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https://read.qxmd.com/read/30777679/age-related-deterioration-of-saccule-related-neural-function-is-associated-with-decreased-estimated-glomerular-filtration-rate-and-increased-free-thyroxine
#1
Ileok Jung, Su-Hyun Ahn, Juyoung Lee, Sun-Uk Lee, Hui Jong Oh, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim
OBJECTIVE: This study attempted to identify systemic factors for age-related decline in neural function originating from the saccule using cervical vestibular-evoked myogenic potentials (cVEMP) parameters. METHODS: We recruited 129 symptomatic vertiginous patients who did not have known disorder affecting the cVEMP pathway (mean age = 52.4 ± 13.9). The indicators of saccule-related neural function were the sum of normalized cVEMP amplitude (SNA) and the average of p13 latency on both sides (average latency, AL)...
February 12, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/30759189/abnormal-visuo-vestibular-interactions-in-vestibular-migraine-a-cross-sectional-study
#2
Nadja F Bednarczuk, Angela Bonsu, Marta Casanovas Ortega, Anne-Sophie Fluri, John Chan, Heiko Rust, Fabiano de Melo, Mishaal Sharif, Barry M Seemungal, John F Golding, Diego Kaski, Adolfo M Bronstein, Qadeer Arshad
Vestibular migraine is among the commonest causes of episodic vertigo. Chronically, patients with vestibular migraine develop abnormal responsiveness to both vestibular and visual stimuli characterized by heightened self-motion sensitivity and visually-induced dizziness. Yet, the neural mechanisms mediating such symptoms remain unknown. We postulate that such symptoms are attributable to impaired visuo-vestibular cortical interactions, which in turn disrupts normal vestibular function. To assess this, we investigated whether prolonged, full-field visual motion exposure, which has been previously shown to modulate visual cortical excitability in both healthy individuals and avestibular patients, could disrupt vestibular ocular reflex and vestibular-perceptual thresholds of self-motion during rotations...
February 12, 2019: Brain: a Journal of Neurology
https://read.qxmd.com/read/30737783/the-spectrum-of-vestibular-migraine-clinical-features-triggers-and-examination-findings
#3
Shin C Beh, Shamin Masrour, Stacy V Smith, Deborah I Friedman
OBJECTIVE: To assess the ictal symptoms, interictal symptoms, psychiatric comorbidities, and interictal neuro-otologic examination findings in vestibular migraine (VM). METHODS: Retrospective chart review of 491 patients seen from August 2014 until March 2018 at a tertiary neurology referral center for vestibular disorders to identify patients fulfilling the 2012 VM criteria. RESULTS: One hundred and thirty-one patients (105 women) were identified...
February 8, 2019: Headache
https://read.qxmd.com/read/30733957/assessing-gait-stability-before-and-after-cochlear-implantation
#4
Katarzyna Kaczmarczyk, Michalina Błażkiewicz, Ida Wiszomirska, Katarzyna Pietrasik, Agnieszka Zdrodowska, Andrzej Wit, Gabor Barton, Henryk Skarżyński
Background: It is known that cochlear implantation may alter the inner ear and induce vestibular disorders. Research Question: How does cochlear implantation influence gait stability? Material and Methods . An experimental group of twenty-one subjects scheduled for cochlear implantation underwent gait testing twice, on the day before cochlear implantation (BCI) and three months after cochlear implantation (ACI), using a motion capture system. A control group of 30 age-matched healthy individuals were also tested...
2019: BioMed Research International
https://read.qxmd.com/read/30725124/-the-subjective-perception-of-the-vertical-a-valuable-parameter-for-determination-of-peripheral-vestibular-disorder-in-meni%C3%A3-re-s-disease-in-the-chronic-phase
#5
L J Voß, S I Zabaneh, M Hölzl, H Olze, K Stölzel
The perception of verticality is mainly based on utricular afferent signals and central processing of the transmitted signals. However, there are also extracranial receptors that make a considerable contribution to the perception of verticality. With the subjective visual vertical (SVV) for the utricle and the subjective trunk vertical (STV), two different parameters are available that are not fully understood in terms of their response to physiologic and pathologic changes. The aim of this work was to determine SVV and STV under certain positions of the head and trunk as well as under the influence of Menière's disease (MD) as a chronic vestibular disease...
