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Ebv Vaccine

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https://read.qxmd.com/read/30679646/immunoinformatic-and-systems-biology-approaches-to-predict-and-validate-peptide-vaccines-against-epstein-barr-virus-ebv
#1
Arif Ali, Abbas Khan, Aman Chandra Kaushik, Yanjie Wang, Syed Shujait Ali, Muhammad Junaid, Shoaib Saleem, William C S Cho, Xueying Mao, Dong-Qing Wei
Epstein-Barr virus (EBV), also known as human herpesvirus 4 (HHV-4), is a member of the Herpesviridae family and causes infectious mononucleosis, Burkitt's lymphoma, and nasopharyngeal carcinoma. Even in the United States of America, the situation is alarming, as EBV affects 95% of the young population between 35 and 40 years of age. In this study, both linear and conformational B-cell epitopes as well as cytotoxic T-lymphocyte (CTL) epitopes were predicted by using the ElliPro and NetCTL.1.2 webservers for EBV proteins (GH, GL, GB, GN, GM, GP42 and GP350)...
January 24, 2019: Scientific Reports
https://read.qxmd.com/read/30651362/reduction-of-kaposi-s-sarcoma-associated-herpesvirus-latency-using-crispr-cas9-to-edit-the-latency-associated-nuclear-antigen-gene
#2
For Yue Tso, John T West, Charles Wood
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), an AIDS defining cancer in HIV-1 infected individuals or immune suppressed transplant patients. The prevalence for both KSHV and KS are highest in sub-Saharan Africa where HIV-1 infection is also epidemic. There is no effective treatment for advanced KS; therefore, the survival rate is low. Similar to other herpesviruses, KSHV's ability to establish latent infection in the host presents a major challenge to KS treatment or prevention...
January 16, 2019: Journal of Virology
https://read.qxmd.com/read/30560089/isolated-limb-perfusion-with-melphalan-triggers-immune-activation-in-melanoma-patients
#3
Junko Johansson, Roberta Kiffin, Annica Andersson, Per Lindnér, Peter L Naredi, Roger Olofsson Bagge, Anna Martner
Hyperthermic isolated limb perfusion with melphalan (M-ILP) is a treatment option for melanoma patients with metastases confined to the limbs. This study aimed at defining the role of cellular immunity for the clinical response to M-ILP in melanoma patients. It was observed that patients with enhanced cytotoxic CD8+ T cell reactivity to common antigens (HCMV/EBV/influenza virus) prior to M-ILP were more likely to achieve a complete disappearance of macroscopic tumors (complete response). Following M-ILP treatment, the proportions of CD16+ intermediate and non-classical monocytes in peripheral blood were significantly enhanced along with induction of HLA-DR on CD4+ and CD8+ T cells...
2018: Frontiers in Oncology
https://read.qxmd.com/read/30551205/serologic-status-of-routine-childhood-vaccines-cytomegalovirus-and-epstein-barr-virus-in-children-with-inflammatory-bowel-disease
#4
Jennifer C C deBruyn, Ing Shian Soon, Kevin Fonseca, Sharon Feng, Melanie Purtzki, Caitlin Goedhart, Susan Kuhn, Otto G Vanderkooi, Iwona Wrobel
Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD. Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD...
December 14, 2018: Inflammatory Bowel Diseases
https://read.qxmd.com/read/30521644/immunogenic-particles-with-a-broad-antigenic-spectrum-stimulate-cytolytic-t-cells-and-offer-increased-protection-against-ebv-infection-ex-vivo-and-in-mice
#5
Dwain G van Zyl, Ming-Han Tsai, Anatoliy Shumilov, Viktor Schneidt, Rémy Poirey, Bettina Schlehe, Herbert Fluhr, Josef Mautner, Henri-Jacques Delecluse
The ubiquitous Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is etiologically linked to the development of several malignancies and autoimmune diseases. EBV has a multifaceted life cycle that comprises virus lytic replication and latency programs. Considering EBV infection holistically, we rationalized that prophylactic EBV vaccines should ideally prime the immune system against lytic and latent proteins. To this end, we generated highly immunogenic particles that contain antigens from both these cycles...
