keyword
https://read.qxmd.com/read/38532166/tweeting-your-research-paper-boosts-engagement-but-not-citations
#21
Bianca Nogrady
No abstract text is available yet for this article.
March 27, 2024: Nature
https://read.qxmd.com/read/38532165/a-delay-that-makes-wireless-communication-faster
#22
(no author information available yet)
No abstract text is available yet for this article.
March 26, 2024: Nature
https://read.qxmd.com/read/38532055/tinnitus-clinical-insights-in-its-pathophysiology-a-perspective
#23
JOURNAL ARTICLE
Berthold Langguth, Dirk de Ridder, Winfried Schlee, Tobias Kleinjung
Tinnitus, the perception of sound without a corresponding external sound source, and tinnitus disorder, which is tinnitus with associated suffering, present a multifaceted clinical challenge due to its heterogeneity and its incompletely understood pathophysiology and especially due to the limited therapeutic options. In this narrative review, we give an overview on various clinical aspects of tinnitus including its heterogeneity, contributing factors, comorbidities and therapeutic pathways with a specific emphasis on the implications for its pathophysiology and future research directions...
March 26, 2024: Journal of the Association for Research in Otolaryngology: JARO
https://read.qxmd.com/read/38531976/more-than-double-the-fun-with-two-photon-excitation-microscopy
#24
REVIEW
Peter Luu, Scott E Fraser, Falk Schneider
For generations researchers have been observing the dynamic processes of life through the lens of a microscope. This has offered tremendous insights into biological phenomena that span multiple orders of time- and length-scales ranging from the pure magic of molecular reorganization at the membrane of immune cells, to cell migration and differentiation during development or wound healing. Standard fluorescence microscopy techniques offer glimpses at such processes in vitro, however, when applied in intact systems, they are challenged by reduced signal strengths and signal-to-noise ratios that result from deeper imaging...
March 26, 2024: Communications Biology
https://read.qxmd.com/read/38531972/structure-of-the-intact-tail-machine-of-anabaena-myophage-a-1-l
#25
JOURNAL ARTICLE
Rong-Cheng Yu, Feng Yang, Hong-Yan Zhang, Pu Hou, Kang Du, Jie Zhu, Ning Cui, Xudong Xu, Yuxing Chen, Qiong Li, Cong-Zhao Zhou
The Myoviridae cyanophage A-1(L) specifically infects the model cyanobacteria Anabaena sp. PCC 7120. Following our recent report on the capsid structure of A-1(L), here we present the high-resolution cryo-EM structure of its intact tail machine including the neck, tail and attached fibers. Besides the dodecameric portal, the neck contains a canonical hexamer connected to a unique pentadecamer that anchors five extended bead-chain-like neck fibers. The 1045-Å-long contractile tail is composed of a helical bundle of tape measure proteins surrounded by a layer of tube proteins and a layer of sheath proteins, ended with a five-component baseplate...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531970/macroevolutionary-dynamics-of-gene-family-gain-and-loss-along-multicellular-eukaryotic-lineages
#26
JOURNAL ARTICLE
Mirjana Domazet-Lošo, Tin Široki, Korina Šimičević, Tomislav Domazet-Lošo
The gain and loss of genes fluctuate over evolutionary time in major eukaryotic clades. However, the full profile of these macroevolutionary trajectories is still missing. To give a more inclusive view on the changes in genome complexity across the tree of life, here we recovered the evolutionary dynamics of gene family gain and loss ranging from the ancestor of cellular organisms to 352 eukaryotic species. We show that in all considered lineages the gene family content follows a common evolutionary pattern, where the number of gene families reaches the highest value at a major evolutionary and ecological transition, and then gradually decreases towards extant organisms...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531929/genetic-similarity-between-relatives-provides-evidence-on-the-presence-and-history-of-assortative-mating
#27
JOURNAL ARTICLE
