keyword
https://read.qxmd.com/read/38515595/informal-health-sector-and-routine-immunization-making-the-case-for-harnessing-the-potentials-of-patent-medicine-vendors-for-the-big-catch-up-to-reduce-zero-dose-children-in-sub-saharan-africa
#1
JOURNAL ARTICLE
Abdu A Adamu, Rabiu I Jalo, Duduzile Ndwandwe, Charles S Wiysonge
The COVID-19 pandemic caused a surge in the number of unimmunized and under-immunized children in Africa. The majority of unimmunized (or zero-dose) children live in hard-to-reach rural areas, urban slums, and communities affected by conflict where health facilities are usually unavailable or difficult to access. In these settings, people mostly rely on the informal health sector for essential health services. Therefore, to reduce zero-dose children, it is critical to expand immunization services beyond health facilities to the informal health sector to meet the immunization needs of children in underserved places...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38468981/the-rwandan-healthcare-system-can-a-shifting-burden-of-disease-threaten-a-post-war-success-story
#2
EDITORIAL
Iyesatta M Emeli
Rwanda is located in Central Africa, bordered by the Democratic Republic of Congo (DRC), Burundi, Tanzania, and Uganda. In 1994, Rwanda was immersed in a brutal war and genocide. Rwanda's subsequent remarkable post-war recovery has been well documented. What this paper aims to do is to explore Rwanda's successes and the vulnerability it faces with the shifting burdens of diseases. This paper seeks to contribute to the global discourse on effective healthcare models in resource-limited, post-conflict settings, even as such countries achieve improved socio-economic conditions and experience associated changes in population disease patterns...
February 2024: Curēus
https://read.qxmd.com/read/38450719/limited-impact-of-vector-control-on-the-population-genetic-structure-of-glossina-fuscipes-fuscipes-from-the-sleeping-sickness-focus-of-maro-chad
#3
JOURNAL ARTICLE
Sophie Ravel, Adeline Ségard, Brahim Guihini Mollo, Mahamat Hissène Mahamat, Rafael Argiles-Herrero, Jérémy Bouyer, Jean-Baptiste Rayaisse, Philippe Solano, Mallaye Pèka, Justin Darnas, Adrien Marie Gaston Belem, Wilfrid Yoni, Camille Noûs, Thierry de Meeûs
Tsetse flies (genus Glossina) transmit deadly trypanosomes to human populations and domestic animals in sub-Saharan Africa. Some foci of Human African Trypanosomiasis due to Trypanosoma brucei gambiense (g-HAT) persist in southern Chad, where a program of tsetse control was implemented against the local vector Glossina fuscipes fuscipes in 2018 in Maro. We analyzed the population genetics of G. f. fuscipes from the Maro focus before control (T0), one year (T1), and 18 months (T2) after the beginning of control efforts...
2024: Parasite: Journal de la Société Française de Parasitologie
https://read.qxmd.com/read/38429065/towards-a-multi-lateral-framework-for-cross-border-surveillance-and-information-sharing-between-nigeria-and-neighbouring-countries
#4
JOURNAL ARTICLE
Olaoluwa Oluwafemi Akinloluwa, Virgil Lokossou, Geoffrey Okatubo, Oyeladun Okunromade, Onyekachi Nwitte-Eze, Samuel Alabi, Titilope Ajayi-Ogbe, Chinenye Ofoegbunam, Lionel Sogbossi, Kima Appolinaire, Melchior Anathase Aissi
Nigeria sits at the crossroads of West and Central Africa; two increasingly critical regions for global health security. To strengthen cross-border collaboration for health security between its neighbors from West and Central Africa, the Federal Ministry of Health, Nigeria through the public health authority at the Points of Entry-Port Health Services, led the design of a multi-lateral framework for cross-border collaboration between Nigeria, the Republic of Benin, the Republic of Chad, the Republic of Cameroon and the Republic of Niger...
March 1, 2024: BMJ Global Health
https://read.qxmd.com/read/38411453/vaccines-for-mpox-an-unmet-global-need
#5
EDITORIAL
Lori E Dodd, H Clifford Lane, Jean-Jacques Muyembe-Tamfum
In 1970, the first case of mpox (formerly known as monkeypox) was documented in an infant in Equateur Province, Democratic Republic of Congo (DRC).1 Infections with clade I monkeypox virus (MPXV) are endemic in the rainforest regions of central Africa and result from both zoonotic and human-to-human transmission. The cessation of smallpox vaccination in 1980 because of the eradication of smallpox has led to an increase in the number of individuals who are orthopox immune naïve and is felt to be responsible for a recent increase in mpox cases in the DRC...
