keyword
https://read.qxmd.com/read/38547044/construction-and-analysis-of-a-network-of-exercise-induced-mitochondria-related-non-coding-rna-in-the-regulation-of-diabetic-cardiomyopathy
#1
JOURNAL ARTICLE
Shuo Wang, Jiacong Li, Yungang Zhao
Diabetic cardiomyopathy (DCM) is a major factor in the development of heart failure. Mitochondria play a crucial role in regulating insulin resistance, oxidative stress, and inflammation, which affect the progression of DCM. Regular exercise can induce altered non-coding RNA (ncRNA) expression, which subsequently affects gene expression and protein function. The mechanism of exercise-induced mitochondrial-related non-coding RNA network in the regulation of DCM remains unclear. This study seeks to construct an innovative exercise-induced mitochondrial-related ncRNA network...
2024: PloS One
https://read.qxmd.com/read/38546748/molecular-mechanisms-of-resveratrol-and-its-silver-nanoparticle-conjugate-in-addressing-sepsis-induced-lung-injury
#2
JOURNAL ARTICLE
Hilal Üstündağ, Adem Kara, Songül Doğanay, Nezahat Kurt, Elif Erbaş, Ferdane Danişman Kalindemirtaş, İshak Afşin Kariper
Sepsis is a life-threatening condition characterized by a systemic inflammatory response to infection. Despite extensive research on its pathophysiology, effective therapeutic approaches remain a challenge. This study investigated the potential of resveratrol (RV) and silver nanoparticle-enhanced resveratrol (AgNP-RV) as treatments for sepsis-induced lung injury using a rat model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). The study focused on evaluating changes in oxidative status (TAS, TOS, and OSI) and the expression of inflammatory and apoptotic markers (IL-1β, TNF-α, P2X7R, TLR4, Caspase-3, and Bcl-2) in lung tissue...
March 28, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38546352/nephroprotective-effects-of-silymarin-and-its-fabricated-nanoparticles-against-aluminum-induced-oxidative-stress-hyperlipidemia-and-genotoxicity
#3
JOURNAL ARTICLE
Fatma M El-Demerdash, Manal M Ahmed, Raghda A El-Sayed, Tarek M Mohemed, Marian N Gerges
BACKGROUND: Aluminum (Al) is a ubiquitous element with proven nephrotoxicity. Silymarin (SM) is a mixture of polyphenolic components extracted from Silybum marianum and exhibited protective influences. However, SM bioactivity can be enhanced by its incorporation in chitosan (CS) through the use of nanotechnology. This work proposed to assess the protective influence of SM and its loaded chitosan nanoparticles (SM-CS-NPs) on aluminum chloride (AlCl3 )-induced nephrotoxicity. METHODS: Six groups were created randomly from 42 male Wistar rats and each one contains 7 rats (n = 7)...
March 28, 2024: Environmental Toxicology
https://read.qxmd.com/read/38546222/atrial-cardiomyocytes-contribute-to-the-inflammatory-status-associated-with-atrial-fibrillation-in-right-heart-disease
#4
JOURNAL ARTICLE
Ewen Le Quilliec, Charles-Alexandre LeBlanc, Orlane Neuilly, Jiening Xiao, Rim Younes, Yasemin Altuntas, Feng Xiong, Patrice Naud, Louis Villeneuve, Martin G Sirois, Jean-François Tanguay, Jean-Claude Tardif, Roddy Hiram
CONTEXT: Right heart disease (RHD), characterized by right ventricular (RV) and atrial (RA) hypertrophy, and cardiomyocytes' (CM) dysfunctions have been described to be associated with the incidence of atrial fibrillation (AF). RHD and AF have in common, an inflammatory status, but the mechanisms relating RHD, inflammation, and AF remain unclear. HYPOTHESES: RHD generates electrophysiological and morphological remodelling affecting the CM, leading to atrial inflammation and increased AF susceptibility...
