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Nobuhisa Tanioka, Takehiro Okabayashi, Kenta Sui, Takatsugu Matsumoto, Jun Iwata, Sojiro Morita, Yasuhiro Shimada
Neuroendocrine carcinoma (NEC) of the gallbladder is highly aggressive and has a poor prognosis even after curative resection. The purpose of this study was to collate and analyze published data to clarify the surgical outcome of NEC of the gallbladder and the relationships between potential prognostic factors and survival after surgery. We surveyed worldwide literature from 1981 to 2018 and obtained clinicopathological data for 65 patients who had undergone surgical resection for NEC of the gallbladder. The relationships between potential prognostic factors and survival rates were examined by the Kaplan-Meier method and the log-rank test...
March 19, 2019: Surgical Technology International
Sebastian W Holländer, Hans Joachim Klingen, Sarah Hess, Anna Merscher, Matthias Glanemann, Dieter Birk
BACKGROUND: While minimally invasive surgery is a growing sector in medicine, camera assistance remains a problem. Especially in bariatric surgery, the assistant holding the camera faces certain challenges. Furthermore, unless the surgeon controls the camera movement themselves, they will be challenged by an unstable image. The aim of this study was to investigate the benefits of a robotic camera assistant (SoloAssist®, AKTORmed™ GmbH, Barbing, Germany) in bariatric surgery. PATIENTS AND METHODS: Three hundred thirty one consecutive laparoscopic bariatric procedures were performed with the assistance of a camera robot, including Roux-en-Y gastric bypass, laparoscopic gastric banding, sleeve gastrectomy, and gastroplication...
March 18, 2019: Surgical Technology International
Seema Alam, Bikrant Bihari Lal, Vikrant Sood, Rajeev Khanna, Guresh Kumar
BACKGROUND AND AIMS: Doubts have been raised about efficacy of New Wilson's index (NWI) in predicting Liver Transplant (LT) or mortality in decompensated Wilson Disease (WD) patients. APASL ACLF Research Consortium (AARC) has introduced a new score (AARC-ACLF) which has not been studied in children. METHODS: Data of all pediatric WD cases were prospectively collected and analyzed. Cox regression and Area Under Receiver Operative Curve (AUROC) analyses were used to identify best predictive score for mortality at 90 days...
March 19, 2019: Hepatology International
Sven Francque, Luisa Vonghia
Non-alcoholic fatty liver disease (NAFLD) has become the most frequently encountered chronic liver disease. NAFLD is associated with increased liver-related morbidity and mortality, but also contributes to cardiovascular disease, diabetes and non-liver-related malignancy. Non-alcoholic steatohepatitis (NASH) is considered the more severe subtype of NAFLD that drives most of these adverse outcomes. Lifestyle modification and associated weight loss can improve NASH but are not always sufficient and sustained results are difficult to obtain...
March 19, 2019: Advances in Therapy
Nathalie Bakker, Rick S van den Helder, Remy W F Geenen, Michiel A Hunfeld, Huib A Cense, Ahmet Demirkiran, Alexander P J Houdijk
PURPOSE: Weight loss before bariatric surgery with a low-calorie diet (LCD) has several advantages, including reduction of liver volume and an improved access to the lesser sac. Disadvantages include performing surgery in a state of undernutrition, side effects, costs and patient compliance. Omega-3 fatty acids may serve as an alternative to reduce liver steatosis. MATERIALS AND METHODS: A randomised controlled open-label trial was done to compare the effects of a LCD with Modifast (800 kcal/day) during 2 weeks with 2 g of omega-3 fatty acids a day and a normal diet (2000 kcal/day) during 4 weeks...
March 19, 2019: Obesity Surgery
Atit Silsirivanit, Chatchai Phoomak, Karuntarat Teeravirote, Sasiprapa Wattanavises, Wunchana Seubwai, Charupong Saengboonmee, Zhaoqi Zhan, Jin-Ichi Inokuchi, Akemi Suzuki, Sopit Wongkham
Alteration of glycosphingolipid (GSL) synthesis is observed in many types of cancer. In this study, we have analyzed the expression of sphingolipids and GSLs in cholangiocarcinoma (CCA) tissues and adjacent normal liver tissues. Neutral lipids were extracted from tissue samples using mild-alkaline treatment method followed by TLC and LC-MS analysis. The expression of ceramides, hexosylceramides (HexCer), and lactosylceramides (LacCer) was altered in CCA tissues, 61.1% (11/18) of them showing an increase whereas 38...
March 19, 2019: Glycoconjugate Journal
Behrooz Yahyaei, Mahnaz Nouri, Sahar Bakherad, Maryam Hassani, Parastoo Pourali
Gold nanoparticles (GNPs) have different usage in the medical field. The plan of the present research was to evaluate the influence of the biologically produced GNPs on some rat organs. GNPs were produced using Fusarium oxysporum and their presence was confirmed using spectrophotometer, transmission electron microscope (TEM) and X-ray diffraction (XRD) analyses. The non-toxic and toxic doses of GNPs were determined using MTT assay and were injected intraperitoneally into rats in 3 continuous days and their effects on the kidney, liver and testis were analyzed using microscopic technique...