March 2024: NEJM Evid
https://read.qxmd.com/read/38407984/evaluation-of-fendiline-treatment-in-vp40-system-with-nucleation-elongation-process-a-computational-model-of-ebola-virus-matrix-protein-assembly
#6
JOURNAL ARTICLE
Xiao Liu, Monica Husby, Robert V Stahelin, Elsje Pienaar
Ebola virus (EBOV) infection is threatening human health, especially in Central and West Africa. Limited clinical trials and the requirement of biosafety level-4 laboratories hinder experimental work to advance our understanding of EBOV and the evaluation of treatment. In this work, we use a computational model to study the assembly and budding process of EBOV and evaluate the effect of fendiline on these processes in the context of fluctuating host membrane lipid levels. Our results demonstrate for the first time that the assembly of VP40 filaments may follow the nucleation-elongation theory, as this mechanism is critical to maintaining a pool of VP40 dimers for the maturation and production of virus-like particles (VLPs)...
February 26, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38407162/newly-identified-mycobacterium-africanum-lineage-10-central-africa
#7
JOURNAL ARTICLE
Christophe Guyeux, Gaetan Senelle, Adrien Le Meur, Philip Supply, Cyril Gaudin, Jody E Phelan, Taane G Clark, Leen Rigouts, Bouke de Jong, Christophe Sola, Guislaine Refrégier
Analysis of genome sequencing data from >100,000 genomes of Mycobacterium tuberculosis complex using TB-Annotator software revealed a previously unknown lineage, proposed name L10, in central Africa. Phylogenetic reconstruction suggests L10 could represent a missing link in the evolutionary and geographic migration histories of M. africanum.
October 2024: Emerging Infectious Diseases
https://read.qxmd.com/read/38379944/-bacillus-based-biocontrol-beyond-chemical-control-in-central-africa-the-challenge-of-turning-myth-into-reality
#8
REVIEW
Gaspard Nihorimbere, Virginie Korangi Alleluya, François Nimbeshaho, Venant Nihorimbere, Anne Legrève, Marc Ongena
Agricultural productivity in the Great Lakes Countries of Central Africa, including Burundi, Rwanda, and the Democratic Republic of Congo, is affected by a wide range of diseases and pests which are mainly controlled by chemical pesticides. However, more than 30% of the pesticides used in the region are banned in European Union due to their high toxicity. Globally available safe and eco-friendly biological alternatives to chemicals are virtually non-existent in the region. Bacillus PGPR-based biocontrol products are the most dominant in the market and have proven their efficacy in controlling major plant diseases reported in the region...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38333354/the-impact-of-the-ebola-virus-disease-epidemic-among-women-in-the-provinces-of-north-kivu-and-ituri-in-the-democratic-republic-of-the-congo
#9
JOURNAL ARTICLE
Nkechi G Onyeneho, Ngozi Idemili Aronu, Ijeoma Igwe, Joseph Okeibunor, Tieman Diarra, Julienne Ngoudougou Anoko, Mamoudou Harouna Djingarey, Zabulon Yoti, Dick Chamla, Abdou Salam Gueye
Although an outbreak of the Ebola virus disease affects an entire population, women are more susceptible to the virus than men. Throughout the outbreaks of the Ebola virus disease in Central and West Africa, women have been impacted more significantly. Generally, over half of those who become ill are women. The situation is the same in terms of mortality. Further, the outcomes of the epidemic negatively affect women socially, as many become the heads of households following the loss of their spouses, which burdens them with new responsibilities...
May 12, 2023: Journal of Immunological Sciences
https://read.qxmd.com/read/38320310/updating-reproduction-number-estimates-for-mpox-in-the-democratic-republic-of-congo-using-surveillance-data
#10
JOURNAL ARTICLE
Kelly Charniga, Andrea M McCollum, Christine M Hughes, Benjamin Monroe, Joelle Kabamba, Robert Shongo Lushima, Toutou Likafi, Beatrice Nguete, Elisabeth Pukuta, Elisabeth Muyamuna, Jean-Jacques Muyembe Tamfum, Stomy Karhemere, Didine Kaba, Yoshinori Nakazawa
Incidence of human monkeypox (mpox) has been increasing in West and Central Africa, including in the Democratic Republic of Congo (DRC), where monkeypox virus (MPXV) is endemic. Most estimates of the pathogen's transmissibility in the DRC are based on data from the 1980s. Amid the global 2022 mpox outbreak, new estimates are needed to characterize the virus' epidemic potential and inform outbreak control strategies. We used the R package vimes to identify clusters of laboratory-confirmed mpox cases in Tshuapa Province, DRC...