March 28, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/38545904/chondrocyte-targeted-delivery-system-of-sortase-a-engineered-extracellular-vesicles-silencing-mmp13-for-osteoarthritis-therapy
#5
JOURNAL ARTICLE
Wenjing Yan, Ying Li, Shuqian Xie, W Andy, Jing Hu, Haohan Liu, Guiyuan Zhang, Fengying Liu, Yamei Nie, Xue Chen, Xing Zhang, Yufeng Liu, Dong Wei, Changyan Ma, Hao Zhang, Hongtao Xu, Shizhi Wang
Targeted drug delivery and the reduction of off-target effects are crucial for the promising clinical application of nucleic acid drugs. To address this challenge, we developed a new approach for treating osteoarthritis (OA) that accurately delivers antisense oligonucleotides (ASO) targeting matrix metalloproteinase-13 (ASO-MMP13) to chondrocytes. Small extracellular vesicles (exos) were ligated with chondrocyte affinity peptide (CAP) using Sortase A and subsequently incubated with cholesterol-modified ASO-MMP13 to construct a chondrocyte-targeted drug delivery exo (CAP-exoASO)...
March 28, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38545621/obesity-differentially-effects-the-somatosensory-cortex-and-striatum-of-tgf344-ad-rats
#6
Minhal Ahmed, Aaron Y Lai, Mary E Hill, Jessica A Ribeiro, Ashley Amiraslani, JoAnne McLaurin
Lifestyle choices leading to obesity, hypertension and diabetes in mid-life contribute directly to the risk of late-life Alzheimer's disease (AD). However, in late-life or in late-stage AD conditions, obesity reduces the risk of AD and disease progression. To examine the mechanisms underlying this paradox, TgF344-AD rats were fed a varied high-carbohydrate, high-fat (HCHF) diet to induce obesity from nine months of age representing early stages of AD to twelve months of age in which rats exhibit the full spectrum of AD symptomology...
January 22, 2024: bioRxiv
https://read.qxmd.com/read/38545550/the-protective-effect-of-traditional-chinese-medicine-jinteng-qingbi-granules-on-rats-with-rheumatoid-arthritis
#7
JOURNAL ARTICLE
Yingying Wan, Wenting Sun, Jiaxi Yang, Haonan Wang, Wenqian Wang, Wanting Ye, Guoliang Cheng, Bing Li, Jianxun Ren, Qiuai Kou
Introduction: Jinteng Qingbi granules (JTQBG), a traditional Chinese medicine formulation, are widely used for the treatment of rheumatoid arthritis (RA) due to their satisfactory therapeutic efficacy. However, the underlying mechanism of action remains unclear. This study aims to investigate the protective effects of JTQBG against RA and elucidates its potential molecular mechanisms. Methods: A collagen-induced arthritis (CIA) rat model was utilized, and JTQBG (1.25, 2.5, 5 g/kg/day) or methotrexate (MTX, 1 mg/kg/week) was orally administered...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38545129/wenyang-tianjing-jieyu-decoction-improves-depression-rats-of-kidney-yang-deficiency-pattern-by-regulating-t-cell-homeostasis-and-inflammation-level
#8
JOURNAL ARTICLE
Tian Zhang, Jiexin Wang, Yi Wang, Linxi He, Shangbin Lv, Yiran Wang, Weihong Li
PURPOSE: Chronic inflammation is one of the key mechanisms of depression. Wenyang-Tianjin-Jie Decoction (WTJD) is an effective antidepressant found in the course of diagnosis and treatment, but the mechanism of therapeutic effect is not clear. The study aimed to evaluate the efficacy of WTJD in the kidney yang deficiency (KYD) type of depression rats and reveal its mechanisms. MATERIALS AND METHODS: We selected forty 6-week-old male Sprague-Dawley rats for the study...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38544779/-chenopodium-ambrosioides-linn-mitigates-bone-loss-in-rats-with-periodontitis
#9
JOURNAL ARTICLE
Diego Thiers Oliveira Carneiro, Michael Douglas da Silva, Karla Vanessa Pinto Vasconcelos, Romero Dias, Vanessa Costa, Raquel Felipe Vasconcelos, Bárbara Carneiro, Gisele Barreto, Mirna Marques, Hellíada Chaves Vasconcelos, Howard Lopes Ribeiro Júnior, Jonas Nogueira Ferreira Maciel Gusmão, Helson da Silveira, Renata Leitão, Gerly Anne Brito, Karuza Maria Alves Pereira, Delane Viana Gondim, Paula Goes
STATEMENT OF THE PROBLEM: Periodontitis is an inflammatory disease that causes bone loss. Some patients do not respond well to the classic treatment and need therapies that minimize bone loss, the main sequel of the disease. Chenopodium ambrosioides L. has stood out due to its anti-inflammatory and anti-oxidative activities. However, no study has yet investigated its effect on periodontitis. PURPOSE: This study aimed to evaluate the bone protective effect of Chenopodium ambrosioides L...
