Sophia Stoecklein, Stephan Wunderlich, Boris Papazov, Michael Winkelmann, Wolfgang G Kunz, Katharina Mueller, Katharina Ernst, Veit M Stoecklein, Viktoria Blumenberg, Philipp Karschnia, Veit L Bücklein, Kai Rejeski, Christian Schmidt, Michael von Bergwelt-Baildon, Joerg-Christian Tonn, Jens Ricke, Hesheng Liu, Jan Remi, Marion Subklewe, Louisa von Baumgarten, Florian Schoeberl
BACKGROUND: Treatment of hematological malignancies with chimeric antigen receptor modified T cells (CART) is highly efficient, but often limited by an immune effector cell-associated neurotoxicity syndrome (ICANS). As conventional MRI is often unremarkable during ICANS, we aimed to examine whether resting-state functional MRI (rsfMRI) is suitable to depict and quantify brain network alterations underlying ICANS in the individual patient. METHODS: The dysconnectivity index (DCI) based on rsfMRI was longitudinally assessed in systemic lymphoma patients and 1 melanoma patient during ICANS and before or after clinical resolution of ICANS...
2023: Neuro-oncology advances