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Chronic pulmonary obstructive disease

W Wang
No abstract text is available yet for this article.
February 12, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Rodopi Stamatiou, Efrosini Paraskeva, Anna Vasilaki, Apostolia Hatziefthimiou
BACKGROUND: Muscarinic receptor antagonists are a usual treatment for chronic airway diseases, with increased bronchoconstriction, like asthma and chronic obstructive pulmonary disease. These diseases are usually accompanied by airway remodeling, involving airway smooth muscle cell (ASMC) proliferation. The purpose of this study was to examine the effect of the muscarinic receptor modulator gallamine on rabbit tracheal ASMC proliferation. METHODS: ASMCs were incubated with gallamine (1 nM-10 mM), atropine (1 fM-10 mM), and/or acetylcholine (1 nM-1 mM), in the presence or absence of FBS (1% or 10%)...
October 23, 2018: Pharmacological Reports: PR
Rachael C Walker, Allison Tong, Kirsten Howard, Suetonia C Palmer
OBJECTIVES: To describe the range of patients' beliefs, attitudes, expectations, and experiences of remote monitoring for chronic conditions across different healthcare contexts and populations. DESIGN: We searched MEDLINE, Embase, PsychINFO, and CINAHL, Google Scholar, and reference lists of related studies through to July 2017. Thematic synthesis was used to analyse the findings of the primary studies. Study characteristics were examined to explain differences in findings...
April 2019: International Journal of Medical Informatics
Marta García-Clemente, Ana Isabel Enríquez-Rodríguez, Marta Iscar-Urrutia, Beatriz Escobar-Mallada, Miguel Arias-Guillén, Francisco Julián López-González, Claudia Madrid-Carbajal, Liliana Pérez-Martínez, Teresa Gonzalez-Budiño
OBJECTIVE: The aim of our study was to determine the tomographic findings and prevalence of bronchiectasis in our population of patients with severe asthma, and to identify factors associated with the presence of bronchiectasis in these patients. MATERIALS AND METHODS: We retrospectively collected data from the medical histories of patients referred to the asthma unit of our hospital, with a diagnosis of severe asthma between 2015 and 2017. Patients with ABPA, cystic fibrosis, immunodeficiency or systemic disease were excluded...
February 20, 2019: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Sanhui Tang, Fanghua Gong
No abstract text is available yet for this article.
February 14, 2019: Minerva Medica
Erwan L'her, Samir Jaber, Daniel Verzilli, Christophe Jacob, Brigitte Huiban, Emmanuel Futier, Thomas Kerforne, Victoire Pateau, Pierre-Alexandre Bouchard, Maellen Gouillou, Emmanuel Nowak, François Lellouche
INTRODUCTION: Hypoxemia and hyperoxia may occur after surgery with potential related complications. The FreeO2 PostOp trial is a prospective, multicentre, randomised controlled trial that evaluates the clinical impact of automated O2 administration versus conventional O2 therapy after major abdominal or thoracic surgeries. The study is powered to demonstrate benefits of automated oxygen titration and weaning in term of oxygenation, which is an important surrogate for complications after such interventions...
January 17, 2019: BMJ Open
Rob Cook, Vaughan Thomas, Rosie Martin
The studyHome treatment of COPD exacerbation selected by DECAF score: a non-inferiority, randomised controlled trial and economic evaluationEchevarria C, Gray J, Hartley T, Miller J, Simpson AJ, Gibson GJ, Bourke SCPublished on 24 April 2018 Thorax 2018;73:713-22This project was funded by the National Institute for Health Research-Research for Patient Benefit Programme (project number PB-PG-0213-30105).To read the full NIHR Signal, go to:
February 19, 2019: BMJ: British Medical Journal
Jun-Jun Yeh, Cheng-Li Lin, Chung Y Hsu, Zonyin Shae, Chia-Hung Kao
BACKGOUND AND AIMS: We aimed at determining the effects of statin use on coronary artery disease (CAD) and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). METHODS: We retrospectively enrolled patients with ACOS treated with (N = 916) and without (N = 6338) statins. The cumulative incidence of CAD and stroke (ischemic and hemorrhagic) was analyzed through time-dependent Cox proportional regression. After adjustment for sex, age, comorbidities, inhaled corticosteroid steroid (ICS) use, and oral steroid (OS) use, we calculated the adjusted hazard ratios (aHRs) and their 95% confidence intervals (CIs) for CAD or stroke in the statin users (long-term [>600 days] and short-term [≤600 days]) compared with the non-users...
