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https://read.qxmd.com/read/30877973/therapeutic-potentials-of-plant-iridoids-in-alzheimer-s-and-parkinson-s-diseases-a-review
#1
REVIEW
Biswanath Dinda, Manikarna Dinda, Goutam Kulsi, Ankita Chakraborty, Subhajit Dinda
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related neurodegenerative disorders, affecting several millions of aged people globally. Among these disorders, AD is more severe, affecting about 7% of individuals aged 65 and above. AD is primarily a dementia-related disorder from progressive cognitive deterioration and memory impairment, while PD is primarily a movement disorder illness having three major kinesia or movement disorder symptoms, bradykinesia (slowness of movements), hypokinesia (reduction of movement amplitude), and akinesia (absence of normal unconscious movements) along with muscle rigidity and tremor at rest...
March 8, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/30877868/development-of-novel-2-substituted-acylaminoethylsulfonamide-derivatives-as-fungicides-against-botrytis-cinerea
#2
Minlong Wang, Ying Du, Chunhui Liu, Xinling Yang, Peiwen Qin, Zhiqiu Qi, Mingshan Ji, Xinghai Li
Botrytis cinerea is an economically important fungal pathogen with a host range of over 200 plant species. Unfortunately, gray mold disease caused by B. cinerea has not been effectively controlled because of its high risk for fungicide resistance development. As a part of our ongoing efforts to develop novel sulfonamides as agricultural fungicides against Botrytis cinerea, we introduced 2-aminoethanesulfonic acid (taurine) substructure, designed and synthesized a series of novel 2-substituted acylaminoethylsulfonamides...
March 9, 2019: Bioorganic Chemistry
https://read.qxmd.com/read/30876405/population-genomic-and-evolutionary-modelling-analyses-reveal-a-single-major-qtl-for-ivermectin-drug-resistance-in-the-pathogenic-nematode-haemonchus-contortus
#3
Stephen R Doyle, Christopher J R Illingworth, Roz Laing, David J Bartley, Elizabeth Redman, Axel Martinelli, Nancy Holroyd, Alison A Morrison, Andrew Rezansoff, Alan Tracey, Eileen Devaney, Matthew Berriman, Neil Sargison, James A Cotton, John S Gilleard
BACKGROUND: Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of resistance in a number of species that infect livestock and companion animals, and there are growing concerns regarding the reduced efficacy in some human-infective helminths. Understanding the mechanisms by which resistance evolves is the focus of increasing interest; robust genetic analysis of helminths is challenging, and although many candidate genes have been proposed, the genetic basis of resistance remains poorly resolved...
March 15, 2019: BMC Genomics
https://read.qxmd.com/read/30875866/identification-of-candidate-ergosterol-responsive-proteins-associated-with-the-plasma-membrane-of-arabidopsis-thaliana
#4
Thembisile G Khoza, Ian A Dubery, Lizelle A Piater
The impact of fungal diseases on crop production negatively reflects on sustainable food production and overall economic health. Ergosterol is the major sterol component in fungal membranes and regarded as a general elicitor or microbe-associated molecular pattern (MAMP) molecule. Although plant responses to ergosterol have been reported, the perception mechanism is still unknown. Here, Arabidopsis thaliana protein fractions were used to identify those differentially regulated following ergosterol treatment; additionally, they were subjected to affinity-based chromatography enrichment strategies to capture and categorize ergosterol-interacting candidate proteins using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)...
March 14, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30870755/is-anaerobic-digestion-a-reliable-barrier-for-deactivation-of-pathogens-in-biosludge
#5
REVIEW
Qian Zhao, Yu Liu
As World Health Organization advocates, the global burden of sanitation related disease and access to safely managed sanitation and safely treated wastewater should be monitored strictly. However, the spread of pathogens through various agricultural applications or direct discharge of sewage sludge generated in municipal wastewater treatment plants poses a serious challenge on the environment and public health. Anaerobic digestion (AD), the principal method of stabilizing biosolids, can efficiently and largely deactivate viable pathogens, including parasite, virus, and the pathogens harboring antibiotic resistance genes...