March 2024: Journal of Dentistry
https://read.qxmd.com/read/38544285/repeated-exposure-to-eucalyptus-wood-smoke-alters-pulmonary-gene-and-metabolic-profiles-in-male-long-evans-rats
#10
JOURNAL ARTICLE
Samuel J Cochran, Katelyn Dunigan-Russell, Grace M Hutton, Helen Nguyen, Mette C Schladweiler, Dean P Jones, Wanda C Williams, Anna A Fisher, M Ian Gilmour, Janice A Dye, M Ryan Smith, Colette N Miller, Kymberly M Gowdy
Exposure to wildfire smoke is associated with both acute and chronic cardiopulmonary illnesses, which are of special concern for wildland firefighters who experience repeated exposure to wood smoke. It is necessary to better understand the underlying pathophysiology by which wood smoke exposure increases pulmonary disease burdens in this population. We hypothesize that wood smoke exposure produces pulmonary dysfunction, lung inflammation, and gene expression profiles associated with future pulmonary complications...
March 27, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38543192/gellan-based-hydrogel-as-a-drug-delivery-system-for-caffeic-acid-phenethyl-ester-in-the-treatment-of-oral-candida-albicans-infections
#11
JOURNAL ARTICLE
Maíra Terra Garcia, Paulo Henrique Fonseca do Carmo, Lívia Mara Alves Figueiredo-Godoi, Natália Inês Gonçalves, Patrícia Michelle Nagai de Lima, Lucas de Paula Ramos, Luciane Dias de Oliveira, Alexandre Luiz Souto Borges, Anita Shukla, Juliana Campos Junqueira
Candida albicans can cause various types of oral infections, mainly associated with denture stomatitis. Conventional therapy has been linked to high recurrence, toxicity, and fungal resistance, necessitating the search for new drugs and delivery systems. In this study, caffeic acid phenethyl ester (CAPE) and gellan gum (GG) were studied as an antifungal agent and carrier system, respectively. First, we observed that different GG formulations (0.6 to 1.0% wt/vol) were able to incorporate and release CAPE, reaching a controlled and prolonged release over 180 min at 1...
February 20, 2024: Pharmaceutics
https://read.qxmd.com/read/38543083/an-inulin-type-fructan-cp-a-from-codonopsis-pilosula-alleviated-5-fluorouracil-induced-intestinal-mucositis-via-the-erk-mlck-mlc2-pathway-and-regulation-of-gut-microbiota
#12
JOURNAL ARTICLE
Jiangtao Zhou, Deyun Li, Jiajing Wang, Zhuoyang Cheng, Changjian Wang, Xuepeng Zhang, Xiexin Xu, Jianping Gao
Intestinal mucositis (IM) is a common adverse effect of chemotherapy, limiting its clinical application. Codonopsis pilosula -derived CP-A (an inulin-type fructan) is an edible Chinese medicine with anti-inflammatory and gastrointestinal protective effects, which may be useful for treating IM. Here, we explored CP-A's role in ameliorating IM induced by 5-fluorouracil (5-FU) and investigated the underlying mechanism using in vitro experiments and rat models. Western blotting, immunohistochemistry (IHC), and real-time PCR (RT-PCR) analyses were used to assess protein expression related to the extracellular-regulated protein kinases (ERK)/myosin light chain kinase (MLCK)/myosin light chain 2 (MLC2) signaling pathway and tight junction proteins...
