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Inflammation rats

Larissa Lucena Périco, Vinícius Peixoto Rodrigues, Rie Ohara, Vânia Vasti Alfieri Nunes, Lúcia Regina Machado da Rocha, Wagner Vilegas, Catarina Dos Santos, Clélia Akiko Hiruma-Lima
ETHNOPHARMACOLOGICAL RELEVANCE: Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used as a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, and gastroprotective effects have already been characterized. We evaluated the gastric healing effect of the hydroalcoholic extract of the leaves of E. punicifolia (HEEP) in male and female Wistar rats against nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol...
February 11, 2019: Journal of Ethnopharmacology
Markus Berger, João Alfredo de Moraes, Walter Orlando Beys-da-Silva, Lucélia Santi, Paula Barros Terraciano, David Driemeier, Elizabeth Obino Cirne-Lima, Eduardo Pandolfi Passos, Maria Aparecida Ribeiro Vieira, Thereza Christina Barja-Fidalgo, Jorge Almeida Guimarães
BACKGROUND: Lonomia obliqua venom is nephrotoxic and acute kidney injury (AKI) is the main cause of death among envenomed victims. Mechanism underlying L. obliqua-induced AKI involves renal hypoperfusion, inflammation, tubular necrosis and loss of glomerular filtration and tubular reabsorption capacities. In the present study, we aimed to investigate the contribution of kallikrein to the hemodynamic instability, inflammation and consequent renal and vascular impairment. METHODOLOGY/PRINCIPAL FINDINGS: Addition of L...
February 14, 2019: PLoS Neglected Tropical Diseases
Hao Wu, Qianwen Lv, Huina Zhang, Yanwen Qin, Fang Fang, Haili Sun, Yongxiang Wei
PURPOSE: We aimed to investigate the effect of obstructive sleep apnea (OSA) and apnea-hypopnea duration on endothelial, ventricular function, blood pressure, and inflammation in a rat model. METHODS: We established a novel rat model of OSA. Wistar rats were randomized to six groups according to 4-week different treatments: (1) OSA (apnea for 60 s in a 90-s window of breathing [60 s/90 s] with anesthesia), (2) OSA 30 s/90 s with anesthesia, (3) partial recovery (60 s/90 s for 2 weeks, followed by 15 s/90 s for 2 weeks with anesthesia), (4) complete recovery (60 s/90 s for 2 weeks with anesthesia, and then normal breathing for 2 weeks), (5) sham (normal breathing in the device with anesthesia), and (6) control group (normal breathing, normal cage, no anesthesia)...
February 14, 2019: Sleep & Breathing, Schlaf & Atmung
Yang Wang, De-Jun Bao, Bin Xu, Chuan-Dong Cheng, Yong-Fei Dong, Xiang-Pin Wei, Chao-Shi Niu
The Wnt/Frizzled signaling pathway participates in many inflammation-linked diseases. However, the inflammatory response mediated by the Wnt/Frizzled signaling pathway in experimental subarachnoid hemorrhage has not been thoroughly investigated. Consequently, in this study, we examined the potential role of the Wnt/Frizzled signaling pathway in early brain injury in rat models of subarachnoid hemorrhage. Simultaneously, possible neuroprotective mechanisms were also investigated. Experimental subarachnoid hemorrhage rat models were induced by injecting autologous blood into the prechiasmatic cistern...
June 2019: Neural Regeneration Research
Hua Jia, Ying Wang, Jiao Chen, Jun-Ping Li, Huai-Qin Han, Xiao-Jie Tong, Zhong-Yi He, Wen-Zhi Ma
Peripheral nerve gaps often lead to interrupted innervation, manifesting as severe sensory and motor dysfunctions. The repairs of the nerve injuries have not achieved satisfactory curative effects in clinic. The transplantation of bone marrow stromal cells (BMSCs)-laden acellular nerve xenografts (ANX) has been proven more effective than the acellular nerve allografting. Besides, granulocyte-colony stimulating factor (G-CSF) can inhibit inflammation and apoptosis, and thus is conducive to the microenvironmental improvement of axonal regeneration...
