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Bone scan for breast cancer mets

Qian Wang, Bing Sun, Xiangying Meng, Chao Liu, Yang Cong, Shikai Wu
The aim of this study was to assess local response to radiotherapy (RT) in a quantitative manner by evaluating the bone density of metastases. Spinal and pelvic bone metastases in 44 patients with breast cancer who were treated between May 2010 and December 2016 were retrospectively assessed. Bone density values of irradiated and unirradiated bone metastases before, 1-3 months after, 4-6 months after, and 7-9 months after RT were compared. At each time point, mean bone density ± standard deviation values were measured in Hounsfield units (HU) from computed tomography (CT) scans...
February 20, 2019: Journal of Radiation Research
Asaka Kodera, Hiroaki Inoue, Kaoru Ogura, Shiho Sakaguchi, Hiroko Yukawa, Aya Matsuoka, Natsuko Tanaka, Jun Kinoshita, Kazuhiko Yoshimatsu, Yoshihiko Naritaka, Akira Hirano
A 69-year-old woman noticed a tumor of the right breast, and presented to our hospital with dysphagia. A tumor of size 10 cm exposed to the skin and swollen axillary lymph node were observed. She was diagnosed with invasive ductal carcinoma, luminal-B by core-needle biopsy. CT scan revealed primary breast cancer with lung, bone, and lymph node metastasis. Endoscopic and fluoroscopic findings of the esophagus showed severe stenosis by extrinsic compression. In order to improve the quality of life(QOL)immediately, bevacizumab plus paclitaxel therapy was initiated...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Michala Skovlund Sørensen, Klaus Hindsø, Peter Frederik Horstmann, Anders Troelsen, Stig Dalsgaard, Tobias Fog, Tomasz Zimnicki, Michael Mørk Petersen
BACKGROUND: The incidence of surgery due to metastatic bone disease in the extremities (MBDex) and postoperative survival remain uninvestigated in the population. The aim of the current study was: to identify (1) incidence, demographics and survival of a population-based cohort of patients having surgery for MBDex (2) rate of referrals and referral pattern to a musculoskeletal tumour centre (MTC). MATERIAL AND METHOD: A prospective study of a consecutive population-based cohort of patients having surgery for MBDex from 2014 to 2016...
January 11, 2019: Acta Oncologica
Adesina O Adewale, Ladeji A Mofoluwake, Opaleye T Olamide, Salami A Yussuf
Metastatic tumours of the oral cavity are not common. The most common site for bone metastases in the head and neck region is the mandible. Metastatic lesion of the mandible most commonly originate from the lungs in men and breast in women, and these lesions (or tumours) usually are carcinomas rather than sarcomas. We report two cases of metastatic lesions in the mandible: (1) A 19year old male with right mandibular swelling and a nodular swelling in the distal two-third of the right tibia. Radiograghs revealed sclerotic lesion with a sunburst appearance in both the jaw and tibia...
September 2018: Ghana Medical Journal
Cahyanur Rahmat, Rinaldi Ikhwan
Breast cancer is the most common cancer in females worldwide and also in Indonesia. Symptomatic bone marrow metastasis is an uncommon presentation of metastatic breast cancer patient. A retrospective study showed that, out of 12970 patients with breast cancer, only 0.17% had symptomatic bone marrow metastasis. Management of patients with bone marrow metastasis also creates dilemma for the clinician. Risk and benefit from treatment should be discussed and carefully considered. We describe here a case report of a 58-year-old female patient with pancytopenia, who had a history of breast cancer four years before...
September 2018: Mædica
Amie Y Lee, Ryan Navarro, Lindsay P Busby, Heather I Greenwood, Matthew D Bucknor, Kimberly M Ray, Bonnie N Joe
RATIONALE AND OBJECTIVES: Detecting sternal lesions is not the purpose of breast MRI, but diagnosing metastasis has major clinical implications. Our purpose was to determine the breast MRI features of sternal metastases detected on PET-CT and bone-scan. MATERIALS AND METHODS: Between 01/2010-09/2018, 379 patients with breast cancer had sternal findings on PET-CT or bone-scan, 21 of which underwent breast MRI within 100 days. Sternal lesions were considered metastatic if (1) biopsy demonstrated metastasis, (2) the lesion had similar appearance to synchronous sites of biopsy-proven osseous metastases, or (3) there were numerous suspicious lesions in which widespread osseous metastasis was presumed...
December 5, 2018: Academic Radiology
Shelvin K Vadi, Bhagwant R Mittal, Ashwani Sood, Gurpreet Singh, Amanjit Bal, Ashwin S Parihar, Anish Bhattacharya, Rajender K Basher, Rakesh Kapoor
PURPOSE: Male breast cancer (MBC) is a rare malignancy, with recurrence being one of the main adverse predictors for prognosis. The aim of the study was to evaluate the diagnostic and predictive value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in the setting of suspected recurrence of MBC. PATIENTS AND METHODS: Retrospective analysis of PET/CT findings was performed in 23 previously treated, histologically proven patients with MBC (mean age: 59.3±10.9 years; range: 36-79 years) with suspected recurrence...