February 26, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542959/tangeretin-mitigates-trimethylamine-oxide-induced-arterial-inflammation-by-disrupting-choline-trimethylamine-conversion-through-specific-manipulation-of-intestinal-microflora
#13
JOURNAL ARTICLE
Yu Cao, Changlong Leng, Kuan Lin, Youwei Li, Meiling Zhou, Mei Zhou, Xiji Shu, Wei Liu
Previous studies have revealed the microbial metabolism of dietary choline in the gut, leading to its conversion into trimethylamine (TMA). Polymethoxyflavones (PMFs), exemplified by tangeretin, have shown efficacy in mitigating choline-induced cardiovascular inflammation. However, the specific mechanism by which these compounds exert their effects, particularly in modulating the gut microbiota, remains uncertain. This investigation focused on tangeretin, a representative PMFs, to explore its influence on the gut microbiota and the choline-TMA conversion process...
March 16, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542814/effects-of-npy-2-receptor-antagonists-semaglutide-pyy-3-36-and-empagliflozin-on-early-masld-in-diet-induced-obese-rats
#14
JOURNAL ARTICLE
Simon Kloock, Niklas Haerting, Gloria Herzog, Marie Oertel, Niklas Geiger, Andreas Geier, Vasco Sequeira, Alexander Nickel, Michael Kohlhaas, Martin Fassnacht, Ulrich Dischinger
(1) Background: Modulators of the Neuropeptide Y (NPY) system are involved in energy metabolism, but the effect of NPY receptor antagonists on metabolic-dysfunction-associated steatotic liver disease (MASLD), a common obesity-related comorbidity, are largely unknown. In this study, we report on the effects of antagonists of the NPY-2 receptor (Y2R) in comparison with empagliflozin and semaglutide, substances that are known to be beneficial in MASLD. (2) Methods: Diet-induced obese (DIO) male Wistar rats were randomized into the following treatment groups: empagliflozin, semaglutide ± PYY3-36 , the Y2R antagonists JNJ 31020028 and a food-restricted group, as well as a control group...
March 21, 2024: Nutrients
https://read.qxmd.com/read/38542743/plant-derived-substances-for-prevention-of-necrotising-enterocolitis-a-systematic-review-of-animal-studies
#15
REVIEW
Cheryl Anne Mackay, Chandra Rath, Shripada Rao, Sanjay Patole
Inflammation, oxidative injury, and gut dysbiosis play an important role in the pathogenesis of necrotising enterocolitis (NEC). Plant-derived substances have historically been used as therapeutic agents due to their anti-inflammatory, antioxidant, and antimicrobial properties. We aimed to review pre-clinical evidence for plant-derived substances in the prevention and treatment of NEC. A systematic review was conducted using the following databases: PubMed, EMBASE, EMCARE, MEDLINE and Cochrane Library (PROSPERO CRD42022365477)...
March 14, 2024: Nutrients
https://read.qxmd.com/read/38542309/a-novel-model-of-staphylococcus-aureus-induced-lymphoplasmacytic-rhinosinusitis-in-rats
#16
JOURNAL ARTICLE
William Murphy, Sha Liu, Karen Hon, John Finnie, George Spyro Bouras, Sholeh Feizi, Ghais Houtak, Gohar Shaghayegh, Erich Vyskocil, Peter-John Wormald, Sarah Vreugde, Alkis J Psaltis
Chronic rhinosinusitis (CRS) is characterized by sinonasal mucosal inflammation. Staphylococcus aureus (S. aureus) is associated with severe CRS phenotypes. Different animal models have been proposed to study the association of CRS and S. aureus . However, current animal models are expensive due to the use of large animals, have high barriers to ethics approval, or require invasive surgical intervention, necessitating a need for a model that can overcome these limitations. This study aimed at establishing a reliable and efficient rat lymphoplasmacytic inflammatory model for rhinosinusitis...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542269/gc-ms-with-headspace-extraction-for-non-invasive-diagnostics-of-ibd-dynamics-in-a-model-of-dss-induced-colitis-in-rats
#17
JOURNAL ARTICLE
Olga Yu Shagaleeva, Daria A Kashatnikova, Dmitry A Kardonsky, Elena Yu Danilova, Viktor A Ivanov, Suleiman S Evsiev, Eugene A Zubkov, Olga V Abramova, Yana A Zorkina, Anna Y Morozova, Dmitry N Konanov, Artemiy S Silantiev, Boris A Efimov, Irina V Kolesnikova, Julia A Bespyatykh, Joanna Stimpson, Natalya B Zakharzhevskaya
