FPPA

BACKGROUND: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are one of the most commonly used groups of medicinal compounds in the world. The wide access to NSAIDs and the various ways of storing them due to their easy accessibility often entail the problem with the stability and durability resulting from the exposure of drugs to external factors. The aim of the research was to evaluate in vitro the mechanism of competition between ibuprofen (IBU) and its degradation products, i.e., 4'-isobutylacetophenone (IBAP) and (2RS)-2-(4- formylphenyl)propionic acid (FPPA) during transport in a complex with fatted (HSA) and defatted (dHSA) human serum albumin...

CONTEXT: Anterior cruciate ligament injuries are directly related to the control of dynamic knee valgus in the landing of a jump, and this is mainly due to the correct activation and neuromuscular function of the lower-extremity muscles. The aim of the study is to assess the relationship between lower limb muscle activity during a single-legged drop jump and knee frontal plane projection angle (FPPA). DESIGN: A correlation study. METHODS: Thirty healthy collegiate female athletes were included in the study...

OBJECTIVES: Fatigue can decrease knee stability and increase the injury risk. However, fatigue is rarely being applied throughout movement analysis. The aim of this study was to investigate if the knee stability throughout SLDLs differ between cyclic and acyclic sports, before and after fatigue in general, and between the dominant and non-dominant leg of soccer players. METHODS: A total of 43 active male ( n  = 34) and female ( n  = 9) athletes (age: 26...

BACKGROUND: Dynamic knee valgus (DKV) during dynamic activity is associated with patellofemoral pain, one of the most common sports disorders, especially in females. No studies have examined the factors that can lead to DKV in females as compared to males while addressing the influence of factors on each other. OBJECTIVE: To identify factors of pelvis and lower joints kinematics affecting DKV during single-leg squat (SLS) in females compared to males with multiple regression analysis...

Vidos from a first-person or egocentric perspective offer a promising tool for recognizing various activities related to daily living. In the egocentric perspective, the video is obtained from a wearable camera, and this enables the capture of the person's activities in a consistent viewpoint. Recognition of activity using a wearable sensor is challenging due to various reasons, such as motion blur and large variations. The existing methods are based on extracting handcrafted features from video frames to represent the contents...

BACKGROUND: Clinicians typically measure the knee frontal plane projection angle (FPPA) during a single-leg squat to identify females with patellofemoral pain (PFP). A limitation of this measure is minimal attention to movement of the pelvis on the femur that can create knee valgus loading. The dynamic valgus index (DVI) may be a better assessment. HYPOTHESIS/PURPOSE: The purpose of this study was to compare the knee FPPA and DVI between females with and without PFP and determine if the DVI better identified females with PFP than the knee FPPA...

The binding affinity of G protein-coupled receptor (GPCR) ligands is customarily measured by radio-ligand competition experiments. As an alternative approach, 19 F nuclear magnetic resonance spectroscopy (19 F-NMR) is used for the screening of small-molecule lead compounds in drug discovery; the two methods are complementary in that the measurements are performed with widely different experimental conditions. Here, we used the structure of the A2A adenosine receptor (A2A AR) complex with V-2006 (3-(4-amino-3-methylbenzyl)-7-(furan-2-yl)-3 H -[1,2,3]triazolo[4,5- d ]pyrimidin-5-amine) as the basis for the design of a fluorine-containing probe molecule, FPPA (4-(furan-2-yl)-7-(4-(trifluoromethyl)benzyl)-7 H -pyrrolo[2,3- d ]pyramidin-2-amine), for binding studies with A2A AR...

BACKGROUND: /Objectives: A cystic lesion is common in the pancreas. Focal pancreatic parenchymal atrophy (FPPA) has been reported as a sign of high-grade pancreatic intraepithelial neoplasia/carcinoma in situ (HGP/CIS). Some cystic lesions accompany FPPA. However, the relationship between a cystic lesion, FPPA, and the histopathological background of the pancreatic duct is unknown. METHODS: We retrospectively evaluated the data of 98 patients with a cystic lesion who underwent serial pancreatic juice aspiration cytologic examination (SPACE) because of accompanying FPPA, increased size of the cystic lesion, and pancreatic duct stricture at the base...

BACKGROUND: Overhead squat (OHS) and single-leg squat (SLS) tests have been used as screening tools to identify injury risk in athletic populations. Yet, no study has examined the association between specific trunk and lower extremity (LE) kinematic measures acquired during OHS and SLS performance and LE injury incidence in female collegiate athletes. The purpose of this study was to examine the association between LE and trunk kinematics captured during OHS and SLS performance and LE injury in female collegiate athletes...

OBJECTIVE: To characterize intrapancreatic late enhancement (ILE) observed in the early stages of pancreatic adenocarcinoma (PAC). METHODS: Among 203 patients pathologically diagnosed with PAC between October 2011 and February 2021, 32 patients with pre-diagnostic abdominal contrast-enhanced CT performed from 6 months to 5 years before the diagnosis were enrolled in this study. Indirect findings (IFs) on pre-diagnostic CT, including ILE, were evaluated and examined for various clinical data and time intervals to diagnosis (TIDs)...