February 6, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38273529/protecting-an-artificial-savanna-as-a-nature-based-solution-to-restore-carbon-and-biodiversity-in-the-democratic-republic-of-the-congo
#11
JOURNAL ARTICLE
Brice Yannick Djiofack, Hans Beeckman, Nils Bourland, Basile Luse Belanganayi, Félix Laurent, Bhely Angoboy Ilondea, Laurent Nsenga, Alain Huart, Menard Mbende Longwwango, Victor Deklerck, Geert Lejeune, William W M Verbiest, Jan Van den Bulcke, Joris Van Acker, Tom De Mil, Wannes Hubau
A large share of the global forest restoration potential is situated in artificial 'unstable' mesic African savannas, which could be restored to higher carbon and biodiversity states if protected from human-induced burning. However, uncertainty on recovery rates in protected unstable savannas impedes science-informed forest restoration initiatives. Here, we quantify the forest restoration success of anthropogenic fire exclusion within an 88-ha mesic artificial savanna patch in the Kongo Central province of the Democratic Republic of the Congo (DR Congo)...
January 2024: Global Change Biology
https://read.qxmd.com/read/38271382/genetic-diversity-of-hpv35-in-chad-and-the-central-african-republic-two-landlocked-countries-of-central-africa-a-cross-sectional-study
#12
JOURNAL ARTICLE
Ralph-Sydney Mboumba Bouassa, Juval Avala Ntsigouaye, Paola Candyse Lemba Tsimba, Zita Aleyo Nodjikouambaye, Damtheou Sadjoli, Marcel Mbeko Simaleko, Serge Police Camengo, Jean De Dieu Longo, Gérard Grésenguet, David Veyer, Hélène Péré, Christian Diamant Mossoro-Kpinde, Laurent Bélec
Human Papillomavirus (HPV)-35 accounts for up 10% of cervical cancers in Sub-Saharan Africa. We herein assessed the genetic diversity of HPV35 in HIV-negative women from Chad (identified as #CHAD) and HIV-infected men having sex with men (MSM) in the Central African Republic (CAR), identified as #CAR. Ten HPV35 DNA from self-collected genital secretions (n = 5) and anal margin samples (n = 5) obtained from women and MSM, respectively, were sequenced using the ABI PRISM® BigDye Sequencing technology. All but one HPV35 strains belonged to the A2 sublineage, and only #CAR5 belonged to A1...
2024: PloS One
https://read.qxmd.com/read/38238806/genomic-insights-into-plasmodium-vivax-population-structure-and-diversity-in-central-africa
#13
JOURNAL ARTICLE
Valerie Gartner, Benjamin D Redelings, Claudia Gaither, Jonathan B Parr, Albert Kalonji, Fernandine Phanzu, Nicholas F Brazeau, Jonathan J Juliano, Gregory A Wray
BACKGROUND: Though Plasmodium vivax is the second most common malaria species to infect humans, it has not traditionally been considered a major human health concern in central Africa given the high prevalence of the human Duffy-negative phenotype that is believed to prevent infection. Increasing reports of asymptomatic and symptomatic infections in Duffy-negative individuals throughout Africa raise the possibility that P. vivax is evolving to evade host resistance, but there are few parasite samples with genomic data available from this part of the world...
January 18, 2024: Malaria Journal
https://read.qxmd.com/read/38223569/oral-health-delivery-in-refugee-camps-in-east-region-of-cameroon
#14
JOURNAL ARTICLE
Agbor Michael, Kaptue Bruno, Acha-Teku Tetu, Ernest Tambo, Keboa Mark, Naidoo Sudeshni
BACKGROUND: Oral health care affects the quality of life and plays an essential role in the general health of vulnerable populations especially refugees. The purpose of the study was to evaluate the quality of oral health care delivery in the Gado-Badzeré refugee camp in the Eastern region of Cameroon. METHODS: We carried out a cross-sectional study between January and July 2020 using a structured questionnaire in French and translated orally to Fulfulde language...
June 2023: African Health Sciences
https://read.qxmd.com/read/38220995/the-megachilidae-hymenoptera-apoidea-apiformes-of-the-democratic-republic-of-congo-curated-at-the-royal-museum-for-central-africa-rmca-belgium
#15
JOURNAL ARTICLE
Alain Tshibungu Nkulu, Alain Pauly, Achik Dorchin, Nicolas J Vereecken
Natural history collections are a cornerstone of entomology, and the conservation of specimens is the essential prerequisite for the development of research into systematics, biogeography, ecology, evolution and other disciplines. Yet, specimens collected during decades of entomological research conducted in less developed countries across Sub-Saharan Africa on pests, beneficial insects and insect biodiversity in general have largely been exported to be permanently preserved in developed countries, mainly in Europe and the United States of America...
