Lucy H R Whitaker, Lee J Middleton, Jane P Daniels, Alistair R W Williams, Lee Priest, Smita Odedra, Versha Cheed, Clive E Stubbs, T Justin Clark, Mary-Ann Lumsden, Dharani K Hapangama, Siladitya Bhattacharya, Paul P Smith, Elaine P Nicholls, Neil Roberts, Scott I Semple, Lucky Saraswat, Jane Walker, Rohan R Chodankar, Hilary O D Critchley
BACKGROUND: Heavy menstrual bleeding affects one in four women and negatively impacts quality of life. Ulipristal acetate is prescribed to treat symptoms associated with uterine fibroids. We compared the effectiveness of ulipristal acetate and the levonorgestrel-releasing intrauterine system at reducing the burden of heavy menstrual bleeding, irrespective of the presence of fibroids. METHODS: This randomised, open-label, parallel group phase III trial enrolled women over 18 years with heavy menstrual bleeding from 10 UK hospitals...
June 2023: EClinicalMedicine