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https://read.qxmd.com/read/30772899/immunogenicity-characterization-of-genetically-fused-or-chemically-conjugated-heat-stable-toxin-sta-toxoids-of-enterotoxigenic-escherichia-coli-etec-in-mice-and-pigs
#1
Hyesuk Seo, Ti Lu, Rahul M Nandre, Qiangde Duan, Weiping Zhang
Enterotoxigenic Escherichia coli (ETEC) producing type Ib heat-stable toxin (STa) are a top cause of children's diarrhea and travelers' diarrhea, thus STa needs to be targeted in ETEC vaccine development. However, since this 19-amino acid STa is poorly immunogenic, the effort to genetically fuse or chemically couple to carrier proteins has been made to enhance STa immunogenicity. In this study, we selected one genetic fusion and one chemical conjugate to comparatively evaluate STa immunogenicity. The genetic fusion is 3xSTaN12S-mnLTR192G/L211A carrying three toxoid (STaN12S) genetically fused to a double mutant LT monomer (mnLTR192G/L211A); the chemical conjugate is BSA-STaA14T which has toxoid STaA14T chemically coupled to bovine serum albumin (BSA)...
February 17, 2019: FEMS Microbiology Letters
https://read.qxmd.com/read/30772648/investigation-on-the-effect-of-alkyl-chain-linked-mono-thioureas-as-jack-bean-urease-inhibitors-sar-pharmacokinetics-admet-parameters-and-molecular-docking-studies
#2
Fayaz Ali Larik, Muhammad Faisal, Aamer Saeed, Pervaiz Ali Channar, Jan Korabecny, Farukh Jabeen, Ihsan Ali Mahar, Mehar Ali Kazi, Qamar Abbas, Ghulam Murtaza, Gul Shahzada Khan, Mubashir Hassan, Sung-Yum Seo
The increasing resistance of pathogens to common antibiotics, as well as the need to control urease activity to improve the yield of soil nitrogen fertilization in agricultural applications, has stimulated the development of novel classes of molecules that target urease as an enzyme. In this context, the newly developed compounds on the basis of 1-heptanoyl-3-arylthiourea family were evaluated for Jack bean urease enzyme inhibition activity to validate their role as potent inhibitors of this enzyme. 1-Heptanoyl-3-arylthioureas were obtained in excellent yield and characterized through spectral and elemental analysis...
February 8, 2019: Bioorganic Chemistry
https://read.qxmd.com/read/30772647/synthesis-and-structure-activity-relationship-of-tyrosinase-inhibiting-novel-bi-heterocyclic-acetamides-mechanistic-insights-through-enzyme-inhibition-kinetics-and-computational-studies
#3
Abdul Rehman Sadiq Butt, Muhammad Athar Abbasi, Aziz-Ur-Rehman, Sabahat Zahra Siddiqui, Hussain Raza, Mubashir Hassan, Syed Adnan Ali Shah, Muhammad Shahid, Sung-Yum Seo
The present research was designed for the selective synthesis of novel bi-heterocyclic acetamides, 9a-n, and their tyrosinase inhibition to overwhelm the problem of melanogenesis. The structures of newly synthesized compounds were confirmed by spectral techniques such as 1 H NMR, 13 C NMR, and EI-MS along with elemental analysis. The inhibitory effects of these bi-heterocyclic acetamides (9a-n) were evaluated against tyrosinase and all these molecules were recognized as potent inhibitors relative to the standard used...
January 26, 2019: Bioorganic Chemistry
https://read.qxmd.com/read/30772588/improved-real-time-optical-diagnosis-of-colorectal-polyps-following-a-comprehensive-training-program
#4
Jung Ho Bae, Changhyun Lee, Hae Yeon Kang, Min-Sun Kwak, Eun Young Doo, Ji Yeon Seo, Ji Hyun Song, Sun Young Yang, Jong In Yang, Seon Hee Lim, Jeong Yoon Yim, Joo Hyun Lim, Goh Eun Chung, Su Jin Chung, Eun Hyo Jin, Boram Park, Joo Sung Kim
BACKGROUND & AIMS: The optimal training method for endoscopic characterization of colorectal polyps using narrow-band imaging is uncertain, and sessile serrated lesions (SSLs) optical diagnosis data are lacking. We aimed to evaluate a comprehensive training program for real-time optical diagnosis of colorectal polyps, including SSLs. METHODS: We performed a single-institution prospective study of 15 endoscopists trained with the Workgroup Serrated Polyps and Polyposis classification system...