March 6, 2019: Science of the Total Environment
https://read.qxmd.com/read/30868815/-construction-of-tn5-transposon-insertion-mutants-of-ralstonia-solanacearum-isolated-from-pogostemon-cablin
#6
Ya-Qin Wang, Yu-Yao Zhang, Hong He, Zhuan Li, Zhi-Cheng Deng, Hua Jin, Guang-Wei Li
Ralstonia solanacearum strain PRS-84 used in this study was isolated from diseased Pogostemon cablin plants in our previous study.The competent cells of R.solanacearum strain PRS-84 were transformed by electroporation with Tn5 transposon and then were plated on TTC agar plates containing kanamycin to select for kanamycin-resistant colonies.The detection of kanamycin-resistant gene in kanamycin-resistant colonies was performed by PCR.Further,the flanking fragments of Tn5 transposon insertion site in the mutants were amplified by inverse PCR,and the flanking fragments were sequenced and analyzed...
January 2019: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/30867670/ethnopharmacology-study-of-plants-from-atlantic-forest-with-leishmanicidal-activity
#7
Beatriz Mendes Santos, Adriana Bezerra-Souza, Sonia Aragaki, Eliana Rodrigues, Eric Umehara, João Henrique Ghilardi Lago, Márcia Dalastra Laurenti, Susan Pereira Ribeiro, Luiz Felipe Domingues Passero
Leishmaniasis is an infectious disease caused by a protozoan belonging to Leishmania genus. Different clinical outcomes can be observed depending on the parasite species and patient's health condition. The outcomes can range from single cutaneous lesions to lethal visceral form. The treatment of all forms of leishmaniasis is based on pentavalent antimonials, and, in some cases, the second-line drug, amphotericin B, is used. Beside the toxicity of both classes of drugs, in some areas of the world, parasites are resistant to antimonial...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30867331/genetic-engineering-for-disease-resistance-in-plants-recent-progress-and-future-perspectives
#8
Oliver Xiaoou Dong, Pamela C Ronald
No abstract text is available yet for this article.
March 13, 2019: Plant Physiology
https://read.qxmd.com/read/30866817/confirmation-of-fusarium-root-rot-resistance-qtl-fsp-ps-2-1-of-pea-under-controlled-conditions
#9
Clarice J Coyne, Lyndon D Porter, Gilles Boutet, Yu Ma, Rebecca J McGee, Angélique Lesné, Alain Baranger, Marie-Laure Pilet-Nayel
BACKGROUND: Dry pea production has increased substantially in North America over the last few decades. With this expansion, significant yield losses have been attributed to an escalation in Fusarium root rots in pea fields. Among the most significant rot rotting pathogenic fungal species, Fusarium solani fsp. pisi (Fsp) is one of the main causal agents of root rot of pea. High levels of partial resistance to Fsp has been identified in plant genetic resources. Genetic resistance offers one of the best solutions to control this root rotting fungus...
March 12, 2019: BMC Plant Biology
https://read.qxmd.com/read/30864048/polyamines-levels-increase-in-smut-teliospores-after-contact-with-sugarcane-glycoproteins-as-a-plant-defensive-mechanism
#10
Elena Sánchez-Elordi, Laura Morales de Los Ríos, Carlos Vicente, María-Estrella Legaz
Previous studies have already highlighted the correlation between Sporisorium scitamineum pathogenicity and sugarcane polyamine accumulation. It was shown that high infectivity correlates with an increase in the amount of spermidine, spermine and cadaverine conjugated to phenols in the sensitive cultivars whereas resistant plants mainly produce free putrescine. However, these previous studies did not clarify the role of these polyamides in the disorders caused to the plant. Therefore, the purpose of this research is to clarify the effect of polyamines on the development of smut disease...
