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Keywords Nanoparticles intratumoral inj...

Nanoparticles intratumoral injection

https://read.qxmd.com/read/38520335/multifunctional-inorganic-organic-composite-carriers-for-synergistic-dual-therapy-of-melanoma
#1
JOURNAL ARTICLE
Kseniya A Mitusova, Darya R Akhmetova, Anna Rogova, Timofey E Karpov, Yulia A Tishchenko, Daler R Dadadzhanov, Anna O Matyushevskaya, Nina V Gavrilova, Evgeny E Priakhin, Alexander S Timin
Many methods for cancer treatment have been developed. Among them photothermal therapy (PTT) has drawn the most significant attention due to its noninvasiveness, remote control activation, and low side effects. However, a limited depth of light penetration of PTT is the main drawback. To improve the therapeutic efficiency, the development of combined PTT with other therapeutic agents is highly desirable. In this work, we have designed multifunctional composite carriers based on polylactic acid ( PLA ) particles decorated with gold nanorods ( Au NRs ) as nanoheaters and selenium nanoparticles ( Se NPs ) for reactive oxygen species (ROS) production in order to perform a combined PTT against B16-F10 melanoma...
March 23, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38516744/laser-synthesized-germanium-nanoparticles-as-biodegradable-material-for-near-infrared-photoacoustic-imaging-and-cancer-phototherapy
#2
JOURNAL ARTICLE
Iaroslav B Belyaev, Ivan V Zelepukin, Polina A Kotelnikova, Gleb V Tikhonowski, Anton A Popov, Alina Yu Kapitannikova, Jugal Barman, Alexey N Kopylov, Daniil N Bratashov, Ekaterina S Prikhozhdenko, Andrei V Kabashin, Sergey M Deyev, Andrei V Zvyagin
Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical applications. Ge NPs synthesized by femtosecond-laser ablation in liquids rapidly dissolve in physiological-like environment through the oxidation mechanism. The biodegradation of Ge nanoparticles is preserved in tumor cells in vitro and in normal tissues in mice with a half-life as short as 3...
March 22, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38514186/immunogenicity-and-effectiveness-of-an-mrna-therapeutic-vaccine-for-hpv-related-malignancies
#3
JOURNAL ARTICLE
Jing Wang, Ling Ma, Yunfeng Chen, Rui Zhou, Qixin Wang, Tingting Zhang, Dongrong Yi, Qian Liu, Yongxin Zhang, Weiguo Zhang, Yijie Dong, Shan Cen
Human papillomavirus (HPV) infections account for several human cancers. There is an urgent need to develop therapeutic vaccines for targeting preexisting high-risk HPV (such as HPV 16 and 18) infections and lesions, which are insensitive to preventative vaccines. In this study, we developed a lipid nanoparticle-formulated mRNA-based HPV therapeutic vaccine (mHTV), mHTV-02, targeting the E6/E7 of HPV16 and HPV-18. mHTV-02 dramatically induced antigen-specific cellular immune response and robust memory T-cell immunity in mice, besides significant CD8+ T-cell infiltration and cytotoxicity in TC-1 tumors expressing HPV E6/E7, resulting in tumor regression and prolonged survival in mice...
June 2024: Life Science Alliance
https://read.qxmd.com/read/38499244/efficient-chemo-immunotherapy-leveraging-minimalist-electrostatic-complex-nanoparticle-as-in-situ-vaccine-integrated-tumor-icd-and-immunoagonist
#4
JOURNAL ARTICLE
Yunfei Han, Mingxia Jiang, Yanju Sun, Wenqiang Chen, Yanli Zhao, Xiuwen Guan, Weifen Zhang
INTRODUCTION: Immunotherapy has unprecedentedly opened up a series of neoteric tactics for cancer treatment. As a burgeoning approach, chemo-immunotherapy has innovatively expanded the accomplishments of conventional chemotherapeutic agents for cancer governing. OBJECTIVES: An efficacious chemo-immunotherapy leveraging minimalist electrostatic complex nanoparticle (NP) integrated tumor immunogenic cell death (ICD) and immunoagonist was developed as a watertight "in situ" vaccine for cancer therapy through convenient intratumoral administration with minimized systemic toxicity...