Hans Fredrik Sunde, Nikolai Haahjem Eftedal, Rosa Cheesman, Elizabeth C Corfield, Thomas H Kleppesto, Anne Caroline Seierstad, Eivind Ystrom, Espen Moen Eilertsen, Fartein Ask Torvik
Assortative mating - the non-random mating of individuals with similar traits - is known to increase trait-specific genetic variance and genetic similarity between relatives. However, empirical evidence is limited for many traits, and the implications hinge on whether assortative mating has started recently or many generations ago. Here we show theoretically and empirically that genetic similarity between relatives can provide evidence on the presence and history of assortative mating. First, we employed path analysis to understand how assortative mating affects genetic similarity between family members across generations, finding that similarity between distant relatives is more affected than close relatives...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531906/meta-analysis-shows-the-impacts-of-ecological-restoration-on-greenhouse-gas-emissions
#28
JOURNAL ARTICLE
Tiehu He, Weixin Ding, Xiaoli Cheng, Yanjiang Cai, Yulong Zhang, Huijuan Xia, Xia Wang, Jiehao Zhang, Kerong Zhang, Quanfa Zhang
International initiatives set ambitious targets for ecological restoration, which is considered a promising greenhouse gas mitigation strategy. Here, we conduct a meta-analysis to quantify the impacts of ecological restoration on greenhouse gas emissions using a dataset compiled from 253 articles. Our findings reveal that forest and grassland restoration increase CH4 uptake by 90.0% and 30.8%, respectively, mainly due to changes in soil properties. Conversely, wetland restoration increases CH4 emissions by 544...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531902/tomosyns-attenuate-snare-assembly-and-synaptic-depression-by-binding-to-vamp2-containing-template-complexes
#29
JOURNAL ARTICLE
Marieke Meijer, Miriam Öttl, Jie Yang, Aygul Subkhangulova, Avinash Kumar, Zicheng Feng, Torben W van Voorst, Alexander J Groffen, Jan R T van Weering, Yongli Zhang, Matthijs Verhage
Tomosyns are widely thought to attenuate membrane fusion by competing with synaptobrevin-2/VAMP2 for SNARE-complex assembly. Here, we present evidence against this scenario. In a novel mouse model, tomosyn-1/2 deficiency lowered the fusion barrier and enhanced the probability that synaptic vesicles fuse, resulting in stronger synapses with faster depression and slower recovery. While wild-type tomosyn-1m rescued these phenotypes, substitution of its SNARE motif with that of synaptobrevin-2/VAMP2 did not. Single-molecule force measurements indeed revealed that tomosyn's SNARE motif cannot substitute synaptobrevin-2/VAMP2 to form template complexes with Munc18-1 and syntaxin-1, an essential intermediate for SNARE assembly...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531900/spatial-transcriptomics-reveals-molecular-dysfunction-associated-with-cortical-lewy-pathology
#30
JOURNAL ARTICLE
Thomas M Goralski, Lindsay Meyerdirk, Libby Breton, Laura Brasseur, Kevin Kurgat, Daniella DeWeerd, Lisa Turner, Katelyn Becker, Marie Adams, Daniel J Newhouse, Michael X Henderson
A key hallmark of Parkinson's disease (PD) is Lewy pathology. Composed of α-synuclein, Lewy pathology is found both in dopaminergic neurons that modulate motor function, and cortical regions that control cognitive function. Recent work has established the molecular identity of dopaminergic neurons susceptible to death, but little is known about cortical neurons susceptible to Lewy pathology or molecular changes induced by aggregates. In the current study, we use spatial transcriptomics to capture whole transcriptome signatures from cortical neurons with α-synuclein pathology compared to neurons without pathology...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531897/author-correction-a-hif-independent-oxygen-sensitive-pathway-for-controlling-cholesterol-synthesis
#31
Anna S Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M Ortmann, James A West, Norbert Volkmar, Anthony W Martinelli, Zhaoqi Li, Niek Wit, Dennis Vitkup, Arthur Kaser, Paul J Lehner, James A Nathan
No abstract text is available yet for this article.
