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Bone scan osteoporosis

M López Picazo, L Humbert, S Di Gregorio, M A González Ballester, L M Del Río Barquero
A retrospective case-control study assessing the association of DXA-derived 3D measurements with osteoporosis-related vertebral fractures was performed. Trabecular volumetric bone mineral density was the measurement that best discriminates between fracture and control groups. INTRODUCTION: The aim of the present study was to evaluate the association of DXA-derived 3D measurements at the lumbar spine with osteoporosis-related vertebral fractures. METHODS: We retrospectively analyzed a database of 74 postmenopausal women: 37 subjects with incident vertebral fractures and 37 age-matched controls without any type of fracture...
February 15, 2019: Osteoporosis International
Alexis Laugerette, Benedikt J Schwaiger, Kevin Brown, Lena C Frerking, Felix K Kopp, Kai Mei, Thorsten Sellerer, Jan Kirschke, Thomas Baum, Alexandra S Gersing, Daniela Pfeiffer, Alexander A Fingerle, Ernst J Rummeny, Roland Proksa, Peter B Noël, Franz Pfeiffer
OBJECTIVES: To develop and evaluate a method for areal bone mineral density (aBMD) measurement based on dual-layer spectral CT scout scans. METHODS: A post-processing algorithm using a pair of 2D virtual mono-energetic scout images (VMSIs) was established in order to semi-automatically compute the aBMD at the spine similarly to DXA, using manual soft tissue segmentation, semi-automatic segmentation for the vertebrae, and automatic segmentation for the background...
February 13, 2019: European Radiology
Stefano Giaretta, Alberto Momoli, Giovanna Porcelli, Gian Mario Micheloni
INTRODUCTION: Periprosthetic femoral fracture represent a severe complication, at present the third cause of revision surgery, with an estimated incidence from 0,1 to 2,1%. The number of these fracture can be expect to increase in line with the aging of population and amount of THA implants also in younger high demanding patients. MATERIALS AND METHODS: The aim of this study is analyze the diagnostic and therapeutic decision making processes performed in 64 patients with periprosthetic fractures treated surgically from January 2012 and October 2016 in our center...
February 2, 2019: Injury
Marion Geoffroy, Isabelle Charlot-Lambrecht, Jan Chrusciel, Isabelle Gaubil-Kaladjian, Ana Diaz-Cives, Jean-Paul Eschard, Jean-Hugues Salmon
INTRODUCTION: Bariatric surgery is used to treat severe obesity. We aimed to investigate the incidence of clinically significant bone mineral density (BMD) loss at 6 and 12 months after bariatric surgery. METHODS: Observational study performed in a specialized center for the treatment of obesity at the University Hospital of Reims, France. Surface BMD was measured by dual x-ray absorptiometry (DEXA). A reduction of > 0.03 g/cm2 was considered clinically significant...
February 7, 2019: Obesity Surgery
Jessica González, Macarena Rodríguez-Fraile, Pilar Rivera, Patricia Restituto, Inmaculada Colina, María de Los Desamparados Calleja, Ana B Alcaide, Aránzazu Campo, Juan Bertó, Luís M Seijo, Teresa Pérez, Javier Zulueta, Nerea Varo, Juan P de-Torres
BACKGROUND: Smoking is a recognized risk factor for osteoporosis. Trabecular bone score (TBS) is a novel texture parameter to evaluate bone microarchitecture. TBS and their main determinants are unknown in active and former smokers. OBJECTIVE: To assess TBS in a population of active or former smokers with and without Chronic Obstructive Pulmonary Disease (COPD) and to determine its predictive factors. METHODS: Active and former smokers from a pulmonary clinic were invited to participate...
2019: PloS One
Kyongsong Kim, Toyohiko Isu, Daijiro Morimoto, Rinko Kokubo, Naotaka Iwamoto, Akio Morita
In rare cases, pedicle fracture is associated with spine surgery, spondylolysis, or stress fracture. We report a patient without trauma whose bilateral lumbar pedicle fracture was detected incidentally. A 67-year-old woman reported leg numbness and pain. Lumbar MRI showed spinal canal stenosis at the L4/L5 level. Drug treatment was only partially effective. A lumbar computed tomography (CT) scan performed 3 months later revealed bilateral pedicle fracture at L4. A second lumbar MRI showed fresh bilateral L4 pedicle fracture that was not observed on the first scan...
January 2019: NMC Case Report Journal
Zheng Ding, Huifeng Shi, Wei Yang
OBJECTIVES: Present investigation determines the protective effect of cimiracemate A against glucocorticoid-induced osteoporosis rat. METHODS: Osteoporosis was induced by injecting methylprednisolone acetate (21 mg/kg) for the period of 6 weeks, and the rats were treated with cimiracemate A 5 and 10 mg/kg, p.o. 60 min after the administration of methylprednisolone acetate (21 mg/kg) for the duration of 6 weeks. Effect of cimiracemate A was observed by estimating the microarchitecture of bone and histopathological changes by micro-CT scan and light microscope...
