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Salvia effects

Rui Zhu, Wei Wang, Suxia Yang
Cryptotanshinone (CTS), an active component extracted from the root of Salvia miltiorrhiza Bunge , was reported to attenuate hepatic ischemia/reperfusion (I/R) injury. However, its protective effect against renal I/R injury remains unclear. In this study, the role of CTS in renal I/R injury in vitro and its possible mechanism were investigated. Our results showed that CTS improved cell viability in HK-2 cells exposed to hypoxia/reoxygenation (H/R). CTS also inhibited the H/R-mediated production of reactive oxygen species, as well as increased the activities of superoxide dismutase and catalase in H/R-stimulated HK-2 cells...
March 19, 2019: Journal of Cellular Biochemistry
Yu-Ting Wu, Yi-Ming Bi, Zhang-Bin Tan, Ling-Peng Xie, Hong-Lin Xu, Hui-Jie Fan, Hong-Mei Chen, Jun Li, Bin Liu, Ying-Chun Zhou
Vascular smooth muscle cell (VSMC) proliferation plays a critical role in arterial remodeling during various vascular diseases including atherosclerosis and hypertension. Tanshinone I, a major component of Salvia miltiorrhiza, exerts protective effects against cardiovascular diseases. In this study, we investigated the effects of tanshinone I on VSMC proliferation, as well as the underlying mechanisms. We found that this compound inhibited the proliferation of VSMCs in a dose-dependent manner, based on 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) and 5-ethynyl-2'-deoxyuridine (EdU) assays...
March 13, 2019: European Journal of Pharmacology
Jia-Ming Gao, Ming Lyu, Wei-Wei Xie, Xin-Yan Liu, Bu-Chang Zhao, Yan Zhu
To explore the regularity of traditional Chinese medicine(TCM) prescriptions for cardio-cerebrovascular diseases,the core drug groups with common therapeutic effects on cerebrovascular diseases represented by stroke and cardiovascular diseases represented by coronary artery disease were extracted,and their consistency and difference in the treatment of different diseases were analyzed.A total of 388 Chinese patent medicines were collected for the treatment of cerebrovascular diseases,cardiovascular diseases and cardio-cerebrovascular diseases...
January 2019: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Natalie Z M Eichner, Nicole M Gilbertson, Luca Musante, Sabrina La Salvia, Arthur Weltman, Uta Erdbrügger, Steven K Malin
Although extracellular vesicles (EVs) are a novel biomediator of type 2 diabetes (T2D) and cardiovascular disease (CVD), the effects of hyperglycemia on EVs in humans is unknown. We tested the hypothesis that a 75-g oral glucose tolerance test (OGTT) would promote changes in EVs in relation to CVD risk. Twenty-five obese adults (Age: 52.4 ± 3.2 year, BMI: 32.5 ± 1.2 kg/m²) were screened for normal glucose tolerance (NGT, n = 8) and prediabetes (PD, n = 17) using American Diabetes Association criteria (75 g OGTT and/or HbA1c)...
March 8, 2019: Nutrients
Vahideh Oveissi, Mahboobe Ram, Roodabeh Bahramsoltani, Farnaz Ebrahimi, Roja Rahimi, Rozita Naseri, Tarun Belwal, Hari Prasad Devkota, Zahra Abbasabadi, Mohammad Hosein Farzaei
BACKGROUND: Chemotherapy, as one of the main approaches of cancer treatment, is accompanied with several adverse effects, including chemotherapy-induced peripheral neuropathy (CIPN). Since current methods to control the condition are not completely effective, new treatment options should be introduced. Medicinal plants can be suitable candidates to be assessed regarding their effects in CIPN. Current paper reviews the available preclinical and clinical studies on the efficacy of herbal medicines in CIPN...
March 9, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Qiangqiang Jia, Ruyuan Zhu, Yimiao Tian, Beibei Chen, Rui Li, Lin Li, Lili Wang, Yiwen Che, Dandan Zhao, Fangfang Mo, Sihua Gao, Dongwei Zhang
BACKGROUND: Salvia miltiorrhiza (SM), one of the frequently used herbs in traditional Chinese medicine (TCM), has now attracted rising interests for a possible alternative in the management of diabetes. This review is aimed to providing a comprehensive perspective of SM in phytochemical constituents, pharmacological activities against diabetes and its complications, and safety. METHODS: A comprehensive search of published literatures was conducted to locate original publications pertaining to SM and diabetes till the end of 2017 using PubMed, China National Knowledge Infrastructure, National Science and Technology Library, China Science and Technology Journal Database, and Web of Science database...
February 18, 2019: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Martina Jakovljević, Stela Jokić, Maja Molnar, Midhat Jašić, Jurislav Babić, Huska Jukić, Ines Banjari
Salvia officinalis L., also known as the "Salvation Plant", has been long used and well-documented in traditional medicine around the globe. Its bioactive compounds, and especially its polyphenol profile, have been extensively researched and reviewed. However, sage's beneficial effects reach much further, and nowadays, with a range of new extraction techniques, we are discovering new components with new therapeutic effects, especially in the context of neurodegenerative diseases and various carcinomas...