October 11, 2018: Nuclear Medicine Communications
Gurdip K Azad, Francois Cousin, Musib Siddique, Benjamin Taylor, Vicky Goh, Gary J R Cook
PURPOSE: To establish whether first-order statistical features from [18 F]fluoride and 2-deoxy-2-[18 F] fluoro-D-glucose ([18 F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) demonstrate incremental value in skeletal metastasis response assessment compared with maximum standardised uptake value (SUVmax ). PROCEDURES: Sixteen patients starting endocrine treatment for de novo or progressive breast cancer bone metastases were prospectively recruited to undergo [18 F]fluoride and [18 F]FDG PET/CT scans before and 8 weeks after treatment...
September 24, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Saeed Ali, Basher Atiquzzaman, Konrad Krall, Ranjeet Kumar, Bo Liu, Shantel Hebert-Magee
Renal cell carcinoma (RCC) has the propensity to hematogenously metastasize to the lung, bone, or liver, however, metastasis to the esophagus is exceedingly rare. We report a case of ulcerative esophagitis secondary to recurrent metastatic renal cell cancer status post remote nephrectomy. An 82-year-old Caucasian male presented with dark tarry stools for two days, progressive dysphagia to solid food for several weeks and unintentional weight loss. His past medical history was significant for hypertension, diverticulosis and right-sided renal cell cancer for which he underwent nephrectomy 13 years ago...
June 18, 2018: Curēus
X Y Meng, S T Song
Osteoblastic metastasis of breast cancer is relatively rare, but there are cases of misdiagnosis and mistreatment in clinical treatment. They can only be diagnosed by X ray or CT bone scan and must be identified from bone repair after effective treatment in patients with osteolytic or mixed bone metastases. Bone metastasis is often seen in the disease-free condition of breast cancer, and very few can occur in stage Ⅳ lesions prior to surgery. Based on the analysis of clinical phenomena, we questioned the evaluation criteria of the therapeutic effect on bone metastasis of breast cancer created by the World Health Organization and the MD Anderson Cancer Center and concluded the formation mechanism of bone metastasis...
June 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Yanxia Qin, Kui Chen, Weihong Gu, Xinghua Dong, Ruihong Lei, Yanan Chang, Xue Bai, Shibo Xia, Li Zeng, Jiaxin Zhang, Sihan Ma, Juan Li, Shan Li, Gengmei Xing
BACKGROUND: Tumor metastasis is the primary cause of mortality in cancer patients. Migratory breast cancer cells in lymphatic and blood vessels seek new sites and form metastatic colonies in the lung and bone, and then these cancer cells often wreak considerable havoc. With advances in nanotechnology, nanomaterials and nanotechnologies are widely applied in tumor therapy. In this paper, small size fullerenol nanoparticles, which are separated by isoelectric focusing electrophoresis (IFE) for discrepancy of isoelectric point (pI), are used in the study of tumor metastasis...
June 23, 2018: Journal of Nanobiotechnology
Sivanath Reddy Gajjala, Narendra Hulikal, Silpa Kadiyala, Radhika Kottu, Tekchand Kalawat
Background & objectives: Locally advanced breast cancer (LABC) is associated with substantial risk of occult metastases. The patients with LABC have high rate of systemic relapse, suggesting inadequacy of the current conventional staging in detecting the occult metastatic spread. 18 F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is a new modality in the staging of breast cancer patients. Hence, this study was conducted to evaluate the role of 18 F-FDG PET/CT in initial staging of LABC and to compare it with conventional methods...
March 2018: Indian Journal of Medical Research
Giuseppe Falco, Simone Mele, Maurizio Zizzo, Graziella Di Grezia, Paolo Cecinato, Giulia Besutti, Saverio Coiro, Gianluca Gatta, Rita Vacondio, Guglielmo Ferrari
INTRODUCTION: Metastatic spread in invasive lobular carcinoma (ILC) of breast mainly occurs in bones, gynecological organs, peritoneum, retroperitoneum, and gastrointestinal (GI) tract. Metastases to the GI tract may arise many years after initial diagnosis and can affect the tract from the tongue to the anus, stomach being the most commonly involved site. Clinical presentations are predominantly nonspecific, and rarely asymptomatic. CEA, CA 15-3, and CA 19-9 may be informative for symptomatic patients who have had a previous history of breast cancer...