January 29, 2019: Pharmacology
K J Beek, T Rusman, Mac van der Weijden, W F Lems, J C van Denderen, M Konsta, I Visman, M T Nurmohamed, I E van der Horst-Bruinsma
Objectives The aim of this cohort study was to evaluate the long term effects of TNF-inhibitors (TNFi) on Bone Mineral Density (BMD) and the incidence of Vertebral Fractures (VFx) in patients with Ankylosing Spondylitis (AS). Method Consecutive patients with active AS with a TNFi treatment duration up to 4 years, with available DXA scans and spine X-rays, were included. BMD (classified according to the WHO criteria for osteoporosis) of hip and lumbar spine, the VFx (classified as a Genant-score > 1/> 20% height loss) and radiological progression (modified stoke ankylosing spondylitis spinal score; mSASSS) scores were performed at baseline and 4 years of TNFi treatment...
January 28, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
H Lyu, K Yoshida, S K Tedeschi, S Zhao, C Xu, S U Nigwekar, B Z Leder, D H Solomon
Intervals between dual-energy X-ray absorptiometry (DXA) scans were evaluated in a large cohort of typical clinical practice. Intensive DXA scanning (intervals < 23 months) decreased substantially, from 16.7% in 2006 to 6.7% in 2015. INTRODUCTION: Serial dual-energy X-ray absorptiometry (DXA) measurements are suggested for patients at high risk of fractures. However, little is known about how often DXA testing occurs in clinical practice. METHODS: We examined time intervals between DXA testing for monitoring purpose at two academic medical centers in the US between 2004 and 2017...
January 24, 2019: Osteoporosis International
Wenpu Ma, Qingjun Dou, Xin Ha
PURPOSE: The aim of this study was to investigate the mechanism of let-7a-5p in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in postmenopausal osteoporosis (PMOP) mice. METHODS: A mouse model of PMOP was established and osteoporosis model was identified by micro-CT scan. BMSCs in the sham group and PMOP group were cultured and osteogenic differentiation was induced. The expression of let-7a-5p in BMSCs was detected by qRT-PCR, and BMSCs was induced by osteogenic differentiation in sham and PMOP group...
January 16, 2019: Biochemical and Biophysical Research Communications
Chuan Qiu, Hui Shen, Xiaoying Fu, Chao Xu, Qing Tian, Hongwen Deng
Osteoporosis is a skeletal disorder characterized by low bone mineral density (BMD) and deterioration of bone microarchitecture. To identify novel genetic loci underlying osteoporosis, an effective strategy is to focus on scanning of variants with high potential functional impacts. Enhancers play a crucial role in regulating cell-type-specific transcription. Therefore, single-nucleotide polymorphisms (SNPs) located in enhancers (enhancer-SNPs) may represent strong candidate functional variants. Here, we performed a targeted analysis for potential functional enhancer-SNPs that may affect gene expression and biological processes in bone-related cells, specifically, osteoblasts, and peripheral blood monocytes (PBMs), using five independent cohorts (n = 5905) and the genetics factors for osteoporosis summary statistics, followed by comprehensive integrative genomic analyses of chromatin states, transcription, and metabolites...
January 17, 2019: Human Genetics
Ganesan Ram Ganesan, Phagal Varthi Vijayaraghavan
Context  Osteoporosis is a silent disease until it is complicated by trivial fall fractures. There is an increasing interest within the orthopaedic community in the noninvasive cost-effective measurement of the bone mineral density. Aims  The aim of the study is to assess whether urinary N-telopeptide level can be a new diagnostic tool in diagnosing osteoporosis. Methods and Material  This prospective study was done at Sri Ramachandra Medical Centre (SRMC) hospital from October 2015 to October 2017. The study was conducted among patients who comes to SRMC as inpatient or outpatient with suspected osteoporosis and underwent dual-energy X-ray absorptiometry (DXA) scan and urinary N-telopeptide...
January 2019: Surgery Journal
Dongye Zhang, Mariana Miranda, Xiaofei Li, Jiangmeng Han, Yueli Sun, Nancy Rojas, Shan He, Minyi Hu, Liangjun Lin, Xiaodong Li, Hua Zhu Ke, Yi-Xian Qin
Prolonged mechanical unloading in bedridden patients and concurrent hormonal dysregulation represents the cause of one of the severest forms of osteoporosis, a condition for which there are very few efficacious interventions available to date. Sclerostin, a Wnt antagonist, acts as a negative regulator of bone formation. Sclerostin antibody (Scl-Ab)-mediated blockade of sclerostin can dramatically enhance bone formation and reduce bone resorption. This study was designed to investigate the therapeutic effect of the Scl-Ab on severe bone loss induced by concurrent mechanical unloading and estrogen deficiency in a hindlimb-suspended and ovariectomized rat model, and to study the cellular mechanisms underlying severe osteoporosis and Scl-Ab action...
