keyword
https://read.qxmd.com/read/38529522/a-short-treatment-with-resveratrol-after-a-renal-ischaemia-reperfusion-injury-prevents-maladaptive-repair-and-long-term-chronic-kidney-disease-in-rats
#21
JOURNAL ARTICLE
Miguel Ángel Martínez-Rojas, Hiram Balcázar, María Susana Ponce-Nava, Isaac González-Soria, Brenda Marquina-Castillo, Rosalba Pérez-Villalva, Norma A Bobadilla
Acute kidney injury (AKI) often triggers physiological processes aimed at restoring renal function and architecture. However, this response can become maladaptive, leading to nephron loss and fibrosis. Although the therapeutic effects of resveratrol (RSV) are well established, its impact after AKI and for subsequent chronic kidney disease (CKD) remains unclear. This study assessed whether transient administration of RSV following ischaemia-reperfusion injury (IRI) could prevent the progression to CKD. Forty-one male Wistar rats were assigned randomly to sham surgery, bilateral renal ischaemia for 30 min (IR) or IR+RSV...
March 26, 2024: Journal of Physiology
https://read.qxmd.com/read/38529479/inhibitory-effect-of-p22077-on-airway-inflammation-in-rats-with-copd-and-its-mechanism
#22
JOURNAL ARTICLE
Di Zeng, Wenbo Zhang, Xiaoju Chen, Guochun Ou, Yuewei Huang, Chengxiu Yu
PURPOSE: Here, we studied the pharmacological effect of P22077 on airway inflammation induced by lipopolysaccharide and cigarette smoke and explored the therapeutic mechanism of P22077 in COPD model RAT. PATIENTS AND METHODS: The COPD model was established by lipopolysaccharide combined with fumigation; animals were treated with vehicle or P22077. Serum, bronchoalveolar lavage fluid (BALF), and lung tissues were collected for analysis. RESULTS: Our results showed that P22077 treatment significantly improved the airway inflammation of COPD model RAT and reduced the recruitment of leukocytes in BALF, and hypersecretion of interleukin-18 (IL-18), interleukin-1β (IL-1β) in BALF and serum...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38529200/impact-of-saussurea-lappa-against-foodborne-parasite-trichinella-spiralis-experimental-infections-induced-variation-in-dna-damage-oxidative-stress-and-pcna-expression-in-rat-skeletal-muscles
#23
JOURNAL ARTICLE
Areej Jameel M Alghabban, Lamiaa Bakr, Aya A Elbatawy, Afaf El Atrash, Ehab Tousson
Trichinellosis is a parasite zoonosis that is spread through ingesting raw or undercooked meat that contains the Trichinella spiralis ( T. spiralis ) infective larvae. It has three clinical phases: intestinal, migratory, and muscular. Kuth root, also known as Costus (Saussurea lappa) roots, is used in many traditional medical systems all over the world to treat a variety of illnesses, such as dyspepsia, diarrhoea, vomiting, and inflammation. Current study assessed the therapeutic Potential of costus roots extract (CRE) treatment on experimental trichinellosis induce changes in DNA damage, oxidative stress and Proliferating cell nuclear antigen (PCNA) expression in muscle fibers in male rats...
April 2024: Toxicology Research
https://read.qxmd.com/read/38528993/intestinal-flora-imbalance-induced-by-antibiotic-use-in-rats
#24
JOURNAL ARTICLE
Guojun Tong, Hai Qian, Dongli Li, Jing Li, Jing Chen, Xiongfeng Li, Zhenhua Tan
AIM: This study aims to explore the effect of different doses of antibiotics on rats in order to observe alterations in their fecal microbiota, inflammatory changes in the colonic mucosa and four types of inflammatory markers in blood serum. METHODS: Our methodology involved separating 84 female Sprague Dawley rats into groups A-G, with each group consisting of 12 rats. We collected the rat feces for analysis, using a distinct medium for bacterial cultivation and counting colonies under a microscope...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38528529/p2x7-receptor-antagonists-modulate-experimental-autoimmune-neuritis-via-regulation-of-nlrp3-inflammasome-activation-and-th17-and-th1-cell-differentiation
#25
JOURNAL ARTICLE
Yuhan Xie, Ranran Han, Yulin Li, Weiya Li, Shichao Zhang, Yu Wu, Yuexin Zhao, Rongrong Liu, Jie Wu, Wei Jiang, Xiuju Chen
BACKGROUND: Guillain-Barré syndrome (GBS), a post-infectious, immune-mediated, acute demyelinating disease of the peripheral nerves and nerve roots, represents the most prevalent and severe acute paralyzing neuropathy. Purinergic P2X7 receptors (P2X7R) play a crucial role in central nervous system inflammation. However, little is known about their role in the immune-inflammatory response within the peripheral nervous system. METHODS: Initially, we assessed the expression of purinergic P2X7R in the peripheral blood of patients with GBS using flow cytometry and qRT-PCR...