May 2018: Medicine (Baltimore)
Lanell M Peterson, Janet O'Sullivan, Qian Vicky Wu, Alena Novakova-Jiresova, Isaac Jenkins, Jean H Lee, Andrew Shields, Susan Montgomery, Hannah M Linden, Julie R Gralow, Vijayakrishna K Gadi, Mark Muzi, Paul E Kinahan, David A Mankoff, Jennifer M Specht
Assessing therapy response of breast cancer bone metastases is challenging. In retrospective studies, serial 18 F-FDG PET was predictive of time to skeletal related events (tSRE) and time-to-progression (TTP). 18 F-NaF PET improves bone metastasis detection compared to bone scans. We prospectively tested 18 F-FDG PET and 18 F-NaF PET to predict tSRE, TTP, and overall survival (OS) in patients with bone-dominant metastatic breast cancer (BD MBC). Methods: Patients with BD MBC were imaged with 18 F-FDG PET and 18 F-NaF PET prior to starting new therapy (scan1) and again at a range of times centered around approximately 4 months later (scan2)...
May 10, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Michael A Jacobs, Katarzyna J Macura, Atif Zaheer, Emmanuel S Antonarakis, Vered Stearns, Antonio C Wolff, Thorsten Feiweier, Ihab R Kamel, Richard L Wahl, Li Pan
RATIONALE AND OBJECTIVES: The purpose of this study was to investigate the use of multiparametric, whole-body, diffusion-weighted imaging (WB-DWI) and apparent diffusion coefficient (ADC) maps with T2 -weighted magnetic resonance imaging (MRI) at 3T for the detection and monitoring of metastatic disease in patients. MATERIALS AND METHODS: Fifty-four participants (32 healthy subjects and 22 patients) were scanned with WB-DWI methods using a 3T MRI scanner. Axial, sagittal, or coronal fat-suppressed T2 -weighted (T2 WI), T1 -weighted (T1 WI), and DWI images were acquired...
November 2018: Academic Radiology
Yasuhiro Fukui, Shinichiro Kashiwagi, Koji Takada, Wataru Goto, Yuka Asano, Tamami Morisaki, Satoru Noda, Tsutomu Takashima, Naoyoshi Onoda, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
A 67-year-old female was referred to our hospital because she was pointed out mass in her right breast by her previous doctor. Core needle biopsy examination was performed at that time which revealed invasive ductal carcinoma. There'reno palpable masses in her breast or any superficial lymph nodes on her visiting our hospital. Breast ultrasonography images showed multiple nodules in C area of right breast. Breast enhanced MRI image revealed multiple enhanced nodules which showed rapid arising and plateau or slowly decreasing pattern in time intensity curve...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Wouter A M Broos, Friso M van der Zant, Maurits Wondergem, Remco J J Knol
OBJECTIVE: Determination of the accuracy of sodium fluorine-18-fluoride (F-NaF) PET/computed tomography (CT) for the evaluation of bone metastases, and the impact on patient management in breast cancer patients. PATIENTS AND METHODS: Patients with breast cancer, referred for F-NaF PET/CT between February 2014 and June 2016, were included in a database. Baseline characteristics, clinical indication, definitive diagnosis according to follow-up data, as well as changes in patient management were recorded...
April 2018: Nuclear Medicine Communications
S G D Gangadaran
Introduction: Staging investigations at diagnosis are customary to accurately assign a clinical stage before therapy. The practice of routine imaging in patients asymptomatic for metastasis is not recommended but widely adopted. This study was done to reexamine the basis behind guideline recommendations and to identify the factors predictive of asymptomatic metastasis. Methods: Oncology records of 200 breast cancer patients in clinical Stages I-III at diagnosis were prospectively reviewed...
October 2017: Indian Journal of Medical and Paediatric Oncology
Rohan Verma, Kevin C Chen, Hema L Ramkumar, Michael H Goldbaum, Carol L Shields
A 68-year-old woman with a recent history of blurring in the left eye had undergone mastectomy for breast cancer 20 years ago. A series of bone metastases started 5 years after her diagnosis. Examination of the optic nerve head of the left eye revealed an isolated peripapillary mass. Indocyanine green angiography displayed vessels within the mass, and fluorescein angiography demonstrated hyperfluorescence of the mass from vascular leakage plus lobular spots of blocked fluorescence. B-scan ultrasound revealed a hyperechoic-elevated nodular mass on the optic disc...
October 9, 2017: Survey of Ophthalmology
Payam Azadeh, Nasser Rakhashani, Ali Yaghobi Joybari, Pegah Gorji Bayani, Samaneh Sarbaz, Maryam Farasatinasab
The oral cavity is uncommon site for metastatic disease usually discovered secondary to malignancy. We encountered with a rare case in which metastasis to mandibular bone was the first clinical sign in the diagnosis of breast cancer without any radiographic findings. A 49-yr-old premenopausal woman, was referred to the Department of Medical Oncology of Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2014, presented with pain and tenderness in the left mandibular and temporal bone and paresthesia of the lower left lip and chin...
2016: Iranian Journal of Pathology
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