March 6, 2019: Plants (Basel, Switzerland)
Tian An, Jing Zhang, Bohan Lv, Yufei Liu, Jiangpinghao Huang, Juan Lian, Yanxiang Wu, Sihua Gao, Guangjian Jiang
Background: Adipose tissue plays a central role in obesity-related metabolic diseases such as type 2 diabetes. Salvianolic acid B (Sal B), a water-soluble ingredient derived from Salvia miltiorrhiza , has been shown to reduce obesity and obesity-related metabolic diseases by suppressing adipogenesis. However, the role of Sal B in white adipose tissue (WAT) is not yet clear. Methods: Illumina Hiseq 4000 was used to study the effects of Sal B on the expression of long non-coding RNA (lncRNA) and circular RNA (circRNA) in epididymal white adipose tissue induced by a high fat diet in obese mice...
2019: PeerJ
Lunkun Ma, Liling Tang, Qian Yi
Salvianolic acids, the most effective and abundant compounds extracted from Salvia miltiorrhiza (Danshen), are well known for its good anti-oxidative activity. Danshen has been extensively used as a traditional medicine to treat cardiovascular-related diseases in China and other Asian countries for hundreds of years. Recently, more and more studies have demonstrated that salvianolic acids also have a good effect on the alleviation of fibrosis disease and the treatment of cancer. In vivo and in vitro experiments have demonstrated that salvianolic acids can modulate signal transduction within fibroblasts and cancer cells...
2019: Frontiers in Pharmacology
Sevda Güzel, Yusuf Özay, Meltem Kumaş, Coşar Uzun, Ebru Gökalp Özkorkmaz, Zuhal Yıldırım, Mahmut Ülger, Gizem Güler, Ayla Çelik, Yusuf Çamlıca, Ahmet Kahraman
Diabetic patients suffer from persistent and non-healing wounds. Salvia species are traditionally used for the treatment of wounds and colds. The aims of the present study were to evaluate the in vivo wound healing potential, in vitro antimicrobial and antioxidant activities, and total phenolic and flavonoid contents of the aerial parts of two endemic taxa, Salvia kronenburgii Rech. f. (SK) and Salvia euphratica Montbret, Aucher & Rech. f. var. euphratica (SE). Two different concentrations (0.5% and 1% (w/w)) of ethanol extracts were investigated in incision and excision wound models on Streptozotocin-induced diabetic rats using biomechanical, biochemical, histopathological, macroscopic, and genotoxic methods for 7 and 14 days...
March 2019: Biomedicine & Pharmacotherapy
Ninon G E R Etsassala, Tesfaye Waryo, Olugbenga K Popoola, Adewale O Adeloye, Emmanuel I Iwuoha, Ahmed A Hussein
South Africa is a country with a wide variety of plants that may contain excellent anti-tyrosinase inhibitors. With wide applications in cosmetics, pharmaceuticals and food products, tyrosinase inhibitors have received very special attention in the recent past as a way of preventing the overproduction of melanin in epidermal layers which often over time brings detrimental effects on human skin. In this present study, a fast screening method using a cyclic voltammetry technique was applied in the evaluation of methanolic extracts of twenty-five species of plants from the Lamiaceae family for anti-tyrosinase activity...
February 28, 2019: Sensors
Ching-Mao Chang, Po-Hsuan Shih, Tzeng-Ji Chen, Wen-Chao Ho, Chun-Pai Yang
ETHNOPHARMACOLOGICAL RELEVANCE: The issue of whether integrated treatment with conventional medicine (CM) and herbal medicine (HM) can reduce mortality in patients with polymyositis/dermatomyositis (PM/DM) had not been addressed. AIM OF THE STUDY: In this study, we investigated the effect of integrated therapy on mortality in a retrospective PM/DM cohort in the Taiwan National Health Insurance Research Database (NHIRD). MATERIALS AND METHODS: Patients with PM/DM were retrospectively enrolled from the PM/DM Registry of Catastrophic Illnesses cohort in the Taiwan NHIRD between 1997 and 2011...
February 25, 2019: Journal of Ethnopharmacology
Wei Huiping, Wang Yu, Jin Pei, Li Jiao, Zhang Shian, Jiang Hugang, Wang Zheng, Li Yingdong
BACKGROUND: Chronic stable angina (CSA) resulted in a considerable burden for both individuals and the society. In this study we aimed to critically evaluate the effectiveness and safety of Compound salvia pellet compared with nitrates in the treatment of Chronic Stable Angina (CSA) pectoris, and to provide more credible evidence for clinical practice. METHODS: A comprehensive and exhaustive search strategy was formulated to identify potential RCTs of compound salvia pellet for CSA in international and Chinese databases from their inception to July 4th, 2018...