March 16, 2024: Journal of Advanced Research
https://read.qxmd.com/read/38445883/non-viral-gene-therapy-for-melanoma-using-lysenin-from-eisenia-foetida
#5
JOURNAL ARTICLE
Min Ren, Ling Yang, Liming He, Jie Wang, Wei Zhao, Chunli Yang, Shuai Yang, Hao Cheng, Meijuan Huang, Maling Gou
Earthworms, long utilized in traditional medicine, serve as a source of inspiration for modern therapeutics. Lysenin, a defensive factor in the coelom fluid of the earthworm Eisenia fetida, has multiple bioactivities. However, the inherent toxicity of Lysenin as a pore-forming protein (PFP) restricts its application in therapy. Here, a gene therapy strategy based on Lysenin for cancer treatment is presented. The formulation consists of polymeric nanoparticles complexed with the plasmid encoding Lysenin. After transfection in vitro, melanoma cells can express Lysenin, resulting in necrosis, autophagy, and immunogenic cell death...
March 6, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38412284/irreversible-electroporation-induced-inflammation-facilitates-neutrophil-mediated-drug-delivery-to-enhance-pancreatic-cancer-therapy
#6
JOURNAL ARTICLE
Teng Huang, Xiaofei Wen, Yuxuan Liang, Xiao Liu, Jun Zhao, Xin Long
Pancreatic cancer is a deadly disease with a five-year overall survival rate of around 11%. Chemotherapy is a cornerstone in the treatment of this malignancy, but the intratumoral delivery of chemotherapy drugs is impaired by the highly fibrotic tumor-associated stroma. Irreversible electroporation (IRE) is an ablative technique for treating locally advanced pancreatic cancer. During a typical IRE procedure, high-intensity electric pulses are released to kill tumor cells through the irreversible disruption of the cytoplasm membranes...
February 27, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38284224/breaking-down-tumoral-physical-barrier-by-remotely-unwrapping-metal-polyphenol-packaged-hyaluronidase-for-optimizing-photothermal-photodynamic-therapy-induced-immune-response
#7
JOURNAL ARTICLE
Quanwei Sun, Yunlong Li, Wei Shen, Wencui Shang, Yujing Xu, Jinming Yang, Jie Chen, Wenheng Gao, Qinghua Wu, Fan Xu, Ye Yang, Dengke Yin
The therapy of solid tumors is often hindered by the compact and rigid tumoral extracellular matrix (TECM). Precise reduction of TECM by hyaluronidase (HAase) in combination with nanotechnology is promising for solid tumor therapeutics, yet remains an enormous challenge. Inspired by the treatment of iron poisoning, here we propose a remotely unwrapping strategy of metal-polyphenol-packaged HAase (named PPFH) by sequentially injecting PPFH and a clinically used iron-chelator deferoxamine (DFO). The in situ dynamic disassembly of PPFH could be triggered by the intravenously injected DFO, resulting in the release, reactivation and deep penetration of encapsulated HAase inside tumors...
January 29, 2024: Advanced Materials
https://read.qxmd.com/read/38270686/brachytherapy-at-the-nanoscale-with-protein-functionalized-and-intrinsically-radiolabeled-169-yb-yb-2-o-3-nanoseeds
#8
JOURNAL ARTICLE
Sanchita Ghosh, Sourav Patra, Muhsin H Younis, Avik Chakraborty, Apurav Guleria, Santosh K Gupta, Khajan Singh, Sutapa Rakhshit, Sudipta Chakraborty, Weibo Cai, Rubel Chakravarty
PURPOSE: Classical brachytherapy of solid malignant tumors is an invasive procedure which often results in an uneven dose distribution, while requiring surgical removal of sealed radioactive seed sources after a certain period of time. To circumvent these issues, we report the synthesis of intrinsically radiolabeled and gum Arabic glycoprotein functionalized [169 Yb]Yb2 O3 nanoseeds as a novel nanoscale brachytherapy agent, which could directly be administered via intratumoral injection for tumor therapy...
