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https://read.qxmd.com/read/30772812/short-communication-discovery-and-molecular-docking-simulation-of-7-hydroxy-6-methoxy-2h-chromen-2-one-as-a-lox-inhibitor
#1
Tajur Rahman, Ghias Uddin, Muhammad Iqbal Choudhary
Millettia ovalifolia is traditionally used in variety of diseases including inflammation. In our investigation in to the phytochemical constituents of Millettia ovalifolia an effort was made to find out bioactive constituent from medicinal Plant M. ovalifolia to scientifically validate its use in inflammatory disorders. The compound 7-hydroxy-6-methoxy-2H-chromen-2-one was isolated from the bark of M. ovalifolia and was found to exhibited significant lipoxygenase (LOX) inhibitory activity with (IC50 value: 116...
January 2019: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/30771504/forms-of-extracellular-mitochondria-and-their-impact-in-health
#2
REVIEW
Sophia Miliotis, Bryan Nicolalde, Mayra Ortega, Jackie Yepez, Andrés Caicedo
Mitochondria play an important role as an intracellular energy plant and signaling organelle. However, mitochondria also exist outside cells where they could mediate cell-to-cell communication, repair and serve as an activator of the immune response. Their effects depend on the mitochondrial state or the form in which it is present, either as a whole functional structure as fragments or only as mitochondrial DNA. Herein, we provide evidence of why extracellular mitochondria and their varying forms are considered regenerative factors or pro-inflammatory activators...
February 13, 2019: Mitochondrion
https://read.qxmd.com/read/30771255/disruption-of-gene-spl35-encoding-a-novel-cue-domain-containing-protein-leads-to-cell-death-and-enhanced-disease-response-in-rice
#3
Jian Ma, Yongfei Wang, Xiaoding Ma, Lingzhi Meng, Ruonan Jing, Fan Wang, Shuai Wang, Zhijun Cheng, Xin Zhang, Ling Jiang, Jiulin Wang, Jie Wang, Zhichao Zhao, Xiuping Guo, Qibing Lin, Fuqing Wu, Shanshan Zhu, Wu Chuanyin, Yulong Ren, Cailin Lei, Huqu Zhai, Jianmin Wan
Lesion mimic mutants that exhibit spontaneous hypersensitive response (HR)-like necrotic lesions are ideal experimental systems for elucidating molecular mechanisms involved in plant cell death and defense responses. Here we report identification of a rice lesion mimic mutant, spotted leaf 35 (spl35), and cloning of the causal gene by TAIL-PCR strategy. spl35 exhibited decreased chlorophyll content, higher accumulation of H2 O2 , up-regulated expression of defense-related marker genes, and enhanced resistance to both fungal and bacterial pathogens of rice...
February 16, 2019: Plant Biotechnology Journal
https://read.qxmd.com/read/30770836/an-eds1-heterodimer-signalling-surface-enforces-timely-reprogramming-of-immunity-genes-in-arabidopsis
#4
Deepak D Bhandari, Dmitry Lapin, Barbara Kracher, Patrick von Born, Jaqueline Bautor, Karsten Niefind, Jane E Parker
Plant intracellular NLR receptors recognise pathogen interference to trigger immunity but how NLRs signal is not known. Enhanced disease susceptibility1 (EDS1) heterodimers are recruited by Toll-interleukin1-receptor domain NLRs (TNLs) to transcriptionally mobilise resistance pathways. By interrogating the Arabidopsis EDS1 ɑ-helical EP-domain we identify positively charged residues lining a cavity that are essential for TNL immunity signalling, beyond heterodimer formation. Mutating a single, conserved surface arginine (R493) disables TNL immunity to an oomycete pathogen and to bacteria producing the virulence factor, coronatine...
February 15, 2019: Nature Communications
https://read.qxmd.com/read/30770404/multilocus-sequence-analysis-reveals-three-distinct-populations-of-candidatus-phytoplasma-palmicola-with-a-specific-geographical-distribution-on-the-african-continent
#5
Fabian Pilet, Robert Nketsia Quaicoe, Isaac Jesuorobo Osagie, Marcos Freire, Xavier Foissac
To sustain epidemiological studies on coconut lethal yellowing disease (CLYD), a devastating disease in Africa caused by a phytoplasma, we developed a multilocus sequence typing (MLST) scheme for ' Candidatus Phytoplasma palmicola' based on 8 housekeeping genes. At the continental level, eight different sequence types were identified among 132 ' Ca. Phytoplasma palmicola-' infected coconuts collected in Ghana, Nigeria and Mozambique where CLYD epidemics are still very active.' Ca. Phytoplasma palmicola' appeared to be a bacterium submitted to strong bottlenecks, reducing the fixation of positively selected beneficial mutations into the bacterial population...
