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Tingxian Ling, Limin Liu, Yueming Song, Shilian Zhou, Chunguang Zhou
PURPOSE: POEMS syndrome is a rare clonal plasma cell disease characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. We report a rare case of neurological impairment in patients with concurrent cervical disc herniation and POEMS syndrome. METHODS: A patient presented to a local hospital with C3/4 and C4/5 disc herniation, apparent spinal cord compression concomitant with neurological signs, and concurrent POEMS syndrome. Anterior cervical discectomy and fusion was performed...
February 13, 2019: European Spine Journal
Marwa Kaisey, Andrew J Solomon, Michael Luu, Barbara S Giesser, Nancy L Sicotte
BACKGROUND: Multiple Sclerosis (MS) specialists routinely evaluate misdiagnosed patients, or patients incorrectly assigned a diagnosis of MS. Misdiagnosis has significant implications for patient morbidity and healthcare costs, yet its contemporary incidence is unknown. We examined the incidence of MS misdiagnosis in new patients referred to two academic MS referral centers, their most common alternate diagnoses, and factors associated with misdiagnosis. METHODS: Demographic data, comorbidities, neurological examination findings, radiographic and laboratory results, a determination of 2010 McDonald Criteria fulfillment, and final diagnoses were collected from all new patient evaluations completed at the Cedars-Sinai Medical Center and the University of California, Los Angeles MS clinics over twelve months...
February 2, 2019: Multiple Sclerosis and related Disorders
Euddeum Shim, Joon Woo Lee, Eugene Lee, Yusuhn Kang, Heung Sik Kang, Woo Young Kang, Tae Seong Im
BACKGROUND: Although both 1.5-Tesla (T) and 3-T magnetic resonance imaging (MRI) are widely used for the diagnosis of cervical spondylotic myelopathy (CSM), there have been no comparative studies. PURPOSE: This study compared the performance of both imaging modalities for diagnosing CSM among radiologists with varying experience levels. MATERIAL AND METHODS: Four independent readers with different levels of experience reviewed 1.5-T and 3-T MR images of 79 patients with cervical spondylopathies...
January 23, 2019: Acta Radiologica
I-C Chiang, W-S Chuang, I-T Hang, Y-T Kuo, T-J Hsieh
AIM: To evaluate efficacy of T2-weighted (T2W) iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL)-fast spin echo (FSE) imaging of the cervical spine. MATERIALS AND METHODS: The cervical spine of 100 symptomatic patients was imaged using routine magnetic resonance imaging (MRI) versus IDEAL-FSE imaging. The signal-to-noise ratios (SNRs), contrast-to-noise ratios (CNRs), and image quality were analysed. To compare the diagnostic efficiency of degenerative spondylopathy, evaluations of spondylolisthesis, retrolisthesis, disc herniation, myelopathy, disc degeneration, and bone marrow oedema were also performed...
October 9, 2018: Clinical Radiology
Albert Roso-Llorach, Concepción Violán, Quintí Foguet-Boreu, Teresa Rodriguez-Blanco, Mariona Pons-Vigués, Enriqueta Pujol-Ribera, Jose Maria Valderas
OBJECTIVE: The aim was to compare multimorbidity patterns identified with the two most commonly used methods: hierarchical cluster analysis (HCA) and exploratory factor analysis (EFA) in a large primary care database. Specific objectives were: (1) to determine whether choice of method affects the composition of these patterns and (2) to consider the potential application of each method in the clinical setting. DESIGN: Cross-sectional study. Diagnoses were based on the 263 corresponding blocks of the International Classification of Diseases version 10...
March 22, 2018: BMJ Open
Paolo Perrini, Federico Cagnazzo, Nicola Benedetto, Riccardo Morganti, Carlo Gambacciani
OBJECTIVES: To compare retrospectively the clinical and radiological outcomes in cervical spinal alignment after two consecutive levels PEEK cage-assisted ACDF when performed with or without plate fixation PATIENTS AND METHODS: Seventy-eight patients underwent two consecutive levels PEEK cage-assisted ACDF without plating (56 patients) or supplemented with plating (22 patients). The average clinical follow-up was 31.40±12.98months. The authors compared clinical parameters (Neck disability index and Robinson criteria), perioperative parameters (hospital stays, complications), and radiological parameters (global lordotic curvature, segmental lordosis, segmental height)...
