keyword
https://read.qxmd.com/read/38306899/validating-a-minipig-model-of-reversible-cerebral-demyelination-using-human-diagnostic-modalities-and-electron-microscopy
#21
JOURNAL ARTICLE
Mihai Ancău, Goutam Kumar Tanti, Vicki Marie Butenschoen, Jens Gempt, Igor Yakushev, Stephan Nekolla, Mark Mühlau, Christian Scheunemann, Sebastian Heininger, Benjamin Löwe, Erik Löwe, Silke Baer, Johannes Fischer, Judith Reiser, Sai S Ayachit, Friederike Liesche-Starnecker, Jürgen Schlegel, Kaspar Matiasek, Martina Schifferer, Jan S Kirschke, Thomas Misgeld, Tim Lueth, Bernhard Hemmer
BACKGROUND: Inflammatory demyelinating diseases of the central nervous system, such as multiple sclerosis, are significant sources of morbidity in young adults despite therapeutic advances. Current murine models of remyelination have limited applicability due to the low white matter content of their brains, which restricts the spatial resolution of diagnostic imaging. Large animal models might be more suitable but pose significant technological, ethical and logistical challenges. METHODS: We induced targeted cerebral demyelinating lesions by serially repeated injections of lysophosphatidylcholine in the minipig brain...
February 1, 2024: EBioMedicine
https://read.qxmd.com/read/38294487/-epilepsy-in-children-and-adults-part-1-childhood-epilepsy
#22
JOURNAL ARTICLE
Sarah Baer, Anne de Saint-Martin
No abstract text is available yet for this article.
December 2023: La Revue du Praticien
https://read.qxmd.com/read/38272031/mutations-in-samd7-cause-autosomal-recessive-macular-dystrophy-with-or-without-cone-dysfunction
#23
JOURNAL ARTICLE
Miriam Bauwens, Elifnaz Celik, Dinah Zur, Siying Lin, Mathieu Quinodoz, Michel Michaelides, Andrew R Webster, Filip Van Den Broeck, Bart P Leroy, Leah Rizel, Abigail R Moye, Audrey Meunier, Hoai Viet Tran, Alexandre P Moulin, Quinten Mahieu, Mattias Van Heetvelde, Gavin Arno, Carlo Rivolta, Elfride De Baere, Tamar Ben-Yosef
Sterile alpha motif domain containing 7 (SAMD7) is a component of the Polycomb repressive complex 1, which inhibits transcription of many genes, including those activated by the transcription factor Cone-Rod Homeobox (CRX). Here we report bi-allelic mutations in SAMD7 as a cause of autosomal-recessive macular dystrophy with or without cone dysfunction. Four of these mutations affect splicing, while another mutation is a missense variant that alters the repressive effect of SAMD7 on CRX-dependent promoter activity, as shown by in vitro assays...
February 1, 2024: American Journal of Human Genetics
https://read.qxmd.com/read/38260617/spatial-characterization-of-interface-dermatitis-in-cutaneous-lupus-reveals-novel-chemokine-ligand-receptor-pairs-that-drive-disease
#24
Saeed Shakiba, Nazgol-Sadat Haddadi, Khashayar Afshari, Janet E Lubov, Haya S Raef, Robert Li, Ümmügülsüm Yildiz-Altay, Mridushi Daga, Maggi Ahmed Refat, Evangeline Kim, Johanna Galindo de Laflin, Andressa Akabane, Shany Sherman, Elizabeth MacDonald, James P Strassner, Liang Zhang, Michael Leon, Christina E Baer, Karen Dresser, Yan Liang, James B Whitley, Sladjana Skopelja-Gardner, John E Harris, April Deng, Matthew D Vesely, Mehdi Rashighi, Jillian Richmond
UNLABELLED: Chemokines play critical roles in the recruitment and activation of immune cells in both homeostatic and pathologic conditions. Here, we examined chemokine ligand-receptor pairs to better understand the immunopathogenesis of cutaneous lupus erythematosus (CLE), a complex autoimmune connective tissue disorder. We used suction blister biopsies to measure cellular infiltrates with spectral flow cytometry in the interface dermatitis reaction, as well as 184 protein analytes in interstitial skin fluid using Olink targeted proteomics...
January 6, 2024: bioRxiv
https://read.qxmd.com/read/38243599/proof-of-concept-for-multiple-aon-delivery-by-a-single-u7snrna-vector-to-restore-splicing-defects-in-abca4
#25
JOURNAL ARTICLE
Nuria Suárez-Herrera, Iris B Riswick, Irene Vázquez-Domínguez, Lonneke Duijkers, Dyah W Karjosukarso, Davide Piccolo, Miriam Bauwens, Elfride De Baere, Michael E Cheetham, Alejandro Garanto, Rob W J Collin
The high allelic heterogeneity in Stargardt Disease (STGD1) complicates the design of intervention strategies. A significant proportion of pathogenic intronic ABCA4 variants alters the pre-mRNA splicing process. Antisense oligonucleotides (AONs) are an attractive yet mutation-specific therapeutic strategy to restore these splicing defects. In this study, we experimentally assessed the potential of a splicing modulation therapy to target multiple intronic ABCA4 variants. Firstly, AONs were inserted into U7snRNA gene cassettes and tested in midigene-based splice assays...
January 18, 2024: Molecular Therapy
https://read.qxmd.com/read/38215492/influence-of-peptoid-sequence-on-the-mechanisms-and-kinetics-of-2d-assembly
#26
JOURNAL ARTICLE
Sakshi Yadav Schmid, Xiang Ma, Joshua A Hammons, Sebastian T Mergelsberg, Bradley S Harris, Thomas Ferron, Wenchao Yang, Wenhao Zhou, Renyu Zheng, Shuai Zhang, Benjamin Adam Legg, Anthony Van Buuren, Marcel D Baer, Chun-Long Chen, Jinhui Tao, James J De Yoreo
Two-dimensional (2D) materials have attracted intense interest due to their potential for applications in fields ranging from chemical sensing to catalysis, energy storage, and biomedicine. Recently, peptoids, a class of biomimetic sequence-defined polymers, have been found to self-assemble into 2D crystalline sheets that exhibit unusual properties, such as high chemical stability and the ability to self-repair. The structure of a peptoid is close to that of a peptide except that the side chains are appended to the amide nitrogen rather than the α carbon...