March 19, 2019: AMB Express
Hiroko Naganuma, Hideaki Ishida, Hiroshi Nagai, Masahiro Ogawa, Yoko Ohyama
Range-ambiguity artifacts (RAAs) are an erroneous mapping of returning echoes into a composite picture. The purpose of this review was to illustrate the mechanism of RAAs and to present the diagnostic problems caused by RAAs. RAA features differ slightly from organ to organ. At the level of the urinary bladder, RAAs take the form of a cloud-like, ill-demarcated, immobile, echogenic area, and the depth of the echogenic area differs depending on the pulse repetition frequency (PRF). This form is referred to as "static RAA" in this review...
March 19, 2019: Journal of Medical Ultrasonics
P Garcia-Gallastegi, A Ruiz-García, G Ibarretxe, S Rivero-Hinojosa, A D González-Siccha, J Laborda, O Crende, F Unda, J J García-Ramírez
DLK1 and DLK2 are transmembrane proteins belonging to the EGF-like repeat-containing family that function as non-canonical NOTCH inhibitory ligands. DLK1 is usually downregulated after embryo development and its distribution in some adult and embryonic tissues has been described. However, the expression and role of DLK2 in embryo and adult tissues remains unclear. To better understand the relevance of both proteins during embryo development, we analyzed the expression pattern of DLK1 and DLK2 in 16.5-day-old mouse embryos (E16...
March 19, 2019: Histochemistry and Cell Biology
Rodrigo Canellas, Midhir J Patel, Sheela Agarwal, Dushyant V Sahani
OBJECTIVE: To assess the lesion detection performance of an abbreviated MRI (AMRI-M) protocol consisting of ultrafast SE T2W, DWI, and T1W-HBP at 20 min for colorectal liver metastasis (CRLM) surveillance. METHODS: In this Institutional Review Board (IRB)-approved retrospective study, gadoxetic acid-enhanced MRI scans of 57 patients (43 with pathologically proven CRLMs) were assessed. Two readers independently evaluated two sets of images per patient and commented on the number, location, and size of liver lesions...
March 19, 2019: European Radiology
Mehdi Karoui, Olivier Scatton
AIM: To report on the feasibility and the safety of a novel strategy in patients with colorectal cancer and synchronous liver metastases (SLM) requiring major or complex procedures for both the primary and liver deposits. PATIENTS AND METHODS: The strategy consisted in performing the two major procedures (liver first and colorectal) by laparoscopy within a short interval in order to keep both oncological advantages and short-terms outcome benefits. RESULTS: Two patients were treated with this strategy: one with a laparoscopic resection of segment VIII extended to the segment IVb followed by the laparosopic rectal resection; the second with a laparoscopic left hepatectomy with a microwave ablation of the lesion located in the segment VII followed by the laparoscopic resection of the sigmoid colon...
March 19, 2019: World Journal of Surgery
Christopher L Welle, Brian T Welch, Waleed Brinjikji, Eric C Ehman, Sudhakar K Venkatesh, Matthew P Johnson, Vivek N Iyer, Michael D Leise, Christopher P Wood
PURPOSE: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant multi-organ vascular disorder that commonly affects the gastrointestinal tract and the liver resulting in telangiectasias and arteriovenous malformations (AVMs). Previous studies looking at the prevalence of liver and abdominal organ involvement in HHT have been limited by differing imaging techniques and sample size limitations. We sought to define the prevalence of HHT related abdominal vascular abnormalities using optimized multiphasic contrast-enhanced abdominal computed tomography (CT) exams in a large cohort of HHT patients...
March 19, 2019: Abdominal Radiology
Miet Schetz, Audrey De Jong, Adam M Deane, Wilfried Druml, Pleun Hemelaar, Paolo Pelosi, Peter Pickkers, Annika Reintam-Blaser, Jason Roberts, Yasser Sakr, Samir Jaber
The World Health Organization defines overweight and obesity as the condition where excess or abnormal fat accumulation increases risks to health. The prevalence of obesity is increasing worldwide and is around 20% in ICU patients. Adipose tissue is highly metabolically active, and especially visceral adipose tissue has a deleterious adipocyte secretory profile resulting in insulin resistance and a chronic low-grade inflammatory and procoagulant state. Obesity is strongly linked with chronic diseases such as type 2 diabetes, hypertension, cardiovascular diseases, dyslipidemia, non-alcoholic fatty liver disease, chronic kidney disease, obstructive sleep apnea and hypoventilation syndrome, mood disorders and physical disabilities...
March 19, 2019: Intensive Care Medicine
Hong Shen, Lin Jiang, Jiandie D Lin, M Bishr Omary, Liangyou Rui
Chronic alcohol consumption causes liver injury, inflammation and fibrosis, thereby increasing morbidity and mortality. Paradoxically, modest drinking is believed to confer metabolic improvement, but the underlying mechanism remains elusive. Here, we have identified a novel hepatoprotective brain/brown adipose tissue (BAT)/liver axis. Alcohol consumption or direct alcohol administration into the brain stimulated hypothalamic neural circuits and sympathetic nerves innervating BAT, and dramatically increased BAT uncoupling protein 1 (Ucp1) expression and activity in a BAT sympathetic nerve-dependent manner...