February 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30770968/whole-tumor-ablation-of-locally-recurred-hepatocellular-carcinoma-including-retained-iodized-oil-after-transarterial-chemoembolization-improves-progression-free-survival
#5
Dong Ho Lee, Jeong Min Lee, Pyo Nyun Kim, Yun-Jin Jang, Tae Wook Kang, Hyunchul Rhim, Jung Wook Seo, Young Joon Lee
OBJECTIVES: To evaluate and compare clinical outcomes of two different radiofrequency ablation (RFA) methods for locally recurred hepatocellular carcinoma (LrHCC) after locoregional treatment. METHODS: Our institutional review board approved this study with a waiver of informed consent. A total of 313 patients previously treated with transarterial chemoembolization (TACE) (n = 167) and RFA (n = 146) with a single LrHCC ≤ 3 cm was included from five tertiary referral hospitals...
February 15, 2019: European Radiology
https://read.qxmd.com/read/30770704/functional-connectivity-associated-with-tau-levels-in-ageing-alzheimer-s-and-small-vessel-disease
#6
Nicolai Franzmeier, Anna Rubinski, Julia Neitzel, Yeshin Kim, Alexander Damm, Duk L Na, Hee Jin Kim, Chul Hyoung Lyoo, Hana Cho, Sofia Finsterwalder, Marco Duering, Sang Won Seo, Michael Ewers
In Alzheimer's disease, tau pathology spreads hierarchically from the inferior temporal lobe throughout the cortex, ensuing cognitive decline and dementia. Similarly, circumscribed patterns of pathological tau have been observed in normal ageing and small vessel disease, suggesting a spatially ordered distribution of tau pathology across normal ageing and different diseases. In vitro findings suggest that pathological tau may spread 'prion-like' across neuronal connections in an activity-dependent manner. Supporting this notion, functional brain networks show a spatial correspondence to tau deposition patterns...
February 15, 2019: Brain: a Journal of Neurology
https://read.qxmd.com/read/30770070/the-potential-role-of-arginine-supplements-on-erectile-dysfunction-a-systemic-review-and-meta-analysis
#7
REVIEW
Hye Chang Rhim, Min Seo Kim, Young-Jin Park, Woo Suk Choi, Hyoung Keun Park, Hyeong Gon Kim, Aram Kim, Sung Hyun Paick
INTRODUCTION: The efficacy and safety of arginine supplements in erectile dysfunction (ED) remain debatable. AIM: To assess the potential role of arginine supplements on ED as alternatives to phosphodiesterase inhibitors. METHODS: Studies published up to April 2018 that evaluated the efficacy of arginine supplements were identified from multiple databases (Google Scholar, PubMed, Medline, Embase, Kiss, DBpia, and Cochrane databases). Studies comparing arginine supplements with placebo or no treatment; focusing only on patients with mild to moderate severity of ED; and presenting outcomes such as improvement rate, International Index of Erectile Function (IIEF) score, and adverse effects were included...
February 2019: Journal of Sexual Medicine
https://read.qxmd.com/read/30769924/systematic-degradation-rate-analysis-of-surface-functionalized-porous-silicon-nanoparticles
#8
Rae Hyung Kang, Seo Hyeon Lee, Sangrim Kang, Jinyoung Kang, Junho K Hur, Dokyoung Kim
Porous silicon nanoparticles (pSiNPs) have been utilized within a wide spectrum of biological studies, as well as in chemistry, chemical biology, and biomedical fields. Recently, pSiNPs have been constantly coming under the spotlight, mostly in biomedical applications, due to their advantages, such as controlled-release drug delivery in vivo by hydrolysis-induced degradation, self-reporting property through long life-time photoluminescence, high loading efficiency of substrate into pore, and the homing to specific cells/organ/bacteria by surface functionalization...