March 25, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38528238/correlation-between-pd-1-pd-l1-and-rankl-opg-in-chronic-apical-periodontitis-model-of-sprague-dawley-rats
#26
JOURNAL ARTICLE
Qi Wang, Liping Wang, Li Sheng, Bei Zhang, Burlen Jieensi, Shutao Zheng, Yishan Liu
Chronic apical periodontitis (CAP) is characterized by inflammation and destruction of the apical periodontium that is of pulpal origin, appearing as an apical radiolucent area, and does not produce clinical symptoms. Little is known about whether the PD-1/PD-L1 ratio is associated with the balance between RANKL and OPG in CAP. The relationship between PD-1/PD-L1 and RANKL/OPG in CAP is investigated in this study. A CAP rat model was established using Sprague-Dawley rats. The pulp chambers were exposed to the oral cavity to allow bacterial contamination...
March 25, 2024: Odontology
https://read.qxmd.com/read/38527567/shikonin-attenuates-cerebral-ischemia-reperfusion-injury-via-inhibiting-nod2-rip2-nf-%C3%AE%C2%BAb-mediated-microglia-polarization-and-neuroinflammation
#27
JOURNAL ARTICLE
Ya Yang, Yuxiang Fei, Xuejiao Xu, Jun Yao, Jianing Wang, Chao Liu, Haiyan Ding
OBJECTIVES: Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process of multiple neurological disorders such as ischemic stroke, which still lacks effective therapeutic agents. Shikonin possesses anti-inflammatory and neuroprotective properties. However, its underlying mechanism remains elusive. This study aimed to investigate whether Shikonin confers protection against cerebral ischemia/reperfusion (I/R) injury by modulating microglial polarization and elucidate the associated mechanisms...
March 23, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38527023/retinoic-acid-attenuates-ischemic-injury-induced-activation-of-glial-cells-and-inflammatory-factors-in-a-rat-stroke-model
#28
JOURNAL ARTICLE
Ju-Bin Kang, Hyun-Kyoung Son, Murad-Ali Shah, Phil-Ok Koh
Stroke is a leading cause of death and long-term disability which can cause oxidative damage and inflammation of the neuronal cells. Retinoic acid is an active metabolite of vitamin A that has various beneficial effects including antioxidant and anti-inflammatory effects. In this study, we investigated whether retinoic acid modulates oxidative stress and inflammatory factors in a stroke animal model. A middle cerebral artery occlusion (MCAO) was performed on adult male rats to induce focal cerebral ischemia...
2024: PloS One
https://read.qxmd.com/read/38526919/cxcl13-cxcr5-promote-chronic-postsurgical-pain-and-astrocyte-activation-in-rats-by-targeting-nlrp3
#29
JOURNAL ARTICLE
Hongda Yi, Bin Zhu, Caihong Zheng, Zhenyang Ying, Mei Cheng
Chronic postsurgical pain (CPSP) with high incidence negatively impacts the quality of life. X-C motif chemokine 13 (CXCL13) has been associated with postsurgery inflammation and exacerbates neuropathic pain in patients with CPSP. This study was aimed to illustrate the relationship between CXCL13 and nod-like receptor protein-3 (NLRP3), which is also involved in CPSP. A CPSP model was constructed by skin/muscle incision and retraction (SMIR) in right medial thigh, and the rats were divided into three groups: Sham, SMIR, and SMIR + anti-CXCL13 (intrathecally injected with anti-CXCL13 antibody)...
March 8, 2024: Neuroreport
https://read.qxmd.com/read/38526918/annexin-a1-conveys-neuroprotective-function-via-inhibiting-oxidative-stress-in-diffuse-axonal-injury-of-rats
#30
JOURNAL ARTICLE
Fengwei Zheng, Weixin Li, Shaobo Su, Qiaoyan Hui
Diffuse axonal injury (DAI) is a critical pathological facet of traumatic brain injury (TBI). Oxidative stress plays a significant role in the progress of DAI. Annexin A1 (AnxA1) has been demonstrated to benefit from recovery of neurofunctional outcomes after TBI. However, whether AnxA1 exhibits neuronal protective function by modulating oxidative stress in DAI remains unknown. Expression of AnxA1 was evaluated via real-time PCR and western blotting in rat brainstem after DAI. The neurological effect of AnxA1 following DAI through quantification of modified neurologic severity score (mNSS) was compared between wild-type and AnxA1-knockout rats...
