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Poppy Datta, Kun Do Rhee, Rylee J Staudt, Jacob M Thompson, Ying Hsu, Salma Hassan, Arlene V Drack, Seongjin Seo
Adeno-associated virus (AAV) is a safe and efficient gene delivery vehicle for gene therapies. However, its relatively small packaging capacity limits its use as a gene transfer vector. Here, we describe a strategy to deliver large genes that exceed the AAV's packaging capacity using up to four AAV vectors and the CRE-lox DNA recombination system. We devised novel lox sites by combining non-compatible and reaction equilibrium-modifying lox site variants. These lox sites facilitate sequence-specific and near-unidirectional recombination of AAV vector genomes, enabling efficient reconstitution of up to 16 kb of therapeutic genes in a pre-determined configuration...
April 10, 2024: bioRxiv
#22
JOURNAL ARTICLE
Younghee Seo, Kyung Won Chang, Jihyeon Lee, Chanho Kong, Jaewoo Shin, Jin Woo Chang, Young Cheol Na, Won Seok Chang
AIMS: Previous studies have reported that focused ultrasound (FUS) helps modulate the blood-brain barrier (BBB). These studies have generally used the paracellular pathway owing to tight junction proteins (TJPs) regulation. However, BBB transport pathways also include diffusion and transcytosis. Few studies have examined transcellular transport across endothelial cells. We supposed that increased BBB permeability caused by FUS may affect transcytosis. We investigated drug delivery through transcytosis and paracellular transport to the brain after BBB modulation using FUS...
April 30, 2024: Heliyon
#23
JOURNAL ARTICLE
Eriko Seo, Yoshiteru Seo
In bivalves and gastropods, ventricle contraction causes a negative pressure in the auricles, and increases venous return from the afferent oblique vein (AOV): the constant-volume (CV) mechanism. The flow in the AOV should be a pulsative flow synchronized with the ventricular contraction. The flow in the heart and adjacent vessels of the Mytilus galloprovincialis were measured by magnetic resonance imaging to confirm this hypothesis. Under a regular heartbeat, pulsative flows in the AOV and branchial vessels (BVs) were almost completely synchronized with the flow in the aorta, while filling in the ventricle was in the opposite phase...
April 22, 2024: Journal of Experimental Biology
#24
JOURNAL ARTICLE
Kwang-Hyun Hur, Youyoung Lee, Audrey Lynn Donio, Seon-Kyung Kim, Bo-Ram Lee, Jee-Yeon Seo, Dooti Kundu, Kyeong-Man Kim, Stephen J Kohut, Seok-Yong Lee, Choon-Gon Jang
BACKGROUND AND PURPOSE: Methamphetamine (METH) use disorder has risen dramatically over the past decade, and there are currently no FDA-approved medications due, in part, to gaps in our understanding of the pharmacological mechanisms related to METH action in the brain. EXPERIMENTAL APPROACH: Here, we investigated whether transient receptor potential ankyrin 1 (TRPA1) mediates each of several METH abuse-related behaviours in rodents: self-administration, drug-primed reinstatement, acquisition of conditioned place preference, and hyperlocomotion...
April 21, 2024: British Journal of Pharmacology
#25
JOURNAL ARTICLE
Inki Moon, Su Yeong Park, Dongon Kim, Minae Park, Sojeong Park, Seong Soon Kwon, Min Gyu Kong, Hyun Woo Park, Hyung Oh Choi, Jon Suh, Yoon Haeng Cho, Nae Hee Lee, Hye-Sun Seo
BACKGROUND: Regarding the pathophysiology of renal infarction (RI), cardioembolic causes could have large proportion. However, there are notable variations in prevalence of atrial fibrillation (AF) among patients with RI across different studies, ranging from 17 to 65%. The primary objective of this study is to analyze the incidence of AF in patients with RI. METHODS: This nationwide retrospective cohort study enrolled 5200 patients with RI from the Korean National Institute of Health Services database spanning the years 2013 to 2019...