December 6, 2018: PLoS Pathogens
https://read.qxmd.com/read/30502418/human-oncoviruses-mucocutaneous-manifestations-pathogenesis-therapeutics-and-prevention-part-i-papillomaviruses-and-merkel-cell-polyomavirus
#6
REVIEW
Christopher T Haley, Uyen Ngoc Mui, Ramya Vangipuram, Peter L Rady, Stephen K Tyring
In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Additionally, oncoviruses are associated with multiple benign mucocutaneous diseases...
November 28, 2018: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30502415/human-oncoviruses-mucocutaneous-manifestations-pathogenesis-therapeutics-and-prevention-part-ii-hepatitis-viruses-human-t-cell-leukemia-viruses-herpesviruses-and-epstein-barr-virus
#7
REVIEW
Uyen Ngoc Mui, Christopher T Haley, Ramya Vangipuram, Stephen K Tyring
In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Additionally, oncoviruses are associated with many benign mucocutaneous diseases...
November 28, 2018: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30497081/characterization-of-the-nucleocytoplasmic-transport-mechanisms-of-epstein-barr-virus-bflf2
#8
Meili Li, Tao Chen, Xingmei Zou, Zuo Xu, Yuanfang Wang, Ping Wang, Xiaowen Ou, Yiwen Li, Daixiong Chen, Tao Peng, Yao Wang, Mingsheng Cai
BACKGROUND/AIMS: Epstein-Barr virus (EBV) BFLF2, the homologue of herpes simplex virus 1 (HSV-1) UL31, is crucial for the efficient viral DNA packaging and primary egress across the nuclear membrane. However, we still do not know its subcellular transport mechanisms. METHODS: Interspecies heterokaryon assays were utilized to detect the nucleocytoplasmic shuttling of BFLF2, and mutation analysis, plasmid transfection and fluorescence microscopy assays were performed to identify the functional nuclear localization sequence (NLS) and nuclear export sequence (NES) of BFLF2 in live cells...
2018: Cellular Physiology and Biochemistry
https://read.qxmd.com/read/30444879/experimental-co-transmission-of-simian-immunodeficiency-virus-siv-and-the-macaque-homologs-of-the-kaposi-sarcoma-associated-herpesvirus-kshv-and-epstein-barr-virus-ebv
#9
A Gregory Bruce, Serge Barcy, Jeannette Staheli, Helle Bielefeldt-Ohmann, Minako Ikoma, Kellie Howard, Timothy M Rose
Macaque RFHV and LCV are close homologs of human KSHV and EBV, respectively. No experimental model of RFHV has been developed due to the lack of a source of culturable infectious virus. Screening of macaques at the Washington National Primate Research Center detected RFHV in saliva of SIV-infected macaques from previous vaccine studies. A pilot experimental infection of two naïve juvenile pig-tailed macaques was initiated by inoculation of saliva from SIV-infected pig-tailed and cynomolgus macaque donors, which contained high levels of DNA (> 106 genomes/ml) of the respective species-specific RFHV strain...
2018: PloS One
https://read.qxmd.com/read/30380978/epstein-barr-virus-ebv-status-in-colorectal-cancer-a-mini-review
#10
Shahinaz Bedri, Ali A Sultan, Moussa Alkhalaf, Ala-Eddin Al Moustafa, Semir Vranic
Epstein-Barr virus (EBV) is a well-characterized oncovirus, associated with several malignancies. The complex and heterogeneous nature of colorectal cancer (CRC) has led to many epidemiological causal associations with CRC. However, a direct causal link between microbial infections and CRC has not been established yet. Our review indicates that the current evidence for the presence and role in EBV in CRC is insufficient and contradictory. The design of the analyzed studies, sample size as well as methodology used for EBV detection varied markedly and consequently may not lead to meaningful conclusions...
