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https://read.qxmd.com/read/30765662/-a-case-of-advanced-cardia-gastric-cancer-with-pernicious-anemia
#1
Takashi Katsumori, Hisami Ohshima, Hiromitsu Hamaguchi, Shinichi Yamamoto, Yukika Tsukamoto, Tomohiro Iwanaga, Susumu Ohkawara
A 70s male was referred to our hospital with anemia that was detected during a medical checkup. Upper gastrointestinal endoscopy showed advanced cardia gastric cancer. A diagnosis of pernicious anemia was made due to the macrocytic hyperchromic anemia and detection of intrinsic factor antibody. A CT scan showed fundic wall thickening and regional lymph node metastasis. After anemia improved following vitamin B12 injection, total gastrectomy with lymphadenectomy was performed. The histopathological findings showed adenocarcinoma(tub1>tub2), Type2 , pT3(SS), pN1(2/24), Stage ⅡB, INF b, ly1, v2, PM0, DM0, EW(+), pR1...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/30753268/nutritional-management-for-chronic-kidney-disease-patients-who-undergo-bariatric-surgery-a-narrative-review
#2
Tair Ben-Porat, Anat Weiss-Sadan, Amihai Rottenstreich, Shiri Sherf-Dagan, Chaya Schweiger, Irit Mor Yosef-Levi, Dana Weiner, Odile Azulay, Nasser Sakran, Rivki Harari, Ram Elazary
Bariatric surgery (BS) may be effective for chronic kidney disease (CKD) patients by reducing microalbuminuria and proteinuria, and by facilitating their meeting inclusion criteria for kidney transplantation. However, nutritional management for this population is complex and specific guidelines are scarce. A literature search was performed to create dietetic practice for these patients based on the most recent evidence. For the purposes of nutritional recommendations, we divided the patients into 2 subgroups: 1) patients with CKD and dialysis, and 2) patients after kidney transplantation...
January 1, 2019: Advances in Nutrition
https://read.qxmd.com/read/30743280/management-of-patients-taking-oral-anticoagulants-who-need-urgent-surgery-for-hip-fracture
#3
Elvira Grandone, Angelo Ostuni, Giovanni L Tiscia, Francesco Marongiu, Doris Barcellona
The number of hip fractures in anticoagulated patients is predicted to increase, due to people living longer. However, evidence regarding urgent perioperative management of elderly patients with hip fracture who take oral anticoagulants (vitamin K antagonists or direct oral anticoagulants) is scarce. In this article, the authors present a narrative review of the evidence to date supporting the urgent management of hip fracture in anticoagulated elderly patients. They discuss the complexity of managing the high risk of procedure-related bleeding and, at the same time, the high risk of thromboembolism...
February 11, 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30739288/effects-of-a-simple-home-exercise-program-and-vitamin-d-supplementation-on-health-related-quality-of-life-after-a-hip-fracture-a-randomized-controlled-trial
#4
K Renerts, K Fischer, B Dawson-Hughes, E J Orav, G Freystaetter, H-P Simmen, H-C Pape, A Egli, R Theiler, H A Bischoff-Ferrari
PURPOSE: To test the effects of vitamin D intervention and a simple home exercise program (HE) on health-related quality of life (HRQL) in the first 12 months after hip fracture. METHODS: HRQL was reported in 173 acute hip fracture patients (mean age 84 years, 79% females, 77% community dwelling) who were enrolled in the 12-month 2 × 2 factorial Zurich Hip Fracture Trial. Pre-fracture HRQL was assessed at baseline (4.2 ± 2.2 days post-surgery) and then again at 6 and 12 months after hip fracture surgery by the EuroQol EQ-5D-3L index value (EQ-5D-3L questionnaire)...
February 9, 2019: Quality of Life Research
https://read.qxmd.com/read/30734230/impact-of-bariatric-surgery-on-bone-mineral-density-observational-study-of-110-patients-followed-up-in-a-specialized-center-for-the-treatment-of-obesity-in-france
#5
Marion Geoffroy, Isabelle Charlot-Lambrecht, Jan Chrusciel, Isabelle Gaubil-Kaladjian, Ana Diaz-Cives, Jean-Paul Eschard, Jean-Hugues Salmon
INTRODUCTION: Bariatric surgery is used to treat severe obesity. We aimed to investigate the incidence of clinically significant bone mineral density (BMD) loss at 6 and 12 months after bariatric surgery. METHODS: Observational study performed in a specialized center for the treatment of obesity at the University Hospital of Reims, France. Surface BMD was measured by dual x-ray absorptiometry (DEXA). A reduction of > 0.03 g/cm2 was considered clinically significant...