April 19, 2024: International Journal of Cardiology
#26
JOURNAL ARTICLE
Min Pyeong Kim, Swatilekha Kayal, Chiwon Hwang, Jonghoon Bae, Hyunseok Kim, Dong Gyu Hwang, Min Ho Jeon, Jeong Kon Seo, Dowon Ahn, Wonjoo Lee, Sangwon Seo, Joong-Hyun Chun, Youngchang Yu, Sung You Hong
The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. In this work, we report an example of a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the fluorosulfate unit is regenerated. The oligosulfate sequences are determined by high resolution mass spectrometry of the hydrolyzed fragments, and polysulfate periodic copolymers are synthesized by using oligomeric bisfluorosulfates in a bi-directional fashion...
April 20, 2024: Nature Communications
#27
JOURNAL ARTICLE
Christina N Kyriakos, Olufemi Erinoso, Pete Driezen, James F Thrasher, Kota Katanoda, Anne C K Quah, Takahiro Tabuchi, Cristina de Abreu Perez, Hong Gwan Seo, Su Young Kim, Amer Siddiq Amer Nordin, Farizah Mohd Hairi, Geoffrey T Fong, Filippos T Filippidis
INTRODUCTION: The global market of flavour capsule cigarettes (FCCs) has grown significantly over the past decade; however, prevalence data exist for only a few countries. This study examined prevalence and perceptions of FCCs among adults who smoke across five countries. METHODS: Cross-sectional data among adults who smoked cigarettes came from the International Tobacco Control Policy Evaluation Project Surveys-Brazil (2016/2017), Japan (2021), Republic of Korea (2021), Malaysia (2020) and Mexico (2021)...
April 19, 2024: BMJ Open
#28
JOURNAL ARTICLE
Soo Yong Lee, Jangho Lee, David Chung, Jung-Keun Oh, Ki-Wan Park, Taekyung Kim, Jinwon Seo
In the southeast and east coasts of the Republic of Korea, it is essential to monitor mercury accumulation in coastal organisms in view of the higher mercury distribution in sediments and human samples. However, mercury pollution monitoring in organisms, especially higher trophic-level organisms that can exhibit high mercury accumulation, is limited. Here, we examined the applicability of the eggs of the black-tailed gull (Larus crassirostris), which belongs to a high trophic level, for mercury monitoring in coastal areas...
April 18, 2024: Environmental Pollution
#29
JOURNAL ARTICLE
Young Hoon Song, Hye Min Cho, Yeong Chae Ryu, Byeong Hee Hwang, Jeong Hyun Seo
In this study, we synthesized levan shell hydrophobic silica nanoclusters encapsulating doxorubicin (L-HSi-Dox) and evaluated their potential as ultrasound-responsive drug delivery systems for cancer treatment. L-HSi-Dox nanoclusters were successfully fabricated by integrating a hydrophobic silica nanoparticle-doxorubicin complex as the core and an amphiphilic levan carbohydrate polymer as the shell by using an electrospray technique. Characterization analyses confirmed the stability, size, and composition of the nanoclusters...
April 20, 2024: ACS Applied Materials & Interfaces
#30
DongSeok Seo, Yong-Hoon Lee, JiMin Jo
No abstract text is available yet for this article.
April 19, 2024: Scientific Reports
#31
JOURNAL ARTICLE
Jungyoon Seo, Shuangying Li, Dashdendev Tsogbayar, Taehoon Hwang, Jisu Park, Eun Ko, Su-Jeong Park, Chanwoo Yang, Hwa Sung Lee
A physical sensor with a sensing medium comprising multiparallel-connected (MPC) piezoresistive pathways in both the vertical and horizontal directions was developed to achieve improved sensing performance. The MPC sensing medium reduces the total resistance and offsets noise, offering enhanced signal stability and device reliability and providing a high-performance sensing platform. The signal change and gauge factor (GF) of the 3PW-5L strain sensor (comprising three lines and five layers of piezoresistive pathways horizontally and vertically, respectively) were, respectively, 5...
