keyword
https://read.qxmd.com/read/38546751/overexpression-of-transmembrane-phosphatase-with-tensin-homology-tpte-in-prostate-cancer-is-clinically-significant-suggesting-its-potential-as-a-valuable-biomarker
#1
JOURNAL ARTICLE
Nahid Zainodini, Maryam Abolhasani, Monireh Mohsenzadegan, Mohammad M Farajollahi, Elham Rismani
PURPOSE: Cancer testis antigens (CTAs) are a family of proteins typically expressed in male testicles but overexpressed in various cancer cell types. Transmembrane Phosphatase with Tensin homology (TPTE) is expressed only in the testis of healthy individuals and is a member of the family of CTAs. The current study, for the first time, examined the significance of TPTE expression in prostate cancer (PCa) tissues by generating a novel antibody marker targeting TPTE protein. METHODS: Polyclonal antibodies were prepared for TPTE-p1 and TPTE-p2 peptides, which are derived from the extracellular domains of TPTE...
March 28, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38546609/in-vitro-assays-for-immuno-oncology-drug-efficacy-assessment-and-screening-for-personalized-cancer-therapy-scopes-and-challenges
#2
REVIEW
Marufur Rahman, Greg Wells, Juha K Rantala, Thomas Helleday, Munitta Muthana, Sarah J Danson
INTRODUCTION: Immunotherapies have revolutionized cancer treatment, but often fail to produce desirable therapeutic outcomes in all patients. Due to the inter-patient heterogeneity and complexity of the tumor microenvironment, personalized treatment approaches are gaining demand. Researchers have long been using a range of in-vitro assays including 2D models, organoid co-cultures, and cancer-on-a-chip platforms for cancer drug screening. A comparative analysis of these assays with their suitability, high-throughput capacity, and clinical translatability is required for optimal translational use...
March 28, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38546297/co-prevalence-of-arterial-aneurysm-location-a-correlation-analysis-based-on-a-retrospective-cross-sectional-observational-study
#3
JOURNAL ARTICLE
Daniel Körfer, Samuel Kilian, Caspar Grond-Ginsbach, Johannes Hatzl, Maani Hakimi, Dittmar Böckler, Philipp Erhart
<b/> Background: The aim of this retrospective single-centre cross-sectional observational study was to investigate co-prevalence of arterial aneurysm location systematically. Patients and methods: Patients with the diagnosis of any arterial aneurysm from January 2006 to January 2016 were investigated in a single centre. Patients with hereditary disorders of connective tissue, systemic inflammatory disease, or arterial pathologies other than true aneurysms were excluded. Aneurysm locations were assessed for every patient included...
March 28, 2024: VASA. Zeitschrift Für Gefässkrankheiten
https://read.qxmd.com/read/38546226/different-metal-mn-fe-co-ni-and-zr-decorated-cu-ceo-2-catalysts-for-efficient-co-oxidation-in-a-rich-co-2-h-2-atmosphere
#4
JOURNAL ARTICLE
Yue Xing, Jiaxin Wu, Daosheng Liu, Caishun Zhang, Jiao Han, Honghao Wang, Yinfu Li, Xiaoning Hou, Lei Zhang, Zhixian Gao
In this work, CuM/CeO2 (M = Mn, Fe, Co, Ni, and Zr) catalysts with a low Cu content of 1 wt% were purposely designed and prepared using the co-impregnation method. The samples were characterized using various techniques (TG-DTA, XRD, N2 -adsorption/desorption measurements, H2 -TPR, XPS and Raman spectroscopy) and CO preferential oxidation (CO-Prox) under H2 /CO2 -rich conditions was performed. The results have shown that enhanced catalytic performance was achieved upon the introduction of Mn, Co and Ni, and little impact was observed with Zr doping, but Fe showed a negative effect, as compared with the Cu/CeO2 catalyst...
March 28, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38545796/microbial-composition-and-diversity-in-intraradicular-biofilm-formed-in-situ-new-concepts-based-on-next-generation-sequencing
#5
JOURNAL ARTICLE
Felipe Barros Matoso, Francisco Montagner, Fabiana Soares Grecca, Pabulo Henrique Rampelotto, Patrícia Maria Poli Kopper
This study aimed to characterize the taxonomic composition of intraradicular multispecies biofilms (IMB) formed in situ in a model to reproduce clinical conditions. Twelve palatal roots of maxillary molars had its canals prepared. Two roots were randomly selected to sterility control. Ten intraoral prosthetic appliances with lateral slots were fabricated. The roots were positioned in the slots with the canal access open to the oral cavity. Eight volunteers wore the appliance for 21 days, and two wore it at two different time points...