March 19, 2019: Journal of Clinical Investigation
Jose Serrano, Mark A Tapper, Richard C Kolanczyk, Barbara R Sheedy, Tylor Lahren, Dean E Hammermeister, Jeffrey S Denny, Michael W Hornung, Alena Kubátová, Patricia A Kosian, Jessica Voelker, Patricia K Schmieder
1. Cyclic phenones are chemicals of interest to the USEPA due to their potential for endocrine disruption to aquatic and terrestrial species. 2. Prior to this report, there was very limited information addressing metabolism of cyclic phenones by fish species and the potential for Estrogen Receptor (ER) binding and Vitellogenin (Vtg) gene activation by their metabolites. 3. The main objectives of the current research were to characterize rainbow trout (rt) liver slice-mediated in vitro metabolism of model parent cyclic phenones exhibiting disparity between ER binding and ER-mediated Vtg gene induction, and to assess the metabolic competency of fish liver in vitro tests to help determine the chemical form (parent and/or metabolite) associated with the observed biological response...
March 19, 2019: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Allan Weimann, George McLeod, Trine Henriksen, Vanja Cejvanovic, Henrik E Poulsen
Isoguanine (2-hydroxyadenine), considered to be a non-natural nucleobase has, however, been shown to occur in the croton bean, butterfly wings and a mollusk. For the first time, to the best of our knowledge, we report the identification of isoguanosine (2-hydroxyadenosine), the ribonucleoside, in humans and mouse. Isoguanosine is identified and quantified in RNA from mouse liver samples and in human urine and cerebrospinal fluid. Isoguanine could not be detected as the 2'-deoxyribonucleoside in mouse liver DNA...
March 19, 2019: Scandinavian Journal of Clinical and Laboratory Investigation
Afreen Usmani, Anuradha Mishra, Md Arshad, Asif Jafri
OBJECTIVE: The development of self nano emulsifying co-delivery system of doxorubicin and Nigella sativa oil for potentiating the anticancer effects against HepG2 cell lines. MATERIALS AND METHODS: SNEDDS were formulated by using Labrafil and N. sativa oil (3:2% w/w), Kolliphor RH40 (15% w/w), glycerol (5% w/w) as oil phase, surfactant and co-surfactant while deionized water (75% v/v) used as an aqueous phase. Optimized SNEDDS was evaluated for drug release and in vitro anticancer efficacy in liver cancer (HepG2) cell line...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Nicolas Bonnet, Jérôme Paul, Thibault Helleputte, Francis Veyckemans, Thierry Pirotte, Caroline Prégardien, Stéphane Eeckhoudt, Cédric Hermans, Thierry Detaille, Philippe Clapuyt, Renaud Menten, Dana Dumitriu, Raymond Reding, Isabelle Scheers, Sharat Varma, Françoise Smets, Etienne Sokal, Xavier Stéphenne
OBJECTIVES: Cirrhotic children wait-listed for liver transplant are prone to bleeding from gastrointestinal varices. Grade 2-3 esophageal varices, red signs, and gastric varices are well-known risk factors. However, the involvement of hemostatic factors remains controversial because of the rebalanced state of coagulation during cirrhosis. METHODS: Children suffering from decompensated cirrhosis were prospectively included while being on waitlist. Portal hypertension was assessed by ultrasound and endoscopy...
March 19, 2019: Pediatric Transplantation
Jo Ellen Wilson, Leanne Boehm, Lauren R Samuels, Deborah Unger, Martha Leonard, Christianne Roumie, E Wesley Ely, Robert S Dittus, Sumi Misra, Jin H Han
OBJECTIVE: Many patients with advanced serious illness or at the end of life experience delirium, a potentially reversible form of acute brain dysfunction, which may impair ability to participate in medical decision-making and to engage with their loved ones. Screening for delirium provides an opportunity to address modifiable causes. Unfortunately, delirium remains underrecognized. The main objective of this pilot was to validate the brief Confusion Assessment Method (bCAM), a two-minute delirium-screening tool, in a veteran palliative care sample...
March 19, 2019: Palliative & Supportive Care
Lurdes Gano, Teresa Pinheiro, António Pedro Matos, Francisco Tortosa, Tiago Filipe Jorge, Maria Salomé Gonçalves, Marta Martins, Tânia S Morais, Ana Isabel Tomaz, Andreia Valente, Maria Helena Garcia, Fernanda Marques
BACKGROUND: Ruthenium complexes have been extensively investigated for their prospective value as alternatives to cisplatin. Recently, we reported the in vitro anticancer properties of a family of organometallic ruthenium(II)-cyclopentadienyl complexes and have explored their mechanism of action. OBJECTIVE: The purpose of this study was to evaluate the in vivo antitumour efficacy and toxicity of one of these Ru(II) compounds, [RuCp(mTPPMSNa)(2,2'-bipy)][CF3SO2] (TM85) which displayed an interesting spectrum of activity against several cancer cells...
March 18, 2019: Anti-cancer Agents in Medicinal Chemistry
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