Rui Liu, Xiaolei Li, Hui Ma, Qian Yang, Qianwen Shang, Lin Song, Zhiyuan Zheng, Shengchao Zhang, Yongsha Pan, Peiqing Huang, Jiankai Fang, Yanan Li, Zhanhong Liu, Lijuan Cao, Chao Feng, Zheng Gong, Yongjing Chen, Ying Wang, Gerry Melino, Changshun Shao, Yufang Shi
Distinct metabolic programs, either energy-consuming anabolism or energy-generating catabolism, were required for different biological functions. Macrophages can adopt different immune phenotypes in response to various cues and exhibit anti- or pro-inflammatory properties relying on catabolic pathways associated with oxidative phosphorylation (OXPHOS) or glycolysis. Spermidine, a natural polyamine, has been reported to regulate inflammation through inducing anti-inflammatory (M2) macrophages. However, the underlying mechanisms remain elusive...
October 24, 2020: Free Radical Biology & Medicine