January 12, 2024: ACS Nano
https://read.qxmd.com/read/38212068/long-term-overall-survival-after-selective-internal-radiation-therapy-for-locally-advanced-hepatocellular-carcinomas-updated-analysis-of-dosisphere-01-trial
#27
RANDOMIZED CONTROLLED TRIAL
Etienne Garin, Lambros Tselikas, Boris Guiu, Julia Chalaye, Yan Rolland, Thierry de Baere, Eric Assenat, Vania Tacher, Xavier Palard, Desirée Déandreis, Denis Mariano-Goulart, Giuliana Amaddeo, Karim Boudjema, Antoine Hollebecque, Mohamad Azhar Meerun, Helen Regnault, Eric Vibert, Boris Campillo-Gimenez, Julien Edeline
Interim analysis of the DOSISPHERE-01 study demonstrated a strong improvement in response and overall survival (OS) on using 90 Y-loaded glass microspheres with personalized dosimetry compared with standard dosimetry in patients with nonoperable locally advanced hepatocellular carcinoma. This report sought to provide a long-term analysis of OS. Methods: In this phase II study (ClinicalTrials.gov identifier NCT02582034), treatment was randomly assigned (1:1) with the goal to deliver either at least 205 Gy (if possible >250-300 Gy) to the index lesion in the personalized dosimetry approach (PDA) or 120 ± 20 Gy to the treated volume in the standard dosimetry approach (SDA)...
February 1, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38184646/combining-a-prioritization-strategy-and-functional-studies-nominates-5-utr-variants-underlying-inherited-retinal-disease
#28
JOURNAL ARTICLE
Alfredo Dueñas Rey, Marta Del Pozo Valero, Manon Bouckaert, Katherine A Wood, Filip Van den Broeck, Malena Daich Varela, Huw B Thomas, Mattias Van Heetvelde, Marieke De Bruyne, Stijn Van de Sompele, Miriam Bauwens, Hanne Lenaerts, Quinten Mahieu, Dragana Josifova, Carlo Rivolta, Raymond T O'Keefe, Jamie Ellingford, Andrew R Webster, Gavin Arno, Carmen Ayuso, Julie De Zaeytijd, Bart P Leroy, Elfride De Baere, Frauke Coppieters
BACKGROUND: 5' untranslated regions (5'UTRs) are essential modulators of protein translation. Predicting the impact of 5'UTR variants is challenging and rarely performed in routine diagnostics. Here, we present a combined approach of a comprehensive prioritization strategy and functional assays to evaluate 5'UTR variation in two large cohorts of patients with inherited retinal diseases (IRDs). METHODS: We performed an isoform-level re-analysis of retinal RNA-seq data to identify the protein-coding transcripts of 378 IRD genes with highest expression in retina...
January 6, 2024: Genome Medicine
https://read.qxmd.com/read/38181336/combined-measurement-of-the-higgs-boson-mass-from-the-h%C3%A2-%C3%AE-%C3%AE-and-h%C3%A2-zz-%C3%A2-4%C3%A2-decay-channels-with-the-atlas-detector-using-sqrt-s-7-8-and-13%C3%A2-tev-pp-collision-data
#29
JOURNAL ARTICLE
G Aad, B Abbott, K Abeling, N J Abicht, S H Abidi, A Aboulhorma, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, C Adam Bourdarios, L Adamczyk, S V Addepalli, M J Addison, J Adelman, A Adiguzel, T Adye, A A Affolder, Y Afik, M N Agaras, J Agarwala, A Aggarwal, C Agheorghiesei, A Ahmad, F Ahmadov, W S Ahmed, S Ahuja, X Ai, G Aielli, A Aikot, M Ait Tamlihat, B Aitbenchikh, I Aizenberg, M Akbiyik, T P A Åkesson, A V Akimov, D Akiyama, N N Akolkar, K Al Khoury, G L Alberghi, J Albert, P Albicocco, G L Albouy, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, F Alfonsi, M Algren, M Alhroob, B Ali, H M J Ali, S Ali, S W Alibocus, M Aliev, G Alimonti, W Alkakhi, C Allaire, B M M Allbrooke, J F Allen, C A Allendes Flores, P P Allport, A Aloisio, F Alonso, C Alpigiani, M Alvarez Estevez, A Alvarez Fernandez, M Alves Cardoso, M G Alviggi, M Aly, Y Amaral Coutinho, A Ambler, C Amelung, M Amerl, C G Ames, D Amidei, S P Amor Dos Santos, K R Amos, V Ananiev, C Anastopoulos, T Andeen, J K Anders, S Y Andrean, A Andreazza, S Angelidakis, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, E Antipov, M Antonelli, F Anulli, M Aoki, T Aoki, J A Aparisi Pozo, M A Aparo, L Aperio Bella, C Appelt, A Apyan, N Aranzabal, S J Arbiol Val, C Arcangeletti, A T H Arce, E Arena, J-F Arguin, S Argyropoulos, J-H Arling, O Arnaez, H Arnold, G Artoni, H Asada, K Asai, S Asai, N A Asbah, J Assahsah, K Assamagan, R Astalos, S Atashi, R J Atkin, M Atkinson, H Atmani, P A Atmasiddha, K Augsten, S Auricchio, A D Auriol, V A Austrup, G Avolio, K Axiotis, G Azuelos, D Babal, H Bachacou, K Bachas, A Bachiu, F Backman, A Badea, T M Baer, P Bagnaia, M Bahmani, A J Bailey, V R Bailey, J T Baines, L Baines, O K Baker, E Bakos, D Bakshi Gupta, V Balakrishnan, R Balasubramanian, E M Baldin, P Balek, E Ballabene, F Balli, L M Baltes, W K Balunas, J Balz, E Banas, M Bandieramonte, A Bandyopadhyay, S Bansal, L Barak, M Barakat, E L Barberio, D Barberis, M Barbero, M Z Barel, K N Barends, T Barillari, M-S Barisits, T Barklow, P Baron, D A Baron Moreno, A Baroncelli, G