October 31, 2018: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/30362500/contriving-multiepitope-subunit-vaccine-by-exploiting-structural-and-nonstructural-viral-proteins-to-prevent-epstein-barr-virus-associated-malignancy
#11
Rupal Ojha, Raj Nandani, Vijay Kumar Prajapati
Cancer is one of the common lifestyle diseases and is considered to be the leading cause of death worldwide. Epstein-Barr virus (EBV)-infected individuals remain asymptomatic; but under certain stress conditions, EBV may lead to the development of cancers such as Burkitt's and Hodgkin's lymphoma and nasopharyngeal carcinoma. EBV-associated cancers result in a large number of deaths in Asian and African population, and no effective cure has still been developed. We, therefore, tried to devise a subunit vaccine with the help of immunoinformatic approaches that can be used for the prevention of EBV-associated malignancies...
October 26, 2018: Journal of Cellular Physiology
https://read.qxmd.com/read/30332435/in-vitro-toxicity-and-efficacy-of-verdinexor-an-exportin-1-inhibitor-on-opportunistic-viruses-affecting-immunocompromised-individuals
#12
Douglas G Widman, Savanna Gornisiewicz, Sharon Shacham, Sharon Tamir
Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses (AdV), BK virus (BKPyV), John Cunningham virus (JCPyV), and human papillomavirus (HPV) are significant concerns for the immunocompromised, including when these viruses exist as a co-infection with human immunodeficiency virus (HIV). These viral infections are more complicated in patients with a weakened immune system, and often manifest as malignancies resulting in significant morbidity and mortality...
2018: PloS One
https://read.qxmd.com/read/30323928/contemporary-analysis-of-functional-immune-recovery-to-opportunistic-and-vaccine-preventable-infections-after-allogeneic-haemopoietic-stem-cell-transplantation
#13
Harini D de Silva, Rosemary A Ffrench, Maya Korem, Eva Orlowski, David J Curtis, Andrew Spencer, Sharon Avery, Sushrut Patil, Catherine Orla Morrissey
Objectives: Infections are a major cause of mortality after allogeneic haemopoietic stem cell transplantation (alloHSCT), and immune recovery is necessary for prevention. Novel transplant procedures have changed the epidemiology of infections but contemporary data on functional immune recovery are limited. In this pilot study, we aimed to measure immune recovery in the current era of alloHSCT. Methods: Twenty, 13, 11, 9 and 9 alloHSCT recipients had blood collected at baseline (time of conditioning) and 3-, 6-, 9-, and 12-months post-alloHSCT, respectively...
2018: Clinical & Translational Immunology
https://read.qxmd.com/read/30312417/differences-in-the-epstein-barr-virus-gp350-iga-antibody-response-are-associated-with-increased-risk-for-co-infection-with-a-second-strain-of-ebv
#14
Nicholas A Smith, Paul C Baresel, Conner L Jackson, Sidney Ogolla, Eunice N Toko, Sara Heit, Erwan Piriou, Odada P Sumba, Jaap M Middeldorp, Kathryn L Colborn, Rosemary Rochford
Background: The EBV viral glycoprotein gp350 has been proposed as a candidate antigen for an EBV vaccine. However, the proposed formulations of these vaccines have not taken into account the presence of two unique EBV strains (EBV-1 and EBV-2) present in areas of high incidence of the EBV associated cancer, Burkitt's lymphoma. Methods: In this study, we analyze the kinetics of EBV-1 and EBV-2 infection in an asymptomatic infant cohort from Kisumu, Kenya. We also analyzed the kinetics of the antibody response against five EBV antigens, gp350 (IgG and IgA), VCA (IgG), EBNA-1 (IgG), EAd (IgG), and Zta (IgG)...
October 12, 2018: Journal of Infectious Diseases
https://read.qxmd.com/read/30311576/immunotherapy-for-ebv-associated-nasopharyngeal-carcinoma
#15
Mengying Hong, Kejun Tang, Jing Qian, Hongyu Deng, Musheng Zeng, Shu Zheng, Kefeng Ding, Yushen Du, Ren Sun
Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is one of the most common head and neck malignancies in southern China and Southeast Asia. Unfortunately, 70% of NPC patients have locally advanced disease at the first diagnosis. Radiotherapy alone and concurrent chemoradiotherapy are important treatment approaches for NPC, but they have a limited effect on patients with locally advanced or distantly metastatic disease. 1-5 Nevertheless, the unique immune environment of the EBV-associated NPC provides rational targets for immunotherapy...
