keyword
https://read.qxmd.com/read/38536662/natural-killer-group%C3%A2-2d-major-histocompatibility-complex-class%C3%A2-i-polypeptide-related-sequence%C3%A2-a-activation-enhances-natural-killer-cell-mediated-immunity-against-hepatocellular-carcinoma-a-review
#1
REVIEW
Jun Arai, Akinori Okumura, Naoya Kato, Kiyoaki Ito
The recent clinical introduction of immune checkpoint inhibitors has improved therapeutic outcomes in patients with advanced hepatocellular carcinoma. However, these therapies targeting CD8+ T lymphocytes have a response rate of approximately 30%. In addition to CD8+ T lymphocytes, natural killer (NK) cells represent promising therapeutic targets for hepatocellular carcinoma, because they comprise 30%-50% of all lymphocytes in the liver and contribute to antitumor immunity. A recent meta-analysis revealed that the percentage of infiltrating NK cells in hepatocellular carcinoma correlates with a better patient outcome...
March 27, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38536170/reduced-aqueous-humor-outflow-pathway-arborization-in-childhood-glaucoma-eyes
#2
JOURNAL ARTICLE
Shikha Gupta, Xiaowei Zhang, Arnav Panigrahi, Shakha, Raymond Fang, Clemens A Strohmaier, Hao F Zhang, Robert N Weinreb, Viney Gupta, Alex S Huang
PURPOSE: To compare aqueous humor outflow (AHO) pathway patterns between eyes of childhood glaucoma patients and non-glaucomatous patients receiving cataract surgery. METHODS: Aqueous angiography was performed in childhood glaucoma eyes (n = 5) receiving glaucoma surgery and in pediatric (n = 1) and healthy adult (n = 5) eyes receiving cataract surgery. Indocyanine green (0.4%) was introduced into the anterior chamber, and AHO was imaged using an angiographic camera (SPECTRALIS HRA+OCT with Flex Module)...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38534361/brain-derived-neurotrophic-factor-bdnf-enhances-osteogenesis-and-may-improve-bone-microarchitecture-in-an-ovariectomized-rat-model
#3
JOURNAL ARTICLE
Eugene J Park, Van-Long Truong, Woo-Sik Jeong, Woo-Kie Min
BACKGROUND: Brain-derived neurotrophic factor (BDNF) has gained attention as a therapeutic agent due to its potential biological activities, including osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of BDNF have not been fully understood. This study aimed to investigate the action of BDNF on the osteoblast differentiation in bone marrow stromal cells, and its influence on signaling pathways. In addition, to evaluate the clinical efficacy, an in vivo animal study was performed...
March 15, 2024: Cells
https://read.qxmd.com/read/38534130/trichothecenes-with-cytotoxic-activity-and-benzene-derivatives-with-hypolipidemic-activity-from-trichothecium-sp
#4
JOURNAL ARTICLE
An-An Yang, Yi-Fan Guo, Ke-Ran Hao, Yi-Ting Wu, Liang Xing
Five trichothecenes including a new one, together with two previously undescribed benzene derivatives were isolated from the solid culture of Trichothecium sp. Their structures were established by 1D and 2D NMR data in conjunction with HR-ESI-MS analysis. Compounds 1-5 exhibited cytotoxicity against MCF-7 cell lines at various levels ranging from IC50 of 7.23 to 16.95  μ M. Compound 6 decreased the concentration of blood lipids in zebra fish at the concentration of 20  μ M.
March 27, 2024: Natural Product Research
https://read.qxmd.com/read/38533597/treatment-outcome-and-long-term-stability-of-orthognathic-surgery-for-facial-asymmetry-a-systematic-review-and-meta-analysis
#5
JOURNAL ARTICLE
Yoon-Ji Kim, Moon-Young Kim, Nayansi Jha, Min-Ho Jung, Yong-Dae Kwon, Ho Gyun Shin, Min Jung Ko, Sang Ho Jun
OBJECTIVE: : This systematic review aimed to provide a comparative analysis of the treatment outcomes, including hard and soft tissues, postoperative stability, temporomandibular disorders (TMD), and quality of life (QoL), in patients with facial asymmetry who underwent orthognathic surgery. METHODS: : The primary objective was to address the question, "How do different factors related to surgery affect the outcomes and stability of orthognathic surgery in the correction of facial asymmetry?" A meta-analysis was conducted on the outcome parameters, such as skeletal, dental, and soft tissue symmetry, TMD, QoL, and relapse, using the Hartung-Knapp-Sidik-Jonkman method for random-effects models...