Barone, A J Barr, J D Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, U Barron, M G Barros Teixeira, S Barsov, F Bartels, R Bartoldus, A E Barton, P Bartos, A Basan, M Baselga, A Bassalat, M J Basso, C R Basson, R L Bates, S Batlamous, J R Batley, B Batool, M Battaglia, D Battulga, M Bauce, M Bauer, P Bauer, L T Bazzano Hurrell, J B Beacham, T Beau, J Y Beaucamp, P H Beauchemin, F Becherer, P Bechtle, H P Beck, K Becker, A J Beddall, V A Bednyakov, C P Bee, L J Beemster, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, J F Beirer, F Beisiegel, M Belfkir, G Bella, L Bellagamba, A Bellerive, P Bellos, K Beloborodov, D Benchekroun, F Bendebba, Y Benhammou, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, E Bergeaas Kuutmann, N Berger, B Bergmann, J Beringer, G Bernardi, C Bernius, F U Bernlochner, F Bernon, A Berrocal Guardia, T Berry, P Berta, A Berthold, I A Bertram, S Bethke, A Betti, A J Bevan, N K Bhalla, M Bhamjee, S Bhatta, D S Bhattacharya, P Bhattarai, V S Bhopatkar, R Bi, R M Bianchi, G Bianco, O Biebel, R Bielski, M Biglietti, M Bindi, A Bingul, C Bini, A Biondini, C J Birch-Sykes, G A Bird, M Birman, M Biros, S Biryukov, T Bisanz, E Bisceglie, J P Biswal, D Biswas, A Bitadze, K Bjørke, I Bloch, C Blocker, A Blue, U Blumenschein, J Blumenthal, G J Bobbink, V S Bobrovnikov, M Boehler, B Boehm, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, M Bomben, M Bona, M Boonekamp, C D Booth, A G Borbély, I S Bordulev, H M Borecka-Bielska, G Borissov, D Bortoletto, D Boscherini, M Bosman, J D Bossio Sola, K Bouaouda, N Bouchhar, J Boudreau, E V Bouhova-Thacker, D Boumediene, R Bouquet, A Boveia, J Boyd, D Boye, I R Boyko, J Bracinik, N Brahimi, G Brandt, O Brandt, F Braren, B Brau, J E Brau, R Brener, L Brenner, R Brenner, S Bressler, D Britton, D Britzger, I Brock, G Brooijmans, W K Brooks, E Brost, L M Brown, L E Bruce, T L Bruckler, P A Bruckman de Renstrom, B Brüers, A Bruni, G Bruni, M Bruschi, N Bruscino, T Buanes, Q Buat, D Buchin, A G Buckley, O Bulekov, B A Bullard, S Burdin, C D Burgard, A M Burger, B Burghgrave, O Burlayenko, J T P Burr, C D Burton, J C Burzynski, E L Busch, V Büscher, P J Bussey, J M Butler, C M Buttar, J M Butterworth, W Buttinger, C J Buxo Vazquez, A R Buzykaev, S Cabrera Urbán, L Cadamuro, D Caforio, H Cai, Y Cai, Y Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, G Calderini, P Calfayan, G Callea, L P Caloba, D Calvet, S Calvet, T P Calvet, M Calvetti, R Camacho Toro, S Camarda, D Camarero Munoz, P Camarri, M T Camerlingo, D Cameron, C Camincher, M Campanelli, A Camplani, V Canale, A Canesse, J Cantero, Y Cao, F Capocasa, M Capua, A Carbone, R Cardarelli, J C J Cardenas, F Cardillo, G Carducci, T Carli, G Carlino, J I Carlotto, B T Carlson, E M Carlson, L Carminati, A Carnelli, M Carnesale, S Caron, E Carquin, S Carrá, G Carratta, F Carrio Argos, J W S Carter, T M Carter, M P Casado, M Caspar, F L Castillo, L Castillo Garcia, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, V Cavaliere, N Cavalli, V Cavasinni, Y C Cekmecelioglu, E Celebi, F Celli, M S Centonze, V Cepaitis, K Cerny, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, B Cervato, A Cervelli, G Cesarini, S A Cetin, Z Chadi, D Chakraborty, J Chan, W Y Chan, J D Chapman, E Chapon, B Chargeishvili, D G Charlton, T P Charman, M Chatterjee, C Chauhan, S Chekanov, S V Chekulaev, G A Chelkov, A Chen, B Chen, B Chen, H Chen, H Chen, J Chen, J Chen, M Chen, S Chen, S J Chen, X Chen, X Chen, Y Chen, C L Cheng, H C Cheng, S Cheong, A Cheplakov, E Cheremushkina, E Cherepanova, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, N Chiedde, G Chiodini, A S Chisholm, A Chitan, M Chitishvili, M V Chizhov, K Choi, A R Chomont, Y Chou, E Y S Chow, T Chowdhury, K L Chu, M C Chu, X Chu, J Chudoba, J J Chwastowski, D Cieri, K M Ciesla, V Cindro, A Ciocio, F Cirotto, Z H Citron, M Citterio, D A Ciubotaru, B M Ciungu, A Clark, P J Clark, C Clarry, J M Clavijo Columbie, S E Clawson, C Clement, J Clercx, L Clissa, Y Coadou, M Cobal, A Coccaro, R F Coelho Barrue, R Coelho Lopes De Sa, S Coelli, H Cohen, A E C Coimbra, B Cole, J Collot, P Conde Muiño, M P Connell, S H Connell, I A Connelly, E I Conroy, F Conventi, H G Cooke, A M Cooper-Sarkar, A Cordeiro Oudot Choi, L D Corpe, M Corradi, F Corriveau, A Cortes-Gonzalez, M J Costa, F Costanza, D Costanzo, B M Cote, G Cowan, K Cranmer, D Cremonini, S Crépé-Renaudin, F Crescioli, M Cristinziani, M Cristoforetti, V Croft, J E Crosby, G Crosetti, A Cueto, T Cuhadar Donszelmann, H Cui, Z Cui, W R Cunningham, F Curcio, P Czodrowski, M M Czurylo, M J Da Cunha Sargedas De Sousa, J V Da Fonseca Pinto, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, D Dal Santo, C Dallapiccola, M Dam, G D'amen, V D'Amico, J Damp, J R Dandoy, M F Daneri, M Danninger, V Dao, G Darbo, S Darmora, S J