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531896/accounting-for-albedo-change-to-identify-climate-positive-tree-cover-restoration
#32
JOURNAL ARTICLE
Natalia Hasler, Christopher A Williams, Vanessa Carrasco Denney, Peter W Ellis, Surendra Shrestha, Drew E Terasaki Hart, Nicholas H Wolff, Samantha Yeo, Thomas W Crowther, Leland K Werden, Susan C Cook-Patton
Restoring tree cover changes albedo, which is the fraction of sunlight reflected from the Earth's surface. In most locations, these changes in albedo offset or even negate the carbon removal benefits with the latter leading to global warming. Previous efforts to quantify the global climate mitigation benefit of restoring tree cover have not accounted robustly for albedo given a lack of spatially explicit data. Here we produce maps that show that carbon-only estimates may be up to 81% too high. While dryland and boreal settings have especially severe albedo offsets, it is possible to find places that provide net-positive climate mitigation benefits in all biomes...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531894/abundant-pleiotropy-across-neuroimaging-modalities-identified-through-a-multivariate-genome-wide-association-study
#33
JOURNAL ARTICLE
E P Tissink, A A Shadrin, D van der Meer, N Parker, G Hindley, D Roelfs, O Frei, C C Fan, M Nagel, T Nærland, M Budisteanu, S Djurovic, L T Westlye, M P van den Heuvel, D Posthuma, T Kaufmann, A M Dale, O A Andreassen
Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from one neuroimaging modality (e.g. structural, functional or diffusion magnetic resonance imaging [MRI]). A better understanding of pleiotropy across modalities could inform us on the integration of brain function, micro- and macrostructure. Here we show extensive genetic overlap across neuroimaging modalities at a locus and gene level in the UK Biobank (N = 34,029) and ABCD Study (N = 8607)...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531889/electricity-generation-from-carbon-dioxide-adsorption-by-spatially-nanoconfined-ion-separation
#34
JOURNAL ARTICLE
Zhuyuan Wang, Ting Hu, Mike Tebyetekerwa, Xiangkang Zeng, Fan Du, Yuan Kang, Xuefeng Li, Hao Zhang, Huanting Wang, Xiwang Zhang
Selective ion transport underpins fundamental biological processes for efficient energy conversion and signal propagation. Mimicking these 'ionics' in synthetic nanofluidic channels has been increasingly promising for realizing self-sustained systems by harvesting clean energy from diverse environments, such as light, moisture, salinity gradient, etc. Here, we report a spatially nanoconfined ion separation strategy that enables harvesting electricity from CO2 adsorption. This breakthrough relies on the development of Nanosheet-Agarose Hydrogel (NAH) composite-based generators, wherein the oppositely charged ions are released in water-filled hydrogel channels upon adsorbing CO2 ...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531886/metal-free-cross-dehydrogenative-n-n-coupling-of-primary-amides-with-lewis-basic-amines
#35
JOURNAL ARTICLE
Subban Kathiravan, Prakriti Dhillon, Tianshu Zhang, Ian A Nicholls
Hydrazides, N-N containing structural motifs, are important due to their presence in a wide variety of biologically significant compounds. While the homo N-N coupling of two NH moieties to form the hydrazide N-N bond is well developed, the cross-dehydrogenative hetero N-N coupling remains very unevolved. Here we present an efficient intermolecular N-N cross-coupling of a series of primary benzamides with broad range of Lewis basic primary and secondary amines using PhI(OAc)2 as both a terminal oxidant and a cross-coupling mediator, without the need for metal catalysts, high temperatures, and inert atmospheres, and with substantial potential for use in the late-stage functionalization of drugs...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531884/engineering-biology-and-climate-change-mitigation-policy-considerations
#36
REVIEW
Jonathan Symons, Thomas A Dixon, Jacqueline Dalziell, Natalie Curach, Ian T Paulsen, Anthony Wiskich, Isak S Pretorius
