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Prognostic Value of Quantitative Contrast-Enhanced Cardiovascular Magnetic Resonance for the Evaluation of Sudden Death Risk in Patients With Hypertrophic Cardiomyopathy

Raymond H Chan, Barry J Maron, Iacopo Olivotto, Michael J Pencina, Gabriele Egidy Assenza, Tammy Haas, John R Lesser, Christiane Gruner, Andrew M Crean, Harry Rakowski, James E Udelson, Ethan Rowin, Massimo Lombardi, Franco Cecchi, Benedetta Tomberli, Paolo Spirito, Francesco Formisano, Elena Biagini, Claudio Rapezzi, Carlo Nicola De Cecco, Camillo Autore, E Francis Cook, Susie N Hong, C Michael Gibson, Warren J Manning, Evan Appelbaum, Martin S Maron
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden death in the young, although not all patients eligible for sudden death prevention with an implantable cardioverter-defibrillator are identified. Contrast-enhanced cardiovascular magnetic resonance with late gadolinium enhancement (LGE) has emerged as an in vivo marker of myocardial fibrosis, although its role in stratifying sudden death risk in subgroups of HCM patients remains incompletely understood. METHODS AND RESULTS: We assessed the relation between LGE and cardiovascular outcomes in 1293 HCM patients referred for cardiovascular magnetic resonance and followed up for a median of 3...
August 5, 2014: Circulation
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