Das, S D'Auria, C David, T Davidek, B Davis-Purcell, I Dawson, H A Day-Hall, K De, R De Asmundis, N De Biase, S De Castro, N De Groot, P de Jong, H De la Torre, A De Maria, A De Salvo, U De Sanctis, A De Santo, J B De Vivie De Regie, D V Dedovich, J Degens, A M Deiana, F Del Corso, J Del Peso, F Del Rio, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, P A Delsart, S Demers, M Demichev, S P Denisov, L D'Eramo, D Derendarz, F Derue, P Dervan, K Desch, C Deutsch, F A Di Bello, A Di Ciaccio, L Di Ciaccio, A Di Domenico, C Di Donato, A Di Girolamo, G Di Gregorio, A Di Luca, B Di Micco, R Di Nardo, C Diaconu, M Diamantopoulou, F A Dias, T Dias Do Vale, M A Diaz, F G Diaz Capriles, M Didenko, E B Diehl, L Diehl, S Díez Cornell, C Diez Pardos, C Dimitriadi, A Dimitrievska, J Dingfelder, I-M Dinu, S J Dittmeier, F Dittus, F Djama, T Djobava, J I Djuvsland, C Doglioni, A Dohnalova, J Dolejsi, Z Dolezal, K M Dona, M Donadelli, B Dong, J Donini, A D'Onofrio, M D'Onofrio, J Dopke, A Doria, N Dos Santos Fernandes, P Dougan, M T Dova, A T Doyle, M A Draguet, E Dreyer, I Drivas-Koulouris, M Drnevich, A S Drobac, M Drozdova, D Du, T A du Pree, F Dubinin, M Dubovsky, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, E R Duden, M D'uffizi, L Duflot, M Dührssen, C Dülsen, A E Dumitriu, M Dunford, S Dungs, K Dunne, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, B L Dwyer, G I Dyckes, M Dyndal, B S Dziedzic, Z O Earnshaw, G H Eberwein, B Eckerova, S Eggebrecht, E Egidio Purcino De Souza, L F Ehrke, G Eigen, K Einsweiler, T Ekelof, P A Ekman, S El Farkh, Y El Ghazali, H El Jarrari, A El Moussaouy, V Ellajosyula, M Ellert, F Ellinghaus, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, I Ene, S Epari, J Erdmann, P A Erland, M Errenst, M Escalier, C Escobar, E Etzion, G Evans, H Evans, L S Evans, M O Evans, A Ezhilov, S Ezzarqtouni, F Fabbri, L Fabbri, G Facini, V Fadeyev, R M Fakhrutdinov, S Falciano, L F Falda Ulhoa Coelho, P J Falke, J Faltova, C Fan, Y Fan, Y Fang, M Fanti, M Faraj, Z Farazpay, A Farbin, A Farilla, T Farooque, S M Farrington, F Fassi, D Fassouliotis, M Faucci Giannelli, W J Fawcett, L Fayard, P Federic, P Federicova, O L Fedin, G Fedotov, M Feickert, L Feligioni, D E Fellers, C Feng, M Feng, Z Feng, M J Fenton, A B Fenyuk, L Ferencz, R A M Ferguson, S I Fernandez Luengo, P Fernandez Martinez, M J V Fernoux, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D Ferrere, C Ferretti, F Fiedler, P Fiedler, A Filipčič, E K Filmer, F Filthaut, M C N Fiolhais, L Fiorini, W C Fisher, T Fitschen, P M Fitzhugh, I Fleck, P Fleischmann, T Flick, M Flores, L R Flores Castillo, L Flores Sanz De Acedo, F M Follega, N Fomin, J H Foo, B C Forland, A Formica, A C Forti, E Fortin, A W Fortman, M G Foti, L Fountas, D Fournier, H Fox, P Francavilla, S Francescato, S Franchellucci, M Franchini, S Franchino, D Francis, L Franco, V Franco Lima, L Franconi, M Franklin, G Frattari, A C Freegard, W S Freund, Y Y Frid, J Friend, N Fritzsche, A Froch, D Froidevaux, J A Frost, Y Fu, S Fuenzalida Garrido, M Fujimoto, E Fullana Torregrosa, K Y Fung, E Furtado De Simas Filho, M Furukawa, J Fuster, A Gabrielli, A Gabrielli, P Gadow, G Gagliardi, L G Gagnon, E J Gallas, B J Gallop, K K Gan, S Ganguly, Y Gao, F M Garay Walls, B Garcia, C García, A Garcia Alonso, A G Garcia Caffaro, J E García Navarro, M Garcia-Sciveres, G L Gardner, R W Gardner, N Garelli, D Garg, R B Garg, J M Gargan, C A Garner, C M Garvey, P Gaspar, V K Gassmann, G Gaudio, V Gautam, P Gauzzi, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, A A Geanta, C M Gee, A Gekow, C Gemme, M H Genest, S Gentile, A D Gentry, S George, W F George, T Geralis, P Gessinger-Befurt, M E Geyik, M Ghani, M Ghneimat, K Ghorbanian, A Ghosal, A Ghosh, A Ghosh, B Giacobbe, S Giagu, T Giani, P Giannetti, A Giannini, S M Gibson, M Gignac, D T Gil, A K Gilbert, B J Gilbert, D Gillberg, G Gilles, N E K Gillwald, L Ginabat, D M Gingrich, M P Giordani, P F Giraud, G Giugliarelli, D Giugni, F Giuli, I Gkialas, L K Gladilin, C Glasman, G R Gledhill, G Glemža, M Glisic, I Gnesi, Y Go, M Goblirsch-Kolb, B Gocke, D Godin, B Gokturk, S Goldfarb, T Golling, M G D Gololo, D Golubkov, J P Gombas, A Gomes, G Gomes Da Silva, A J Gomez Delegido, R Gonçalo, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, R Y González Andana, S González de la Hoz, S Gonzalez Fernandez, R Gonzalez Lopez, C Gonzalez Renteria, M V Gonzalez Rodrigues, R Gonzalez Suarez, S Gonzalez-Sevilla, G R Gonzalvo Rodriguez, L Goossens, B Gorini, E Gorini, A Gorišek, T C Gosart, A T Goshaw, M I Gostkin, S Goswami, C A Gottardo, S A Gotz, M Gouighri, V Goumarre, A G Goussiou, N Govender, I Grabowska-Bold, K Graham, E Gramstad, S Grancagnolo, M Grandi, C M Grant, P M Gravila, F G Gravili, H M Gray, M Greco, C Grefe, I M Gregor, P Grenier, S G