April 19, 2024: ACS Applied Materials & Interfaces
#32
JOURNAL ARTICLE
Matthew R Lam, Garrett N Manion, Benjamin K Young
PURPOSE: This study investigated whether websites regarding diabetic retinopathy are readable for patients, and adequately designed to be found by search engines. METHODS: The term "diabetic retinopathy" was queried in the Google search engine. Patient-oriented websites from the first 10 pages were categorized by search result page number and website organization type. Metrics of search engine optimization (SEO) and readability were then calculated. RESULTS: Among the 71 sites meeting inclusion criteria, informational and organizational sites were best optimized for search engines, and informational sites were the most visited...
April 19, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
#33
JOURNAL ARTICLE
So-Young Park, So Young Park, Sujin Seo, Hyouk-Soo Kwon, Seung-Hyun Kim, Sae-Hoon Kim, Hye-Kyung Park, Yoon-Seok Chang, Cheol-Woo Kim, Byung Jae Lee, Hae-Sim Park, You Sook Cho, Heung-Bum Oh, David A Ostrov, Sungho Won, Tae Bum Kim
BACKGROUND: Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to predict this hypersensitivity reaction. We aimed to evaluate the possible involvement of genes in cefaclor induced type I hypersensitivity. METHODS: Whole exome sequencing (WES) and HLA genotyping were performed in 43 patients with cefaclor induced type I hypersensitivity...
May 2024: World Allergy Organization Journal
#34
JOURNAL ARTICLE
Sungkyu Lee, Steve S Xu, Mi Yan, Shannon Gravely, Anne C K Quah, Hong Gwan Seo, Sujin Lim, Sung-Il Cho, Yeol Kim, Geoffrey T Fong
INTRODUCTION: Non-combustible nicotine products (NCNPs), such as heated tobacco products (HTPs) and nicotine vaping products (NVPs) have gained a significant nicotine market share in South Korea. This descriptive study examined patterns of regular cigarette and NCNP use among South Korean adults. METHODS: Data were from the 2020 International Tobacco Control Korea Survey and included 4016 adults (aged ≥19 years) in the Republic of Korea who were regularly (at least weekly) using at least one NCNP (NVP/HTP, n=2117) and/or smoked cigarettes (n=3763) at the time of the survey...
2024: Tobacco Induced Diseases
#35
Deuk-Yeong Lee, Jong-Wook Song, Ji-Young An, Yeong-Jin Kim, Jong-Su Seo, Jong-Hwan Kim
No abstract text is available yet for this article.
April 18, 2024: Scientific Reports
#36
REVIEW
Seunga Lee, Young Seo Park, Ji Hoon Rhee, Hyojeong Chu, Jennifer M Frost, Yeonhee Choi
Plants, known for their immobility, employ various mechanisms against stress and damage. A prominent feature is the formation of callus tissue-a cellular growth phenomenon that remains insufficiently explored, despite its distinctive cellular plasticity compared to vertebrates. Callus formation involves dedifferentiated cells, with a subset attaining pluripotency. Calluses exhibit an extraordinary capacity to reinitiate cellular division and undergo structural transformations, generating de novo shoots and roots, thereby developing into regenerated plants-a testament to the heightened developmental plasticity inherent in plants...
April 18, 2024: Plant Cell Reports
#37
JOURNAL ARTICLE
Yoo Min Han, Jeong Hee Yoon, Seokha Yoo, Su Jin Chung, Jeong Min Lee, Ji Min Choi, Eun Hyo Jin, Ji Yeon Seo
BACKGROUND AND AIMS: Visceral obesity is a risk factor for reflux esophagitis (RE). We investigated the risk of RE according to visceral adipose tissue (VAT) measured by deep neural network architecture using computed tomography and evaluated the longitudinal association between abdominal adipose tissue changes and the disease course of RE. METHODS: Individuals receiving health checkups who underwent esophagogastroduodenoscopy (EGD) and abdominal computed tomography (CT) at Seoul National University Healthcare System Gangnam Center between 2015 and 2016 were included...