December 2017: Clinical Neurology and Neurosurgery
Hao Zheng, Zhe Wang, Wenwei Liu, Hongtao Jin, Jinlan Zhang
Biqi capsule is a well-known traditional Chinese medicine formula that has been widely applied for the clinical treatment of such diseases as rheumatoid arthritis, scapulohumeral periarthritis and cervical spondylopathy. However, there is concern regarding the toxicity of Biqi capsule owing to its active ingredients, strychnine and brucine. To investigate the toxicokinetics of strychnine and brucine after oral administration of Biqi capsule to rats, a sensitive and simple rapid-resolution liquid chromatography/tandem mass spectrometry method was developed to determine the levels of strychnine and brucine in rat plasma...
March 2018: Biomedical Chromatography: BMC
Jose Miguel Baena-Díez, Maria Garcia-Gil, Marc Comas-Cufí, Rafel Ramos, Daniel Prieto-Alhambra, Betlem Salvador-González, Roberto Elosua, Irene R Dégano, Judith Peñafiel, María Grau
OBJECTIVE: To examine the association between chronic immune-mediated diseases (rheumatoid arthritis, systemic lupus erythematosus or the following chronic immune-mediated inflammatory diagnoses groups: inflammatory bowel diseases, inflammatory polyarthropathies, systemic connective tissue disorders and spondylopathies) and the 6-year coronary artery disease, stroke, cardiovascular disease incidence and overall mortality; and to estimate the population attributable fractions for all four end-points for each chronic immune-mediated inflammatory disease...
January 2018: Heart: Official Journal of the British Cardiac Society
Nosaiba Tawfik Al-Ryalat, Saif Aldeen Saleh, Walid Sulaiman Mahafza, Osama Ahmad Samara, Abdee Tawfiq Ryalat, Azmy Mohammad Al-Hadidy
BACKGROUND: Cervical intervertebral disc herniation can lead to myelopathy. Aging is an established variable related to spondylotic myelopathy. Studying this association will help in controlling the increase in spondylotic myelopathy with age. OBJECTIVES: To study the association between cervical disc level, its direction, and the frequency of my-elopathy with age, and to assess the epidemiology of age-related cervical disc herniation and myelopathy. DESIGN: Retrospective review of magnetic resonance (MR) images...
March 2017: Annals of Saudi Medicine
Eun-Young Park, Won-Ho Kim
[Purpose] This study aimed to investigate the prevalence of secondary impairments in adults with cerebral palsy. [Subjects and Methods] The study sample included 52 adults with cerebral palsy who attended a convalescent or rehabilitation center for disabled individuals or a special school for physical disabilities in South Korea. [Results] The univariate analysis showed that the Gross Motor Functional Classification System level was a significant predictor of spondylopathies, general pain, arthropathies, and motor ability loss...
February 2017: Journal of Physical Therapy Science
Lei Xia, Ming-Xing Liu, Jun Zhong, Ning-Ning Dou, Massimiliano Visocchi
BACKGROUND: Anterior cervical discectomy and fusion is currently the most commonly used technique in cervical surgery. But the implantation of a traditional plate is time-consuming and exposes the patient to additional adverse events. In this study, we analyzed results in patients who underwent anterior cervical discectomy and fusion with C-JAWS fixation. The C-JAWS device is a new cervical compressive staple developed to stabilize the spacer. METHODS: At our department, between January 2012 and December 2013, nine consecutive patients with cervical spondylopathy underwent an anterior cervical discectomy and fusion process in which we used a polyether ether ketone cervical spacer prefilled with bone substitute and secured with a cervical compressive staple...
2017: Acta Neurochirurgica. Supplement
O Lista-Martínez, V M Moreno-Barrueco, J Castro-Castro, P Varela-Rois, A Pastor-Zapata
INTRODUCTION: Although they are freqqently described in the literature, lumbar synovial cysts are a relative uncommon cause of low back and radicular leg pain. OBJECTIVE: To evaluate the treatment and surgical outcomes of the lumbar synovial cysts operated on in our hospital during a 5 year period. MATERIAL AND METHODS: A retrospective study was conducted on patients surgically treated in our department from August 2009 to September 2014, using a visual analogue scale for the clinical follow-up in the first year after surgery...
January 2017: Revista Española de Cirugía Ortopédica y Traumatología
Jeffrey R Curtis, Leslie R Harrold, Maryam M Asgari, Atul Deodhar, Craig Salman, Joel M Gelfand, Jashin J Wu, Lisa J Herrinton
INTRODUCTION: Few studies have assessed the prevalence and features of axial spondyloarthritis (axSpA) and ankylosing spondylitis in diverse, population-based, community settings. OBJECTIVES: We used computerized diagnoses to estimate the prevalence of axSpA and ankylosing spondylitis in Kaiser Permanente Northern California (KPNC). METHODS: We identified persons aged 18 years or older with 1 or more International Classification of Diseases, Ninth Revision (ICD-9) diagnosis Code 720...