March 12, 2019: Journal of Plant Research
https://read.qxmd.com/read/30863696/rnai-mediated-protection-against-banana-diseases-and-pests
#11
REVIEW
Siddhesh B Ghag, Thumballi R Ganapathi
Pests and pathogens restrict the production potential of many crop plants. The losses incurred due to pests and diseases are huge threatening food security. Management strategies include use of chemical pesticides which can be detrimental to human health and environment and other physical and biological methods which have serious limitations. An alternative would be to utilize the advanced technology such as RNA interference (RNAi) to engineer disease resistance in crop plants. The phenomenon of RNAi is very well studied in organisms across genera and found to be conserved...
March 2019: 3 Biotech
https://read.qxmd.com/read/30863693/a-novel-function-of-n-signaling-in-plants-with-special-reference-to-trichoderma-interaction-influencing-plant-growth-nitrogen-use-efficiency-and-cross-talk-with-plant-hormones
#12
Bansh Narayan Singh, Padmanabh Dwivedi, Birinchi Kumar Sarma, Gopal Shankar Singh, Harikesh Bahadur Singh
Trichoderma spp. is considered as a plant growth promoter and biocontrol fungal agents. They colonize on the surface of root in most of the agriculture crops. They secrete different secondary metabolites and enzymes which promote different physiological processes as well as protect plants from various environmental stresses. This is part of their vital functions. They are widely exploited as a biocontrol agent and plant growth promoter in agricultural fields. Colonization of Trichoderma with roots can enhance nutrient acquisition from surrounding soil to root and can substantially increase nitrogen use efficiency (NUE) in crops and linked with activation of plant signaling cascade...
March 2019: 3 Biotech
https://read.qxmd.com/read/30863414/application-of-genetic-engineering-for-control-of-bacterial-wilt-disease-of-enset-ethiopia-s-sustainability-crop
#13
REVIEW
Ibsa Fite Merga, Leena Tripathi, Anne Kathrine Hvoslef-Eide, Endale Gebre
Enset ( Ensete ventricosum (Welw.) Cheesman) is one of the Ethiopia's indigenous sustainability crops supporting the livelihoods of about 20 million people, mainly in the densely populated South and Southwestern parts of the country. Enset serves as a food security crop for humans, animal feed, and source of fiber for the producers. The production of enset has been constrained by plant pests, diseases, and abiotic factors. Among these constraints, bacterial wilt disease has been the most important limiting factor for enset production since its outbreak five decades ago...
2019: Frontiers in Plant Science
https://read.qxmd.com/read/30863068/nano-biotechnology-a-new-approach-to-treat-and-prevent-malaria
#14
REVIEW
Khaista Rahman, Shahid Ullah Khan, Shah Fahad, Ming Xian Chang, Aqleem Abbas, Wasim Ullah Khan, Lutfur Rahman, Zaheer Ul Haq, Ghulam Nabi, Dilfaraz Khan
Malaria, the exterminator of ~1.5 to 2.7 million human lives yearly, is a notorious disease known throughout the world. The eradication of this disease is difficult and a challenge to scientists. Vector elimination and effective chemotherapy for the patients are key tactics to be used in the fight against malaria. However, drug resistance and environmental and social concerns are the main hurdles in this fight against malaria. Overcoming these limitations is the major challenge for the 21st-century malarial researchers...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30861483/cell-surface-immune-receptors-the-guardians-of-the-plant-s-extracellular-spaces
#15
REVIEW
Kostya Kanyuka, Jason J Rudd
Since the original 'Zigzag model', several iterations have been proposed to reconcile both the Pattern Triggered Immunity (PTI) and the Effector Triggered Immunity (ETI) branches of the plant immune system. The recent cloning of new disease resistance genes, functioning in gene-for-gene interactions, which structurally resemble cell surface broad spectrum Pattern Recognition Receptors, have further blurred the distinctions between PTI and ETI in plant immunity. In an attempt to simplify further the existing conceptual models, we, herein, propose a scheme based on the spatial localization of the key proteins (receptors) which function to induce plant immune responses...