February 6, 2019: HNO
https://read.qxmd.com/read/30719316/minocycline-induced-transient-depersonalization-a-case-report
#6
Yassein Shamout, Alissa Sigal, Ivan V Litvinov
Minocycline is a medication commonly used for the treatment of acne vulgaris. The central nervous system-induced side effects of minocycline include headaches, pseudotumor cerebri, ataxia, and vestibular dysfunction. Many minocycline-related side effects have been presented in the literature, however, reports of depersonalization symptoms induced by the medication are rare. We present the case of a 37-year-old female diagnosed with perioral dermatitis treated with minocycline, who within 1 week suffered from severe depersonalization symptoms...
2019: SAGE open medical case reports
https://read.qxmd.com/read/30706590/myocardial-injury-in-transient-global-amnesia-a-case-control-study
#7
Hebun Erdur, Bob Siegerink, Ramanan Ganeshan, Heinrich J Audebert, Matthias Endres, Christian H Nolte, Jan F Scheitz
BACKGROUND: Elevation of cardiac troponin (cTn), a sensitive biomarker of myocardial injury, is observed frequently in severe acute neurological disorders. Case reports suggest that cardiac dysfunction may also occur in patients with transient global amnesia (TGA). Until now, no study has systematically assessed this phenomenon. METHODS: We performed a case-control study using data of consecutive patients presenting with TGA from 2010 to 2015. Multiple logistic regression analysis accounting for age, sex, and cardiovascular risk factors was performed to compare the likelihood of myocardial injury (defined as elevation of cTn>99th percentile, ≥14ng/L; high-sensitivity cTnT assay) in TGA with three reference groups: migraine with aura, vestibular neuritis, transient ischemic attack (TIA)...
January 31, 2019: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://read.qxmd.com/read/30704196/-chinese-multidisciplinary-expert-consensus-on-assessment-and-management-of-vestibular-migraine
#8
(no author information available yet)
Vestibular migraine (VM) is a common disorder characterized by recurrent dizziness and/or vertigo, which involves a number of specialites and is easily misdiagnosed. The Stroke and Vertigo Association of Chinese Stroke Association and Vertigo Professional Committee of Neurology Branch of Chinese Physicians Association organized multi-disciplinary experts to discuss clinical issues of VM. The purpose of this consensus is to establish a standard framework for the diagnosis and management of VM in China.
February 1, 2019: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/30690105/a-nanoliter-resolution-implantable-micropump-for-murine-inner-ear-drug-delivery
#9
Farzad Forouzandeh, Xiaoxia Zhu, Ahmed Alfadhel, Bo Ding, Joseph P Walton, Denis Cormier, Robert D Frisina, David A Borkholder
Advances in protective and restorative biotherapies have created new opportunities to use site-directed, programmable drug delivery systems to treat auditory and vestibular disorders. Successful therapy development that leverages the transgenic, knock-in, and knock-out variants of mouse models of human disease requires advanced microsystems specifically designed to function with nanoliter precision and with system volumes suitable for implantation. Here we present results for a novel biocompatible, implantable, scalable, and wirelessly controlled peristaltic micropump...
January 25, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30671239/differentiating-overlapping-symptoms-of-vulvodynia-and-pudendal-neuralgia
#10
Anna Ghizzani, Serafino Carta, Annalisa Casoni, Paolo Ferrata, Stefano Luisi, Mattia Fortina
Context: Vulvodynia is defined as a chronic vulvar pain non-associated with infectious, inflammatory, neoplastic or hormonal disorders. Objectives: To present a case demonstrating the difficulty in assessing concomitant disease in vulvodynia. Methods: A 26-year-old woman, presented with persistent vulvodynia. She received oral and topical medications and behavioural interventions to lessen sexual pain and restore sexuality. As sexual pain decreased, the patient reported symptoms previously not mentioned: continuous, intense periclitoral pain and numbness at the perineum when sitting for a long time...
February 2019: British Journal of Pain
https://read.qxmd.com/read/30670701/improved-tmc1-gene-therapy-restores-hearing-and-balance-in-mice-with-genetic-inner-ear-disorders
#11
Carl A Nist-Lund, Bifeng Pan, Amy Patterson, Yukako Asai, Tianwen Chen, Wu Zhou, Hong Zhu, Sandra Romero, Jennifer Resnik, Daniel B Polley, Gwenaelle S Géléoc, Jeffrey R Holt
Fifty percent of inner ear disorders are caused by genetic mutations. To develop treatments for genetic inner ear disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding sequence for Transmembrane Channel-Like (Tmc) 1 or 2 into sensory hair cells of mice with hearing and balance deficits due to mutations in Tmc1 and closely related Tmc2. Here we report restoration of function in inner and outer hair cells, enhanced hair cell survival, restoration of cochlear and vestibular function, restoration of neural responses in auditory cortex and recovery of behavioral responses to auditory and vestibular stimulation...
