Nooshin Heshmati-Fakhr, Fattah Sotoodehnejadnematalahi, Niloufar Yousefi, Mohammad Sayyah, Sayed Masoud Hosseini, Hamid Gholami Pourbadie
Synaptic function and memory performance are disrupted by soluble form of β-amyloid (Aβ). In the previous study, we found that early activation of microglia by toll-like receptor 2 (TLR2) attenuated Alzheimer's disease-associated cognitive deficit. This study was designed to investigate whether pretreatment with the TLR2 receptor ligand can regulate microglia to produce interferon β (INFβ) in a rat model of Alzheimer's disease. For this purpose, the BV-2 cell line was cultured in a 24-well plate, treated with Pam3Cys (1 μg/ml), and then incubated with oligomeric Aβ for 24 h...
December 5, 2018: Neuroreport