February 15, 2019: Materials
https://read.qxmd.com/read/30769910/hm-chromanone-isolated-from-portulaca-oleracea-l-protects-ins-1-pancreatic-%C3%AE-cells-against-glucotoxicity-induced-apoptosis
#9
Jae Eun Park, Youngwan Seo, Ji Sook Han
In this study, we investigated whether ( E )-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone, a homoisoflavonoid compound isolated from Portulaca oleracea L., protects INS-1 pancreatic β cells against glucotoxicity-induced apoptosis. Treatment with high glucose (30 mM) induced apoptosis in INS-1 pancreatic β cells; however, the level of cell viability was significantly increased by treatment with ( E )-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone. Treatment with 10⁻20 µM of ( E )-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone dose-dependently increased cell viability and significantly decreased the intracellular level of reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), and nitric oxide levels in INS-1 pancreatic β cells pretreated with high glucose...
February 14, 2019: Nutrients
https://read.qxmd.com/read/30769056/comparison-of-spot-versus-long-stenting-for-femoropopliteal-artery-disease
#10
Young-Guk Ko, Chul-Min Ahn, Seung-Woon Rha, Cheol Woong Yu, Sang Ho Park, Seung Jin Lee, Jae-Hwan Lee, Sung-Ho Her, Woong Chol Kang, Young-Seok Cho, Jae-Bin Seo, Yun Hyeong Cho, Donghoon Choi
BACKGROUND: Optimal stenting strategy for long femoropopliteal artery lesions still remains undefined. Longer stent length has been shown to be associated with increased risk of restenosis. We sought to compare the efficacy of spot versus long stenting in the treatment of femoropopliteal artery disease. METHODS: This study was designed as a multicenter randomized controlled trial to compare immediate and mid-term outcomes of spot versus long primary stenting for femoropopliteal arterial lesions...
February 12, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30769030/abuse-potential-of-2-4-iodo-2-5-dimethoxyphenyl-n-2-methoxybenzyl-ethanamine-25inbome-in-vivo-and-ex-vivo-approaches
#11
Seo Young Jeon, Young-Hoon Kim, Sung Jin Kim, Soo Kyung Suh, Hye Jin Cha
25INBOMe ("25-I", "N-Bomb"), one of new psychoactive substances (NPSs), is being abused for recreational purpose. However, the liability for abuse or dependence has not been systematically studied yet. The objective of the present study was to evaluate rewarding and reinforcing effects of 25INBOMe using conditioned place preference (CPP) and self-administration (SA) paradigms. In addition, ultrasonic vocalizations (USVs) were measured to investigate relationships between USVs and emotional state regarding dependence on psychoactive substances...
February 12, 2019: Neurochemistry International
https://read.qxmd.com/read/30768462/randomized-trial-comparing-early-and-late-administration-of-rocuronium-before-and-after-checking-mask-ventilation-in-patients-with-normal-airways
#12
Se-Hee Min, Hyunjae Im, Bo Rim Kim, Susie Yoon, Jae-Hyon Bahk, Jeong-Hwa Seo
BACKGROUND: During induction of general anesthesia, it is common practice to delay neuromuscular blockade until the ability to deliver mask ventilation has been confirmed. However, the benefits of this approach have never been scientifically validated. We thus compared the early and late administration of rocuronium before and after checking mask ventilation to investigate the efficiency of mask ventilation and the time to tracheal intubation in patients with normal airways. METHODS: Patients (n = 114) were randomized to receive IV rocuronium either before (early rocuronium group, n = 58) or after (late rocuronium group, n = 56) checking mask ventilation...