March 15, 2024: Neuroreport
https://read.qxmd.com/read/38526658/neferine-pretreatment-attenuates-isoproterenol-induced-cardiac-injury-through-modulation-of-oxidative-stress-inflammation-and-apoptosis-in-rats
#31
JOURNAL ARTICLE
Xiaoqian Sun, Yongwen Gu, Xinghua Liu, Praveen Kumar Korla, Junjun Hao
Heart attacks, also known as myocardial infarctions (MIs), are one of the main reasons people die from cardiovascular diseases (CVDs) worldwide. Neferine, an alkaloid derived from Nelumbo nucifera seeds, has garnered interest due to its purported medicinal effects. In the current research, we induced MI in rats using the β-adrenergic agonist isoproterenol to investigate whether neferine can improve cardiac dysfunction. The rats were separated into four groups: control, isoproterenol (ISO), and two treatment groups received neferine at doses of 10 or 20 mg/kg once daily for 28 days...
March 25, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38526590/effect-of-indian-gooseberry-extract-on-improving-methylglyoxal-associated-leptin-resistance-in-peripheral-tissues-of-high-fat-diet-fed-rats
#32
JOURNAL ARTICLE
Sheng-Yi Chen, Yue-Ning Huang, Jer-An Lin, Gow-Chin Yen
Increased leptin resistance and methylglyoxal (MG) levels are observed in obese patients. However, whether MG deposits contribute to leptin resistance, oxidative stress, and inflammation in peripheral tissues remains unclear. In addition, the edible fruit of Indian gooseberry (Phyllanthus emblica L.) contains abundant bioactive components such as vitamin C, β-glucogallin (β-glu), gallic acid (GA), and ellagic acid (EA). Water extract of Indian gooseberry fruit (WEIG) and GA has been shown to improve cognitive decline by suppressing brain MG-induced insulin resistance in rats administered a high-fat diet (HFD)...
March 15, 2024: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526326/identification-of-key-pathways-and-mrnas-in-interstitial-cystitis-bladder-pain-syndrome-treatment-with-quercetin-through-bioinformatics-analysis-of-mrna-sequence-data
#33
JOURNAL ARTICLE
Guang Wang, Pei Li, Si-Wei Su, Rui Xu, Zi-Ye Huang, Tong-Xin Yang, Jiong-Ming Li
BACKGROUND: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition with painful bladder. At present, the pathogenesis of IC/BPS is still unknown. Quercetin (QCT) is a kind of natural flavonoid with wide sources and multiple biological activities. The purpose of this study was to explore the effects of QCT on mRNA expression and related regulatory signal pathways in IC model rats. METHODS: LL-37 was used to induce the IC/BPS model rats. 20 mg/kg QCT was injected intraperitoneally into IC/BPS rats...
March 22, 2024: Aging
https://read.qxmd.com/read/38526288/single-cell-rna-sequencing-analysis-of-the-retina-under-acute-high-intraocular-pressure
#34
JOURNAL ARTICLE
Shaojun Wang, Siti Tong, Xin Jin, Na Li, Pingxiu Dang, Yang Sui, Ying Liu, Dajiang Wang
JOURNAL/nrgr/04.03/01300535-202419110-00032/figure1/v/2024-03-08T184507Z/r/image-tiff High intraocular pressure causes retinal ganglion cell injury in primary and secondary glaucoma diseases, yet the molecular landscape characteristics of retinal cells under high intraocular pressure remain unknown. Rat models of acute hypertension ocular pressure were established by injection of cross-linked hyaluronic acid hydrogel (Healaflow®). Single-cell RNA sequencing was then used to describe the cellular composition and molecular profile of the retina following high intraocular pressure...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38526158/a-graphene-composite-film-based-wearable-far-infrared-therapy-apparatus-graft-for-effective-prevention-of-postoperative-peritoneal-adhesion
#35
JOURNAL ARTICLE
Xiaohuan Lu, Luming Xu, Yu Song, Xiangnan Yu, Qilin Li, Feng Liu, Xiaoqiong Li, Jiangbo Xi, Shuai Wang, Lin Wang, Zheng Wang
Postoperative peritoneal adhesion (PPA) is the most frequent complication after abdominal surgery. Current anti-adhesion strategies largely rely on the use of physical separating barriers creating an interface blocking peritoneal adhesion, which cannot reduce inflammation and suffers from limited anti-adhesion efficacy with unwanted side effects. Here, by exploiting the alternative activated macrophages to alleviate inflammation in adhesion development, a flexible graphene-composite-film (F-GCF) generating far-infrared (FIR) irradiation that effectively modulates the macrophage phenotype toward the anti-inflammatory M2 type, resulting in reduced PPA formation, is designed...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38525803/the-efficacy-of-vitamin-e-in-preventing-arthrofibrosis-after-joint-replacement
#36
JOURNAL ARTICLE
Yingfang Fan, Jean Yuh, Sashank Lekkala, Mehmet D Asik, Andrew Thomson, Madeline McCanne, Mark A Randolph, Antonia F Chen, Ebru Oral
BACKGROUND: Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint tissues. Vitamin E is an antioxidant with potential anti-fibroblastic effect. The aim of this study was to establish an arthrofibrosis rat model after joint replacement and assess the effects of vitamin E supplementation on joint fibrosis. METHODS: We simulated knee replacement in 16 male Sprague-Dawley rats. We immobilized the surgical leg with a suture in full flexion...