February 14, 2019: Synapse
Chang Tu, Xiaojian Huang, Yifan Xiao, Mingyu Song, Yongzhuang Ma, Jiyuan Yan, Hongbo You, Hua Wu
Osteoarthritis (OA) is a common joint disease in the elderly population. Its development has been reported to be associated with cartilage degradation and inflammatory responses. Schisandrin A, a bioactive lignin in Schisandra sphenanthera , has shown its anti-inflammatory potential in various inflammation diseases. However, the effects of Schisandrin A on OA remain to explore. In this study, rat chondrocytes were treated with IL-1β (10 ng/ml) with or without different concentrations of Schisandrin A for 24 h...
2019: Frontiers in Pharmacology
Saad M Alshahrani
Ostrich oil, a natural bird fat oil, has significant biological activities in preventing various pains and inflammation. The aim of the current study was to develop ostrich oil loaded nanoemulsions to check the anti-inflammatory efficacy. The developed nanoemulsions(F1-F3) were evaluated in vitro for various physicochemical parameters including thermodynamic stability, nanoemulsifying potential, mean droplet size, polydispersity index (PDI), zeta potential (ZP), viscosity (η), refractive index (RI) and transmittance (%T)...
February 13, 2019: Journal of Oleo Science
Soo-Wang Hyun, Junghyun Kim, Bongkyun Park, Kyuhyung Jo, Tae Gu Lee, Jin Sook Kim, Chan-Sik Kim
Exposure to particulate matter is a risk factor for various ocular surface diseases, including keratoconjunctivitis sicca (KCS). In this study, we investigated the protective effects of apricot kernel extract (AKE) and its bioactive compound, amygdalin, on KCS induced by exposure to urban particulate matter (UPM). In the in vivo experiments, eye drops containing 0.5 mg/mL AKE (AKE-0.5) or 1 mg/mL AKE (AKE-1) were administered directly into the eyes of female rats after UPM exposure. Additionally, the effect of AKE and amygdalin on matrix metalloproteinases (MMPs) activity and the expressions of inflammatory factors, including tumor necrosis factor (TNF)-α and interleukin (IL)-6, was investigated in conjunctival epithelial cells in vitro...
February 12, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Natália Emerim Lemos, Cristine Dieter, Rodrigo Carlessi, Jakeline Rheinheimer, Letícia de Almeida Brondani, Cristiane Bauermann Leitão, Andrea Carla Bauer, Daisy Crispim
Organ transplantation is the gold standard therapy for the majority of patients with terminal organ failure. However, it is still a limited treatment especially due to the low number of brain death (BD) donors in relation to the number of waiting list recipients. Strategies to increase the quantity and quality of donor organs have been studied, and the administration of exendin-4 (Ex-4) to the donor may be a promising approach. Male Wistar rats were randomized into 3 groups: (1) control, without central nervous system injury; (2) BD induced experimentally, and (3) BD induced experimentally + Ex-4 administered immediately after BD induction...
February 13, 2019: Molecular Biology Reports
Mathilde Calvez, George Hseeh, Simon Benzer, Amanda M Brown
Despite the fact that human immunodeficiency virus type 1 (HIV-1) does not enter or replicate in neurons, its infection of a subset of resident brain glia cells (microglia and astrocytes) induces via disparate mechanisms, dysregulation of glutamate metabolism, neurotoxicity, and inflammation. Antiretroviral therapies suppress viral load, but cellular activation and release of proinflammatory factors, some of which is likely related to viral reservoirs, continue to promote a microenvironment that is injurious to neurons...