Grewe, C Grieco, A A Grillo, K Grimm, S Grinstein, J-F Grivaz, E Gross, J Grosse-Knetter, C Grud, J C Grundy, L Guan, W Guan, C Gubbels, J G R Guerrero Rojas, G Guerrieri, F Guescini, R Gugel, J A M Guhit, A Guida, T Guillemin, E Guilloton, S Guindon, F Guo, J Guo, L Guo, Y Guo, R Gupta, R Gupta, S Gurbuz, S S Gurdasani, G Gustavino, M Guth, P Gutierrez, L F Gutierrez Zagazeta, M Gutsche, C Gutschow, C Gwenlan, C B Gwilliam, E S Haaland, A Haas, M Habedank, C Haber, H K Hadavand, A Hadef, S Hadzic, A I Hagan, J J Hahn, E H Haines, M Haleem, J Haley, J J Hall, G D Hallewell, L Halser, K Hamano, M Hamer, G N Hamity, E J Hampshire, J Han, K Han, L Han, L Han, S Han, Y F Han, K Hanagaki, M Hance, D A Hangal, H Hanif, M D Hank, R Hankache, J B Hansen, J D Hansen, P H Hansen, K Hara, D Harada, T Harenberg, S Harkusha, M L Harris, Y T Harris, J Harrison, N M Harrison, P F Harrison, N M Hartman, N M Hartmann, Y Hasegawa, R Hauser, C M Hawkes, R J Hawkings, Y Hayashi, S Hayashida, D Hayden, C Hayes, R L Hayes, C P Hays, J M Hays, H S Hayward, F He, M He, Y He, Y He, N B Heatley, V Hedberg, A L Heggelund, N D Hehir, C Heidegger, K K Heidegger, W D Heidorn, J 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Siegert, Dj Sijacki, R Sikora, F Sili, J M Silva, M V Silva Oliveira, S B Silverstein, S Simion, R Simoniello, E L Simpson, H Simpson, L R Simpson, N D Simpson, S Simsek, S Sindhu, P Sinervo, S Singh, S Sinha, S Sinha, M Sioli, I Siral, E Sitnikova, S Yu Sivoklokov, J Sjölin, A Skaf, E Skorda, P Skubic, M Slawinska, V Smakhtin, B H Smart, J Smiesko, S Yu Smirnov, Y Smirnov, L N Smirnova, O Smirnova, A C Smith, E A Smith, H A Smith, J L Smith, R Smith, M Smizanska, K Smolek, A A Snesarev, S R Snider, H L Snoek, S Snyder, R Sobie, A Soffer, C A Solans Sanchez, E Yu Soldatov, U Soldevila, A A Solodkov, S Solomon, A Soloshenko, K Solovieva, O V Solovyanov, V Solovyev, P Sommer, A Sonay, W Y Song, J M Sonneveld, A Sopczak, A L Sopio, F Sopkova, I R Sotarriva Alvarez, V Sothilingam, O J Soto Sandoval, S Sottocornola, R Soualah, Z Soumaimi, D South, N Soybelman, S Spagnolo, M Spalla, D Sperlich, G Spigo, S Spinali, D P Spiteri, M Spousta, E J Staats, A Stabile, R Stamen, A Stampekis, M Standke, E Stanecka, M V Stange, B Stanislaus, M M Stanitzki, B Stapf, E A Starchenko, G H Stark, J Stark, D M Starko, P Staroba, P Starovoitov, S Stärz, R Staszewski, G Stavropoulos, J Steentoft, P Steinberg, B Stelzer, H J Stelzer, O Stelzer-Chilton, H Stenzel, T J Stevenson, G A Stewart, J R Stewart, M C Stockton, G Stoicea, M Stolarski, S Stonjek, A Straessner, J Strandberg, S Strandberg, M Stratmann, M Strauss, T Strebler, P Strizenec, R Ströhmer, D M Strom, L R Strom, R Stroynowski, A Strubig, S A Stucci, B Stugu, J Stupak, N A Styles, D Su, S Su, W Su, X Su, K Sugizaki, V V Sulin, M J Sullivan, D M S Sultan, L Sultanaliyeva, S Sultansoy, T Sumida, S Sun, S Sun, O Sunneborn Gudnadottir, N Sur, M R Sutton, H Suzuki, M Svatos, M Swiatlowski, T Swirski, I Sykora, M Sykora, T Sykora, D Ta, K Tackmann, A Taffard, R Tafirout, J S Tafoya Vargas, E P Takeva, Y Takubo, M Talby, A A Talyshev, K C Tam, N M Tamir, A Tanaka, J Tanaka, R Tanaka, M Tanasini, Z Tao, S Tapia Araya, S Tapprogge, A Tarek Abouelfadl Mohamed, S Tarem, K Tariq, G Tarna, G F Tartarelli, P Tas, M Tasevsky, E Tassi, A C Tate, G Tateno, Y Tayalati, G N Taylor, W Taylor, A S Tee, R Teixeira De Lima, P Teixeira-Dias, J J Teoh, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, A Thaler, O Theiner, N Themistokleous, T Theveneaux-Pelzer, O Thielmann, D W Thomas, J P Thomas, E A Thompson, P D Thompson, E Thomson, Y Tian, V Tikhomirov, Yu A Tikhonov, S Timoshenko, D Timoshyn, E X L Ting, P Tipton, S H Tlou, A Tnourji, K Todome, S Todorova-Nova, S Todt, M Togawa, J Tojo, S Tokár, K Tokushuku, O Toldaiev, R Tombs, M Tomoto, L Tompkins, K W Topolnicki, E Torrence, H Torres, E Torró Pastor, M Toscani, C Tosciri, M Tost, D R Tovey, A Traeet, I S Trandafir, T Trefzger, A Tricoli, I M Trigger, S Trincaz-Duvoid, D A Trischuk, B Trocmé, C Troncon, L Truong, M Trzebinski, A Trzupek, F Tsai, M Tsai, A Tsiamis, P V Tsiareshka, S Tsigaridas, A Tsirigotis, V Tsiskaridze, E G Tskhadadze, M Tsopoulou, Y Tsujikawa, I I Tsukerman, V Tsulaia, S Tsuno, O Tsur, K Tsuri, D Tsybychev, Y Tu, A Tudorache, V Tudorache, A N Tuna, S Turchikhin, I Turk Cakir, R Turra, T Turtuvshin, P M Tuts, S Tzamarias, P Tzanis, E Tzovara, F Ukegawa, P A Ulloa Poblete, E N Umaka, G Unal, M Unal, A Undrus, G Unel, J Urban, P Urquijo, P Urrejola, G Usai, R Ushioda, M Usman, Z Uysal, V Vacek, B Vachon, K O H Vadla, T Vafeiadis, A Vaitkus, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, E Valiente Moreno, A Vallier, J A Valls Ferrer, D R Van Arneman, T R Van Daalen, A Van Der Graaf, P Van Gemmeren, M Van Rijnbach, S Van Stroud, I Van