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catalytic nanomedicine

Xiangsheng Han, Xiaochen Wu, Lili Lv, Chaoxu Li
Proteins are naturally exposed to diverse interfaces in living organisms, from static solid to dynamic fluid. Solid interfaces can enrich proteins as corona, and then catalyze, retard or hinder amyloid fibrillation. But fluid interfaces abundant in biology have rarely been studied for their correlation with protein fibrillation. Unsaturated fatty acids own growing essential roles in diet, whose fluid interfaces are found in vitro to catalyze amyloid fibrillation under certain physiologic conditions. It is determined by the location of double bonds within alkyl chains as well as the presence of physical shear...
February 22, 2019: Journal of Colloid and Interface Science
Lei Zhang, Penghe Zhao, Caiping Yue, Zhaokui Jin, Qiong Liu, Xiubo Du, Qianjun He
Oxidative stress-induced mitochondrial dysfunction plays an important role in the pathogenesis of Alzheimer's disease (AD). Hydrogen molecule, a special antioxidant, can selectively scavenge highly cytotoxic reactive oxygen species such as ·OH, exhibiting a potential to treat AD by reducing oxidative stress. However, there is no effective route to realize the continuous and efficient accumulation of administrated hydrogen in AD brain owing to its low solubility. Here, we develop the small-sized Pd hydride (PdH) nanoparticles for high payload of hydrogen and in situ sustained hydrogen release in AD brain...
January 24, 2019: Biomaterials
Yong Yang, Pankaj Ghildiyal, Michael R Zachariah
Metal nanoclusters (1-10 nm) have drawn great attention due to their potential applications including energy storage, catalysis, nanomedicine and electronic devices. However, manufacturing ultra-small metal nanoparticles at high concentrations in an unaggregated state is not a solved problem. Here we report an aerosol-based thermal shock technique for in situ synthesis of well-dispersed metal nanoclusters in on-the-fly graphene aerosols. A rapid thermal shock to the graphene aerosol has been used to nucleate and grow the metal nanoclusters with subsequent quenching to freeze the newly formed nanoclusters in the graphene aerosol matrix...
January 30, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Bilal Momin, Shakeelur Rahman, Neetu Jha, Uday S Annapure
The present study reports the optimization of a green method for the synthesis of silver nanoparticles (AgNPs) via reduction of Ag+ ions using cell-free supernatant of mutant Bacillus licheniformis M09. UV-Visible spectroscopy showing an absorption peak at ~ 430 nm confirmed the synthesis of AgNPs. Transmission electron microscope (TEM) analysis exhibited spherical AgNPs within the size range of 10-30 nm. Fourier transform infrared (FTIR) measurements assured the presence of effective functional molecules which could be responsible for stabilizing the AgNPs...
January 2, 2019: Bioprocess and Biosystems Engineering
Patel Puja, Ponnuchamy Kumar
In recent era, the interest on inorganic nanoparticles is augmenting due to their engrossing and uncanny properties. Among them, platinum nanoparticles (PtNPs) are highly remarkable owing to their intrinsic physicochemical and biological properties making them an effective candidate towards catalytic and biomedical applications. Nevertheless, conventional physical and chemical methodologies of PtNPs synthesis are among the most prevalent protocols to synthesize PtNPs of desired shape and size. However, the above methods create notable concern to health and environment due to the use of harsh and toxic chemicals as well as violent reaction conditions...
November 19, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Tessy López-Goerne, Paola Ramírez, Daniel Alvarez, Francisco Rodríguez-Reinoso, Ana M Silvestre-Albero, Esteban Gómez, Enrique Rodríguez-Castellon
AIM: Sol-gel is a suitable and advantageous method to synthesize mixed oxide nanomaterials with unique physicochemical and biological properties. MATERIALS & METHODS: In this work, TiO2 -SiO2 nanopowders cogeled with platinum acetylacetonate were developed and studied in the perspective of nanomedicine. The physicochemical properties of the Pt/TiO2 -SiO2 nanopowders, named NanoRa2 -Pt, were evaluated in detail by means of complementary spectroscopic and microscopic tools...
September 2018: Nanomedicine
V Sokolova, K Loza, T Knuschke, J Heinen-Weiler, H Jastrow, M Hasenberg, J Buer, A M Westendorf, M Gunzer, M Epple
Nanoparticles can act as transporters for synthetic molecules and biomolecules into cells, also in immunology. Antigen-presenting cells like dendritic cells are important targets for immunotherapy in nanomedicine. Therefore, we have used primary murine bone marrow-derived phagocytosing cells (bmPCs), i.e. dendritic cells and macrophages, to study their interaction with spherical barium sulphate particles of different size (40 nm, 420 nm, and 1 µm) and to follow their uptake pathway. Barium sulphate is chemically and biologically inert (no dissolution, no catalytic effects), i...