January 25, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38253759/chitosan-loaded-piperlongumine-nanoparticles-and-kaempferol-enhance-the-anti-cancer-action-of-doxorubicin-in-targeting-of-ehrlich-solid-adenocarcinoma-in-vivo-and-in-silico-modeling-study
#9
JOURNAL ARTICLE
Fawziya A R Ibrahim, Neveen A Hussein, Aisha Y M Soliman, Thanaa I Shalaby, Mona M Rashad, Noura A Matar, Tarek S El-Sewedy
Doxorubicin is a chemotherapeutic drug that generates free radical-induced toxicities. Natural agents are used to potentiate or ameliorate the toxicity of chemotherapy. None of the studies investigating whether antioxidants or prooxidants should be used with chemotherapy have addressed their efficacy in the same study. Therefore, the aim of this study was to investigate the potential synergy between doxorubicin and two natural rarely in vivo studied anticancer agents; the antioxidant "Kaempferol" and prooxidant "Piperlongumine" in Ehrlich tumor mice model...
January 23, 2024: Medical Oncology
https://read.qxmd.com/read/38228704/improving-tumor-treatment-through-intratumoral-injection-of-drug-loaded-magnetic-nanoparticles-and-low-intensity-ultrasound
#10
JOURNAL ARTICLE
Asma Hosseinpour, Madjid Soltani, Mohammad Souri
The intratumoral injection of therapeutic agents responsive to external stimuli has gained considerable interest in treating accessible tumors due to its biocompatibility and capacity to reduce side effects. For the first time, a novel approach is explored to investigate the feasibility of utilizing low-intensity ultrasound in combination with intratumoral injection of drug-loaded magnetic nanoparticles (MNPs) to thermal necrosis and chemotherapy with the objective of maximizing tumor damage while avoiding harm to surrounding healthy tissue...
January 16, 2024: Scientific Reports
https://read.qxmd.com/read/38133040/an-in-situ-chemotherapy-drug-combined-with-immune-checkpoint-inhibitor-for-chemoimmunotherapy
#11
JOURNAL ARTICLE
Xinyuan Yuan, Xiupeng Wang
Clinically, cancer chemotherapy still faces unsatisfactory efficacy due to drug resistance and severe side effects, including tiredness, hair loss, feeling sick, etc. The clinical benefits of checkpoint inhibitors have revived hope for cancer immunotherapy, but the objective response rate of immune checkpoint inhibitors remains around 10-40%. Herein, two types of copper-doped mesoporous silica nanoparticles (MS-Cu-1 with a diameter of about 30 nm and MS-Cu-2 with a diameter of about 200 nm) were synthesized using a one-pot method...
December 15, 2023: Nanomaterials
https://read.qxmd.com/read/38131289/radiotherapy-triggered-in-situ-tumor-vaccination-boosts-checkpoint-blockaded-immune-response-via-antigen-capturing-nanoadjuvants
#12
JOURNAL ARTICLE
Pei Xu, Jie Ma, Yang Zhou, Yuan Gu, Xiaju Cheng, Yangyun Wang, Yong Wang, Mingyuan Gao
In situ vaccination (ISV) formed with the aid of intratumorally injected adjuvants has shed bright light on enhancing the abscopal therapeutic effects of radiotherapy. However, the limited availability of antigens resulting from the radiotherapy-induced immunogenic cell death largely hampers the clinical outcome of ISV. To maximally utilize the radiotherapy-induced antigen, we herein developed a strategy by capturing the radiotherapy-induced antigen in situ with a nanoadjuvant comprised of CpG-loaded Fe3 O4 nanoparticles...