March 28, 2024: Molecular Oral Microbiology
https://read.qxmd.com/read/38545693/biocompatible-gold-nanoparticles-modified-fluorine-doped-tin-oxide-electrode-for-the-fabrication-of-enzyme-free-glucose-sensor
#6
JOURNAL ARTICLE
S M Abu Nayem, Santa Islam, Syed Shaheen Shah, Abdul Awal, William Ghann, Deepak Anand, Irshad Ahmad, Jamal Uddin, Md Abdul Aziz, A J Saleh Ahammad
This work demonstrates the use of jute stick extract as a reducing and stabilizing agent for the synthesis of spherical gold nanoparticles (AuNPs). In UV-Vis spectroscopy, peak at 550 nm was used to confirm the formation of AuNPs. The spherical surface morphology of AuNPs was determined through SEM and TEM analysis. While XRD investigation revealed the crystallinity of the prepared AuNPs. To ensure the biocompatibility of synthesized AuNPs, a bacterial investigation was conducted with negative results towards bacterial strain...
March 28, 2024: Chemistry, An Asian Journal
https://read.qxmd.com/read/38545314/psychological-challenges-of-female-caregivers-in-providing-home-based-palliative-care-for-patients-with-advanced-cancer-a-descriptive-exploratory-study
#7
JOURNAL ARTICLE
Sharifeh Monemian, Mohammad R Sharbafchi, Fariba Taleghani
BACKGROUND: Family caregivers play a key role in providing care for patients with advanced cancer. Most of this care burden is shouldered by female caregivers in the family. Compared to their male counterparts, female caregivers face numerous psychological challenges in the process of caregiving. The aim of this study was to identify the psychological challenges of female caregivers in providing care to patients with advanced cancer. MATERIALS AND METHODS: This descriptive-exploratory study began with purposive sampling method in 2020-2021 in Isfahan and continued until data saturation was reached...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38545146/micro-and-nano-plastics-in-fruits-and-vegetables-a-review
#8
REVIEW
Nina-Nicoleta Lazăr, Mădălina Călmuc, Ștefania-Adelina Milea, Puiu-Lucian Georgescu, Cătălina Iticescu
Plastics are becoming common environmental pollutants. Plants behave as access routes for plastics in the trophic chain since they can adsorb particles through their roots or on their surfaces. In this review, various methods for sample preparation and analytical methods for plastic isolation and identification from vegetables, fruits, and their seedlings were discussed. The effects that plastic particles have on them were also addressed. All of the studies offer convincing proof that micro and nano plastics already exist in fruits and vegetables, or can easily enter into their seedlings and have a variety of effects...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38544894/optimized-intermediate-layer-formation-and-electroless-plating-methods-to-obtain-supported-dense-pd-surfaces
#9
JOURNAL ARTICLE
Gamze Gümüşlü Gür, Berna Toprak
Dense metallic membranes, especially Pd and Pd alloys, have been intensely investigated to provide an alternative and economical way to obtain H2 with ultrahigh purity. To overcome the high cost of Pd, composite membrane structures that comprise a thin layer of Pd are utilized. However, it is a challenge to obtain a thin, dense, and uniform Pd layer on the support materials. This study investigates the parametric analysis of γ-Al2 O3 interlayer formation and the electroless Pd plating (Pd ELP) procedures on α-Al2 O3 supports with the aim to achieve a thin, uniform Pd surface without annealing...
2024: Turkish Journal of Chemistry
https://read.qxmd.com/read/38544893/chromium-speciation-in-water-using-magnetic-polyaniline-nanoparticles-coupled-with-microsampling-injection-flame-atomic-absorption-spectroscopy
#10
JOURNAL ARTICLE
Osman Çaylak
The chromium speciation procedure was optimized using magnetic polyaniline nanoparticles (Fe3 O4 @PANI NPs) solid-phase extraction coupled with microsampling injection-flame atomic absorption spectrometry (MIS-FAAS). Chromium speciation was successfully achieved by Fe3 O4 @PANI NPs at pH 8.0. The recoveries obtained for Cr(III) and Cr(VI) were above 95% and under 5%, respectively. Recoveries of over 95% for Cr(III) from 40.0 mL of the sample were obtained using 25 mg Fe3 O4 @PANI NPs and 500 μL of 0.2% (w/v) thiourea (TU) solution prepared in 2 mol L-1 HCl as eluent...
2024: Turkish Journal of Chemistry
https://read.qxmd.com/read/38544348/assessment-of-faecal-microbiota-transplant-stability-in-deep-freeze-conditions-a-12-month-ex%C3%A2-vivo-viability-analysis
#11
JOURNAL ARTICLE
Hana Soukupova, Veronika Rehorova, Ivana Cibulkova, Frantisek Duska
BACKGROUND: Faecal microbiota transplantation (FMT) is an established treatment for Clostridioides difficile infection and is under investigation for other conditions. The availability of suitable donors and the logistics of fresh stool preparation present challenges, making frozen, biobanked stools an attractive alternative. AIMS: This study aimed to evaluate the long-term viability of bacterial populations in faecal samples stored at -80°C for up to 12 months, supporting the feasibility of using frozen grafts for FMT...