March 9, 2019: Current Opinion in Plant Biology
https://read.qxmd.com/read/30858855/transcriptional-reprogramming-of-rice-cells-by-xanthomonas-oryzae-tales
#16
Stefanie Mücke, Maik Reschke, Annett Erkes, Claudia-Alice Schwietzer, Sebastian Becker, Jana Streubel, Richard D Morgan, Geoffrey G Wilson, Jan Grau, Jens Boch
Rice-pathogenic Xanthomonas oryzae bacteria cause severe harvest loss and challenge a stable food supply. The pathogen virulence relies strongly on bacterial TALE (transcription activator-like effector) proteins that function as transcriptional activators inside the plant cell. To understand the plant targets of TALEs, we determined the genome sequences of the Indian X. oryzae pv. oryzae ( Xoo ) type strain ICMP 3125T and the strain PXO142 from the Philippines. Their complete TALE repertoire was analyzed and genome-wide TALE targets in rice were characterized...
2019: Frontiers in Plant Science
https://read.qxmd.com/read/30854956/medicinal-plant-compounds-for-combating-the-multi-drug-resistant-pathogenic-bacteria-a-review
#17
Mulugeta Mulat, Archana Pandita, Fazlurrahman Khan
BACKGROUND: Globally, people utilize plants as a main source of remedy to heal various ailments. Medicinal plants have been utilized to treat ailments since the invention of modern scientific systems of medicine. The common remedy of infectious diseases, mainly depends on the inhibition capacity of compounds or killing potential. The issue may give a clue for development of a novel antimicrobial agent. METHODS: Currently, microorganisms which are resistant towards antibiotics are probably a matter of serious concern for the overall well-being of health...
March 8, 2019: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/30854208/validation-of-snp-markers-for-fruit-quality-and-disease-resistance-loci-in-apple-malus-%C3%A3-domestica-borkh-using-the-openarray%C3%A2-platform
#18
David Chagné, Stijn Vanderzande, Chris Kirk, Natalie Profitt, Rosemary Weskett, Susan E Gardiner, Cameron P Peace, Richard K Volz, Nahla V Bassil
Genome mapping has promised much to tree fruit breeding during the last 10 years. Nevertheless, one of the greatest challenges remaining to tree fruit geneticists is the translation of trait loci and whole genome sequences into diagnostic genetic markers that are efficient and cost-effective for use by breeders, who must select genetically optimal parents and subsequently select genetically superior individuals among their progeny. To take this translational step, we designed the apple International RosBREED SNP Consortium OpenArray v1...
2019: Horticulture Research
https://read.qxmd.com/read/30853964/global-responses-of-resistant-and-susceptible-sorghum-sorghum-bicolor-to-sugarcane-aphid-melanaphis-sacchari
#19
Hannah M Tetreault, Sajjan Grover, Erin D Scully, Tammy Gries, Nathan A Palmer, Gautam Sarath, Joe Louis, Scott E Sattler
The sugarcane aphid ( Melanaphis sacchari ) has emerged as a significant pest for sorghum. The use of sugarcane aphid-resistant sorghum germplasm with integrated pest management strategies appears to be an excellent solution to this problem. In this study, a resistant line (RTx2783) and a susceptible line (A/BCK60) were used to characterize the differences in plant responses to the sugarcane aphid through a series of experiments, which examined global sorghum gene expression, aphid feeding behavior and inheritance of aphid resistance...
2019: Frontiers in Plant Science
https://read.qxmd.com/read/30853061/the-auxin-regulated-protein-zmauxrp1-coordinates-the-balance-between-root-growth-and-stalk-rot-disease-resistance-in-maize
#20
Jianrong Ye, Tao Zhong, Dongfeng Zhang, Chuanyu Ma, Lina Wang, Lishan Yao, Qianqian Zhang, Mang Zhu, Mingliang Xu
To optimize fitness, plants must efficiently allocate their resources between growth and defense. Although phytohormone crosstalk has emerged as a major player in balancing growth and defense, the genetic basis by which plants manage this balance remains elusive. We previously identified a quantitative disease-resistance locus, qRfg2, in maize (Zea mays) that protects against the fungal disease Gibberella stalk rot. Here, through map-based cloning, we demonstrate that the causal gene at qRfg2 is ZmAuxRP1, which encodes a plastid stroma-localized auxin-regulated protein...
March 4, 2019: Molecular Plant
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