BACKGROUND: Patellofemoral pain (PFP) is a major source of knee pain. Identifying who may develop PFP is of paramount importance. PURPOSE: To assess whether Frontal plane projection angles (FPPA) and hand held dynamometry (HHD) strength measures can predict development of PFP. STUDY DESIGN: Prospective evaluation of individuals undertaking a military training programme. METHODS: Male military recruits were enrolled and prospectively followed up from enrolment to completion of 12-weeks training...

BACKGROUND: Although dynamic knee valgus can be visually identified using the 2D frontal plane projection angle (FPPA), the validity of the FPPA in terms of predicting frontal plane knee kinematics has been questioned. The biomechanical utility of the FPPA may lie in its ability to predict frontal plane knee moments. HYPOTHESIS/PURPOSE: The purpose of the current study was to comprehensively evaluate the ability of the FPPA to predict the frontal plane knee kinetics (peak moment, average moment, and moment at peak knee flexion) across a wide range of tasks (stepping, landing, and change of direction)...

OBJECTIVE: To determine if proximal and distal neuromuscular parameters (EMG amplitude and median frequency - MDF) can predict frontal plane kinematics during single-leg landing. STUDY DESIGN: Cross sectional study. SETTING: Laboratory. PARTICIPANTS: Fifteen participants (7 female) performed six single-leg landings with measures of frontal plane kinematics and EMG obtained 230 ms after first foot contact, totalizing 90 landings...

BACKGROUND/OBJECTIVES: Radiological evidence of focal pancreatic parenchymal atrophy (FPPA) may presage early pancreatic ductal adenocarcinoma (PDAC) development. We aimed to clarify the incidence of FPPA and the clinicopathological features of PDAC with FPPA before diagnosis. METHODS: Data on endoscopic ultrasound-guided fine-needle biopsies and surgical samples from 170 patients with pancreatic cancer histologically diagnosed between 2014 and 2019 were extracted from the pathology database of Komagome Hospital and Juntendo University hospital and retrospectively evaluated together with 51 patients without PDAC...

Objectives: Given the high prevalence of patellofemoral pain syndrome (PFPS) and the effectiveness of proximal control exercises, as well as the lack of studies addressing the predictors of this effect, we conducted this study to examine the effects of age, body mass index, symptom duration, and dynamic valgus of the knee on the pain and function responses to proximal control exercises in women with PFPS. Methods: Fifty women with PFPS with a mean age of 25 years, recruited from Ain Shams University, performed proximal control exercises twice weekly for 4 weeks...

Nascimento, N, Sideris, V, and Read, PJ. Biomechanical analysis of the tuck jump assessment. J Strength Cond Res 36(10): 2946-2949, 2022-The tuck jump assessment (TJA) examines plyometric technique flaws associated with the increased risk of anterior cruciate ligament injury. Biomechanical data to investigate the mechanics used during the TJA are limited and assessing each jump individually across the entire test period is time inefficient. This study examined performance characteristics and movement mechanics in 16 professional soccer players during a standardized TJA protocol (10 jumps) to determine if sensitive periods exist within the test period (first 5 vs...

BACKGROUND: Ankle range of motion abnormalities have been often linked with alteration in knee kinematics leading to the development of patellofemoral pain syndrome (PFPS). Literature exploring the relationship between ankle dorsiflexion range of motion (DF ROM) and knee kinematics during functional tasks is scanty. This study aims to assess the relation between ankle DF ROM and frontal plane projection angle (FPPA), one of the knee kinematic variables, in individuals with and without PFPS during a step-down test...

OBJECTIVE: To compare trunk and lower extremity frontal plane projection angles (FPPA) during single leg squat (SLS) performance, perceived hip and groin function and symptoms, and isometric hip strength of adolescent athletes with chronic hip adductor-related groin injury (HARGI) symptoms and age, gender, and sport-matched healthy subjects. DESIGN: Case-control study. SETTING: Junior Olympic Development Training Centre. PARTICIPANTS: Twenty-six athletes at 59...

Currently, it is still a huge challenge to prepare high performance eco-friendly poly(lactic acid) (PLA) with high thermal stability, good processability, excellent crystallization behavior, good transparency and highly-efficient fire safety. In this paper, a novel bio-based nucleation agent N-(furan-2-ylmethyl)-P,P-diphenylphosphinic amide (FPPA) was prepared and used for the fabrication of fire safety PLA/FPPA composites. The chemical structure of FPPA was measured by FTIR, NMR and MS. Further, the crystallization behavior, thermal stability, fire safety and mechanical properties of PLA/FPPA composites were performed by TGA, DSC, polarization microscope, LOI, UL94, cone calorimeter, DMA and, SEM, Raman, GC-MS, and TGA-FTIR...

Dynamic knee valgus (DKV) is a frontal plane knee kinematic alteration that has been associated with patellofemoral pain (PFP) in female runners. DKV is commonly assessed in clinical practice by measuring frontal plane knee projection angle (FPPA) during squat tests. However, it remains unclear whether the DKV observed in these tests is similar to or correlates with that observed during running in female runners. The aims of this cross-sectional study were to correlate and compare DKV, by measuring FPPA values, in a lateral step-down (LSD) squat test and running in female runners with and without PFP...