Inflammatory bowel diseases are extremely common throughout the world. However, in most cases, it is asymptomatic at the initial stage. Therefore, it is important to develop non-invasive diagnostic methods that allow identification of the IBD risks in a timely manner. It is well known that gastrointestinal microbiota secrete volatile compounds (VOCs) and their composition may change in IBD. We propose a non-invasive method to identify the dynamics of IBD development in the acute and remission stage at the level of VOCs in model of dextran sulfate sodium (DSS) with chemically induced colitis measured by headspace GC/MS (HS GC/MS)...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542266/assessing-the-impact-of-influenza-vaccination-timing-on-experimental-arthritis-effects-on-disease-progression-and-inflammatory-biomarkers
#18
JOURNAL ARTICLE
Vera Tarjányi, Ákos Ménes, Leila Hamid, Andrea Kurucz, Dániel Priksz, Balázs Varga, Rudolf Gesztelyi, Rita Kiss, Ádám István Horváth, Nikolett Szentes, Zsuzsanna Helyes, Zoltán Szilvássy, Mariann Bombicz
Numerous studies have indicated a link between vaccines and the exacerbation of autoimmune diseases including rheumatoid arthritis (RA). However, there is no consensus in clinical practice regarding the optimal timing of immunization. Therefore, this study aimed to investigate the impact of the 3Fluart influenza vaccine on the complete Freund's adjuvant (CFA)-induced chronic arthritis rat model and to identify new biomarkers with clinical utility. CFA was injected into the plantar surface of one hind paw and the root of the tail on day 0, and the tail root injection was repeated on day 1...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542210/gut-microbiota-and-inflammation-modulation-in-a-rat-model-for-ulcerative-colitis-after-the-intraperitoneal-administration-of-apigenin-luteolin-and-xanthohumol
#19
JOURNAL ARTICLE
Patricia Magadán-Corpas, Álvaro Pérez-Valero, Suhui Ye, Sandra Sordon, Ewa Huszcza, Jarosław Popłoński, Claudio J Villar, Felipe Lombó
Ulcerative colitis (UC) is a chronic inflammatory disorder affecting the colon, with symptomatology influenced by factors including environmental, genomic, microbial, and immunological interactions. Gut microbiota dysbiosis, characterized by bacterial population alterations, contributes to intestinal homeostasis disruption and aberrant immune system activation, thereby exacerbating the inflammatory state. This study assesses the therapeutic efficacy of intraperitoneal (IP) injected flavonoids (apigenin, luteolin, and xanthohumol) in the reduction of inflammatory parameters and the modulation of the gut microbiota in a murine model of ulcerative colitis...
March 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542192/evaluating-the-anti-osteoarthritis-potential-of-standardized-boswellia-serrata-gum-resin-extract-in-alleviating-knee-joint-pathology-and-inflammation-in-osteoarthritis-induced-models
#20
JOURNAL ARTICLE
Yean-Jung Choi, Jae In Jung, Jaewoo Bae, Jae Kyoung Lee, Eun Ji Kim
Osteoarthritis is a widespread chronic degenerative disease marked by the deterioration of articular cartilage, modifications in subchondral bone, and a spectrum of symptoms, including pain, stiffness, and disability. Ultimately, this condition impairs the patient's quality of life. This study aimed to evaluate the therapeutic efficacy of standardized Boswellia serrata gum resin extract (BSRE) in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis. A total of 60 rats were allocated into six groups: normal control group (NC), osteoarthritis control (injected with MIA, OC), O + B50 (injected with MIA and treated with 50 mg/kg body weight (BW) BSRE), O + B75 (injected with MIA and treated with 75 mg/kg BW BSRE), O + B100 (injected with MIA and treated with 100 mg/kg BW BSRE), and O + M (injected with MIA and treated with 150 mg/kg BW methyl sulfonyl methane)...
March 12, 2024: International Journal of Molecular Sciences
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