October 15, 2018: Acta Biomaterialia
Dehong Hu, Zhuwen Chen, Zonghai Sheng, Duyang Gao, Fei Yan, Teng Ma, Hairong Zheng, Mei Hong
Photodynamic therapy (PDT) is an alternative strategy for treating pancreatic cancer (PC) in clinics. However, the therapeutic efficacy is generally suppressed by inadequate oxygen supply in the hypoxic tumor microenvironment. Herein, hierarchical zeolite nanocarriers with hydrophilic mesoporous nanostructures and excellent biodegradability are synthesized via a one-pot wet chemical method. By co-loading with catalase and methylene blue (MB), a new type of oxygen self-sufficient PDT platform, a zeolite-catalase-MB nanocapsule (ZCM nanocapsule), is developed...
September 20, 2018: Nanoscale
Youkun Zheng, Weiwei Liu, Zhaojian Qin, Yun Chen, Hui Jiang, Xuemei Wang
Widespread bacterial resistance induced by the abuse of antibiotics eagerly needs the exploitation of novel antimicrobial agents and strategies. Gold nanoclusters (Au NCs) have recently emerged as an innovative nanomedicine, but study on their antibacterial properties especially toward multidrug resistant (MDR) bacteria is scarce. Herein, we demonstrate that a novel class of Au NCs, mercaptopyrimidine conjugated Au NCs, can act as potent nanoantibiotics targeting these intractable superbugs in vitro and in vivo, without induction of bacterial antibiotic resistance and noticeable cytotoxicity to mammalian cells...
September 19, 2018: Bioconjugate Chemistry
Jinhwan Kim, Donghyun Jang, Hyeongmok Park, Sungjin Jung, Dae Heon Kim, Won Jong Kim
The discovery of sequence-specific hybridization has allowed the development of DNA nanotechnology, which is divided into two categories: 1) structural DNA nanotechnology, which utilizes DNA as a biopolymer; and 2) dynamic DNA nanotechnology, which focuses on the catalytic reactions or displacement of DNA structures. Recently, numerous attempts have been made to combine DNA nanotechnologies with functional DNAs such as aptamers, DNAzymes, amplified DNA, polymer-conjugated DNA, and DNA loaded on functional nanoparticles for various applications; thus, the new interdisciplinary research field of "functional DNA nanotechnology" is initiated...
July 30, 2018: Advanced Materials
N V Srikanth Vallabani, Sanjay Singh
Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as chemically inert materials and, therefore, being extensively applied in the areas of imaging, targeting, drug delivery and biosensors. Their unique properties such as low toxicity, biocompatibility, potent magnetic and catalytic behavior and superior role in multifunctional modalities have epitomized them as an appropriate candidate for biomedical applications. Recent developments in the area of materials science have enabled the facile synthesis of Iron oxide nanoparticles (IONPs) offering easy tuning of surface properties and surface functionalization with desired biomolecules...
June 2018: 3 Biotech
Margarita Vázquez-González, Itamar Willner
Recent advances addressing the development of stimuli-responsive nucleic acid (DNA)-functionalized micro/nanocarriers for the controlled release of drugs are presented. The DNA associated with the drug-loaded carriers acts as capping units that lock the drugs in the carriers. In the presence of appropriate triggers, the capping units are unlocked, resulting in the release of the drugs. Three types of DNA-modified carriers are discussed, including mesoporous SiO2 nanoparticles (MP SiO2 NPs), metal-organic framework nanoparticles (NMOFs) and micro/nanocapsules...
June 25, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Piao Zhu, Yu Chen, Jianlin Shi
Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low tissue-penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still not satisfactorily high in combating cancer at the current stage. Here we report on augmenting the SDT efficacy based on catalytic nanomedicine, which takes the efficient catalytic features of nanoenzymes to modulate the tumor microenvironment (TME). The multifunctional nanosonosensitizers have been successfully constructed by the integration of a MnO x component with biocompatible/biodegradable hollow mesoporous organosilica nanoparticles, followed by conjugation with protoporphyrin (as the sonosensitizer) and cyclic arginine-glycine-aspartic pentapeptide (as the targeting peptide)...
April 24, 2018: ACS Nano
Maria V Efremova, Maxim M Veselov, Alexander V Barulin, Sergey L Gribanovsky, Irina M Le-Deygen, Igor V Uporov, Elena V Kudryashova, Marina Sokolsky-Papkov, Alexander G Majouga, Yuri I Golovin, Alexander V Kabanov, Natalia L Klyachko
Magnetomechanical modulation of biochemical processes is a promising instrument for bioengineering and nanomedicine. This work demonstrates two approaches to control activity of an enzyme, α-chymotrypsin immobilized on the surface of gold-coated magnetite magnetic nanoparticles (GM-MNPs) using a nonheating low-frequency magnetic field (LF MF). The measurement of the enzyme reaction rate was carried out in situ during exposure to the magnetic field. The first approach involves α-chymotrypsin-GM-MNPs conjugates, in which the enzyme undergoes mechanical deformations with the reorientation of the MNPs under LF MF (16-410 Hz frequency, 88 mT flux density)...