2018: Critical Reviews in Oncogenesis
https://read.qxmd.com/read/30294429/a-single-epitope-of-epstein-barr-virus-stimulate-igg-production-in-mice
#16
Widodo, Bambang Pristiwanto, Muhaimin Rifa'i, Irfan Mustafa, Fahrul Zaman Huyop
Background: Epstein-Barr virus (EBV) is closely associated with the high incidence of nasopharyngeal carcinoma in worldwide. Vaccination is one strategy with the potential to prevent the occurrence of EBV-associated cancers, but a suitable vaccine is yet to be licensed. Much vaccine development research focuses on the GP350/220 protein of EBV as it contains an immunogenic epitope at residues 147-165, which efficiently stimulates IgG production in vitro . We examined the ability of this epitope (EBVepitope) to induce IgG production in mice...
November 2018: Annals of Medicine and Surgery
https://read.qxmd.com/read/30258468/immunosenescence-and-lymphomagenesis
#17
REVIEW
Salvatrice Mancuso, Melania Carlisi, Marco Santoro, Mariasanta Napolitano, Simona Raso, Sergio Siragusa
One of the most important determinants of aging-related changes is a complex biological process emerged recently and called "immunosenescence". Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysregulation may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. At present, the relationship between immunosenescence and lymphoma in elderly patients is not defined in a satisfactory way...
2018: Immunity & Ageing: I & A
https://read.qxmd.com/read/30185062/malignancy-trends-in-hiv-infected-patients-over-the-past-10-years-in-a-single-center-retrospective-observational-study-in-the-united-states
#18
Nancy Rihana, Sowmya Nanjappa, Cara Sullivan, Ana Paula Velez, Narach Tienchai, John N Greene
The introduction of antiretroviral therapy (ART) in 1995 had a dramatic impact on the morbidity and mortality of the HIV population, and subsequently, the natural history of cancer has changed. The purpose of our study was to review the prevalence of AIDS-defining malignancies and non-AIDS defining cancers (NADC), taking into consideration racial and gender variations. After the institutional review board approval, the study was conducted as a retrospective chart review of 279 HIV-infected patients who were treated at the Moffitt Cancer Center between January 1, 2000 and December 31, 2010...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/30135622/cd40l-adjuvanted-dna-vaccine-carrying-ebv-lmp2-antigen-enhances-anti-tumor-effect-in-npc-transplantation-tumor-animal
#19
Lei Lei, Jianhui Li, Meiqing Liu, Xiaoming Hu, Ya Zhou, Shiming Yang
CD40L, a costimulatory molecule for dendritic cells (DCs) and B cells, can serve as an adjuvant for enhancing the specific immune response induced by DNA vaccine carrying tumor-associated antigens. In this study, we investigated the potential of CD40L as an adjuvant to enhance the anti-tumor effect mediated by a DNA vaccine based on the Epstein-Barr virus-latent membrane protein 2 (EBV-LMP2) antigen. The plasmids capable of expressing the fusion protein EBV-LMP2-CD40L were constructed. Expression vector pVAX1 and plasmid expressing the individual antigen EBV-LMP2 were used as control groups...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30111570/sequence-variation-of-epstein-barr-virus-viral-types-geography-codon-usage-and-diseases
#20
Samantha Correia, Ray Bridges, Fanny Wegner, Cristina Venturini, Anne Palser, Jaap M Middeldorp, Jeffrey I Cohen, Mario A Lorenzetti, Irene Bassano, Robert E White, Paul Kellam, Judith Breuer, Paul J Farrell
One hundred thirty-eight new Epstein-Barr virus (EBV) genome sequences have been determined. One hundred twenty-five of these and 116 from previous reports were combined to produce a multiple-sequence alignment of 241 EBV genomes, which we have used to analyze variation within the viral genome. The type 1/type 2 classification of EBV remains the major form of variation and is defined mostly by EBNA2 and EBNA3, but the type 2 single-nucleotide polymorphisms (SNPs) at the EBNA3 locus extend into the adjacent gp350 and gp42 genes, whose products mediate infection of B cells by EBV...
November 15, 2018: Journal of Virology
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