Vulpen, M Vanadia, W Vandelli, M Vandenbroucke, E R Vandewall, D Vannicola, L Vannoli, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, L Varriale, K E Varvell, M E Vasile, L Vaslin, G A Vasquez, A Vasyukov, F Vazeille, T Vazquez Schroeder, J Veatch, V Vecchio, M J Veen, I Veliscek, L M Veloce, F Veloso, S Veneziano, A Ventura, S Ventura Gonzalez, A Verbytskyi, M Verducci, C Vergis, M Verissimo De Araujo, W Verkerke, J C Vermeulen, C Vernieri, M Vessella, M C Vetterli, A Vgenopoulos, N Viaux Maira, T Vickey, O E Vickey Boeriu, G H A Viehhauser, L Vigani, M Villa, M Villaplana Perez, E M Villhauer, E Vilucchi, M G Vincter, G S Virdee, A Vishwakarma, A Visibile, C Vittori, I Vivarelli, E Voevodina, F Vogel, J C Voigt, P Vokac, Yu Volkotrub, J Von Ahnen, E Von Toerne, B Vormwald, V Vorobel, K Vorobev, M Vos, K Voss, J H Vossebeld, M Vozak, L Vozdecky, N Vranjes, M Vranjes Milosavljevic, M Vreeswijk, N K Vu, R Vuillermet, O Vujinovic, I Vukotic, S Wada, C Wagner, J M Wagner, W Wagner, S Wahdan, H Wahlberg, M Wakida, J Walder, R Walker, W Walkowiak, A Wall, T Wamorkar, A Z Wang, C Wang, C Wang, H Wang, J Wang, R-J Wang, R Wang, R Wang, S M Wang, S Wang, T Wang, W T Wang, W Wang, X Wang, X Wang, X Wang, Y Wang, Y Wang, Z Wang, Z Wang, Z Wang, A Warburton, R J Ward, N Warrack, A T Watson, H Watson, M F Watson, E Watton, G Watts, B M Waugh, C Weber, H A Weber, M S Weber, S M Weber, C Wei, Y Wei, A R Weidberg, E J Weik, J Weingarten, M Weirich, C Weiser, C J Wells, T Wenaus, B Wendland, T Wengler, N S Wenke, N Wermes, M Wessels, A M Wharton, A S White, A White, M J White, D Whiteson, L Wickremasinghe, W Wiedenmann, C Wiel, M Wielers, C Wiglesworth, D J Wilbern, H G Wilkens, D M Williams, H H Williams, S Williams, S Willocq, B J Wilson, P J Windischhofer, F I Winkel, F Winklmeier, B T Winter, J K Winter, M Wittgen, M Wobisch, Z Wolffs, J Wollrath, M W Wolter, H Wolters, A F Wongel, E L Woodward, S D Worm, B K Wosiek, K W Woźniak, S Wozniewski, K Wraight, C Wu, J Wu, M Wu, M Wu, S L Wu, X Wu, Y Wu, Z Wu, J Wuerzinger, T R Wyatt, B M Wynne, S Xella, L Xia, M Xia, J Xiang, M Xie, X Xie, S Xin, A Xiong, J Xiong, D Xu, H Xu, L Xu, R Xu, T Xu, Y Xu, Z Xu, B Yabsley, S Yacoob, Y Yamaguchi, E Yamashita, H Yamauchi, T Yamazaki, Y Yamazaki, J Yan, S Yan, Z Yan, H J Yang, H T Yang, S Yang, T Yang, X Yang, X Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, H Ye, H Ye, J Ye, S Ye, X Ye, Y Yeh, I Yeletskikh, B K Yeo, M R Yexley, P Yin, K Yorita, S Younas, C J S Young, C Young, C Yu, Y Yu, M Yuan, R Yuan, L Yue, M Zaazoua, B Zabinski, E Zaid, T Zakareishvili, N Zakharchuk, S Zambito, J A Zamora Saa, J Zang, D Zanzi, O Zaplatilek, C Zeitnitz, H Zeng, J C Zeng, D T Zenger, O Zenin, T Ženiš, S Zenz, S Zerradi, D Zerwas, M Zhai, B Zhang, D F Zhang, J Zhang, J Zhang, K Zhang, L Zhang, P Zhang, R Zhang, S Zhang, S Zhang, T Zhang, X Zhang, X Zhang, Y Zhang, Y Zhang, Y Zhang, Z Zhang, Z Zhang, H Zhao, P Zhao, T Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zheng, K Zheng, X Zheng, Z Zheng, D Zhong, B Zhou, H Zhou, N Zhou, Y Zhou, C G Zhu, J Zhu, Y Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, N I Zimine, J Zinsser, M Ziolkowski, L Živković, A Zoccoli, K Zoch, T G Zorbas, O Zormpa, W Zou, L Zwalinski
A measurement of the mass of the Higgs boson combining the H→ZZ^{*}→4ℓ and H→γγ decay channels is presented. The result is based on 140  fb^{-1} of proton-proton collision data collected by the ATLAS detector during LHC run 2 at a center-of-mass energy of 13 TeV combined with the run 1 ATLAS mass measurement, performed at center-of-mass energies of 7 and 8 TeV, yielding a Higgs boson mass of 125.11±0.09(stat)±0.06(syst)=125.11±0...
December 22, 2023: Physical Review Letters
https://read.qxmd.com/read/38128121/spleen-function-is-reduced-in-individuals-with-nr5a1-variants-with-or-without-dsd-a-cross-sectional-study
#30
JOURNAL ARTICLE
Martine Cools, Celien Grijp, Jana Neirinck, Simon J Tavernier, Petra Schelstraete, Julie Van De Velde, Lieve Morbée, Elfride De Baere, Carolien Bonroy, Yolande van Bever, Hennie Bruggenwirth, Clementien Vermont, Sabine E Hannema, Yolanda De Rijke, Maha Abdulhadi-Atwan, David Zangen, Hannah Verdin, Filomeen Haerynck
OBJECTIVE: NR5A1 is a key regulator of sex differentiation and has been implicated in spleen development through transcription activation of TLX1. Concerns exist about hypo- or asplenism in individuals who have a difference of sex development (DSD) due to an NR5A1 disease-causing variant. We aimed to assess spleen anatomy and function in a clinical cohort of such individuals, and in their asymptomatic family member carriers. DESIGN: Cross-sectional assessment in 22 patients with a DSD or primary ovarian insufficiency and five asymptomatic carriers from 18 families, harboring 14 different NR5A1 variants...