March 27, 2024: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/38543795/recommendations-for-uniform-variant-calling-of-sars-cov-2-genome-sequence-across-bioinformatic-workflows
#12
JOURNAL ARTICLE
Ryan Connor, Migun Shakya, David A Yarmosh, Wolfgang Maier, Ross Martin, Rebecca Bradford, J Rodney Brister, Patrick S G Chain, Courtney A Copeland, Julia di Iulio, Bin Hu, Philip Ebert, Jonathan Gunti, Yumi Jin, Kenneth S Katz, Andrey Kochergin, Tré LaRosa, Jiani Li, Po-E Li, Chien-Chi Lo, Sujatha Rashid, Evguenia S Maiorova, Chunlin Xiao, Vadim Zalunin, Lisa Purcell, Kim D Pruitt
Genomic sequencing of clinical samples to identify emerging variants of SARS-CoV-2 has been a key public health tool for curbing the spread of the virus. As a result, an unprecedented number of SARS-CoV-2 genomes were sequenced during the COVID-19 pandemic, which allowed for rapid identification of genetic variants, enabling the timely design and testing of therapies and deployment of new vaccine formulations to combat the new variants. However, despite the technological advances of deep sequencing, the analysis of the raw sequence data generated globally is neither standardized nor consistent, leading to vastly disparate sequences that may impact identification of variants...
March 11, 2024: Viruses
https://read.qxmd.com/read/38543758/characterization-of-the-rna-mycovirome-associated-with-grapevine-fungal-pathogens-analysis-of-mycovirus-distribution-and-their-genetic-variability-within-a-collection-of-botryosphaeriaceae-isolates
#13
JOURNAL ARTICLE
Gwenaëlle Comont, Chantal Faure, Thierry Candresse, Marie Laurens, Sophie Valière, Jérôme Lluch, Marie Lefebvre, Sébastien Gambier, Jérôme Jolivet, Marie-France Corio-Costet, Armelle Marais
Botryosphaeriaceae are fungi involved in the decay of various woody species, including the grapevine, leading to significant production losses. This fungal family is largely ubiquitous, and seven species of Botryosphaeriaceae have been identified in French vineyards, with variable levels of aggressiveness, both in vitro and in planta. Mycoviruses can impact the life traits of their fungal hosts, including aggressiveness, and are one of the factors influencing fungal pathogenicity. In this study, the RNA mycovirome of fifteen Botryosphaeriaceae isolates was characterized through the high-throughput sequencing of double-stranded RNA preparations from the respective samples...
March 1, 2024: Viruses
https://read.qxmd.com/read/38543458/ethylene-scavenging-films-based-on-ecofriendly-plastic-materials-and-nano-tio-2-preparation-characterization-and-in-vivo-evaluation
#14
JOURNAL ARTICLE
Alba Maldonado, Tomas Aguilar, Carolin Hauser, Gerd Wehnert, Dominik Söthje, Herbert Schlachter, Alejandra Torres, Julio Bruna, Ximena Valenzuela, Francisco Rodríguez-Mercado
It is known that ethylene plays an important role in the quality characteristics of fruits, especially in storage. To avoid the deterioration of fruits caused by ethylene, titanium dioxide (TiO2 ) has been used due to its photocatalytic capacity. The aim of this study was to develop films based on two types of biopolymers, Mater-Bi (MB) and poly-lactic acid (PLA), with nanoparticles of TiO2 and to determine their ethylene removal capacity and its application in bananas. First, the films were fabricated through an extrusion process with two different concentrations of TiO2 (5 and 10% w/w )...
March 20, 2024: Polymers
https://read.qxmd.com/read/38543416/effect-of-modified-natural-rubber-on-the-mechanical-and-thermal-properties-of-poly-lactic-acid-and-its-composites-with-nanoparticles-from-biowaste
#15
JOURNAL ARTICLE
Preeyaporn Injorhor, Supharat Inphonlek, Yupaporn Ruksakulpiwat, Chaiwat Ruksakulpiwat
The brittle behavior of poly(lactic acid) (PLA) and PLA composites with inorganic filler limits their applications; the addition of a toughening agent, such as a rubbery phase, was selected to transform the brittle to ductile behavior for versatility in various applications. This work aims to study the properties of PLA and PLA composite with filled nanosized hydroxyapatite (nHA) after adding modified natural rubber (MoNR), which acts as a toughening agent. MoNR refers to poly(acrylic acid-co-acrylamide)-grafted deproteinized natural rubber...