February 15, 2019: Applied and Environmental Microbiology
https://read.qxmd.com/read/30769935/dissipation-dynamics-and-dietary-risk-assessment-of-kresoxim-methyl-residue-in-rice
#6
MingNa Sun, Lu Yu, Zhou Tong, Xu Dong, Yue Chu, Mei Wang, TongChun Gao, JinSheng Duan
Kresoxim-methyl is a high-efficiency and broad-spectrum fungicide used for the control of rice fungal diseases; however, its residues after application potentially threaten human health. Investigations on the dissipation of kresoxim-methyl residue in rice field systems and dietary risk assessment of kresoxim-methyl in humans are limited. The present study employed the QuEChERS-GC-MS/MS method for residue analysis of kresoxim-methyl in rice plants, brown rice, and rice husks. The samples were extracted with acetonitrile and purified by PSA, C18 column, and GCB...
February 15, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30769881/inhibition-of-amyloid-beta-aggregation-and-deposition-of-cistanche-tubulosa-aqueous-extract
#7
Chien-Liang Chao, Hsin-Wen Huang, Hui-Chi Huang, Hsin-Fan Chao, Shuen-Wen Yu, Muh-Hwan Su, Chao-Jih Wang, Hang-Ching Lin
Cistanche tubulosa aqueous extract (CTE) is already used as a botanical prescription drug for treating dementia in China. Our previous studies reported that phenylethanoid glycosides of CTE have anti-Alzheimer's disease (AD) activity by inhibiting amyloid β peptide (Aβ) aggregation and deposition. However, recent studies considered that the phenylethanoid glycosides may be metabolized by intestinal bacteria, because all analysis results showed that the bioavailability of phenylethanoid glycosides is extremely low...
February 14, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30769316/one-health-cycling-of-diverse-microbial-communities-as-a-connecting-force-for-soil-plant-animal-human-and-ecosystem-health
#8
REVIEW
Ariena H C van Bruggen, Erica M Goss, Arie Havelaar, Anne D van Diepeningen, Maria R Finckh, J Glenn Morris
The One Health concept proposes that there is a connection between human, animal and environmental health. Plants and their health are not explicitly included. In this review, we broaden the One Health concept to include soil, plant, animal and ecosystem health. We argue that the health conditions of all organisms in an ecosystem are interconnected through the cycling of subsets of microbial communities from the environment (in particular the soil) to plants, animals and humans, and back into the environment...
February 6, 2019: Science of the Total Environment
https://read.qxmd.com/read/30769039/medicinal-plants-with-concomitant-anti-diabetic-and-anti-hypertensive-effects-as-potential-sources-of-dual-acting-therapies-against-diabetes-and-hypertension-a-review
#9
REVIEW
Chika Ifeanyi Chukwuma, Motlalepula G Matsabisa, Mohammed Auwal Ibrahim, Ochuko L Erukainure, Matimbha H Chabalala, Md Shahidul Islam
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes and hypertension are pathophysiologically related diseases that co-exist with a wider complex of metabolic diseases having similar set of risk factors. There are numerous ethnopharmacological evidences on the anti-diabetic and/or anti-hypertensive properties of medicinal plants from various parts of the world, which are used as therapies to concomitantly manage diabetes and hypertension. AIM OF THE REVIEW: This article reviewed findings on medicinal plants with both anti-diabetic and anti-hypertensive effects reported in same experimental study to facilitate the development of dual-acting therapies against diabetes and hypertension...