January 22, 2019: Nature Communications
https://read.qxmd.com/read/30664399/video-head-impulse-test-relevance-in-the-early-postoperative-period-after-cochlear-implantation
#12
Roseli Saraiva Moreira Bittar, Eduardo Sato, Douglas Josimo Silva Ribeiro, Jeanne Oiticica, Signe Schuster Grasel, Raquel Mezzalira, Robinson Koji Tsuji, Ricardo Ferreira Bento
BACKGROUND: Cochlear implantation (CI) is the gold standard therapy for profound or severe sensorineural hearing loss. It is a safe surgical procedure but, because of the proximity of the cochlea and vestibule, postoperative vestibular disorder may occur. Our hypothesis is that the video head impulse test (vHIT) may be a good tool to achieve a topographic diagnosis of dizziness in the early postoperative period after CI. AIMS/OBJECTIVES: To evaluate patients with instability, imbalance and vertigo between 7 and 14 days after CI procedure...
January 21, 2019: Acta Oto-laryngologica
https://read.qxmd.com/read/30658837/postoperative-compensation-after-neurotomy-in-meniere-s-disease-retrospective-study-of-15-cases
#13
L Lemnos, K Aubry, J-J Moreau, F Caire, H Salle
INTRODUCTION: Vestibular neurotomy is a functional surgery for Meniere's disease in the event of medical treatment failure. The aim of the study was to assess the efficacy and complications of vestibular neurotomy, and to address the question of postoperative compensation. MATERIAL AND METHOD: All patients included in this retrospective study underwent a vestibular neurotomy at our center between 2009 and 2016. A preoperative evaluation was performed including MRI, audiometry, and videonystagmography...
January 15, 2019: Neuro-Chirurgie
https://read.qxmd.com/read/30635145/challenges-in-evaluating-the-oculomotor-function-in-individuals-with-rett-syndrome-using-electronystagmography
#14
Laurèl H M de Breet, Gillian S Townend, Leopold M G Curfs, Herman Kingma, Eric E J Smeets, Floor Lucieer, Josine Widdershoven, Raymond van de Berg
BACKGROUND: Rett syndrome (RTT) is a neurological disorder characterized by a broad spectrum of symptoms. Communication is a major area of difficulty. Use of eye tracking technology offers a potentially effective method of communication when underpinned by intact oculomotor function. In this study, oculomotor function was assessed using electronystagmography (ENG). However, challenges were encountered when examining individuals with RTT. PURPOSE: To improve oculomotor examination in individuals with RTT by evaluating the challenges encountered during ENG examination...
December 18, 2018: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/30634948/phenotype-prediction-of-mohr-tranebjaerg-syndrome-mts-by-genetic-analysis-and-initial-auditory-neuropathy
#15
Hongyang Wang, Li Wang, Ju Yang, Linwei Yin, Lan Lan, Jin Li, Qiujing Zhang, Dayong Wang, Jing Guan, Qiuju Wang
BACKGROUND: Mohr-Tranebjaerg syndrome (MTS) is a rare X-linked recessive neurodegenerative disorder resulting in early-onset hearing impairment, gradual dystonia and optic atrophy. MTS is caused by variations in the nuclear TIMM8A gene, which is involved in mitochondrial transport of metabolites. This study aimed to identify the pathogenic gene variations in three Chinese families associated with predicted MTS with or without X-linked agammaglobulinaemia. METHODS: Otologic examinations, vestibular, neurological, optical and other clinical evaluations were conducted on the family members...
January 11, 2019: BMC Medical Genetics
https://read.qxmd.com/read/30628712/dexamethasone-protects-against-arsanilic-acid%C3%A2-induced-rat-vestibular-dysfunction-through-the-bdnf-and-jnk-1-2-signaling-pathways
#16
Yan Luo, Daogong Zhang, Yueling Chen, Zhongsheng Cao, Zhaomin Fan
The brain‑derived neurotrophic factor (BDNF) and c‑Jun NH 2‑terminal kinase (JNK) signaling pathways are therapeutic targets to prevent degeneration in the central nervous system. Dexamethasone (DXMS), a glucocorticoid, protects against vestibular brain injury, however, the molecular mechanisms have yet to be fully elucidated. To investigate whether the BDNF and JNK signaling pathways are involved in the protective effects of DXMS in rats with vestibular dysfunction, a rat model of severe vestibular deficits was established by middle ear injection of arsanilic acid (AA; 100 mg/ml; 0...