Engineering biology (EngBio) is a dynamic field that uses gene editing, synthesis, assembly, and engineering to design new or modified biological systems. EngBio applications could make a significant contribution to achieving net zero greenhouse gas emissions. Yet, policy support will be needed if EngBio is to fulfil its climate mitigation potential. What form should such policies take, and what EngBio applications should they target? This paper reviews EngBio's potential climate contributions to assist policymakers shape regulations and target resources and, in so doing, to facilitate democratic deliberation on desirable futures...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531883/polygenic-risk-score-for-ulcerative-colitis-predicts-immune-checkpoint-inhibitor-mediated-colitis
#37
JOURNAL ARTICLE
Pooja Middha, Rohit Thummalapalli, Michael J Betti, Lydia Yao, Zoe Quandt, Karmugi Balaratnam, Cosmin A Bejan, Eduardo Cardenas, Christina J Falcon, David M Faleck, Matthew A Gubens, Scott Huntsman, Douglas B Johnson, Linda Kachuri, Khaleeq Khan, Min Li, Christine M Lovly, Megan H Murray, Devalben Patel, Kristin Werking, Yaomin Xu, Luna Jia Zhan, Justin M Balko, Geoffrey Liu, Melinda C Aldrich, Adam J Schoenfeld, Elad Ziv
Immune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event of treatment with immune checkpoint inhibitors (ICI). We hypothesize that genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) predisposes to IMC. In this study, we first develop a polygenic risk scores for CD (PRSCD ) and UC (PRSUC ) in cancer-free individuals and then test these PRSs on IMC in a cohort of 1316 patients with ICI-treated non-small cell lung cancer and perform a replication in 873 ICI-treated pan-cancer patients...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531881/silk-fibroin-hydrogel-adhesive-enables-sealed-tight-reconstruction-of-meniscus-tears
#38
JOURNAL ARTICLE
Xihao Pan, Rui Li, Wenyue Li, Wei Sun, Yiyang Yan, Xiaochen Xiang, Jinghua Fang, Youguo Liao, Chang Xie, Xiaozhao Wang, Youzhi Cai, Xudong Yao, Hongwei Ouyang
Despite orientationally variant tears of the meniscus, suture repair is the current clinical gold treatment. However, inaccessible tears in company with re-tears susceptibility remain unresolved. To extend meniscal repair tools from the perspective of adhesion and regeneration, we design a dual functional biologic-released bioadhesive (S-PIL10) comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrates chemo-mechanical restoration with inner meniscal regeneration...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531880/intracortical-recordings-reveal-vision-to-action-cortical-gradients-driving-human-exogenous-attention
#39
JOURNAL ARTICLE
Tal Seidel Malkinson, Dimitri J Bayle, Brigitte C Kaufmann, Jianghao Liu, Alexia Bourgeois, Katia Lehongre, Sara Fernandez-Vidal, Vincent Navarro, Virginie Lambrecq, Claude Adam, Daniel S Margulies, Jacobo D Sitt, Paolo Bartolomeo
Exogenous attention, the process that makes external salient stimuli pop-out of a visual scene, is essential for survival. How attention-capturing events modulate human brain processing remains unclear. Here we show how the psychological construct of exogenous attention gradually emerges over large-scale gradients in the human cortex, by analyzing activity from 1,403 intracortical contacts implanted in 28 individuals, while they performed an exogenous attention task. The timing, location and task-relevance of attentional events defined a spatiotemporal gradient of three neural clusters, which mapped onto cortical gradients and presented a hierarchy of timescales...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531879/topological-minibands-and-interaction-driven-quantum-anomalous-hall-state-in-topological-insulator-based-moir%C3%A3-heterostructures
#40
JOURNAL ARTICLE
Kaijie Yang, Zian Xu, Yanjie Feng, Frank Schindler, Yuanfeng Xu, Zhen Bi, B Andrei Bernevig, Peizhe Tang, Chao-Xing Liu
The presence of topological flat minibands in moiré materials provides an opportunity to explore the interplay between topology and correlation. In this work, we study moiré minibands in topological insulator films with two hybridized surface states under a moiré superlattice potential created by two-dimensional insulating materials. We show the lowest conduction (highest valence) Kramers' pair of minibands can be <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:msub><mml:mrow><mml:mi>Z</mml:mi></mml:mrow> <mml:mrow><mml:mn>2</mml:mn></mml:mrow> </mml:msub> </mml:math> non-trivial when the minima (maxima) of moiré potential approximately form a hexagonal lattice with six-fold rotation symmetry...
March 26, 2024: Nature Communications
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