December 21, 2023: European Journal of Endocrinology
https://read.qxmd.com/read/38101407/genomic-surveillance-reveals-dynamic-shifts-in-the-connectivity-of-covid-19-epidemics
#31
JOURNAL ARTICLE
Nathaniel L Matteson, Gabriel W Hassler, Ezra Kurzban, Madison A Schwab, Sarah A Perkins, Karthik Gangavarapu, Joshua I Levy, Edyth Parker, David Pride, Abbas Hakim, Peter De Hoff, Willi Cheung, Anelizze Castro-Martinez, Andrea Rivera, Anthony Veder, Ariana Rivera, Cassandra Wauer, Jacqueline Holmes, Jedediah Wilson, Shayla N Ngo, Ashley Plascencia, Elijah S Lawrence, Elizabeth W Smoot, Emily R Eisner, Rebecca Tsai, Marisol Chacón, Nathan A Baer, Phoebe Seaver, Rodolfo A Salido, Stefan Aigner, Toan T Ngo, Tom Barber, Tyler Ostrander, Rebecca Fielding-Miller, Elizabeth H Simmons, Oscar E Zazueta, Idanya Serafin-Higuera, Manuel Sanchez-Alavez, Jose L Moreno-Camacho, Abraham García-Gil, Ashleigh R Murphy Schafer, Eric McDonald, Jeremy Corrigan, John D Malone, Sarah Stous, Seema Shah, Niema Moshiri, Alana Weiss, Catelyn Anderson, Christine M Aceves, Emily G Spencer, Emory C Hufbauer, Justin J Lee, Alison J King, Karthik S Ramesh, Kelly N Nguyen, Kieran Saucedo, Refugio Robles-Sikisaka, Kathleen M Fisch, Steven L Gonias, Amanda Birmingham, Daniel McDonald, Smruthi Karthikeyan, Natasha K Martin, Robert T Schooley, Agustin J Negrete, Horacio J Reyna, Jose R Chavez, Maria L Garcia, Jose M Cornejo-Bravo, David Becker, Magnus Isaksson, Nicole L Washington, William Lee, Richard S Garfein, Marco A Luna-Ruiz Esparza, Jonathan Alcántar-Fernández, Benjamin Henson, Kristen Jepsen, Beatriz Olivares-Flores, Gisela Barrera-Badillo, Irma Lopez-Martínez, José E Ramírez-González, Rita Flores-León, Stephen F Kingsmore, Alison Sanders, Allorah Pradenas, Benjamin White, Gary Matthews, Matt Hale, Ronald W McLawhon, Sharon L Reed, Terri Winbush, Ian H McHardy, Russel A Fielding, Laura Nicholson, Michael M Quigley, Aaron Harding, Art Mendoza, Omid Bakhtar, Sara H Browne, Jocelyn Olivas Flores, Diana G Rincon Rodríguez, Martin Gonzalez Ibarra, Luis C Robles Ibarra, Betsy J Arellano Vera, Jonathan Gonzalez Garcia, Alicia Harvey-Vera, Rob Knight, Louise C Laurent, Gene W Yeo, Joel O Wertheim, Xiang Ji, Michael Worobey, Marc A Suchard, Kristian G Andersen, Abraham Campos-Romero, Shirlee Wohl, Mark Zeller
The maturation of genomic surveillance in the past decade has enabled tracking of the emergence and spread of epidemics at an unprecedented level. During the COVID-19 pandemic, for example, genomic data revealed that local epidemics varied considerably in the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage importation and persistence, likely due to a combination of COVID-19 restrictions and changing connectivity. Here, we show that local COVID-19 epidemics are driven by regional transmission, including across international boundaries, but can become increasingly connected to distant locations following the relaxation of public health interventions...
December 21, 2023: Cell
https://read.qxmd.com/read/38010508/correction-to-local-tumour-control-following-microwave-ablation-protocol-for-the-prospective-observational-ciemar-study
#32
Philippe L Pereira, Reto Bale, Åsmund Avdem Fretland, S Nahum Goldberg, Thomas Helmberger, Martijn R Meijerink, Franco Orsi, Stefan Stättner, Thomas Vogl, Anna Kafkoula, Niels de Jong, Bleranda Zeka, Thierry de Baère
No abstract text is available yet for this article.
November 27, 2023: Cardiovascular and Interventional Radiology
https://read.qxmd.com/read/37968032/clinical-and-hemodynamic-outcomes-of-balloon-expandable-mitral-valve-in-valve-positioning-and-asymmetric-deployment-the-vivid-registry
#33
JOURNAL ARTICLE
Matheus Simonato, Brian K Whisenant, Axel Unbehaun, Jörg Kempfert, Henrique B Ribeiro, Ran Kornowski, Magdalena Erlebach, Sabine Bleiziffer, Stephan Windecker, Thomas Pilgrim, Daijiro Tomii, Mayra Guerrero, Yousif Ahmad, John K Forrest, Matteo Montorfano, Marco Ancona, Matti Adam, Hendrik Wienemann, Ariel Finkelstein, Pedro Villablanca, Pablo Codner, David Hildick-Smith, Enrico Ferrari, Anna Sonia Petronio, Jasmin Shamekhi, Patrizia Presbitero, Giuseppe Bruschi, Tanja Rudolph, Alfredo Cerillo, David Attias, Mohammed Nejjari, Alexandre Abizaid, Maurício Felippi de Sá Marchi, Eric Horlick, Harindra Wijeysundera, Martin Andreas, Arun Thukkani, Marco Agrifoglio, Alessandro Iadanza, L Matthew Baer, Michael G Nanna, Danny Dvir
BACKGROUND: Mitral valve-in-valve (ViV) is associated with suboptimal hemodynamics and rare left ventricular outflow tract (LVOT) obstruction. OBJECTIVES: This study aimed to determine whether device position and asymmetry are associated with these outcomes. METHODS: Patients undergoing SAPIEN 3 (Edwards Lifesciences) mitral ViV included in the VIVID (Valve-in-Valve International Data) Registry were studied. Clinical endpoints are reported according to Mitral Valve Academic Research Consortium definitions...
November 13, 2023: JACC. Cardiovascular Interventions
https://read.qxmd.com/read/37949616/local-and-distant-response-to-intratumoral-immunotherapy-assessed-by-immunopet-in-mice
#34
JOURNAL ARTICLE
Louis Meyblum, Céline Chevaleyre, Sandrine Susini, Benoit Jego, Frederic Deschamps, Dimitri Kereselidze, Baptiste Bonnet, Aurelien Marabelle, Thierry de Baere, Vincent Lebon, Lambros Tselikas, Charles Truillet
BACKGROUND: Despite the promising efficacy of immune checkpoint blockers (ICB), tumor resistance and immune-related adverse events hinder their success in cancer treatment. To address these challenges, intratumoral delivery of immunotherapies has emerged as a potential solution, aiming to mitigate side effects through reduced systemic exposure while increasing effectiveness by enhancing local bioavailability. However, a comprehensive understanding of the local and systemic distribution of ICBs following intratumoral administration, as well as their impact on distant tumors, remains crucial for optimizing their therapeutic potential...