December 22, 2023: ACS Nano
https://read.qxmd.com/read/38104849/combating-multidrug-resistance-of-breast-cancer-with-ginsenoside-rh2-irrigated-nano-in-thermogel
#13
JOURNAL ARTICLE
Jieyu Long, Wanshan Hu, Tao Ren, Xuewen Wang, Chao Lu, Xin Pan, Chuanbin Wu, Tingting Peng
The emergence of multidrug resistance (MDR) is the leading cause of mortality in patients with breast cancer. Overexpressed P-glycoprotein (P-gp) that can pump out chemotherapeutics from multidrug-resistant cancer cells is the main cause of chemotherapy failure. P-gp inhibitors are hence increasingly used to sensitize chemotherapy to breast cancer with MDR by reducing the efflux of drugs. However, representative P-gp inhibitors usually have severe side effects and the effect of their release behavior on chemotherapy are neglected in current studies...
December 15, 2023: International Journal of Pharmaceutics
https://read.qxmd.com/read/38059526/size-dependent-therapeutic-efficiency-of-223-ra-labeled-calcium-carbonate-carriers-for-internal-radionuclide-therapy-of-breast-cancer
#14
JOURNAL ARTICLE
Darya R Akhmetova, Kseniya A Mitusova, Alisa S Postovalova, Arina S Ivkina, Albert R Muslimov, Mikhail V Zyuzin, Sergei A Shipilovskikh, Alexander S Timin
The size of drug carriers strongly affects their biodistribution, tissue penetration, and cellular uptake in vivo . As a result, when such carriers are loaded with therapeutic compounds, their size can influence the treatment outcomes. For internal α-radionuclide therapy, the carrier size is particularly important, because short-range α-emitters should be delivered to tumor volumes at a high dose rate without any side effects, i.e. off-target irradiation and toxicity. In this work, we aim to evaluate and compare the therapeutic efficiency of calcium carbonate (CaCO3 ) microparticles (MPs, >2 μ m) and nanoparticles (NPs, <100 nm) labeled with radium-223 (223 Ra) for internal α-radionuclide therapy against 4T1 breast cancer...
December 7, 2023: Biomaterials Science
https://read.qxmd.com/read/38055727/dendritic-cell-based-in-situ-nanovaccine-for-reprogramming-lipid-metabolism-to-boost-tumor-immunotherapy
#15
JOURNAL ARTICLE
You-Teng Qin, Xin-Hua Liu, Jia-Xin An, Jun-Long Liang, Chu-Xin Li, Xiao-Kang Jin, Ping Ji, Xian-Zheng Zhang
Cancer vaccines have been considered to be an alternative therapeutic strategy for tumor therapy in the past decade. However, the popularity and efficacy of cancer vaccines were hampered by tumor antigen heterogeneity and the impaired function of cross-presentation in the tumor-infiltrating dendritic cells (TIDCs). To overcome these challenges, we engineered an in situ nanovaccine (named as TPOP) based on lipid metabolism-regulating and innate immune-stimulated nanoparticles. TPOP could capture tumor antigens and induce specific recognition by TIDCs to be taken up...
December 6, 2023: ACS Nano
https://read.qxmd.com/read/38050716/a-proof-of-concept-study-on-the-theranostic-potential-of-177lu-labeled-biocompatible-covalent-polymer-nanoparticles-for-cancer-targeted-radionuclide-therapy
#16
JOURNAL ARTICLE
Xijian Chen, Fuyuan Tan, Ranxi Liang, Jiali Liao, Jijun Yang, Tu Lan, Yuanyou Yang, Ning Liu, Feize Li
Theranostic nanomedicine combined bioimaging and therapy probably rises more helpful and interesting opportunities for personalized medicine. In this work, 177Lu radiolabeling and surface PEGylation of biocompatible covalent polymer nanoparticles (CPNs) have generated a new theranostic nanoformulation  for targeted diagnosis and treatment of breast cancer. The in vitro anticancer investigations demonstrate that 177Lu-DOTA-PEG-CPNs possess excellent bonding capacity with breast cancer cells (4T1), inhibiting the cell viability, leading to cell apoptosis, arresting the cell cycle, and upregulating the reactive oxygen species (ROS), which can be attributed to the good targeting ability of the nanocarrier and the strong relative biological effect of the radionuclide labelled compound...
