Jonathan Corren, David Larson, Matthew C Altman, R Max Segnitz, Pedro C Avila, Paul A Greenberger, Fuad Baroody, Mark H Moss, Harold Nelson, Allison J Burbank, Michelle L Hernandez, David Peden, Sarbjit Saini, Stephen Tilles, Iftikhar Hussain, Don Whitehouse, Tielin Qin, Miguel Villarreal, Michelle Sever, Lisa M Wheatley, Gerald T Nepom, Srinath Sanda
BACKGROUND: Thymic stromal lymphopoietin (TSLP) has been shown to play a central role in the initiation and persistence of allergic responses. OBJECTIVE: We evaluated whether tezepelumab, a human monoclonal anti-TSLP antibody, improved the efficacy of subcutaneous allergen immunotherapy (SCIT) and promoted the development of tolerance in patients with allergic rhinitis. METHODS: We conducted a double-blind parallel design trial in patients with cat allergy...
January 2023: Journal of Allergy and Clinical Immunology