March 14, 2024: Polymers
https://read.qxmd.com/read/38543364/highly-effective-synthetic-polymer-based-blockers-of-non-specific-interactions-in-immunochemical-analyses
#16
JOURNAL ARTICLE
Vladimír Šubr, Libor Kostka, Jan Plicka, Ondřej Sedláček, Tomáš Etrych
In vitro diagnostic methods face non-specific interactions increasing their background level and influencing the efficacy and reproducibility. Currently, the most important and employed blocker of non-specific interactions is bovine serum albumin (BSA), an animal product with some disadvantages like its batch-to-batch variability and contamination with RNases. Herein, we developed amphiphilic water-soluble synthetic copolymers based on the highly biocompatible, non-immunogenic and nontoxic N -2-(hydroxypropyl)methacrylamide (HPMA)-based copolymers or poly(oxazoline)s as highly effective synthetic blockers of non-specific interactions and an effective BSA alternative...
March 10, 2024: Polymers
https://read.qxmd.com/read/38543363/reactive-deep-eutectic-solvent-for-an-eco-friendly-synthesis-of-cellulose-carbamate
#17
JOURNAL ARTICLE
Vincenzo Algieri, Loredana Maiuolo, Debora Procopio, Paola Costanzo, Fiore Pasquale Nicoletta, Sonia Trombino, Maria Luisa Di Gioia, Antonio De Nino
The limited solubility of natural cellulose in water and common organic solvents hinders its diverse applications, despite being one of the most abundant and easily accessible biopolymers on Earth. Chemical derivatization, such as cellulose carbamate (CC), offers a pathway to enhance both solubility and industrial processability. In this study, CC was synthesized by exploiting a novel type IV deep eutectic solvent (DES) composed of erbium trichloride and urea. This DES was shown to be not only an environmentally friendly reaction medium/catalyst but also actively participated in the synthetic process as a reagent...
March 9, 2024: Polymers
https://read.qxmd.com/read/38543261/development-and-evaluation-of-two-phase-gel-formulations-for-enhanced-delivery-of-active-ingredients-sodium-diclofenac-and-camphor
#18
JOURNAL ARTICLE
Giedre Kasparaviciene, Yuliia Maslii, Nataliia Herbina, Daiva Kazlauskiene, Mindaugas Marksa, Jurga Bernatoniene
The formulation of biphasic gels as potential semi-solid carriers for hydrophilic and lipophilic active substances is promising for the development of pharmaceutical preparations. The aim of this study was to design a stable bigel composition and to determine the influence of the organogel/hydrogel ratio on the gel's physical-chemical and structural-mechanical properties. The investigated compositions of organogel/hydrogel remained stable at ratios ranging from 5/95 to 40/60. After texture and microstructure analysis, bigels with 20/80 and 25/75 ratios were selected as carriers for the active ingredients, sodium diclofenac and camphor, for use as topical preparations for the treatment of muscle-joint inflammation and pain...
March 5, 2024: Pharmaceutics
https://read.qxmd.com/read/38543214/using-nuclear-magnetic-resonance-to-troubleshoot-a-stability-issue-in-a-real-world-formulation-chassis-application-to-consumer-oral-healthcare
#19
JOURNAL ARTICLE
Tomris Coban, Hannah Sykes, Shreedhar Kulkarni, Robert A Lucas, Cameron Robertson, Adam Le Gresley
With direct application to current and future consumer healthcare products, this research sheds light on the importance of packaging and its potential effects on both Active Pharmaceutical Ingredient (API) delivery and stability. Industrially sourced, proprietary experimental formulations (PEFs), specifically oral cleansers, based on salicylic acid and hydrogen peroxide, discolored over time at different rates, depending on packaging type used. This discoloration stemmed from an interplay of two factors, involving both spontaneous formulation degradation and the interaction of both degradants and salicylic acid with the internal surface of the packaging...
February 24, 2024: Pharmaceutics
https://read.qxmd.com/read/38543210/evaluation-of-the-stability-of-newborn-hospital-parenteral-nutrition-solutions
#20
JOURNAL ARTICLE
Luis Otero-Millán, Brais Bea-Mascato, Jose Luis Legido Soto, Noemi Martínez-López-De-Castro, Natividad Lago-Rivero
(1) Background: parenteral nutrition (PN) solutions are an extremely complex mixture. It is composed of a multitude of chemical elements that can give rise to a large number of interactions that condition its stability and safety. The aim of this study was to evaluate the stability of PN solutions for preterm infants. (2) Methods: eight samples were prepared according to the protocol for prescribing PN in preterm infants. Samples PN1-PN7 had the normal progression of macronutrients and standard amounts of micronutrients for a 1 kg preterm infant...
February 23, 2024: Pharmaceutics
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