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https://read.qxmd.com/read/30772447/imatinib-inhibits-the-regrowth-of-human-colon-cancer-cells-after-treatment-with-5-fu-and-cooperates-with-vitamin-d-analogue-pri-2191-in-the-downregulation-of-expression-of-stemness-related-genes-in-5-fu-refractory-cells
#1
Agnieszka Kotlarz, Małgorzata Przybyszewska, Paweł Swoboda, Jacek Neska, Joanna Miłoszewska, Monika Anna Grygorowicz, Andrzej Kutner, Sergiusz Markowicz
Conventional cytotoxic drugs preferentially eliminate differentiated cancer cells but spare relatively more resistant stem-like cancer cells capable to initiate recurrence. Due to cancer cell plasticity, the stem-like phenotype can be also acquired by cancer cells refractory to treatment with cytotoxic drugs. We investigated whether drugs inhibiting receptor tyrosine kinases could be used to target human colon cancer cells initiating cancer regrowth following conventional cytotoxic treatment. The moderately differentiated cell line HT-29 and poorly differentiated cell line HCT-116 were exposed to 5-fluorouracil (5-FU)...
February 14, 2019: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/30771439/targeted-demethylation-of-the-sari-promotor-impairs-colon-tumour-growth
#2
Qin Wang, Lei Dai, Yuan Wang, Jie Deng, Yi Lin, Qingnan Wang, Chao Fang, Zida Ma, Huiling Wang, Gang Shi, Lin Cheng, Yi Liu, Shuang Chen, Junshu Li, Zhexu Dong, Xiaolan Su, Lie Yang, Shuang Zhang, Ming Jiang, Meijuan Huang, Yang Yang, Dechao Yu, Zongguang Zhou, Yuquan Wei, Hongxin Deng
SARI (suppressor of activator protein 1, regulated by IFN) functions as a tumour suppressor and is inactivated in various cancers. However, the mechanism underlying SARI inactivation in cancer remains elusive. In this study, we detected a high level of DNA methylation of the SARI promoter and an inverse correlation between SARI promoter methylation and expression in malignant tissues from patients with colon cancer. Furthermore, we found that the SARI promoter methylation status is a prognostic indicator for patients with colon cancer...
February 13, 2019: Cancer Letters
https://read.qxmd.com/read/30771348/anticancer-and-antimetastatic-potential-of-enterolactone-clinical-preclinical-and-mechanistic-perspectives
#3
REVIEW
Aniket V Mali, Subhash B Padhye, Shrikant Anant, Mahabaleshwar V Hegde, Shivajirao S Kadam
Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. A significant amount of substantiation from epidemiological, clinical and laboratory research highlights the importance of diet and nutrition in cancer chemoprevention...
February 13, 2019: European Journal of Pharmacology
https://read.qxmd.com/read/30771140/the-alterations-of-copper-and-zinc-homeostasis-in-acute-appendicitis-and-the-clinical-significance
#4
Wenhao Lin, Wei Han, Ke Wen, Sunhua Huang, Yao Tang, Zhexuan Lin, Ming Han
Copper (Cu) and zinc (Zn) are involved in inflammatory process. This study was to investigate the clinical significance of Cu and Zn homeostasis alterations in acute appendicitis (AA). One hundred twenty-two AA patients and 102 healthy controls were enrolled in this study. Of which, 85 patients' appendixes were collected after appendectomy. Another six appendixes from colon cancer patients were collected as tissue controls. The contents of Cu and Zn in serum or appendix were detected, and the Cu to Zn ratio (CZr) was calculated...
February 15, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30770873/regulation-of-mirnas-by-snail-during-epithelial-to-mesenchymal-transition-in-ht29-colon-cancer-cells
#5
Patrycja Przygodzka, Izabela Papiewska-Pająk, Helena Bogusz-Koziarska, Ewelina Sochacka, Joanna Boncela, M Anna Kowalska
Epithelial-to-mesenchymal transition (EMT) in cancer cells, represents early stages of metastasis and is a promising target in colorectal cancer (CRC) therapy. There have been many attempts to identify markers and key pathways induced throughout EMT but the process is complex and depends on the cancer type and tumour microenvironment. Here we used the colon cancer cell line HT29, which stably overexpressed Snail, the key transcription factor in early EMT, as a model for colorectal adenocarcinoma cells with a pro-metastatic phenotype...
