Yujia Zhang, Fengjun Qiu, Tingjie Ye, Sau Har Lee, Jiatuo Xu, Lingyan Jia, Rui Zeng, Xiaoling Wang, Xudong Hu, Xiaofeng Yan, Hua Li, Yanlin Lu, Xiaoling Wang, Rilei Jiang, Wei Xu
BACKGROUND: Chemoresistance often causes the failure of treatment and death of patients with advanced non-small-cell lung cancer. However, there is still no resistance genes signature and available enriched signaling derived from a comprehensive RNA-Seq data analysis of lung cancer patients that could act as a therapeutic target to re-sensitize the acquired resistant cancer cells to chemo-drugs. Hence, in this study, we aimed to identify the resistance signature for clinical lung cancer patients and explore the regulatory mechanism...
May 12, 2022: Stem Cell Research & Therapy