April 18, 2024: American Journal of Gastroenterology
#38
JOURNAL ARTICLE
Time-traceable micro-taggants for anti-counterfeiting and secure distribution of food and medicines.
Cheolheon Park, Yunjin Jeong, Huiran Yeom, Seo Woo Song, Wook Park, Daewon Lee
This study presents an innovative solution for the enhanced tracking and security of pharmaceuticals through the development of microstructures incorporating environmentally responsive, coded microparticles. Utilizing maskless photolithography, we engineered these microparticles with a degradable masking layer with 30 μ m thickness that undergoes controlled dissolution. Quantitative analysis revealed that the protective layer's degradation, monitored by red fluorescence intensity, diminishes predictably over 144 h in phosphate-buffered saline under physiological conditions...
March 2024: Biomicrofluidics
#39
JOURNAL ARTICLE
Seung Yeob Yu, Byeong Seob Oh, Seoung Woo Ryu, Jeong Eun Bak, Eun Seo Heo, Jeong Chan Moon, Jae-Ho Jeong, Ju Huck Lee
A novel Gram-negative, obligate anaerobe, non-motile, flagella-lacking, catalase- and oxidase-negative, coccobacilli-shaped bacterial strain designated AGMB02718T was isolated from swine feces. The 16S rRNA gene analysis indicated that strain AGMB02718T belonged to the genus Mesosutterella with the highest similarity to M. multiformis 4NBBH2T (= DSM 106860T ) (sequence similarity of 96.2%), forming a distinct phylogenetic lineage. Its growth occurred at 25-45°C (optimal 37°C) and in 0.5-1% NaCl (optimal 0...
2024: Frontiers in Microbiology
#40
JOURNAL ARTICLE
Xuan Liu, Jay R Turner, Christopher R Oxford, Jacob McNeill, Brenna Walsh, Emmie Le Roy, Crystal L Weagle, Emily Stone, Haihui Zhu, Wenyu Liu, Zilin Wei, Nicole P Hyslop, Jason Giacomo, Ann M Dillner, Abdus Salam, Al-Amin Hossen, Zubayer Islam, Ihab Abboud, Clement Akoshile, Omar Amador-Muñoz, Nguyen Xuan Anh, Araya Asfaw, Rajasekhar Balasubramanian, Rachel Ying-Wen Chang, Craig Coburn, Sagnik Dey, David J Diner, Jinlu Dong, Tareq Farrah, Paterne Gahungu, Rebecca M Garland, Michel Grutter de la Mora, Sina Hasheminassab, Juanette John, Jhoon Kim, Jong Sung Kim, Kristy Langerman, Pei-Chen Lee, Puji Lestari, Yang Liu, Tesfaye Mamo, Mathieu Martins, Olga L Mayol-Bracero, Mogesh Naidoo, Sang Seo Park, Yoav Schechner, Robyn Schofield, Sachchida N Tripathi, Eli Windwer, Ming-Tsang Wu, Qiang Zhang, Michael Brauer, Yinon Rudich, Randall V Martin
Global ground-level measurements of elements in ambient particulate matter (PM) can provide valuable information to understand the distribution of dust and trace elements, assess health impacts, and investigate emission sources. We use X-ray fluorescence spectroscopy to characterize the elemental composition of PM samples collected from 27 globally distributed sites in the Surface PARTiculate mAtter Network (SPARTAN) over 2019-2023. Consistent protocols are applied to collect all samples and analyze them at one central laboratory, which facilitates comparison across different sites...
April 12, 2024: ACS EST Air
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