February 15, 2019: Scientific Reports
https://read.qxmd.com/read/30770794/mir-451a-suppressing-bap31-can-inhibit-proliferation-and-increase-apoptosis-through-inducing-er-stress-in-colorectal-cancer
#6
Ke Xu, Bin Han, Yang Bai, Xiu-Ying Ma, Zhen-Ni Ji, Yao Xiong, Shi-Kun Miao, Yuan-Yuan Zhang, Li-Ming Zhou
The global morbidity and mortality of colorectal cancer (CRC) are ranked the third among gastrointestinal tumors in the world. MiR-451a is associated with several types of cancer, including CRC. However, the roles and mechanisms of miR-451a in CRC have not been elucidated. BAP31 is a predicted target gene of miR-451a in our suppression subtractive hybridization library. Its relationship with miR-451a and function in CRC are unclear. We hypothesized that miR-451a could induce apoptosis through suppressing BAP31 in CRC...
February 15, 2019: Cell Death & Disease
https://read.qxmd.com/read/30770783/soft-fibrin-matrix-downregulates-dab2ip-to-promote-nanog-dependent-growth-of-colon-tumor-repopulating-cells
#7
Meng Zhang, Cong Xu, Hai-Zhou Wang, Ya-Nan Peng, Hai-Ou Li, Yun-Jiao Zhou, Shi Liu, Fan Wang, Lan Liu, Ying Chang, Qiu Zhao, Jing Liu
Colon cancer stem cells (CSCs) have been shown to be responsible for the recurrence and metastasis of colorectal cancer (CRC). As a crucial microenvironmental factor, extracellular matrix (ECM) stiffness is known to affect the stemness of CSCs. Recently, fibrin deposition in the stroma of CRC was demonstrated to be responsible for tumor development. In this study, we used salmon fibrin gel to provide a 3D ECM for colon cancer cells and investigated its effects on cell growth as well as the underlying mechanisms...
February 15, 2019: Cell Death & Disease
https://read.qxmd.com/read/30770752/insluin-and-epithelial-growth-factor-egf-promote-programmed-death-ligand-1-pd-l1-production-and-transport-in-colon-cancer-stem-cells
#8
Mingshui Chen, Aditi Sharma, Yanling Lin, Yanheng Wu, Qi He, Yushu Gu, Zhi Ping Xu, Michael Monteiro, Wenyi Gu
BACKGROUND: Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells). Previously, we reported that colon and breast cancer stem cells (CSCs) expressed much higher levels of PD-L1 than their parental cells, suggesting they will be more resistant to immune attack. METHODS: We investigated the underlining mechanism of PD-L1 increase in colon CSCs, with a special focus on the effect of insulin and epithelial growth factor (EGF), the two fundamental components to sustain the metabolism and stemness in the culture of CSCs...
February 15, 2019: BMC Cancer
https://read.qxmd.com/read/30770730/prognostic-impact-of-mrna-levels-of-lgr5-transcript-variants-in-oscc-patients
#9
Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje Güttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W Eckert, Matthias Kappler
BACKGROUND: The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5FL) in progression and prognosis of several cancers was reported. However, the biological function of three splice variants of LGR5 (LGR5Δ5, LGR5Δ8 and LGR5Δ5-8) has yet to be thoroughly investigated...
February 15, 2019: BMC Cancer
https://read.qxmd.com/read/30770576/in-vitro-and-histological-investigation-of-antitumor-effect-of-some-triazole-compounds-in-colon-cancer-cell-line
#10
Akif Evren Parlak, Suat Tekin, Arzu Karatepe, Pelin Koparir, Hafize Telceken, Ali Osman Ceribası, Mustafa Karatepe
1,2,4-Triazoles are used as antifungal, antibacterial, antimicrobial, and antioxidant against some oxidative radical species. Recently, many 1,2,4-triazoles continue to be synthesized. In this study, the effect of the 1,2,4-triazole derivatives on human colon cancer (HT29) was investigated in vitro and in vivo in rats. MTT test was applied to in in vitro experiments. For in vivo study, rats were divided into seven groups as follows: Control group (negative control), azoxymethane (AOM), AOM + cisplatin 15, AOM + L1, AOM + L2, AOM + L3, and AOM + L4...