February 11, 2019: Atherosclerosis
Liu Nian, Zhang Weidong, Luo Shujuan, Cao Jun, Peng Minlian, Liu Zhiguang
The present study was carried out to evolve an effective treatment strategy for chronic obstructive pulmonary disease (COPD). Astaxanthin (AS) is abundantly present in red pigments of crustaceans, and has also been proven to have considerable biological activities. The anti-inflammatory effect of AS was evaluated in lipopolysaccharide (LPS)-exposed RAW264.7 macrophages. It was found that AS markedly inhibited elevation of NO and pro-inflammatory mediators. Moreover, it downregulated iNOS in LPS-stimulated RAW264...
January 31, 2019: Cellular and Molecular Biology
Shams Rahman, Abu-Sayeef Mirza, Deanna Wathington, Shikerria Green, Yeshuwa Mayers, Elhaam Iranmanesh, Laurie Woodard
OBJECTIVES: Uninsured patients represent an understudied population. The current study aimed to estimate the burden of 10 common chronic conditions and to investigate the associated factors among patients who use free clinics for their health care needs. METHODS: Patient charts from four free clinics were reviewed from January to December of 2015. Proportion of prevalence, adjusted odds ratios (AOR), and 95% confidence intervals (CI) for associations between participant characteristics and chronic conditions are reported...
February 19, 2019: Chronic Illness
Pelin Uysal, Hafize Uzun
Chronic obstructive pulmonary disease (COPD) is influenced by genetic and environmental factors. A protease-antiprotease imbalance has been suggested as a possible pathogenic mechanism for COPD. Here, we examined the relationship between circulating serpina3g, matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 and -2 (TIMP-1 and -2, respectively) and severity of COPD. We included 150 stable COPD patients and 35 control subjects in the study. The COPD patients were classified into four groups (I, II, III, and IV), according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines based on the severity of symptoms and the exacerbation risk...
February 13, 2019: Biomolecules
Ilias Karametos, Paraskevi Tsiboli, Ilias Togousidis, Chrisi Hatzoglou, Grigorios Giamouzis, Konstantinos I Gourgoulianis
(1) Background: Chronic obstructive pulmonary disease (COPD) is defined as an inflammatory disorder that presents an increasingly prevalent health problem. Accelerated aging has been examined as a pathologic mechanism of many chronic diseases like COPD. We examined whether COPD is combined with accelerated aging, studying two hormones, dehydroepiandrosterone (DHEA) and growth hormone (GH), known to be characteristic biological markers of aging. (2) Methods: Data were collected from 119 participants, 70 (58...
February 13, 2019: International Journal of Environmental Research and Public Health
Lukas Ebner, Rohan S Virgincar, Mu He, Kingshuk R Choudhury, Scott H Robertson, Andreas Christe, Achille Mileto, Joseph G Mammarapallil, H Page McAdams, Bastiaan Driehuys, Justus E Roos
OBJECTIVE: The objective of our study was to identify the magnitude and distribution of ventilation defect scores (VDSs) derived from hyperpolarized (HP) 129 Xe-MRI associated with clinically relevant airway obstruction. MATERIALS AND METHODS: From 2012 to 2015, 76 subjects underwent HP 129 Xe-MRI (48 healthy volunteers [mean age ± SD, 54 ± 17 years]; 20 patients with asthma [mean age, 44 ± 20 years]; eight patients with chronic obstructive pulmonary disease [mean age, 67 ± 5 years])...
February 19, 2019: AJR. American Journal of Roentgenology
Beng Leong Lim, Si Oon Cheah, Hsin Kai Goh, Francis Chun Yue Lee, Yih Yng Ng, Wen Jia Guo, Marcus Eng Hock Ong
INTRODUCTION: Hyperoxemia in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) leads to adverse outcomes. It remains prevalent in the pre-hospital Emergency Medical Services (EMS) and Emergency Department (ED). OBJECTIVE: To determine key predictors for hyperoxemia in AECOPD in EMS and ED. METHODS: This was a prospective observational study of AECOPD patients in EMS and two EDs. Hyperoxemia was defined as PaO2 > 65 mmHg (corresponds to SpO2 > 92%)...