February 12, 2019: Anesthesia and Analgesia
https://read.qxmd.com/read/30768313/towards-understanding-the-origin-of-cosmic-ray-positrons
#13
M Aguilar, L Ali Cavasonza, G Ambrosi, L Arruda, N Attig, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeğmez-du Pree, R Battiston, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, V Bindi, W de Boer, K Bollweg, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, W J Burger, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, F Cervelli, Y H Chang, G M Chen, H S Chen, Y Chen, L Cheng, H Y Chou, V Choutko, C H Chung, C Clark, G Coignet, C Consolandi, A Contin, C Corti, M Crispoltoni, Z Cui, K Dadzie, Y M Dai, A Datta, C Delgado, S Della Torre, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, P Fisher, V Formato, Y Galaktionov, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, F Giovacchini, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, K H Guo, S Haino, K C Han, Z H He, M Heil, T H Hsieh, H Huang, Z C Huang, M Incagli, Yi Jia, H Jinchi, K Kanishev, B Khiali, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, A Kulemzin, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, J Q Li, Q Li, T X Li, Z H Li, C Light, C H Lin, T Lippert, F Z Liu, Hu Liu, Z Liu, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, Xi Luo, S S Lyu, F Machate, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, D C Mo, M Molero, P Mott, L Mussolin, T Nelson, J Q Ni, N Nikonov, F Nozzoli, A Oliva, M Orcinha, M Palermo, F Palmonari, M Paniccia, A Pashnin, M Pauluzzi, S Pensotti, C Perrina, H D Phan, N Picot-Clemente, V Plyaskin, M Pohl, V Poireau, A Popkow, L Quadrani, X M Qi, X Qin, Z Y Qu, P G Rancoita, D Rapin, A Reina Conde, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, C Solano, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, J W Song, Z T Sun, M Tacconi, X W Tang, Z C Tang, J Tian, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, T Urban, V Vagelli, E Valente, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, J Vizán, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, J Wei, Z L Weng, H Wu, R Q Xiong, W Xu, Q Yan, Y Yang, H Yi, Y J Yu, Z Q Yu, M Zannoni, S Zeissler, C Zhang, F Zhang, J H Zhang, Z Zhang, F Zhao, Z M Zheng, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
Precision measurements of cosmic ray positrons are presented up to 1 TeV based on 1.9 million positrons collected by the Alpha Magnetic Spectrometer on the International Space Station. The positron flux exhibits complex energy dependence. Its distinctive properties are (a) a significant excess starting from 25.2±1.8  GeV compared to the lower-energy, power-law trend, (b) a sharp dropoff above 284_{-64}^{+91}  GeV, (c) in the entire energy range the positron flux is well described by the sum of a term associated with the positrons produced in the collision of cosmic rays, which dominates at low energies, and a new source term of positrons, which dominates at high energies, and (d) a finite energy cutoff of the source term of E_{s}=810_{-180}^{+310}  GeV is established with a significance of more than 4σ...
February 1, 2019: Physical Review Letters
https://read.qxmd.com/read/30768237/calcium-binding-polymer-coated-poly-lactide-co-glycolide-microparticles-for-sustained-release-of-quorum-sensing-inhibitors-to-prevent-biofilm-formation-on-hydroxyapatite-surfaces
#14
Minji Kang, Sungwhan Kim, Heejin Kim, Youngjun Song, Dongwook Jung, Sunah Kang, Ji-Hun Seo, Sohee Nam, Yan Lee
Quorum sensing (QS) inhibitor-based therapy is an attractive strategy to inhibit bacterial biofilm formation without excessive induction of antibiotic resistance. Thus, we designed Ca2+ -binding poly(lactide- co-glycolide) (PLGA) microparticles that can maintain a sufficient concentration of QS inhibitors around hydroxyapatite (HA) surfaces in order to prevent biofilm formation on HA-based dental or bone tissues or implants and, therefore, subsequent pathogenesis. Poly(butyl methacrylate- co-methacryloyloxyethyl phosphate) (PBMP) contains both Ca2+ -binding phosphomonoester groups and PLGA-interacting butyl groups...
February 15, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30767177/the-relevance-of-serosal-exposure-without-nodal-metastasis-in-resectional-gastric-cancer
#15
Yoon Ju Jung, Ho Seok Seo, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
BACKGROUND: According to 8th AJCC/UICC TNM criteria, stage IIB includes pT1N3M0, pT2N2M0, pT3N1M0, and pT4aN0M0, which includes not only early gastric cancer but also locally advanced cancer. There are currently no data about whether there is any additional impact of serosal exposed cancer without nodal metastasis (pT4aN0) on patients' survival outcomes compared with other subgroups in IIB. METHODS: Patients who underwent radical gastrectomy for gastric cancer patients were enrolled, including 427 patients in stage IIB; 20 (4...