February 15, 2019: Journal of Cellular Biochemistry
https://read.qxmd.com/read/30770385/bacterial-mix-enhances-immunotherapy-response
#11
(no author information available yet)
Researchers have isolated a mix of 11 strains of bacteria that increase the effectiveness of checkpoint inhibitors in mice. The bacteria boosted IFNγ+ CD8+ T-cell counts and enhanced anti-PD-1 and anti-CTLA4 treatments in mice implanted with colon cancer or melanoma cells, findings that could have implications for patient care.
February 15, 2019: Cancer Discovery
https://read.qxmd.com/read/30769921/hexadecenoic-fatty-acid-positional-isomers-and-de-novo-pufa-synthesis-in-colon-cancer-cells
#12
Roberta Scanferlato, Massimo Bortolotti, Anna Sansone, Chryssostomos Chatgilialoglu, Letizia Polito, Marco De Spirito, Giuseppe Maulucci, Andrea Bolognesi, Carla Ferreri
Palmitic acid metabolism involves delta-9 and delta-6 desaturase enzymes forming palmitoleic acid (9 cis -16:1; n -7 series) and sapienic acid (6 cis -16:1; n -10 series), respectively. The corresponding biological consequences and lipidomic research on these positional monounsaturated fatty acid (MUFA) isomers are under development. Furthermore, sapienic acid can bring to the de novo synthesis of the n -10 polyunsaturated fatty acid (PUFA) sebaleic acid (5 cis ,8 cis -18:2), but such transformations in cancer cells are not known...
February 15, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30769816/novel-o-alkyl-derivatives-of-naringenin-and-their-oximes-with-antimicrobial-and-anticancer-activity
#13
Joanna Kozłowska, Ewa Grela, Dagmara Baczyńska, Agnieszka Grabowiecka, Mirosław Anioł
In our investigation, we concentrated on naringenin ( NG )-a widely studied flavanone that occurs in citrus fruits. As a result of a reaction with a range of alkyl iodides, 7 novel O -alkyl derivatives of naringenin ( 7a ⁻ 11a , 13a , 17a ) were obtained. Another chemical modification led to 9 oximes of O -alkyl naringenin derivatives ( 7b ⁻ 13b , 16b ⁻ 17b ) that were never described before. The obtained compounds were evaluated for their potential antibacterial activity against Escherichia coli , Staphylococcus aureus , and Bacillus subtilis ...
February 14, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30768963/metachronous-neoplasias-arise-in-a-higher-proportion-of-colon-segments-from-which-large-polyps-were-previously-removed-and-can-be-used-to-estimate-incomplete-resection-of-10-20-mm-colorectal-polyps
#14
Jeffrey Adler, Dana Toy, Joseph C Anderson, Douglas J Robertson, Heiko Pohl
BACKGROUND & AIMS: Incomplete resection of polyps could be an important cause of post-colonoscopy colorectal cancer. However, it is difficult to study progression of incompletely removed polyps or their clinical importance. We aimed to estimate incomplete polyp resection using risk of metachronous neoplasia per colon segment. METHODS: We performed a retrospective study of 1031 patients (6186 colon segments) who initially underwent resection of a large (10-20 mm) neoplastic polyp at 2 academic medical centers (from 2000 through 2012) and then underwent a subsequent colonoscopy within 0...
February 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30767044/correction-to-appendicitis-as-a-manifestation-of-colon-cancer-should-we-image-the-colon-after-appendicectomy-in-patients-over-the-age-of-40-years
#15
Imran Mohamed, Sigmund Chan, Aneel Bhangu, Sharad Karandikar
The above article originally published with an error present in Table 1 and is now presented correctly in this article.
