Bih-Rong Wei, Shelley B Hoover, Mark M Ross, Weidong Zhou, Francesco Meani, Jennifer B Edwards, Elizabeth I Spehalski, John I Risinger, W Gregory Alvord, Octavio A Quiñones, Claudio Belluco, Luca Martella, Elio Campagnutta, Antonella Ravaggi, Ren-Ming Dai, Paul K Goldsmith, Kevin D Woolard, Sergio Pecorelli, Lance A Liotta, Emanuel F Petricoin, R Mark Simpson
BACKGROUND: Ovarian cancer is the 5th leading cause of cancer related deaths in women. Five-year survival rates for early stage disease are greater than 94%, however most women are diagnosed in advanced stage with 5 year survival less than 28%. Improved means for early detection and reliable patient monitoring are needed to increase survival. METHODOLOGY AND PRINCIPAL FINDINGS: Applying mass spectrometry-based proteomics, we sought to elucidate an unanswered biomarker research question regarding ability to determine tumor burden detectable by an ovarian cancer biomarker protein emanating directly from the tumor cells...
October 30, 2009: PloS One