February 14, 2019: Annals of Surgical Oncology
https://read.qxmd.com/read/30765006/effect-of-etching-time-and-temperature-on-plating-adhesion-of-acrylonitrile-butadiene-styrene-abs-based-material
#16
Sehun Han, Injoon Son, Jae Sik Seo, Woo Chul Jung, Sungho Yoon
In this study, the effects of etching time and temperature on the adhesion of plated layers of acrylonitrile butadiene styrene (ABS) were investigated. The ABS surface micropores, which act as anchors to improve the adhesion of the plated layer, increased in numbers as the etching temperature increased. Adhesion was maximum at the etching time of 9 min at etching temperatures of 60 and 70 °C. For the etching times of 12 and 15 min, micropores on the ABS surface were incompletely filled during electroplating because the pores were both deep and narrow...
July 1, 2019: Journal of Nanoscience and Nanotechnology
https://read.qxmd.com/read/30764991/effect-of-surface-activation-agents-on-manganese-phosphate-coating-of-carbon-steel
#17
Young-Tai Noh, Ho-Young Kim, Young-Min Byoun, Sun-Kyo Seo, Soong-Keun Hyun, Chi-Hwan Lee
The surface activation agents have been used to form a high quality coating layer on manganese phosphate process. The role of surface activation agents increases the nucleation sites, which leads to obtain a finer phosphate coating. In this study, the effects of surface activation agents on manganese phosphate coating were investigated by changing the chemical composition ratio between sodium pyrophosphate and manganese carbonate. The morphology, chemical composition and corrosion resistance of the coatings were analyzed by SEM, XRD, EDS, XPS and electrochemical polarization method, respectively...
July 1, 2019: Journal of Nanoscience and Nanotechnology
https://read.qxmd.com/read/30764931/metal-ion-mediated-interliposomal-aggregation-of-polydiacetylene-liposomes-incorporating-a-phenolic-lipid
#18
Kyu Ha Park, Seung Yun Yang, Beum-Soo An, Dae Youn Hwang, Jae Ho Lee, Hong Sung Kim, Sungbaek Seo
Intercolloidal behaviors mediated by metal-ligand coordination have rarely been studied. In this work, such intercolloidal behaviors were demonstrated visibly using blue-colored polydiacetylene liposomes containing a phenolic lipid that acts as a binding ligand toward metal ions. The optimized liposomes were 150-200 nm in diameter and stable in aqueous solution. In incubation tests with various neocortical metal ions, iron(III) ions produced the most obvious colloidal aggregation of the liposomes. As the pH of the incubation medium was increased from acid to basic, stronger aggregation and increased precipitation behavior were observed...
July 1, 2019: Journal of Nanoscience and Nanotechnology
https://read.qxmd.com/read/30764706/osmapkkk63-is-involved-in-salt-stress-response-and-seed-dormancy-control
#19
Yeon-Ju Na, Hye-Kyung Choi, Min Young Park, Seo-Wha Choi, Kieu Thi Xuan Vo, Jong-Seong Jeon, Soo Young Kim
Approximately 75 MAP kinase kinase kinases (MAPKKKs) have been identified in the rice genome. However, only a few of them have been functionally characterized. In this paper, we report the function of a rice MAPKKK, OsMAPKKK63. OsMAPKKK63 was found to be induced by several abiotic stresses, including high salinity, chilling and drought. Our data indicate that OsMAPKKK63 possesses in vitro kinase activity and that it interacts with rice MAP kinase kinase OsMKK1 and OsMKK6. The two rice MKKs are known mediator of the salt stress response, implying that OsMAPKKK63 may be involved in the high salinity response...
February 14, 2019: Plant Signaling & Behavior
https://read.qxmd.com/read/30763228/detection-of-circulating-tumour-cells-and-their-potential-use-as-a-biomarker-for-advanced-renal-cell-carcinoma
#20
Tae Heon Kim, Yoon-Tae Kang, Young-Ho Cho, Jeong Hoon Kim, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee
INTRODUCTION: The aim of this study was to detect circulating tumour cells (CTCs) in patients with advanced renal cell carcinoma (RCC) using a novel CTC detection platform. Furthermore, we evaluated the clinical outcomes associated with a CTC-positive status. METHODS: A total of 34 patients with advanced RCC (stage III or IV) were prospectively enrolled, and 104 peripheral blood samples were analyzed for the presence of CTCs at various time points. CTCs were isolated using a tapered-slit filter, which captures CTCs based on size and deformability...
January 21, 2019: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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