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Aging Meta-analysis

Davy Vancampfort, Brendon Stubbs, James Mugisha, Joseph Firth, Tine Van Damme, Lee Smith, Ai Koyanagi
BACKGROUND: Adolescent suicide is a major global mental health problem. Exploring variables associated with suicide attempts is important for the development of targeted interventions. The aim of the current study was to explore associations between leisure-time sedentary behavior and suicide attempts. METHODS: Data from the Global School-based Student Health Survey were analyzed. Data on past 12-month suicide attempts and self-reported leisure-time sedentary time were collected...
March 9, 2019: Journal of Affective Disorders
Laura Marciano, Anne-Linda Camerini, Peter J Schulz
BACKGROUND: Empirical evidence on how health literacy affects diabetes outcomes is inconsistent. The purpose of this meta-analysis was to quantitatively summarize the findings on the associations between health literacy and diabetes knowledge, self-care activities, and glycemic control as disease-related outcomes, with specific focus on the type of health literacy assessment. DATA SOURCES: Nine databases (MEDLINE, CINAHL, Communication and Mass Media Complete, PsychInfo, PsychArticles, Psychology and Behavioral Sciences Collection, ERIC, Sociology, Embase) were searched for peer-reviewed original research articles published until 31 March 2018...
March 15, 2019: Journal of General Internal Medicine
Li Baogui, Chen Juwen
OBJECTIVE: For odontoid fractures, surgical treatment approaches including anterior odontoid screw fixation approach and the posterior C1-C2 arthrodesis approach are generally adopted in practice. However, the choice of different surgical procedures remains controversial. In addition to surgical technique, the fusion rate is an important factor contributing to the clinical efficacy. Therefore, this study was aimed to investigate the discrepancy in fusion rate between these two surgical approaches through synthesizing the currently available evidence on the topic...
March 15, 2019: Archives of Orthopaedic and Trauma Surgery
C Beaudoin, L Moore, M Gagné, L Bessette, L G Ste-Marie, J P Brown, S Jean
There is no consensus on which tool is the most accurate to assess fracture risk. The results of this systematic review suggest that QFracture, Fracture Risk Assessment Tool (FRAX) with BMD, and Garvan with BMD are the tools with the best discriminative ability. More studies assessing the comparative performance of current tools are needed. INTRODUCTION: Many tools exist to assess fracture risk. This review aims to determine which tools have the best predictive accuracy to identify individuals at high risk of non-traumatic fracture...
March 14, 2019: Osteoporosis International
Yawen Jiang, Weiyi Ni
OBJECTIVE: The 2016 Chinese guidelines for the management of dyslipidemia recommended mixed rules that centered around a 10% 10-year risk threshold to initiate statins for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). The present study aimed to evaluate the cost-effectiveness of the guideline statin-initiation strategy and alternative strategies. METHODS: A decision analytic model using discrete event simulation with event probabilities based on a validated ASCVD risk prediction tool for Chinese was constructed...
March 14, 2019: PharmacoEconomics
Peige Song, Diana Rudan, Manli Wang, Xinlei Chang, Igor Rudan
Background: Peripheral artery disease (PAD), the third leading cause of atherosclerotic vascular morbidity, affects approximately 202 million people worldwide, among whom more than two-thirds reside in low- and middle-income countries (LMIC). For China, the largest developing country, little is known about the epidemiology of PAD. We aimed to estimate the prevalence of PAD and the number of affected people in China, establish the main risk factors for PAD and assess the number of people with PAD at the sub-national level...
June 2019: Journal of Global Health
Yan Li, Meizhi He, Yaoyao Zhou, Chen Yang, Shuyi Wei, Xiaohui Bian, Odong Christopher, Lang Xie
Background: Studies evaluating the prognostic significance of programmed death-ligand 1 (PD-L1) expression in colorectal cancer (CRC) are limited and remain controversial. This meta-analysis was conducted in order to evaluate the clinicopathological and prognostic significance of PD-L1 expression in CRC patients. Methods: A comprehensive search was performed against the Medline/PubMed, Embase, Cochrane Library, Web of Science (WoS) and Scopus databases. Data were extracted with name of the first author, year of publication, country of origin, tumor type, number of cases, staining method, cut-off values, PD-L1 positive expression, clinicopathological parameters, outcome, and quality assessment score, and statistical analysis was conducted using Review Manager Version 5...