February 13, 2019: Journal of Neurovirology
T V S Tsosura, F Y Chiba, M S L C Mattera, R F Pereira, L T A Cintra, L C Conti, R M Dos Santos, J H P Mateus, C A S Garbin, D H Sumida
AIM: To investigate the plasma concentrations of glucose, insulin, and tumour necrosis factor-α (TNF-α) of rats with maternal apical periodontitis (AP) and to explore the effect of maternal inflammation on the initial steps of insulin signaling and the inflammatory pathway in the gastrocnemius muscle (GM) and periepididymal white adipose tissue (pWAT) of adult offspring. METHODOLOGY: Fifteen female Wistar rats were distributed into a control group (CN), a group with 1 AP (1AP) and group with 4 AP (4AP)...
February 12, 2019: International Endodontic Journal
Javad Mahmoudi, Ata Mahmoodpoor, Mehdi Amirnia, Tohid Kazemi, Pooneh Chokhachi Baradaran, Shirin Sheikh Najafi, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Huaxi Xu, Mobina Belalzadeh, Siamak Sandoghchian Shotorbani
INTRODUCTION: Toll-like receptors (TLRs) are innate immunity receptors, which have an important role in modulating inflammation in disease. Cerebrolysin is a biotechnologically prepared peptide that stimulates neurotrophic regulation in the central nervous system. The aim of the present study was to investigate the effect of experimenting cerebrolysin on TLR2 and TLR4 in alcoholic liver disease (ALD). MATERIALS AND METHODS: TLR2 and TLR4 expressions were determined using real-time polymerase chain reaction in rats, which have used alcohol and they were separated into five groups...
February 12, 2019: Journal of Cellular Physiology
Juan M Guerra, Martha A Hanes, Cordelia Rasa, Nagarajan Loganathan, Wendy Innis-Whitehouse, Ednia Gutierrez, Saraswathy Nair, Jameela Banu
In women, age-related bone loss is associated with increased risk of bone fracture. Existing therapies are associated with severe side effects; thus, there is a need to find alternative medicines with less or optimal side effects. Cissus quadrangularis (CQ), an Ayurvedic medicine used to enhance fracture healing, was tested for its bone protective properties and studied to discern the mechanism by which it is beneficial to bone. Female Sprague Dawley rats were either sham operated or ovariectomized and were fed CQ for 3 months...
February 12, 2019: Journal of Bone and Mineral Metabolism
Sang Wook Kang, Je-Hoon Park, Hosik Seok, Hae Jeong Park, Joo-Ho Chung, Chang-Ju Kim, Young Ock Kim, Young Rok Han, DongWhan Hong, Young Sik Kim, Su Kang Kim
Chronic prostatitis typically occurs in aging men, and its symptoms include frequent and painful urination. In recent study, several studies have shown that Korean red ginseng (KRG) can be used in the prevention and treatment of various diseases. The objective of this study is to investigate whether KRG can play a role in repressing the development of chronic nonbacterial prostatitis (CNP) in male Wistar rats. To induce CNP, rats were castrated and beta-estradiol (0.25 mg/kg) was subcutaneously (s.c.) injected daily...
2019: BioMed Research International
Caroline Silveira Martinez, Caroline D C Alterman, Gema Vera, Antonio Márquez, José-A Uranga, Franck Maciel Peçanha, Dalton Valentim Vassallo, Christopher Exley, Pâmela B Mello-Carpes, Marta Miguel, Giulia Alessandra Wiggers
Aluminum (Al), which is omnipresent in human life, is a potent neurotoxin. Here, we have tested the potential for Egg White Hydrolysate (EWH) to protect against changes in cognitive function in rats exposed to both high and low levels of Al. Indeed, EWH has been previously shown to improve the negative effects induced by chronic exposure to heavy metals. Male Wistar rats received orally: Group 1) Low aluminum level (AlCl3 at a dose of 8.3 mg/kg b.w. during 60 days) with or without EWH treatment (1 g/kg/day); Group 2) High aluminum level (AlCl3 at a dose of 100 mg/kg b...