2016: Permanente Journal
Lei Xia, Ming-Xing Liu, Jun Zhong, Jin Zhu, Ning-Ning Dou, Massimiliano Visocchi
OBJECTIVE: To evaluate the clinical value of C-JAWS in anterior cervical discectomy and fusion (ACDF) surgery. METHODS: Between January 2012 and December 2013, nine consecutive patients with cervical spondylopathy underwent ACDF process using a polyetheretherketone cervical spacer prefilled with bone substitute and secured by a cervical compressive staple in our department. The Neck Disability Index (NDI) score and visual analogy scale (VAS) of neck or arm pain as well as radiographic examination were adopted to assess the postoperative outcome and fusion...
December 2016: British Journal of Neurosurgery
Lei Kuang, Yuqiao Chen, Bing Wang, Lei Li, Guohua Lü
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To assess the safety and efficacy of cervical disk arthroplasty (CDA) compared with anterior cervical decompression and fusion (ACDF) for the treatment of 2-level cervical spondylopathy. SUMMARY OF BACKGROUND DATA: CDA has emerged as a potential alternative to ACDF in patients with cervical disk degeneration. But there are no published systematic reviews and meta-analyses comparing CDA with ACDF for the treatment of 2-level cervical spondylopathy...
November 2016: Clinical Spine Surgery
Aliasghar A Kiadaliri, Martin Englund
BACKGROUND: The aim was to assess time trend of mortality with musculoskeletal disorders (MSD) as underlying cause of death in Sweden from 1997 to 2013. METHODS: We obtained data on MSD as underlying cause of death across age and sex groups from the National Board of Health and Welfare's Cause of Death Register. Age-standardized mortality rates per million population for all MSD, its six major subgroups, and all other ICD-10 (International Classification of Disease) chapters were calculated...
April 14, 2016: BMC Musculoskeletal Disorders
Dawei Guan, Guanjun Wang, Morgan Clare, Zhengda Kuang
Brown-Sequard syndrome (BSS) produced by cervical disc disorders has rarely been seen clinically and only 50 cases have been reported in English literatures. However, most of which have resulted from acute disc herniation. Here, we report a case of BSS produced by calcified herniated C4-C5 disc and posterior vertebral osteophyte, in which decompression through anterior approach was performed. This case revealed the potential of cervical spondylopathy leading to BSS in a chronic manner. Once the diagnosis is established, it is advisable to perform decompression as early as possible...
December 2015: Journal of Orthopaedics
W Malcolm McKee, Jonathan J Pink, Toby J Gemmill
OBJECTIVES: To report the radiographic and clinical outcome of an intervertebral bone cement plug technique for the management of disc-associated cervical spondylopathy in Dobermann Pinscher dogs. METHODS: Retrospective study of 52 Dobermann Pinscher dogs. RESULTS: A variable degree of cement plug subsidence with loss of vertebral distraction was evident in all dogs (n = 40) that were radiographed >6 weeks postoperatively. In no case was there definitive evidence of vertebral body fusion...
May 18, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Yuqiao Chen, Guohua Lü, Bing Wang, Lei Li, Lei Kuang
PURPOSE: To evaluate the clinical efficacy and radiological outcomes of anterior cervical discectomy and fusion (ACDF) using self-locking polyetheretherketone (PEEK) cages for treatment of three-level cervical degenerative spondylopathy. METHODS: Twenty-eight patients underwent three-level ACDF using self-locking stand-alone PEEK cages (group A), and 26 patients underwent three-level ACDF using cages and plate fixation (group B) were reviewed retrospectively. Clinical efficacy was evaluated by pre- and post-operative Japanese Orthopedic Association (JOA) scores and Neck Disability Index (NDI)...
July 2016: European Spine Journal
Jonathan Esteban-Sánchez, Almudena Rueda-Marcos, Ricardo Sanz-Fernández, Eduardo Martín-Sanz
INTRODUCTION: The presentation of a down-beating nystagmus force to discard vascular pathology of brain and cervical joint with magnetic resonance imagine (MRI). Recent studies support the low profitability of this study and is subjected that this oculomotor sign has a peripheral origin especially when the patient has a benign paroxysmal positional vertigo (BPPV) with affection of the superior semicircular canal. AIM: To evidence the profitability of MRI in a population of patients with positional down-beating nystagmus...
February 1, 2016: Revista de Neurologia
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