January 15, 2019: Annals of the New York Academy of Sciences
R Ghermandi, V Pipola, S Colangeli, P Parchi, L Andreani, R Capanna, A Gasbarrini
The use of pedicle screws in low bone quality patients implicates risks of secondary implant loosening for grip lack. In fact, the result is a reduced mechanical stability at bone-screw interface and consequently an increased chance of pullout and hardware failure. Augmentation techniques have been described for many years and fenestrated screws that allow cement injection is one of them. This is a retrospective observational study of patients treated at our department with polymethylmethacrylate- (PMMA) augmented fenestrated screws...
November 2018: Journal of Biological Regulators and Homeostatic Agents
Amy C Bereshiem, Susan K Pfeiffer, Marc D Grynpas, Amanda Alblas
OBJECTIVES: Novel information on apartheid health conditions may be obtained through the study of recent skeletal collections. Using a backscattered scanning electron microscopy (BSE-SEM) approach, this study aims to produce bone quality and tissue mineralization data for an understudied South African population from the Western Cape province. METHODS: Using BSE-SEM imaging, cortical porosity (Ct.Po), osteocyte lacunar density (Ot.Lc.Dn), and the degree of tissue mineralization were quantified in midthoracic ribs from the Kirsten Skeletal Collection...
February 2019: American Journal of Physical Anthropology
S L Watson, B K Weeks, L J Weis, A T Harding, S A Horan, B R Beck
Our aim was to assess risk of vertebral fracture during high-intensity resistance and impact training (HiRIT) for postmenopausal women with low bone mass. HiRIT did not induce vertebral fracture, as evidenced by a reduction in kyphosis following 8 months of training and a lack of change in vertebral morphology. INTRODUCTION: The LIFTMOR trial demonstrated a novel, HiRIT program notably improved bone mass in postmenopausal women with osteopenia and osteoporosis. While no clinical signs or symptoms of vertebral crush fracture were evident during the trial, anecdotal feedback suggests that concerns about safety of HiRIT in the osteoporosis demographic remain...
January 5, 2019: Osteoporosis International
Carlos Ruiz Wills, Andy Luis Olivares, Simone Tassani, Mario Ceresa, Veronika Zimmer, Miguel A González Ballester, Luis Miguel Del Río, Ludovic Humbert, Jérôme Noailly
Osteoporotic bone fractures reduce quality of life and drastically increase mortality. Minimally irradiating imaging techniques such as dual-energy X-ray absorptiometry (DXA) allow assessment of bone loss through the use of bone mineral density (BMD) as descriptor. Yet, the accuracy of fracture risk predictions remains limited. Recently, DXA-based 3D modelling algorithms were proposed to analyse the geometry and BMD spatial distribution of the proximal femur. This study hypothesizes that such approaches can benefit from finite element (FE)-based biomechanical analyses to improve fracture risk prediction...
January 3, 2019: Bone
Sophie Roux, Marie-Hélène Massicotte, Alexis Huot Daneault, Lucie Brazeau-Lamontagne, Jean Dufresne
Denosumab is an anti-RANKL antibody that is commonly used for the treatment of osteoporosis; in oncology, bisphosphonates and denosumab have become the standard therapies for the treatment and prevention of skeletal complications in patients with myeloma and solid tumors. In recent years, excessive bone remodeling following the discontinuation of denosumab has raised concerns. Several cases of hypercalcemia have been reported after the discontinuation of high-dose denosumab (120 mg every 4 weeks), mainly in children...
December 17, 2018: Bone
V Frighi, A Morovat, T M Andrews, F Rana, M T Stephenson, S J White, E Fower, J Roast, G M Goodwin
BACKGROUND: People with intellectual disabilities (IDs) have very high rates of osteoporosis and fractures, to which their widespread vitamin D deficiency and other factors could contribute. We aimed to assess in people with IDs previously treated for vitamin D deficiency (1) long-term adherence to vitamin D supplementation and (2) bone mineral density (BMD), as an indicator for risk of fractures, according to vitamin D supplementation and other factors. METHOD: We recorded height, weight, medical, pharmacological, dietary and lifestyle assessment...
December 19, 2018: Journal of Intellectual Disability Research: JIDR
Xian-Wen Yang, Fei Wang, Ru-Zi Qin, Qin-Lin Zhou, Hong-Xing Huang
AIM: To investigate if the serum CC motif ligand 4 (CCL4) levels are linked to disease severity in patients with postmenopausal osteoporosis (PMOP). PATIENTS & METHODS: We enrolled 66 PMOP females, 68 postmenopausal nonosteoporotic women and 67 healthy women of childbearing age. Bone mineral densities were assessed with dual x-ray absorptiometry scans. The Oswestry disability index and the visual analog scale were employed to quantify functional ability and severity of symptoms...
December 18, 2018: Biomarkers in Medicine
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