December 5, 2023: Chemistry: a European Journal
https://read.qxmd.com/read/38023719/intratumoral-nanofluidic-system-enhanced-tumor-biodistribution-of-pd-l1-antibody-in-triple-negative-breast-cancer
#17
JOURNAL ARTICLE
Hsuan-Chen Liu, Simone Capuani, Andrew A Badachhape, Nicola Di Trani, Daniel Davila Gonzalez, Robin S Vander Pol, Dixita I Viswanath, Shani Saunders, Nathanael Hernandez, Ketan B Ghaghada, Shu-Hsia Chen, Elizabeth Nance, Ananth V Annapragada, Corrine Ying Xuan Chua, Alessandro Grattoni
Immune checkpoint inhibitors (ICI), pembrolizumab and atezolizumab, were recently approved for treatment-refractory triple-negative breast cancer (TNBC), where those with Programmed death-ligand 1 (PD-L1) positive early-stage disease had improved responses. ICIs are administered systemically in the clinic, however, reaching effective therapeutic dosing is challenging due to severe off-tumor toxicities. As such, intratumoral (IT) injection is increasingly investigated as an alternative delivery approach. However, repeated administration, which sometimes is invasive, is required due to rapid drug clearance from the tumor caused by increased interstitial fluid pressure...
November 2023: Bioengineering & Translational Medicine
https://read.qxmd.com/read/37968077/-remodeling-of-tumor-stroma-combined-with-photothermal-therapy-in-the-treatment-of-triple-negative-breast-cancer
#18
JOURNAL ARTICLE
J Zhang, Y Li, Y X Tang, F Y Wu, S J Wang
Objective: Polyethylene glycol-modified gold nanostar particles (GNS-PEG) were constructed to investigate whether the degradation of extracellular matrix in triple-negative breast cancer could improve the tumor delivery of GNS-PEG and enhance the efficacy of photothermal therapy. Methods: GNS-PEG were constructed and characterized for physicochemical properties as well as photothermal properties. At the cellular level, the cytotoxicity of halofuginone (HF) and the effect of photothermal therapy were detected...
November 23, 2023: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://read.qxmd.com/read/37931205/liposomal-delivery-of-an-immunostimulatory-cpg-induces-robust-antitumor-immunity-and-long-term-immune-memory-by-reprogramming-tumor-associated-macrophages
#19
JOURNAL ARTICLE
Yujin Kim, Seojung Lee, Sangyong Jon
Tumor-associated macrophages (TAMs)-representative immune-suppressive cells in the tumor microenvironment (TME)-are known to promote tumor progression and metastasis, and thus have been considered an attractive target for cancer therapy. However, current TAM-targeting strategies are insufficient to result in robust antitumor efficacy. Here, we report a small lipid nanoparticle encapsulating immunostimulatory CpG oligodeoxynucleotides (SLNP@CpG) as a new immunotherapeutic modality that can reprogram TAMs and further bridge innate-to-adaptive immunity...
November 6, 2023: Advanced Healthcare Materials
https://read.qxmd.com/read/37915748/temperature-sensitive-nanocarbon-hydrogel-for-photothermal-therapy-of-tumors
#20
JOURNAL ARTICLE
Wanlin Tan, Sijie Chen, Yan Xu, Mingyu Chen, Haiqin Liao, Chengcheng Niu
BACKGROUND: Intelligent hydrogels continue to encounter formidable obstacles in the field of cancer treatment. A wide variety of hydrogel materials have been designed for diverse purposes, but materials with satisfactory therapeutic effects are still urgently needed. METHODS: Here, we prepared an injectable hydrogel by means of physical crosslinking. Carbon nanoparticle suspension injection (CNSI), a sentinel lymph node imaging agent that has been widely used in the clinic, with sodium β-glycerophosphate (β-GP) were added to a temperature-sensitive chitosan (CS) hydrogel (CS/GP@CN) as an agent for photothermal therapy (PTT)...
2023: International Journal of Nanomedicine
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