Hideko Nagasawa, Yoshihiro Uto, Hideyuki Sasaki, Natsuko Okamura, Aya Murakami, Shinichi Kubo, Kenneth L Kirk, Hitoshi Hori
The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5a for neutrophils in inflammation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF)). In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity...
November 2005: Anticancer Research