March 2019: Medicine (Baltimore)
Yan Yu, Tao Wang, Yichao Wu, Yonghong Zhou, Yuanyuan Jiang, Li Zhang
The effect of elicitors on the metabolites in the suspension cells of Salvia miltiorrhiza Bunge was elucidated by comparing and analyzing the metabolites of induced and uninduced suspension cells. The primary metabolites were detected by GC-MS. Twelve types of secondary metabolites, namely, shikimic acid, tanshinol, protocatechuic acid, caffeic acid, p -coumaric acid, rosmarinic acid, salvianolic acid B, salvianolic acid A, dihydrotanshinone, cryptotanshinone, tanshinone I, and tanshinone II A were detected by HPLC...
January 2019: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
Wen-Chi Chen, Tzu-Yang Chou, Huey-Yi Chen, You-Rong Yang, Kee-Ming Man, Ming-Yen Tsai, Yung-Hsiang Chen
Traditional Chinese medicine (TCM) has been prescribed for the treatment of stone disease for thousands of years. Salvia miltiorrhiza (Danshen) was previously shown to have potential for treatment of stone disease in animal and clinical studies. In this study, we further studied the antiurolithiasis effect of Danshen in a fly model. Wild-type male Drosophila melanogaster CS flies were used in this study, with 0.25% ethylene glycol (EG) as a lithogenic agent. 2% potassium citrate (K-citrate) was the positive control agent for prevention (all agents added at the start of experiment) and treatment (drugs added after 2-week addition of lithogenic agent) studies compared with 15, 30, and 60 μ g/ml of Danshen extract...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Miao-Juan Shi, Ben-Sheng Dong, Wen-Na Yang, Shi-Bing Su, Hui Zhang
Liver diseases cause serious public health problems because of their high global prevalence and poor long-term clinical outcomes. With its mild and broad therapeutic efficacy, traditional Chinese medicine (TCM) has played an important role in the prevention and treatment of liver diseases in China for hundreds of years. Tanshinone IIA (TIIA), a major component extracted from the traditional herbal medicine Salvia miltiorrhiza Bunge, has been broadly studied for its multiple biological activities, including antiangiogenic, antioxidant, anti-inflammatory and anticancer properties...
February 20, 2019: Biomedicine & Pharmacotherapy
Renyikun Yuan, Liting Huang, Li-Jun Du, Jian-Fang Feng, Jun Li, Ying-Ying Luo, Qiong-Ming Xu, Shi-Lin Yang, Hongwei Gao, Yu-Lin Feng
Dihydrotanshinone (DHT), one of the major ingredients of Salvia miltiorrhiza Bunge (Danshen), displays many bioactivities. However, the activity and underlying mechanism of DHT in anti-inflammation have not yet been elucidated. In this study, we investigated the anti-inflammatory activity and molecular mechanism of action of DHT both in vitro and in vivo. Our data showed that DHT significantly decreased the release of inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β in lipopolysaccharide (LPS)-stimulated RAW264...
February 19, 2019: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Xian Zhou, Valentina Razmovski-Naumovski, Antony Kam, Dennis Chang, Chun Guang Li, Kelvin Chan, Alan Bensoussan
BACKGROUND: This study investigated the protective effects of the Danshen (DS) and Sanqi (SQ) herb pair on cell survival in the human cardiovascular endothelial (EA.hy926) cell line exposed to injury. METHODS: Nine combination ratios of Danshen-Sanqi extracts (DS-SQ) were screened for their protective effects in the EA.hy926 cell line against two different cellular impairments induced by DL-homocysteine (Hcy) - adenosine (Ado) - tumour necrosis factors (TNF) and oxidative stress (H2 O2 ), respectively...
February 21, 2019: BMC Complementary and Alternative Medicine
Ana Salević, Cristina Prieto, Luis Cabedo, Viktor Nedović, Jose Maria Lagaron
In this study, novel active films made of poly(ε-caprolactone) (PCL) containing a solid dispersion of sage extract (SE) were developed by means of the electrospinning technique and subsequent annealing treatment. Initially, the antioxidant and antimicrobial potential of SE was confirmed. Thereafter, the effect of SE incorporation at different loading contents (5%, 10%, and 20%) on the physicochemical and functional properties of the films was evaluated. The films were characterized in terms of morphology, transparency, water contact angle, thermal stability, tensile properties, water vapor, and aroma barrier performances, as well as antioxidant and antimicrobial activities...
February 15, 2019: Nanomaterials
Yubin Ji, Yichen Liu, Nina Xue, Tingting Du, Liyuan Wang, Rui Huang, Ling Li, Chunhong Yan, Xiaoguang Chen
Purpose: Esophageal squamous-cell carcinoma (ESCC) is the most common subtype of esophageal cancer, with a poor clinical outcome. Cryptotanshinone (CTS) is the main bioactive compound from the root of Salvia miltiorrhiza Bunge. Our study aimed to investigate the anti-cancer effects and molecular mechanisms of CTS on ESCC. Materials and methods: We investigated the anti-tumor activity of CTS on ESCC in vitro and in vivo. Activation of the STAT3 signaling pathway was evaluated in ESCC and HEK-Blue™ IL-6 cells...
2019: OncoTargets and Therapy
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