February 12, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30768614/prevalence-of-w%C3%A4-nzh%C3%A5-u-virus-in-small-mammals-in-yunnan-province-china
#10
Jinxia Wang, Xinglou Yang, Haizhou Liu, Li Wang, Jihua Zhou, Xi Han, Yan Zhu, Weihong Yang, Hong Pan, Yunzhi Zhang, Zhengli Shi
BACKGROUND: Mammarenaviruses are associated with human hemorrhagic fever diseases in Africa and America. Recently, a rodent mammarenavirus, Wēnzhōu virus (WENV) and related viruses, have been reported in China, Cambodia, and Thailand. Moreover, in Cambodia, these viruses were suspected to be associated with human disease. In China, Yunnan Province is famous for its abundant animal and plant diversity and is adjacent to several South-eastern Asia countries. Therefore, it is necessary to know whether WENV-related viruses, or other mammarenaviruses, are prevalent in this province...
February 15, 2019: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/30768427/plant-derived-medicines-for-neuropathies-a-comprehensive-review-of-clinical-evidence
#11
Farnaz Ebrahimi, Mohammad Hosein Farzaei, Roodabeh Bahramsoltani, Mojtaba Heydari, Kiana Naderinia, Roja Rahimi
Neuropathy is defined as the damage to the peripheral or central nervous system accompanied by pain, numbness, or muscle weakness, which can be due to congenital diseases or environmental factors such as diabetes, trauma, or viral infections. As current treatments are not sufficiently able to control the disease, studies focusing on the identification and discovery of new therapeutic agents are necessary. Natural products have been used for a long time for the management of different neurological problems including neuropathies...
February 15, 2019: Reviews in the Neurosciences
https://read.qxmd.com/read/30768201/dietary-protein-intake-and-kidney-function-decline-after-myocardial-infarction-the-alpha-omega-cohort
#12
Kevin Esmeijer, Johanna M Geleijnse, Johan W de Fijter, Daan Kromhout, Ellen K Hoogeveen
BACKGROUND: Post-myocardial infarction (MI) patients have a doubled rate of kidney function decline compared with the general population. We investigated the extent to which high intake of total, animal and plant protein are risk factors for accelerated kidney function decline in older stable post-MI patients. METHODS: We analysed 2255 post-MI patients (aged 60-80 years, 80% men) of the Alpha Omega Cohort. Dietary data were collected with a biomarker-validated 203-item food frequency questionnaire...
February 14, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30767746/novel-herbal-topical-patch-containing-curcumin-and-arnica-montana-for-the-treatment-of-osteoarthritis
#13
Priyanka Kriplani, Kumar Guarve, Uttam Singh Baghel
BACKGROUND: Osteoarthritis (OA) ranks fifth among all forms of disability affecting 10% of the world population. Current treatments available are associated with multiple side effects and do not slow down the progression of disease. Moreover no such effective treatment is available till date in various systems of medicine to treat osteoarthritis. Curcumin and Arnica have shown evident clinical advances in the treatment of osteoarthritis. OBJECTIVE: The aim of the present study was to design, optimize and characterize novel herbal transdermal patches of curcumin and Arnica montana using factorial design...
February 14, 2019: Current Rheumatology Reviews
https://read.qxmd.com/read/30767744/in-silico-inhibition-of-bace-1-by-selective-phytochemicals-as-novel-potential-inhibitors-molecular-docking-and-dft-studies
#14
Nadia Arif, Andleeb Subhani, Waqar Hussain, Nouman Rasool
BACKGROUND: Alzheimer's disease (AD) has become the most common age-dependent disease of dementia. The trademark pathologies of AD are the presence of amyloid aggregates in neurofibrils. Recently phytochemicals being considered as potential inhibitors against various neurodegenerative, anti-fungal, antibacterial and antiviral diseases in human beings. OBJECTIVE: This study targets the inhibition of BACE-1 by phytochemicals using in silico drug discovery analysis...
February 14, 2019: Current Drug Discovery Technologies
https://read.qxmd.com/read/30767224/investigation-of-the-utility-of-curcuma-caesia-in-the-treatment-of-diabetic-neuropathy
#15
REVIEW
Madhuri Grover, Karan Shah, Gaurav Khullar, Jyoti Gupta, Tapan Behl
OBJECTIVES: Curcuma caesia has shown positive results in treating number of diseases, but till date no work was reported on its activity in diabetic neuropathy. So, the present review aims at exploring several hypothesis which can be proposed to explain further its utility in diabetic neuropathy by its antioxidant property, anti-inflammatory, CNS depressant effect, antibacterial and antifungal property. For finding the accurate and exact detail, a thorough review of all the available research and review article was done...