December 27, 2023: Zootaxa
https://read.qxmd.com/read/38176860/seroprevalence-of-anti-sars-cov-2-antibodies-and-risk-of-viral-exposure-among-healthcare-workers-in-the-south-kivu-province-eastern-democratic-republic-of-the-congo-a-cross-sectional-study
#16
JOURNAL ARTICLE
Tshass B Chasinga, Jean-Paul Buhendwa Cikwanine, Sarah Kribi, Jonathan Tunangoya Yoyu, Natalie Hofmann, Marica Grossegesse, Andreas Nitsche, Sara Tomczyk, Ann C Vietor, Fabian H Leendertz, Tim Eckmanns, Aline B Kusinza, Eric Munguakonkwa, Andreas Kalk, Maroyi Raha, Nelson S Kambale, Rodrigue B Ayagirwe, Grit Schubert, Denis Mukwege
OBJECTIVES: Healthcare workers (HCWs) are on the frontline of combating COVID-19, hence are at elevated risk of contracting an infection with SARS-CoV-2. The present study aims to measure the impact of SARS-CoV-2 on HCWs in central sub-Saharan Africa. SETTING: A cross-sectional serological study was conducted at six urban and five rural hospitals during the first pandemic wave in the South Kivu province, Democratic Republic of the Congo (DRC). PARTICIPANTS: Serum specimens from 1029 HCWs employed during the first pandemic wave were collected between August and October 2020, and data on demographics and work-related factors were recorded during structured interviews...
January 4, 2024: BMJ Open
https://read.qxmd.com/read/38140550/covid-19-genomic-surveillance-in-bangui-central-african-republic-reveals-a-landscape-of-circulating-variants-linked-to-validated-antiviral-targets-of-sars-cov-2-proteome
#17
JOURNAL ARTICLE
Ulrich Vickos, Marianna Camasta, Nicole Grandi, Sante Scognamiglio, Tobias Schindler, Marie Roseline Darnycka Belizaire, Ernest Lango-Yaya, Giscard Wilfried Koyaweda, Oscar Senzongo, Simon Pounguinza, Kaleb Kandou Jephté Francis Estimé, Stephanie N'yetobouko, Christelle Luce Bobossi Gadia, Dominos-Alfred Feiganazoui, Alain Le Faou, Massimiliano Orsini, Carlo Federico Perno, Luca Zinzula, Clotaire Donatien Rafaï
Since its outbreak, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread rapidly, causing the Coronavirus Disease 19 (COVID-19) pandemic. Even with the vaccines' administration, the virus continued to circulate due to inequal access to prevention and therapeutic measures in African countries. Information about COVID-19 in Africa has been limited and contradictory, and thus regional studies are important. On this premise, we conducted a genomic surveillance study about COVID-19 lineages circulating in Bangui, Central African Republic (CAR)...
November 24, 2023: Viruses
https://read.qxmd.com/read/38116518/bridging-the-gaps-in-newborn-screening-programmes-challenges-and-opportunities-to-detect-haemoglobinopathies-in-africa
#18
REVIEW
Seth Twum, Kwadwo Fosu, Robin A Felder, Kwabena A N Sarpong
BACKGROUND: Haemoglobinopathies, including sickle cell disease and β-thalassaemia, are monogenic disorders with a relatively higher prevalence among malaria-endemic areas in Africa. Despite this prevalence, most African countries lack the necessary resources for diagnosing and managing these debilitating conditions. AIM: This study provides a critical review of newborn screening for detecting haemoglobinopathies in Africa, highlighting challenges and proposing strategies for improved diagnosis and management...
2023: African Journal of Laboratory Medicine
https://read.qxmd.com/read/38114239/china-s-hidden-role-in-malaria-control-and-elimination-in-africa
#19
JOURNAL ARTICLE
Julius Nyerere Odhiambo, Carrie Dolan, Ammar A Malik, Aaron Tavel
BACKGROUND: Insufficient funding is hindering the achievement of malaria elimination targets in Africa, despite the pressing need for increased investment in malaria control. While Western donors attribute their inaction to financial constraints, the global health community has limited knowledge of China's expanding role in malaria prevention. This knowledge gap arises from the fact that China does not consistently report its foreign development assistance activities to established aid transparency initiatives...
December 18, 2023: BMJ Global Health
https://read.qxmd.com/read/38094483/-oculo-orbital-tumours-at-the-national-university-hospital-centre-of-bangui-cnhub-central-african-republic-in-2022
#20
JOURNAL ARTICLE
Rodrigue Romuald Elien Gagnan Yan Zaou Tou, Jean Michel Mbaïkoua, Jess Elio Kosh Komba Palet, Nouhoum Guirou
INTRODUCTION: Oculo-orbital tumors are common. Their clinical and histological features are multiple. The management of oculo-orbital tumors is a real challenge in sub-Saharan Africa, especially in our context. The aim of this study was to contribute to the improvement of the management of oculo-orbital tumors at the Bangui Teaching Hospital (CNHUB). METHODOLOGY: This was a prospective, observational study of oculo-orbital tumors over 12 months from January 1 to December 31, 2022 in the ophthalmology department of the CNHUB...
September 30, 2023: Med Trop Sante Int
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