February 19, 2019: Clinical Respiratory Journal
Betty Poot, Justin Travers, Mark Weatherall, Melinda McGinty
PURPOSE OF THE STUDY: To determine the prevalence and time course of cognitive impairment in COPD patients during and after an admission to hospital with an exacerbation of COPD. STUDY DESIGN: Patients admitted to hospital with an exacerbation of COPD between October 2013 and November 2014 were administered the Montreal Cognitive Assessment (MoCA) tool, COPD assessment test (CAT), and modified BORG dyspnoea scale at three points in time: within 24 hours of admission, between 48 and 72 hours after admission and 6 weeks post discharge...
February 18, 2019: Internal Medicine Journal
Eric Levesque, Nawel Ait-Ammar, Daniela Dudau, Noémie Clavieras, Cyrille Feray, Françoise Foulet, Françoise Botterel
BACKGROUND: Cirrhosis is not recognised as one of the main risk factors of invasive pulmonary aspergillosis (IPA), although its prevalence is increasing. The aim of our study was to identify factors for IPA in such patients with a positive Aspergillus sp. culture in respiratory samples and to evaluate its impact on outcome. METHODS: We conducted a monocentric retrospective study between January 2005 and December 2015. All cirrhotic patients hospitalised in our liver ICU with a positive Aspergillus sp...
February 18, 2019: Annals of Intensive Care
Mehrab Nasirikenari, Amit A Lugade, Sriram Neelamegham, Zhongwei Gao, Kelley W Moremen, Paul N Bogner, Yasmin Thanavala, Joseph T Y Lau
Inappropriate inflammation exacerbates a vast array of chronic and acute conditions with severe health risks. In certain situations, such as acute sepsis, traditional therapies may be inadequate in preventing severe organ damage or death. We have previously shown cell surface glycan modification by the circulating sialyltransferase ST6Gal-1 regulates de novo inflammatory cell production via a novel extrinsic glycosylation pathway. Here, we show that therapeutic administration of recombinant, bioactive ST6Gal-1 (rST6G) mitigates acute inflammation in a murine model mimicking acute exacerbations experienced by patients with chronic obstructive pulmonary disease (COPD)...
2019: Frontiers in Immunology
Besma Nejim, Devin Zarkowsky, Caitlin W Hicks, Satinderjit Locham, Hanaa Dakour Aridi, Mahmoud Malas
BACKGROUND: Endovascular aneurysm repair (EVAR) offered outstanding survival benefit but at the expense of cost, periodic radiographic monitoring, and higher reinterventions rates. Perioperative complications, although rare, can occur after EVAR, contributing to longer hospitalization, higher cost, and significant comorbidity and mortality. Therefore, the aim of this study was to identify the predictors of in-hospital events (IHEs) after elective EVAR. METHODS: The Vascular Quality Initiative database was explored from 2003 to 2017...
February 15, 2019: Journal of Vascular Surgery
Luis Grau, Fabio R Orozco, Andres F Duque, Zachary D Post, Danielle Y Ponzio, Alvin C Ong
BACKGROUND: Pulmonary complications after total joint arthroplasty are a burden to patients and the healthcare system. The aim of this study is to demonstrate the effectiveness of a pulmonary screening questionnaire and intervention protocol developed at our institution to prevent pulmonary complications. METHODS: Between 2010 and 2015, 7658 consecutive total joint arthroplasty patients at our institution were reviewed. Based on our pre-operative pulmonary risk assessment tool, 1625 patients were flagged as high pulmonary risk...
January 29, 2019: Journal of Arthroplasty
H Eylül Bozkurt Yılmaz, Elif Küpeli, Nazan Şen, İlker Arer, Kenan Çalışkan, Şule Akçay, Mehmet Haberal
OBJECTIVES: We evaluated the frequency and cause of acute respiratory failure in renal transplant recipients. MATERIALS AND METHODS: Our single-center retrospective observational study included consecutive renal transplant recipients who were admitted to an intensive care unit for acute respiratory failure between 2011 and 2017. Acute respiratory failure was defined as oxygen saturation < 92% or partial pressure of oxygen in arterial blood < 60 mm Hg on room air and/or requirement of noninvasive or invasive mechanical ventilation...
January 2019: Experimental and Clinical Transplantation
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