February 14, 2019: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/30766928/characterization-of-the-infection-process-by-peronospora-belbahrii-on-basil-by-scanning-electron-microscopy
#16
Guirong Zhang, Arthur Thompson, David Schisler, Eric T Johnson
Basil downy mildew caused by Peronospora belbahrii is a disease of sweet basil ( Ocimum basilicum ) production worldwide. In this study, sweet basil was grown in plant growth chambers and inoculated with sporangia of P. belbahrii harvested from previously infected plants. Plants were placed in closed, clear plastic bags and leaves harvested over time and observed using scanning electron microscopy. In most cases, sporangia germinated myceliogenically on abaxial and adaxial leaf surfaces as early as three days after inoculation...
January 2019: Heliyon
https://read.qxmd.com/read/30766525/plant-root-exudates-are-involved-in-bacillus-cereus-ar156-mediated-biocontrol-against-ralstonia-solanacearum
#17
Ning Wang, Luyao Wang, Kai Zhu, Sensen Hou, Lin Chen, Dandan Mi, Ying Gui, Yijun Qi, Chunhao Jiang, Jian-Hua Guo
The biological control process mediated by microbes relies on multiple interactions among plants, pathogens and biocontrol agents (BCAs). One such efficient BCA is Bacillus cereus AR156, a bacterial strain that controls a broad spectrum of plant diseases and potentially works as a microbe elicitor of plant immune reactions. It remains unclear, however, whether the interaction between plants and B. cereus AR156 may facilitate composition changes of plant root exudates and whether these changes directly affect the growth of both plant pathogens and B...
2019: Frontiers in Microbiology
https://read.qxmd.com/read/30766425/comparative-evaluation-of-cytotoxic-antimicrobial-and-antioxidant-activities-of-the-crude-extracts-of-three-plectranthus-species-grown-in-saudi-arabia
#18
Ramzi A Mothana, Jamal M Khaled, Ali A El-Gamal, Omar M Noman, Ashok Kumar, Mohamed F Alajmi, Adnan J Al-Rehaily, Mansour S Al-Said
Natural products from medicinal plants represent major resource of novel therapeutic substances for combating serious diseases including cancers and microbial infections. The genus Plectranthus (Family: Labiatae) represents a large and widespread group of species with a diversity of traditional uses in treatment of various ailments. Therefore, this research study aimed to evaluate the cytotoxic, antimicrobial and antioxidant activities of three Plectranthus species growing in Saudi Arabia namely P. cylindraceus Hocst...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30765761/dissecting-quantitative-resistance-to-xanthomonas-campestris-pv-campestris-in-leaves-of-brassica-oleracea-by-qtl-analysis
#19
Laura Iglesias-Bernabé, Pari Madloo, Víctor Manuel Rodríguez, Marta Francisco, Pilar Soengas
Black rot, caused by the bacterium Xanthomonas campestris pv. campestris (Xcc), produces important economic losses in crops of Brassica oleracea worldwide. Resistance to race 1, the most virulent and widespread in B. oleracea, is under quantitative control. Knowledge about the genetics of this resistance would help in designing strategies to control initial stages of invasion and development of the disease. QTL analysis of the resistance in the BolTBDH mapping population was performed. Resistance was measured with five traits related to initial stages of the invasion, success of infection and spread of the pathogen...
February 14, 2019: Scientific Reports
https://read.qxmd.com/read/30765733/detection-of-candidatus-phytoplasma-solani-in-roots-from-bois-noir-symptomatic-and-recovered-grapevines
#20
Lucia Landi, Sergio Murolo, Gianfranco Romanazzi
'Candidatus Phytoplasma solani' is the causal agent of Bois noir (BN) in grapevine (Vitis vinifera). It is usually detected in leaves, where typical disease symptoms are seen. However, little information is available on the presence of this phytoplasma in grapevine roots. Here, we investigated 'Ca. P. solani' in roots collected from 28 symptomatic, 27 recovered and eight asymptomatic grapevine plants. Protocols based on high-resolution melting (HRM) combined with real-time quantitative PCR (qPCR-HRM) and nested-qPCR-HRM were developed to identify 'Ca...
February 14, 2019: Scientific Reports
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