February 12, 2019: Scientific Reports
Alexandre D Gimenes, Bruna F D Andrade, José Victor P Pinotti, Sonia M Oliani, Orfa Y Galvis-Alonso, Cristiane D Gil
BACKGROUND: The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac2-26 in an experimental model of status epilepticus (SE) was evaluated. METHODS: Male Wistar rats were divided into Naive, Sham, SE and SE+Ac2-26 groups, and SE was induced by intrahippocampal injection of pilocarpine...
February 12, 2019: Journal of Neuroinflammation
Tamires Rocha Falcão, Cássio Alexandre Oliveira Rodrigues, Aurigena Antunes de Araújo, Caroline Addison Carvalho Xavier de Medeiros, Luiz Alberto Lira Soares, Magda Rhayanny Assunção Ferreira, Roseane Carvalho Vasconcelos, Raimundo Fernandes de Araújo Júnior, Maria Luiza Diniz de Sousa Lopes, Gerlane Coelho Bernardo Guerra
BACKGROUND: Libidibia ferrea (L. ferrea) has been used in folk medicine to treat several conditions and to prevent cancer. This study performed a chromatographic analysis of the crude aqueous extract of Libidibia ferrea (Mart. ex. Tul.) L.P. Queiroz (LfAE) leaves and evaluated its in vivo antioxidant and anti-inflammatory potential. METHODS: Polyphenols present in LfAE were characterized by high performance liquid chromatography (HPLC). Anti-inflammatory activity was studied in an experimental model of zymosan-induced intra-articular inflammation, conducted in Wistar rats treated with LfAE at the doses of 100, 200 and 300 mg/kg by gavage...
February 12, 2019: BMC Complementary and Alternative Medicine
Pinglan Lin, Ming Wu, Junyan Qin, Jing Yang, Chaoyang Ye, Chen Wang
BACKGROUND: Magnesium lithospermate B (MLB) can promote renal microcirculation. The aim of the current project was to study whether MLB improves renal hemodynamics, oxygen consumption and subsequently attenuates hypoxia in rats induced by 5/6th renal Ablation/Infarction(A/I). METHODS: Chronic renal failure (CRF) was induced in male SD rats by the 5/6 (A/I) surgery. 30 rats were randomly divided into three groups: sham group, 5/6 (A/I) + vehicle group (CRF group) and 5/6 (A/I) + MLB (CRF + MLB) group...
February 12, 2019: BMC Nephrology
Samantha J Snow, Pamela M Phillips, Allen Ledbetter, Andrew F M Johnstone, Mette C Schladweiler, Christopher J Gordon, Urmila P Kodavanti
There is growing interest in understanding how maternal diet might affect the sensitivity of offspring to environmental exposures. Previous studies demonstrated that adult rat offspring (approximately 6-months-old) from dams given a high-fat diet (HFD) prior to, during, and after pregnancy displayed elevated pulmonary responses to an acute ozone (O3 ) exposure. The aim of this study was to examine the influence of maternal and perinatal HFD on pulmonary and metabolic responses to O3 in male and female young-adult offspring (approximately 3-month old)...
February 12, 2019: Journal of Toxicology and Environmental Health. Part A
Jiqian Xu, Hong-Bin Li, Lin Chen, Ya-Xin Wang, Shengzhong Lu, Sheng-Nan Li, Shu-Nan Cui, Hai-Rong Xiao, Lu Qin, Houxiang Hu, Shanglong Yao, You Shang
The timely resolution of pulmonary inflammation coordinated by endogenous pro-resolving mediators helps limit lung tissue injury, but few endogenous pro-resolving mediators that are normally operative during acute inflammation. The protective effects of BML-111 (5(S)-6(R)-7-trihydroxyheptanoic acid methyl ester), a potent commercially available anti-inflammatory and pro-resolving mediator, on ventilation-induced lung injury (VILI) have been extensively studied, but its characteristics as a pro-resolving mediator have not...
February 8, 2019: International Immunopharmacology
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