2019: Frontiers in Pharmacology
Minjia Mo, Shijie Wang, Zun Chen, Xiamusiye Muyiduli, Shuojia Wang, Yu Shen, Bule Shao, Minchao Li, Danqing Chen, Zexin Chen, Yunxian Yu
BACKGROUND/OBJECTIVES: Optimal doses of vitamin D (VitD) supplement in different populations are unclear. We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [25(OH)D] concentration, to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different populations. SUBJECTS/METHODS: Literature search was conducted in Embase, etc. Randomized controlled trials about VitD supplemental intakes and their effect on 25(OH)D concentration were enrolled...
March 14, 2019: European Journal of Clinical Nutrition
Michael Gardner, Stafford Lightman, Diana Kuh, Hannie Comijs, Dorly Deeg, John Gallacher, Marie-Claude Geoffroy, Mika Kivimaki, Meena Kumari, Chris Power, Rebecca Hardy, Marcus Richards, Yoav Ben-Shlomo
Evidence on the association between functioning of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages is mixed. We undertook a systematic review (until October 2016) and individual participant data (IPD) meta-analysis to test if dysregulation of the HPA axis is associated with worse cognitive capability. Five cohort studies were included in the IPD meta-analysis of diurnal cortisol patterns with crystallised and fluid cognitive ability. Higher night time cortisol was associated with worse fluid ability (standardised coefficient per SD increase -0...
March 14, 2019: Scientific Reports
Bruno Rodrigues Rosa, Antonio José Ledo Alves da Cunha, Roberto de Andrade Medronho
BACKGROUND: Randomised controlled trials have evaluated the recombinant tetravalent dengue vaccine (CYD-TDV). However, individual results may have little power to identify differences among the populations studied. OBJECTIVE: To evaluate efficacy, immunogenicity and safety of CYD-TDV in the prevention of dengue in children aged 2-17 years. DESIGN: Systematic review and meta-analysis. DATA SOURCES: MEDLINE (from 1950 to 5 December 2018), EMBASE (from 1947 to 5 December 2018) and Cochrane (from 1993 to 5 December 2018)...
March 13, 2019: BMJ Open
Sravanthi Parasa, Madhav Desai, Anusha Vittal, Viveksandeep T Chandrasekar, Asad Pervez, Kevin F Kennedy, Neil Gupta, Nicholas J Shaheen, Prateek Sharma
BACKGROUND: Biopsies are obtained to confirm intestinal metaplasia and rule out prevalent dysplasia and cancer when Barrett's oesophagus (BE) is detected at index upper endoscopy (oesophagogastroduodenoscopy [EGD]). AIM: The purpose of this systematic review was to obtain summary estimates of the prevalence of high-grade dysplasia (HGD) and oesophageal adenocarcinoma (EAC) associated with BE during index EGD for chronic GERD symptoms, defined as neoplasia detection rate (NDR) which could be used as a quality measure...
March 14, 2019: Gut
(no author information available yet)
BACKGROUND: Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016...
March 11, 2019: Lancet Neurology
Lisa Q Rong, Mohamed K Kamel, Mohamed Rahouma, Ajita Naik, Kritika Mehta, Ahmed A Abouarab, Antonino Di Franco, Michelle Demetres, Taylor L Mustapich, Meghann M Fitzgerald, Kane O Pryor, Mario Gaudino
STUDY OBJECTIVE: We performed a systematic comparison of high-dose and low-dose opioid anesthesia in cardiac surgery. DESIGN: Systematic review and meta-analysis of randomized controlled trials (RCTs). SETTING: Operating room. PATIENTS: 1400 adult patients undergoing cardiac surgery using general anesthesia. INTERVENTIONS: All RCTs comparing the effects of various doses of intravenous opioids (morphine, fentanyl, sufentanil, and remifentanil) during adult cardiac surgery using general anesthesia published until May 2018 (full-text English articles reporting data from human subjects) were included...
March 11, 2019: Journal of Clinical Anesthesia
Sharon G Casavant, Xiaomei Cong, James Moore, Angela Starkweather
BACKGROUND: Every year, an estimated 15 million babies are born preterm (<37 weeks' gestational age [GA]) globally. These preterm infants are exposed to repeated stressful and often painful procedures as part of routine life-saving care within the neonatal intensive care unit (NICU). Preterm birth continues to be a major health issue associated with increased risk of neurodevelopmental and behavioral disorders such as cerebral palsy, cognitive impairment, autism spectrum disorders and psychiatric disease...