November 2023: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/37943798/image-guided-core-biopsy-for-pelvic-lesions-of-unknown-origin
#35
JOURNAL ARTICLE
Camille Batlle, Matthieu Faron, Frédéric Deschamps, Arash Najafi, Adrian Kobe, Baptiste Bonnet, Antoine Hakimé, Christophe Territehau, Sebastian Gouy, Olivier Mir, Jean-Yves Scoazec, Thierry de Baere, Charles Honoré, Lambros Tselikas
No abstract text is available yet for this article.
November 7, 2023: British Journal of Surgery
https://read.qxmd.com/read/37930412/ethiodized-oil-as-an-imaging-biomarker-after-conventional-transarterial-chemoembolization
#36
REVIEW
Mishal Mendiratta-Lala, Anum Aslam, Harrison X Bai, Julius Chapiro, Thiery De Baere, Shiro Miyayama, Victoria Chernyak, Osamu Matsui, Valerie Vilgrain, Nicholas Fidelman
Conventional transarterial chemoembolization (cTACE) utilizing ethiodized oil as a chemotherapy carrier has become a standard treatment for intermediate-stage hepatocellular carcinoma (HCC) and has been adopted as a bridging and downstaging therapy for liver transplantation. Water-in-oil emulsion made up of ethiodized oil and chemotherapy solution is retained in tumor vasculature resulting in high tissue drug concentration and low systemic chemotherapy doses. The density and distribution pattern of ethiodized oil within the tumor on post-treatment imaging are predictive of the extent of tumor necrosis and duration of response to treatment...
November 6, 2023: European Radiology
https://read.qxmd.com/read/37930400/french-interventional-radiology-centers-uptake-of-transradial-approach-and-outpatient-hcc-intra-arterial-treatments
#37
JOURNAL ARTICLE
Jules Grégory, Maxime Ronot, Valérie Laurent, Pascal Chabrot, Thierry de Baere, Patrick Chevallier, Valérie Vilgrain, Christophe Aubé
PURPOSE: This study aims to investigate the uptake of transradial approach (TRA) and outpatient setting for transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) in the treatment of hepatocellular carcinoma (HCC) among French interventional radiology centers. MATERIALS AND METHODS: This cross-sectional study was based on a 34-question survey assessing center activity, radial access, and outpatient care. The survey was developed by a working group, tested by two external experts, and distributed to active members of two French radiological societies via a web-based self-reporting questionnaire in March 2022...
November 6, 2023: Cardiovascular and Interventional Radiology
https://read.qxmd.com/read/37922632/hepatic-arterial-oxaliplatin-plus-intravenous-5-fluorouracil-and-cetuximab-for-first-line-treatment-of-colorectal-liver-metastases-a-multicenter-phase-ii-trial
#38
JOURNAL ARTICLE
David Malka, Benjamin Verret, Matthieu Faron, Rosine Guimbaud, Caroline Caramella, Julien Edeline, Marie-Pierre Galais, Leïla Bengrine-Lefevre, Denis Smith, Eric Dupont-Bierre, Thierry De Baere, Diane Goéré, Peggy Dartigues, Ludovic Lacroix, Valérie Boige, Maximiliano Gelli, Jean-Pierre Pignon, Michel Ducreux
BACKGROUND: The efficacy and tolerability of hepatic arterial infusion (HAI) oxaliplatin plus systemic 5-fluorouracil and cetuximab as frontline treatment in patients with colorectal liver metastases (CRLM) are unknown. METHODS: In this multicenter, single-arm phase II study, patients with CRLM not amenable to curative-intent resection or requiring complex/major liver resection, and no prior chemotherapy for metastatic disease, received HAI oxaliplatin and intravenous 5-fluorouracil, leucovorin and cetuximab, every two weeks until disease progression, limiting toxicity or at least 3 months after complete response or curative-intent resection/ablation...
October 28, 2023: European Journal of Cancer
https://read.qxmd.com/read/37885128/integrating-morphological-molecular-and-cytogenetic-data-for-f2-sea-turtle-hybrids-diagnosis-revealed-balanced-chromosomal-sets
#39
JOURNAL ARTICLE
Caroline Regina Dias Machado, Matheus Azambuja, Camila Domit, Gabriel Fraga da Fonseca, Larissa Glugoski, Camilla Borges Gazolla, Rafael Bonfim de Almeida, Marcela Baer Pucci, Thais Torres Pires, Viviane Nogaroto, Marcelo Ricardo Vicari
Hybridization could be considered part of the evolutionary history of many species. The hybridization among sea turtle species on the Brazilian coast is atypical and occurs where nesting areas and reproductive seasons overlap. Integrated analysis of morphology and genetics is still scarce, and there is no evidence of the parental chromosome set distribution in sea turtle interspecific hybrids. In this study, chromosome markers previously established for pure sea turtle species were combined with morphological and molecular analyses aiming to recognize genetic composition and chromosome sets in possible interspecific hybrids initially identified by mixed morphology...
October 26, 2023: Journal of Evolutionary Biology
https://read.qxmd.com/read/37884801/local-tumour-control-following-microwave-ablation-protocol-for-the-prospective-observational-ciemar-study
#40
JOURNAL ARTICLE
Philippe L Pereira, Reto Bale, Åsmund Avdem Fretland, S Nahum Goldberg, Thomas Helmberger, Martijn R Meijerink, Franco Orsi, Stefan Stättner, Thomas Vogl, Anna Kafkoula, Niels de Jong, Bleranda Zeka, Thierry de Baère
PURPOSE: Microwave ablation (MWA) is a treatment modality for colorectal liver metastases (CRLM). While potentially curative, more information is needed on factors that contribute to long-term local tumour control. The prospective multicentre observational study CIRSE Emprint Microwave Ablation Registry aims to prospectively collect real-world technical data and clinical outcomes on patients treated with MWA in CRLM. METHODS: Eligible patients are adults with up to 9 local treatment naïve CRLM of ≤ 3 cm completely treatable with either MWA alone or MWA with resection and/or radiotherapy within 8 weeks...
October 26, 2023: Cardiovascular and Interventional Radiology
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