March 25, 2024: Korean Journal of Orthodontics
https://read.qxmd.com/read/38533450/alloying-induced-structural-transition-in-the-promising-thermoelectric-compound-caagsb
#6
JOURNAL ARTICLE
A K M Ashiquzzaman Shawon, Weeam Guetari, Kamil Ciesielski, Rachel Orenstein, Jiaxing Qu, Sevan Chanakian, Md Towhidur Rahman, Elif Ertekin, Eric Toberer, Alexandra Zevalkink
AMX Zintl compounds, crystallizing in several closely related layered structures, have recently garnered attention due to their exciting thermoelectric properties. In this study, we show that orthorhombic CaAgSb can be alloyed with hexagonal CaAgBi to achieve a solid solution with a structural transformation at x ∼ 0.8. This transition can be seen as a switch from three-dimensional (3D) to two-dimensional (2D) covalent bonding in which the interlayer M-X bond distances expand while the in-plane M-X distances contract...
February 27, 2024: Chemistry of Materials: a Publication of the American Chemical Society
https://read.qxmd.com/read/38532511/a-hierarchical-fusion-strategy-of-deep-learning-networks-for-detection-and-segmentation-of-hepatocellular-carcinoma-from-computed-tomography-images
#7
JOURNAL ARTICLE
I-Cheng Lee, Yung-Ping Tsai, Yen-Cheng Lin, Ting-Chun Chen, Chia-Heng Yen, Nai-Chi Chiu, Hsuen-En Hwang, Chien-An Liu, Jia-Guan Huang, Rheun-Chuan Lee, Yee Chao, Shinn-Ying Ho, Yi-Hsiang Huang
BACKGROUND: Automatic segmentation of hepatocellular carcinoma (HCC) on computed tomography (CT) scans is in urgent need to assist diagnosis and radiomics analysis. The aim of this study is to develop a deep learning based network to detect HCC from dynamic CT images. METHODS: Dynamic CT images of 595 patients with HCC were used. Tumors in dynamic CT images were labeled by radiologists. Patients were randomly divided into training, validation and test sets in a ratio of 5:2:3, respectively...
March 26, 2024: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://read.qxmd.com/read/38532284/impacts-of-tissue-context-on-extracellular-vesicles-mediated-cancer-host-cell-communications
#8
REVIEW
Nao Nishida-Aoki, Takahiro Ochiya
Tumor tissue is densely packed with cancer cells, non-cancerous cells, and ECM, forming functional structures. Cancer cells transfer extracellular vesicles (EVs) to modify surrounding normal cells into cancer-promoting cells, establishing a tumor-favorable environment together with other signaling molecules and structural components. Such tissue environments largely affect cancer cell properties, and so as EV-mediated cellular communications within tumor tissue. However, current research on EVs focuses on functional analysis of vesicles isolated from the liquid phase, including cell culture supernatants and blood draws, 2D-cultured cell assays, or systemic analyses on animal models for biodistribution...
March 26, 2024: Cancer Science
https://read.qxmd.com/read/38531967/new-polycyclic-tetramate-macrolactams-with-antimycobacterial-activity-produced-by-marine-derived-streptomyces-sp-kkma-0239
#9
JOURNAL ARTICLE
Satoru Shigeno, Miyu Kadowaki, Kenichiro Nagai, Kanji Hosoda, Takeshi Terahara, Tomoyasu Nishimura, Naoki Hasegawa, Hiroshi Tomoda, Taichi Ohshiro
During our screening for anti-mycobacterial agents against Mycobacterium avium complex (MAC), two new polycyclic tetramate macrolactams (PTMs), named hydroxycapsimycin (1) and brokamycin (2), were isolated along with the known PTM, ikarugamycin (3), from the culture broth of marine-derived Streptomyces sp. KKMA-0239. The relative structures of 1 and 2 were elucidated by spectroscopic data analyses, including 1D and 2D NMR. Furthermore, the absolute configuration of 1 was confirmed by a single-crystal X-ray diffraction analysis...