April 24, 2018: ACS Nano
Martina Datteo, Hongsheng Liu, Cristiana Di Valentin
Beyond two-dimensional (2D) materials, interfaces between 2D materials and underlying supports or 2D-coated metal or metal oxide nanoparticles exhibit excellent properties and promising applications. The hybrid interface between graphene and anatase TiO2 shows great importance in photocatalytic, catalytic, and nanomedical applications due to the excellent and complementary properties of the two materials. Water, as a ubiquitous and essential element in practical conditions and in the human body, plays a significant role in the applications of graphene/TiO2 composites for both electronic devices and nanomedicine...
February 14, 2018: ACS Applied Materials & Interfaces
Lewis D Blackman, Spyridon Varlas, Maria C Arno, Alice Fayter, Matthew I Gibson, Rachel K O'Reilly
Enzyme loading of polymersomes requires permeability to enable them to interact with the external environment, typically requiring addition of complex functionality to enable porosity. Herein, we describe a synthetic route towards intrinsically permeable polymersomes loaded with functional proteins using initiator-free visible light-mediated polymerization-induced self-assembly (photo-PISA) under mild, aqueous conditions using a commercial monomer. Compartmentalization and retention of protein functionality was demonstrated using green fluorescent protein as a macro-molecular chromophore...
October 31, 2017: ACS Macro Letters
Jin-Yue Zeng, Xiao-Shuang Wang, Ming-Kang Zhang, Zi-Hao Li, Dan Gong, Pei Pan, Lin Huang, Si-Xue Cheng, Han Cheng, Xian-Zheng Zhang
A universal strategy was reported that enables functional group-capped nanostructures with various morphologies and compositions to be coated by porphyrin metal-organic framework (MOF). Based on the nanostructure-induced heterogeneous nucleation, the controlled growth of MOF shell on the surface of nanostructures can be realized. It was demonstrated that this modification strategy can realize controlled growth of porphyrin MOF on a series of organic and inorganic nanostructures, such as polydopamine (PDA) nanoparticles, PDA@Pt nanoparticles, graphene oxide sheets, and Au nanorods...
December 13, 2017: ACS Applied Materials & Interfaces
Kun Zhang, Tai-Qun Yang, Bing-Qian Shan, Peng-Cheng Liu, Bo Peng, Qing-Song Xue, En-Hui Yuan, Peng Wu, Belén Albela, Laurent Bonneviot
Mesoporous nanospheres are highly regarded for their applications in nanomedicine, optical devices, batteries, nanofiltration, and heterogeneous catalysis. In the last field, the dendritic morphology, which favors molecular diffusion, is a very important morphology known for silica, but not yet for carbon. A one-pot, easy, and scalable co-sol-gel route by using the triphasic resol-surfactant-silica system is shown to yield the topologies of dendritic and core-shell-corona mesoporous sister nanospheres by inner radial phase speciation control on a mass-transfer-limited process, depending on the relative polycondensation rates of the resol polymer and silica phases...
January 9, 2018: Chemistry: a European Journal
Minfeng Huo, Liying Wang, Yu Chen, Jianlin Shi
Tumor cells metabolize in distinct pathways compared with most normal tissue cells. The resulting tumor microenvironment would provide characteristic physiochemical conditions for selective tumor modalities. Here we introduce a concept of sequential catalytic nanomedicine for efficient tumor therapy by designing and delivering biocompatible nanocatalysts into tumor sites. Natural glucose oxidase (GOD, enzyme catalyst) and ultrasmall Fe3 O4 nanoparticles (inorganic nanozyme, Fenton reaction catalyst) have been integrated into the large pore-sized and biodegradable dendritic silica nanoparticles to fabricate the sequential nanocatalyst...
August 25, 2017: Nature Communications
Miaoyi Wang, Ghizal Siddiqui, Ove J R Gustafsson, Aleksandr Käkinen, Ibrahim Javed, Nicolas H Voelcker, Darren J Creek, Pu Chun Ke, Thomas P Davis
Polyethylene glycol (PEG) is widely used as an antifouling and stealth polymer in surface engineering and nanomedicine. However, recent research has revealed adverse effects of bioaccumulation and immunogenicity following the administration of PEG, prompting this proteomic examination of the plasma protein coronae association with superparamagnetic iron oxide nanoparticles (IONPs) grafted with brushed PEG (bPEG) and an alternative, brushed phosphorylcholine (bPC). Using label-free quantitation by liquid chromatography tandem-mass spectrometry, this study determines protein abundances for the in vitro hard coronae of bare, bPC-, and bPEG-grafted IONPs in human plasma...
August 7, 2017: Small
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