Lei-Xiao Hu, Dian Wang, Hua-Ling Liu, Qing-Tao Zhang, Dong-Sheng Sun, Li Zhang, Xin Chen, Gui-Li Chang, Ji-Guang Wang
In a randomized, double-blind, placebo-controlled trial, we investigated antihypertensive treatment effect of a quadruple single-pill combination of reserpine 0.1 mg, dihydralazine 12.5 mg, hydrochlorothiazide 12.5 mg, and triamterene 12.5 mg, and changes in plasma levels of monoamine neurotransmitters (serotonin, norepinephrine, and dopamine) in patients with grade 1 hypertension. Eligible patients with a systolic/diastolic blood pressure (BP, average of six readings at two clinic visits during a 4-week run-in period) of 140-159/90-99 mmHg were randomly assigned to the quadruple combination (n = 30) or placebo (n = 30)...
February 6, 2021: Journal of Clinical Hypertension