum is crucial for the development of semi-transparent solar cells. Herein, we report on the synthesis and spectroscopic, electrochemical, and photophysical characteristics of three new polymers, namely (i) Poly(triamterene-co-terephthalate), (ii) Poly[triamterene-co- 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-p,p'-disulfonamide], and (iii) Poly(5-hydroxyindole-2-carboxylate) that might show promise as materials for semi-transparent solar cells...
April 21, 2021: BMC chemistry
https://read.qxmd.com/read/33851023/liddle-syndrome-due-to-a-novel-c-1713-deletion-in-the-epithelial-sodium-channel-%C3%AE-subunit-in-a-normotensive-adolescent
#33
Raven K Brower, Ida A Ghlichloo, Venus Shabgahi, Daniel Elsholz, Ram K Menon, Arpita K Vyas
OBJECTIVE: Liddle syndrome (LS) is a rare autosomal dominant condition secondary to a gain-of-function mutation affecting the epithelial sodium channels (ENaCs) in the distal nephron. It presents with early-onset hypertension, hypokalemia, and metabolic alkalosis in the face of hyporeninemia and hypoaldosteronism. We report a novel mutation affecting the ENaCs in a normotensive adolescent with LS. METHODS: We describe a pediatric case of LS with a novel mutation and review the condition's presentation and management...
January 2021: AACE Clinical Case Reports
https://read.qxmd.com/read/33825041/hypokalemia-and-hypertensive-urgency-in-a-10-year-old-boy-answers
#34
JOURNAL ARTICLE
Ozlem Yuksel Aksoy, Funda Bastug, Binnaz Celik, Salih Uytun
No abstract text is available yet for this article.
April 6, 2021: Pediatric Nephrology
https://read.qxmd.com/read/33650216/zymogen-locked-mutant-prostasin-prss8-leads-to-incomplete-proteolytic-activation-of-the-epithelial-sodium-channel-enac-and-severely-compromises-triamterene-tolerance-in-mice
#35
JOURNAL ARTICLE
Daniel Essigke, Alexandr V Ilyaskin, Matthias Wörn, Bernhard N Bohnert, Mengyun Xiao, Christoph Daniel, Kerstin Amann, Andreas L Birkenfeld, Roman Szabo, Thomas H Bugge, Christoph Korbmacher, Ferruh Artunc
AIM: The serine protease prostasin (Prss8) is expressed in the distal tubule and stimulates proteolytic activation of the epithelial sodium channel (ENaC) in co-expression experiments in vitro. The aim of this study was to explore the role of prostasin in proteolytic ENaC activation in the kidney in vivo. METHODS: We used genetically modified knockin mice carrying a Prss8 mutation abolishing proteolytic activity (Prss8-S238A) or a mutation leading to a zymogen-locked state (Prss8-R44Q)...
May 2021: Acta Physiologica
https://read.qxmd.com/read/33548084/a-double-blind-placebo-controlled-trial-on-the-antihypertensive-treatment-effect-of-a-quadruple-single-pill-combination
#36
JOURNAL ARTICLE
Lei-Xiao Hu, Dian Wang, Hua-Ling Liu, Qing-Tao Zhang, Dong-Sheng Sun, Li Zhang, Xin Chen, Gui-Li Chang, Ji-Guang Wang
In a randomized, double-blind, placebo-controlled trial, we investigated antihypertensive treatment effect of a quadruple single-pill combination of reserpine 0.1 mg, dihydralazine 12.5 mg, hydrochlorothiazide 12.5 mg, and triamterene 12.5 mg, and changes in plasma levels of monoamine neurotransmitters (serotonin, norepinephrine, and dopamine) in patients with grade 1 hypertension. Eligible patients with a systolic/diastolic blood pressure (BP, average of six readings at two clinic visits during a 4-week run-in period) of 140-159/90-99 mmHg were randomly assigned to the quadruple combination (n = 30) or placebo (n = 30)...
February 6, 2021: Journal of Clinical Hypertension
https://read.qxmd.com/read/33318242/fast-and-furious-flecainide-toxicity-presenting-as-monomorphic-ventricular-tachycardia
#37
JOURNAL ARTICLE
Nisha Donthi, Tejasri Chandrabhatla, Leonard Genovese, Christopher deFilippi
A 63-year-old woman on flecainide, furosemide, and triamterene-hydrochlorothiazide presented with weakness and diarrhoea. She had profound hyponatraemia, hypokalaemia and a pre-renal acute kidney injury (AKI). Her ECG showed a regular wide complex tachycardia concerning for monomorphic ventricular tachycardia. She was haemodynamically stable and treated with aggressive electrolyte repletion and amiodarone. Flecainide toxicity can present as a variety of arrhythmias and early recognition is crucial. This case focuses on flecainide toxicity from multiple concomitant insults: diuretic use, diarrhoea, hypokalaemia, hyponatraemia and pre-renal AKI...
December 13, 2020: BMJ Case Reports
https://read.qxmd.com/read/33185132/effect-of-mechanochemical-inclusion-of-triamterene-into-sulfobutylether-%C3%AE-cyclodextrin-and-its-improved-dissolution-behavior
#38
JOURNAL ARTICLE
Hideko Maeda, Ryoma Shiobara, Masafumi Tanaka, Akihiko Kajinami, Hirokazu Nakayama
The formation of inclusion complexes between triamterene (TT) and cyclodextrins (CDs) to increase the water apparent solubility of TT was investigated. UV data showed that the binding constant of the TT/sulfobutylether-β-cyclodextrin (SBE-β-CD) inclusion complex was 510 L/mol. The phenyl ring of TT was inserted into the secondary hydroxy face of SBE-β-CD, as demonstrated by 1 H-1 H rotating frame nuclear Overhauser effect spectroscopy NMR. Physicochemical properties of solid TT/SBE-β-CD complexes prepared by physical mixing, kneading, freeze-drying, and mechanochemical methods were studied by X-ray diffraction and 13 C cross polarization and magic angle spinning NMR...
November 13, 2020: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/33104388/preparation-and-characterization-of-triamterene-complex-with-ascorbic-acid-derivatives
#39
JOURNAL ARTICLE
Hirotaka Onoda, Yutaka Inoue, Toshinari Ezawa, Isamu Murata, Takron Chantadee, Sontaya Limmatvapirat, Toshio Oguchi, Ikuo Kanamoto
The purpose of this study was to prepare solid dispersions of triamterene (TRT) with ascorbic acid (AA) or ascorbic acid 2 glucoside (AA2G) and to evaluate their physical properties. Solid dispersions were prepared by dissolving each sample in an organic solvent and evaporation (EVP). Powder X-ray diffraction (PXRD) revealed a halo pattern for EVP1 (AA/TRT =1/1) and EVP2 (AA2G/TRT =1/1). In differential scanning calorimetry (DSC), endothermic peaks due to the melting of TRT and AA disappeared for EVP1 (AA/TRT =1/1), and the melting peaks of TRT and AA2G disappeared for EVP2 (AA2G/TRT =1/1)...
October 26, 2020: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/33102031/drug-induced-interstitial-nephritis-as-a-result-of-sodium-valproate-and-triamterene
#40
Ziba Aghsaeifard, Reza Alizadeh
we presented a case of drug-induced interstitial nephritis in a 43-year-old woman, having the history of renal calculi, as a result of sodium valproate and triamterene. Renal biopsy was used to confirm the diagnosis, however, due to poor prognosis along with discontinuation of drugs, she was treated with corticosteroids.
November 2020: Urology Case Reports
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