February 15, 2019: International Journal of Colorectal Disease
https://read.qxmd.com/read/30767041/morphological-predictors-for-lymph-node-metastases-on-computed-tomography-in-colon-cancer
#16
Erik Rollvén, Lennart Blomqvist, Emma Öistämö, Fredrik Hjern, György Csanaky, Mirna Abraham-Nordling
INTRODUCTION/BACKGROUND: The aim of the study was to assess morphological predictors for lymph node metastases (Stage III disease) in colon cancer on computed tomography. METHODS AND MATERIALS: Ninety-four patients with histology-proven colon cancer (adenocarcinoma) who underwent elective primary curative resection between the years 2012 and 2014 were included. Contrast-enhanced CT examinations were independently reviewed by two blinded observers regarding tumor location, depth of tumor invasion, and presence of lymph node metastases...
February 14, 2019: Abdominal Radiology
https://read.qxmd.com/read/30766628/stent-experiences-in-emergency-conditions-in-acute-mechanical-intestinal-obstruction-caused-by-colorectal-cancer
#17
Savas Bayrak, Cihad Tatar, Erdem Kinaci, Ekrem Cakar, Sukru Colak, Mert Mahsuni Sevinc, Hasan Bektas
Introduction: Stent treatment can be applied to avoid surgery in surgically risky patients or to turn a high-risk emergency operation into a lower-risk elective operation and save time. Aim: In this study, the techniques, clinical efficacy, safety and complications of endoscopic stents applied in emergency conditions were evaluated in patients with acute mechanical intestinal obstruction (AMIO) due to colorectal cancer. Material and methods: Between 2013 and 2015, 23 patients with an average age of 69...
January 2019: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://read.qxmd.com/read/30765860/regulation-of-the-bi-directional-cross-talk-between-ovarian-cancer-cells-and-adipocytes-by-sparc
#18
Bincy John, Christine Naczki, Chirayu Patel, Alia Ghoneum, Shadi Qasem, Ziyan Salih, Neveen Said
Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of this study is to investigate the role of SPARC in OvCa interactions with omental adipocytes and its role in OvCa colonization in the omentum. We employed multi-pronged approach using primary omental adipocytes from Sparc knockout mice, genetically engineered human omental adipocytes in 3D co-cultures with OvCa cells, as well as treatment with recombinant SPARC protein...
February 14, 2019: Oncogene
https://read.qxmd.com/read/30765681/-three-cases-of-decompression-failure-in-colon-stent-placement-for-obstructive-colorectal-cancer
#19
Shumei Mineta, Atsushi Tsuruta, Michi Ueno, Yuko Okamoto, Mio Uraoka, Yuusaku Watanabe, Hisako Kubota, Masaharu Higashida, Toshimasa Okada, Yoshinori Fujiwara, Tomio Ueno
Forty-four patients underwent decompression using a self-expandable metallic stent for obstructive colorectal cancer as a bridge to surgery in our department. Three failure cases were examined. Case 1: A Rs, Ra type 2 cancer was treated with WallflexTM 60 mm. Enough decompression could not be obtained, and an additional stent was placed. Consequently, the patient underwent a transverse colostomy. Case 2: A Ra type 2 cancer was treated with Niti-S 60 mm. The patient's chief complaint was not improved due to the tumor ingrowth...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/30765676/-a-case-of-concurrent-robotic-assisted-partial-nephrectomy-and-laparoscopic-ileocecal-resection-for-synchronous-cancer-of-the-kidney-and-ascending-colon
#20
Toru Tonooka, Nobuhiro Takiguchi, Atsushi Ikeda, Hiroaki Soda, Isamu Hoshino, Nami Sato, Yousuke Iwatate, Yoshihiro Nabeya
We report a case of synchronous cancer of the kidney and ascending colon that was resected concurrently using roboticassisted partialnephrectomy and laparoscopic ileocecalresection. A man in his 70s was diagnosed as having renaland ascending colon cancers. Thus, simultaneous resection was planned. First, robotic partial nephrectomy was performed via a transabdominalapproach by the urologicalsurgeon. After changing the position from semi-lateraldecubitus to supine, severalports were added and laparoscopic ileocecal resection was performed...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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