March 11, 2019: Early Human Development
Portia Ho, Max Bulsara, Jenny Downs, Shane Patman, Caroline Bulsara, Anne-Marie Hill
OBJECTIVE: The objective of the review was too synthesize the best available evidence on the incidence and prevalence of falls among adults with intellectual disability (ID). INTRODUCTION: Falls among adults with ID frequently cause physical injury and may negatively impact on their quality of life. Studies investigating falls among people with ID have used differing methods and populations, making it difficult to determine the scope and extent of this problem. INCLUSION CRITERIA: This review considered all studies that included adults with ID aged 18 years and over and which reported percentage/numbers of individuals who fell, and the total number of falls and injurious falls sustained from a fall...
March 2019: JBI Database of Systematic Reviews and Implementation Reports
Jennifer Remington, Karen Winters
OBJECTIVE: The objective of this review was to evaluate the effectiveness of inorganic nitrate on blood pressure in hypertensive adults. INTRODUCTION: Hypertension is associated with increased risk of morbidity and mortality in adults. Inorganic nitrate could be beneficial for lowering blood pressure and reducing cardiovascular disease risks. Evidence related to the treatment of hypertension through sources of inorganic nitrate has been presented. INCLUSION CRITERIA: The review considered studies on adults aged 18 years and over, with blood pressure greater than 120/80 mmHg, undergoing interventions focusing on the effects of inorganic nitrate on blood pressure...
March 2019: JBI Database of Systematic Reviews and Implementation Reports
George C Roush, Ayla Zubair, Kevin Singh, William J Kostis, Domenic A Sica, John B Kostis
BACKGROUND: Recommendations differ regarding how blood pressure targets should vary with age. Crucial to this controversy is whether treatment benefit varies with age. METHODS: Systematic searches were conducted for trials randomizing treatment in intensive arms to the recommended SBP targets: 120-140 mmHg. Head-to-head meta-analyses and meta-regression were conducted. RESULTS: Sixteen trials met criteria. Relative to higher targets, lower targets reduced cardiovascular events, but treatment benefit differed significantly among trials due to patient age...
March 11, 2019: Journal of Hypertension
Vasilios Pergialiotis, Paraskevi Kotrogianni, Diamanto Koutaki, Evangelos Christopoulos-Timogiannakis, Nikolaos Papantoniou, Georgios Daskalakis
AbstractPurpose: To evaluate the potential association of abnormal cord coiling with adverse pregnancy outcomes. MATERIALS AND METHODS: We used the Medline (1966-2018), Scopus (2004-2018), (2008-2018), Embase (1980-2018), Cochrane Central Register of Controlled Trials CENTRAL (1999-2018) and Google Scholar (2004-2018) databases. The date of last search was set at 31 May 2018. Language, country or date restrictions were not applied during the literature research to prevent bias...
March 14, 2019: Journal of Maternal-fetal & Neonatal Medicine
Alison M Haney
Nonsuicidal self-injury (NSSI) is a potentially life-threatening behavior with significant public health implications that may potentiate suicide risk. Religiosity has been identified as a significant protective factor against suicide attempts, and more broadly acts as a buffer against negative mental and physical health outcomes. Whether religiosity may reduce risk for NSSI is unclear. To understand the nature of the association between NSSI and religiosity, correlations from 16 samples (total N = 24,767) were computed to evaluate the magnitude and direction of the association between NSSI and religiosity...
March 14, 2019: American Journal of Orthopsychiatry
Z J Bai, Q Liu, X S Wang, W Y Liu
The clinical role of APC promoter methylation in patients with bladder cancer remains to be determined. The relevant databases (PubMed, EMBASE, EBSCO, Wangfang, CNKI and Cochrane Library) were searched to get eligible studies. The overall odds ratios (ORs) and the corresponding 95% confidence intervals (95% CIs) were calculated to assess the effects of APC promoter methylation on bladder cancer risk and clinicopathological features. 2214 patients with bladder cancer and 665 controls were identified. APC promoter methylation was significantly higher in bladder cancer than in nonmalignant tissue and urine samples (tissue: OR = 11...
March 7, 2019: Neoplasma
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