January 8, 2019: Molecular Medicine Reports
https://read.qxmd.com/read/30615146/preclinical-assessment-of-mek1-2-inhibitors-for-neurofibromatosis-type-2-associated-schwannomas-reveal-differences-in-efficacy-and-drug-resistance-development
#17
Marisa A Fuse, Christine T Dinh, Jeremie Vitte, Joanna Kirkpatrick, Thomas Mindos, Stephani Klingeman Plati, Juan I Young, Jie Huang, Annemarie Carlstedt, Maria Clara Franco, Konstantin Brnjos, Jackson Nagamoto, Alejandra Petrilli, Alicja J Copik, Julia N Soulakova, Olena Bracho, Denise Yan, Rahul Mittal, Rulong Shen, Fred F Telischi, Helen Morrison, Marco Giovannini, Xue-Zhong Liu, Long-Sheng Chang, Cristina Fernandez-Valle
Background: Neurofibromatosis type 2 (NF2) is a genetic tumor-predisposition disorder caused by NF2/merlin tumor suppressor gene inactivation. The hallmark of NF2 is formation of bilateral vestibular schwannomas (VS). Because merlin modulates activity of the Ras/Raf/MEK/ERK pathway, we investigated repurposing drugs targeting MEK1/2 as a treatment for NF2-associated schwannomas. Methods: Mouse and human merlin-deficient Schwann cell lines (MD-MSC/HSC) were screened against six MEK1/2 inhibitors...
January 6, 2019: Neuro-oncology
https://read.qxmd.com/read/30614898/novel-use-of-portable-audiometry-to-track-hearing-fluctuations-in-meni%C3%A3-re-s-disease-a-pilot-study
#18
Darren Tse, Tim Ramsay, Daniel A Lelli
INTRODUCTION: Menière's Disease (MD) is a disorder of the inner ear consisting of episodic attacks of vertigo associated with aural fullness, tinnitus, and fluctuating hearing loss. Hearing levels in MD can often fluctuate over time, and may eventually decline permanently in a step-wise fashion. There are no current studies examining daily hearing fluctuations for prolonged periods in patients with MD. Portable audiometry has the potential to allow the patient to monitor their hearing on a daily basis without attending a center for formal audiology...
February 2019: Otology & Neurotology
https://read.qxmd.com/read/30614540/can-vestibular-stimulation-be-used-to-treat-obesity-vestibular-stimulation-targeting-the-otoliths-could-rebalance-energy-homeostasis-to-trigger-a-leaner-body-habitus-and-thus-treat-metabolic-syndrome
#19
REVIEW
Paul D McGeoch
It is hypothesized that repeated, non-invasive stimulation of the vestibular (balance) system, via a small electrical current to the skin behind the ears, will cause the brain centers that control energy homeostasis to shift the body toward a leaner physique. This is because these centers integrate multiple inputs to, in effect, fix a set-point for body fat, which though difficult to alter is not immutable. They will interpret repeated stimulation of the parts of the vestibular system that detect acceleration as a state of chronic activity...
January 7, 2019: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://read.qxmd.com/read/30606112/optimising-costs-in-reducing-rate-of-falls-in-older-people-with-the-improvement-of-balance-by-means-of-vestibular-rehabilitation-refovere-study-a-randomized-controlled-trial-comparing-computerised-dynamic-posturography-vs-mobile-vibrotactile-posturography-system
#20
Andrés Soto-Varela, Pilar Gayoso-Diz, Ana Faraldo-García, Marcos Rossi-Izquierdo, Isabel Vaamonde-Sánchez-Andrade, María Del-Río-Valeiras, Antonio Lirola-Delgado, Sofía Santos-Pérez
BACKGROUND: Accidental falls, especially for the elderly, are a major health issue. Balance disorders are one of their main causes. Vestibular rehabilitation (VR) has proven to be useful in improving balance of elderly patients with instability. Its major handicap is probably its cost, which has prevented its generalisation. So, we have designed a clinical trial with posturographic VR, to assess the optimum number of sessions necessary for a substantial improvement and to compare computerised dynamic posturography (CDP) (visual feedback) and mobile posturography (vibrotactile feedback)...
January 3, 2019: BMC Geriatrics
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