March 26, 2024: Journal of Antibiotics
https://read.qxmd.com/read/38531804/investigating-the-spatial-distribution-of-proliferating-cells-in-primary-ovarian-cancers
#10
JOURNAL ARTICLE
Mohamed A A A Hegazi, Fabio Pasqualini, Gianluigi Taverna, Robert S Bresalier, Maurizio Chiriva-Internati, Fabio Grizzi
BACKGROUND: Ovarian cancer (OC) accounts for about 4% of female cancers globally. While Ki67-immunopositive (Ki67+ ) cell density is commonly used to assess proliferation in OC, the two-dimensional (2D) distribution pattern of these cells is poorly understood. This study explores the 2D distribution pattern of Ki67+ cells in primary OC tissues and models the proliferation process to improve our understanding of this hallmark of cancer. METHODS: A total of 100 tissue cores, included in a tissue microarray (TMA) representing 5 clear cell carcinomas, 62 serous carcinomas, 10 mucinous adenocarcinomas, 3 endometrioid adenocarcinomas, 10 lymph node metastases from OC, and 10 samples of adjacent normal ovary tissue, were stained using a standardized immunohistochemical protocol...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38530716/exploiting-geometric-features-via-hierarchical-graph-pyramid-transformer-for-cancer-diagnosis-using-histopathological-images
#11
JOURNAL ARTICLE
Mingxin Liu, Yunzan Liu, Pengbo Xu, Hui Cui, Jing Ke, Jiquan Ma
Cancer is widely recognized as the primary cause of mortality worldwide, and pathology analysis plays a pivotal role in achieving accurate cancer diagnosis. The intricate representation of features in histopathological images encompasses abundant information crucial for disease diagnosis, regarding cell appearance, tumor microenvironment, and geometric characteristics. However, recent deep learning methods have not adequately exploited geometric features for pathological image classification due to the absence of effective descriptors that can capture both cell distribution and gathering patterns, which often serve as potent indicators...
March 26, 2024: IEEE Transactions on Medical Imaging
https://read.qxmd.com/read/38530290/proposed-drls-for-mammography-in-switzerland
#12
JOURNAL ARTICLE
Laura Dupont, Christoph Aberle, Diomidis Botsikas, Michael Ith, Thiago Viana Miranda Lima, Roman Menz, Pascal Monnin, Pierre-Alexandre Poletti, Stefano Presilla, Alexander Schegerer, Liana-Cristina Stoica, Philipp Trueb, Marta Sans Merce

The aim of this study is to propose Diagnostic Reference Levels (DRLs) values for mammography in Switzerland.
Methods:
For the data collection, a survey was conducted among a sufficient number of centres, including 5 University hospitals, several cantonal hospitals, and large private clinics, covering all linguistic regions of Switzerland to be representative of the clinical practice. The data gathered contained the mean glandular dose (MGD), the compressed breast thickness (CBT), the mammography model and the examination parameters for each acquisition...
March 26, 2024: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://read.qxmd.com/read/38530022/surface-enhanced-raman-scattering-using-2d-materials
#13
JOURNAL ARTICLE
Beatriz Pinto de Sousa, Sara Isabel Augusto Fateixa, Tito Trindade
The use of surface-enhanced Raman scattering (SERS) as a technique for detecting small amounts of (bio)chemical analytes has become increasingly popular in various fields. While gold and silver nanostructures have been extensively studied as SERS substrates, the availability of other types of substrates is currently expanding the applications of this spectroscopic method. Recently, researchers have begun exploring two-dimensional (2D) materials (e.g., graphene-like nanostructures) as substrates for SERS analysis...
March 26, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38529877/from-nmr-to-ai-designing-a-novel-chemical-representation-to-enhance-machine-learning-predictions-of-physicochemical-properties
#14
JOURNAL ARTICLE
Arkadiusz Leniak, Wojciech Pietruś, Rafał Kurczab
A novel approach to the utilization of nuclear magnetic resonance (NMR) spectroscopy data in the prediction of logD through machine learning algorithms is shown. In the analysis, a data set of 754 chemical compounds, organized into 30 clusters, was evaluated using advanced machine learning models, such as Support Vector Regression (SVR), Gradient Boosting, and AdaBoost, and comprehensive validation and testing methods were employed, including 10-fold cross-validation, bootstrapping, and leave-one-out. The study revealed the superior performance of the Bucket Integration method for dimensionality reduction, consistently yielding the lowest root mean square error (RMSE) across all data sets and normalization schemes...
March 26, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38529447/the-anatomical-variation-of-the-distal-anterior-cerebral-artery-an-angiographic-study-in-a-greek-population-sample
#15
JOURNAL ARTICLE
Christos Chrissicopoulos, Georgios Mavrovounis, Maria Piagkou, George Triantafyllou, Nikolaos Nasis, George Stranjalis, Alexander Andreou, Theodosis Kalamatianos
Objective The current retrospective angiographic study establishes the rates of variants in the distal anterior cerebral artery (DACA) in a sample of the Greek population. Methods Data were collected from 456 patients who underwent two-dimensional (2D) or three-dimensional (3D) digital subtraction angiography (DSA) of the carotid and vertebral arteries bilaterally. The study focused on patients with good visualization of the anterior and posterior circulations and employed magnetic resonance (MR) or computed tomography (CT) angiography for 3D reconstruction...