March 25, 2024: Animal Models and Experimental Medicine
https://read.qxmd.com/read/38525134/protective-effect-of-cilostazol-on-vascular-injury-in-rats-with-acute-ischemic-stroke-complicated-with-chronic-renal-failure
#37
JOURNAL ARTICLE
Ru Sun, Qun Gu, Xufeng Zhang, Ruiqi Zeng, Dan Chen, Jingjing Yao, Jingjing Min
UNLABELLED: Chronic renal failure (CRF) resulting in vascular calcification, which does damage to blood vessels and endothelium, is an independent risk factor for stroke. It has been reported that cilostazol has a protective effect on the focal cerebral ischemic infarct. However, its impact on vascular injury in CRF combined stroke and its molecular protection mechanism have not been investigated. In this study, we carried out the effect of cilostazol on CRF combined stroke rats, and the results confirmed that it improved the neurobehavior, renal function as well as pathologic changes in both the kidney and brain...
April 2024: Toxicological Research
https://read.qxmd.com/read/38525131/n-acetylcysteine-protects-against-diazinon-induced-histopathological-damage-and-apoptosis-in-renal-tissue-of-rats
#38
JOURNAL ARTICLE
Gaiqin Dong, Qingfeng Li, Chun Yu, Qing Wang, Danhua Zuo, Xiaozhong Li
Diazinon (DZN) is a member of organophosphorus insecticides that has cytotoxic effects on different organs. n-Acetyl cysteine (NAC) is a widely used antioxidant in clinical, in vivo and in vitro studies. We evaluated the protective role of NAC against DZN-induced toxicity in kidney tissue of Wistar rats. 30 male Wistar rats were divided into 5 groups of control, single dose of DZN, continuous dose of DZN, single doses of DZN + NAC and continuous doses of DZN + NAC. Kidney function test (blood urea nitrogen, creatinine and uric acid) was provided...
April 2024: Toxicological Research
https://read.qxmd.com/read/38523293/sex-dependent-vulnerability-for-wistar-rats-model-following-intranasal-instillation-with-klebsiella-pneumoniae-atcc-43816-causing-lobar-pneumonia
#39
JOURNAL ARTICLE
Patrick Hervé Diboue Betote, Esther Del Florence Ndedi Moni, Sonia Raïssa Gayap Matchuenkam, Sandrine Suzanne Bayengue Beack, Rodrigue Fifen, Raogo Ouedraogo, Gabriel A Agbor, Rasmané Semde, Nga Nnanga, Maximilienne Ascension Nyegue
BACKGROUND: Klebsiella pneumoniae has become one of the major threats to public health as it causes nosocomial and community-acquired infections like lobar pneumonia. This infection causes acute inflammation in the lung, characterized by the recruitment of polymorphonuclear cells, generating free radicals, and decreasing the endogenous antioxidant balance system. Many experimental studies have focused on the induction, progression and resolution of infection up to its peak, but these documented processes remain highly random and their sex dependence un-elicited...
March 25, 2024: Pneumonia
https://read.qxmd.com/read/38522660/electroacupuncture-alleviates-post-stroke-cognitive-impairment-through-inhibiting-mir-135a-5p-mtor-nlrp3-axis-mediated-autophagy
#40
JOURNAL ARTICLE
Jianchang Luo, Jiawang Lang, Wenbin Xu, Luodan Wang, Zhipeng Zhao, Jie Jia, Boxu Lang
Post-stroke cognitive impairment is a significant challenge with limited treatment options. Electroacupuncture (EA) has shown promise in improving cognitive function after stroke. Our study explores the underlying mechanism of EA in alleviating cognitive impairment through the inhibition of autophagy. We utilized a rat model of stroke induced by middle cerebral artery occlusion (MCAO) to evaluate the efficacy of EA. Treatment with EA was observed to markedly improve cognitive function and reduce inflammation in MCAO rats, as evidenced by decreased neurological deficit scores, shorter latencies in the water maze test, and diminished infarct volumes...
March 22, 2024: Neuroscience
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