Yona Levites, Eric B Dammer, Yong Ran, Wangchen Tsering, Duc Duong, Measho Abreha, Joshna Gadhavi, Kiara Lolo, Jorge Trejo-Lopez, Jennifer L Phillips, Andrea Iturbe, Aya Erqiuzi, Brenda Dawn Moore, Danny Ryu, Aditya Natu, Kristy D Dillon, Jose Torrellas, Corey Moran, Thomas B Ladd, Kazi Farhana Afroz, Tariful Islam, Jaishree Jagirdar, Cory C Funk, Max Robinson, David R Borchelt, Nilufer Ertekin-Taner, Jeffrey W Kelly, Frank L Heppner, Erik Cb Johnson, Karen McFarland, Allan L Levey, Stefan Prokop, Nicholas T Seyfried, Todd E Golde
We report a highly significant correlation in brain proteome changes between Alzheimers disease (AD) and CRND8 APP695NL/F transgenic mice. However, integrating protein changes observed in the CRND8 mice with co-expression networks derived from human AD, reveals both conserved and divergent module changes. For the most highly conserved module (M42, matrisome) we find many proteins accumulate in plaques, cerebrovascular amyloid (CAA), dystrophic processes, or a combination thereof. Overexpression of two M42 proteins, midkine (Mdk) and pleiotrophin (PTN), in CRND8 mice brains leads to increased accumulation of A β ; in plaques and in CAA; further, recombinant MDK and PTN enhance A β ; aggregation into amyloid...
December 7, 2023: bioRxiv