February 2024: Curēus
https://read.qxmd.com/read/38528772/glucose-uptake-stimulating-metabolites-from-aerial-parts-of-centaurea-sicula
#16
JOURNAL ARTICLE
Elena Serino, Daniela Rigano, Maurizio Bruno, Arianna Pastore, Mariano Stornaiuolo, Carmen Formisano, Orazio Taglialatela-Scafati
A comprehensive phytochemical investigation of aerial parts obtained from Centaurea sicula L. led to the isolation of 14 terpenoids ( 1 - 14 ) and nine polyphenols ( 15 - 23 ). The sesquiterpenoid group ( 1 - 11 ) included three structural families, namely, elemanolides ( 1 - 6 ), eudesmanolides ( 7 and 8 ), and germacranolides ( 9 - 11 ) with four unreported secondary metabolites ( 5 - 8 ), whose structure has been determined by extensive spectroscopic analysis, including 1D/2D NMR, HR-MS, and chemical conversion...
March 25, 2024: Journal of Natural Products
https://read.qxmd.com/read/38526894/de-cluttering-scatterplots-with-integral-images
#17
JOURNAL ARTICLE
Hennes Rave, Vladimir Molchanov, Lars Linsen
Scatterplots provide a visual representation of bivariate data (or 2D embeddings of multivariate data) that allows for effective analyses of data dependencies, clusters, trends, and outliers. Unfortunately, classical scatterplots suffer from scalability issues, since growing data sizes eventually lead to overplotting and visual clutter on a screen with a fixed resolution, which hinders the data analysis process. We propose an algorithm that compensates for irregular sample distributions by a smooth transformation of the scatterplot's visual domain...
March 25, 2024: IEEE Transactions on Visualization and Computer Graphics
https://read.qxmd.com/read/38526182/recent-developments-and-future-perspectives-of-molybdenum-borides-and-mbenes
#18
REVIEW
Chandra Sekhar Rout, Pratik V Shinde, Abhinandan Patra, Sang Mun Jeong
Metal borides have received a lot of attention recently as a potentially useful material for a wide range of applications. In particular, molybdenum-based borides and MBenes are of great significance, due to their remarkable properties like good electronic conductivity, considerable stability, high surface area, and environmental harmlessness. Therefore, in this article, the progress made in molybdenum-based borides and MBenes in recent years is reviewed. The first step in understanding these materials is to begin with an overview of their structural and electronic properties...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38525815/resolving-phytosterols-in-microalgae-using-offline-two-dimensional-reversed-phase-liquid-chromatography-supercritical-fluid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#19
JOURNAL ARTICLE
Magali Batteau, Elodie Bouju, Adriana Ramirez-Romero, Sylvie Nuccio, René De Vaumas, Florian Delrue, Karine Faure
Sterols are unsaponifiable lipids resulting from plant metabolism that exhibit interesting bioactive properties. Microalgae are a major source of specific phytosterols, most of which are still not fully characterized. The similarity in sterol structures and the existence of positional isomers make the separation of phytosterols challenging. A method was developed based on an offline two-dimensional (2D) system, reversed-phase liquid chromatography (RPLC)-supercritical fluid chromatography (SFC)/quadrupole time-of-flight (Q-ToF) mass spectrometry, for the identification of sterols in microalgae...
March 25, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38525416/benign-brenner-tumor-of-the-ovary-two-dimensional-and-contrast-enhanced-ultrasound-features-a-retrospective-study-from-a-single-center
#20
JOURNAL ARTICLE
Mei Chen, Shusheng Liao, Yong Cao, Meiya Mao, Xiupeng Jia, Shengmin Zhang, Youfeng Xu
OBJECTIVE: Benign Brenner tumor (BBT) is a rare ovarian tumor, and there are few discrete reports about its manifestation in an ultrasound. This study sought to investigate the two-dimensional (2D) and contrast-enhanced ultrasound (CEUS) features of this entity. METHODS: This is a retrospective single-center study. The clinical manifestations, laboratory examination, and ultrasound data of 25 female patients with BBT were confirmed by pathology when they underwent 2D and/or CEUS examination at Ningbo First Hospital from January 2012 to June 2023...
2024: Frontiers in Oncology
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