February 7, 2019: Obesity Surgery
https://read.qxmd.com/read/30734078/-metabolic-surgery
#6
A T Billeter, B P Müller-Stich
In recent years the surgical treatment of metabolic diseases has become established as an effective alternative to conservative treatment. The new S3 guidelines address these changes and give clear indications for obesity surgery. One of the core points of the new guidelines is the differentiation between obesity surgery and metabolic surgery. In obesity surgery the primary aim of treatment is weight loss whereas for metabolic indications the aim is an improvement of comorbidities independent of the body mass index (BMI)...
February 2019: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://read.qxmd.com/read/30725428/adequate-multivitamin-supplementation-after-roux-en-y-gastric-bypass-results-in-a-decrease-of-national-health-care-costs-a-cost-effectiveness-analysis
#7
Jens Homan, Wendy Schijns, Ignace M C Janssen, Frits J Berends, Edo O Aarts
INTRODUCTION: Patients with morbid obesity undergoing metabolic surgery are prone to develop vitamin and mineral deficiencies, which may worsen in time. In order to prevent these deficiencies after metabolic surgery, all patients are advised to take daily multivitamin supplementation. The aim of the study was to assess the cost-effectiveness of specially developed multivitamins (WLS Forte®) for metabolic surgery and over-the-counter (standard) multivitamin supplementation (sMVS). METHODS: This cost-effectiveness analysis was preformed alongside an RCT for the Netherlands...
February 6, 2019: Obesity Surgery
https://read.qxmd.com/read/30719950/reversal-strategies-in-patients-treated-with-direct-oral-anticoagulants
#8
Paul Gressenberger
Administration of direct oral anticoagulants (DOACs) for the treatment of venous thrombotic events (VTE) or non-valvular atrial fibrillation (AF) is now standard of care and has demonstrated clinical efficacy and safety in numerous clinical studies. Usually these substances have lower overall mortality and less risk of cerebral hemorrhage, but depending on the substance and study, they are more likely to cause gastrointestinal bleeding than vitamin K antagonists (VKA), the medication that used to be standard for VTE and AF...
February 5, 2019: VASA. Zeitschrift Für Gefässkrankheiten
https://read.qxmd.com/read/30717703/the-frequency-clinical-course-and-health-related-quality-of-life-in-adults-with-gilbert-s-syndrome-a-longitudinal-study
#9
Sanaa Kamal, Sara Abdelhakam, Dalia Ghoraba, Yasmin Massoud, Kareem Abdel Aziz, Huda Hassan, Tamer Hafez, Ahmed Abdel Sallam
BACKGROUND: Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, genetic profile and health related quality of life in Egyptian adults. METHODS: An initial cross-sectional study was conducted to assess the frequency of Gilbert syndrome among Egyptian adults. Subjects fulfilling the criteria of GS were enrolled into the study and prospectively followed for the clinical features, risk factors for hyperbilirubinemia, health related quality of life [Short form-36 Health Survey version 2 (SF-36v2) and Chronic Liver Disease Questionnaire (CLDQ)], vitamins assessment and UGT1A1 polymorphisms...
February 4, 2019: BMC Gastroenterology
https://read.qxmd.com/read/30714636/vitamin-d-levels-and-vitamin-d-receptor-variants-are-associated-with-chronic-heart-failure-in-chinese-patients
#10
Yi Hao, Yueling Chen
BACKGROUND: Vitamin D is an indispensable molecule for human health. Wide ranges of diseases are linked with vitamin D deficiencies. Role of vitamin D in chronic heart failure has been demonstrated in different populations; however, reports are limited in Chinese population. Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. In the present study, we hypothesized that both vitamin D levels and VDR variants could be associated with the development of chronic heart failure...
February 4, 2019: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/30709752/long-term-micronutrient-surveillance-after-gastric-bypass-surgery-in-an-integrated-healthcare-system
#11
Wesley Fox, Andrew Borgert, Cary Rasmussen, Kara Kallies, Paul Klas, Shanu Kothari
BACKGROUND: The number of patients undergoing bariatric surgery in the United States is growing. While gastric bypass surgery is an important tool in the management of obesity, it requires lifelong metabolic monitoring and medical management. Data describing compliance with recommended laboratory follow-up are limited, particularly in long-term and primary care settings. OBJECTIVES: To evaluate postoperative follow-up laboratory testing for patients after laparoscopic Roux-en-Y gastric bypass (LRYGB)...
January 9, 2019: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://read.qxmd.com/read/30700693/association-of-appendicitis-helicobacter-pylori-positive-gastritis-and-thrombotic-thrombocytopenic-purpura-in-an-adolescent
#12
Adela Arapović, Sandra Prgomet, Marijan Saraga, Tanja Kovačević, Zoltán Prohászka, Ranka Despot, Eugenija Marušić, Josipa Radić
BACKGROUND Thrombotic thrombocytopenic purpura (TTP) in children is a rare life-threatening syndrome, characterized by microangiopathic hemolytic anemia, thrombocytopenia with renal dysfunction, neurologic symptoms, and fever. TTP is usually caused by deficient activity of von Willebrand factor cleaving protease (ADAMTS13), due to either gene mutations or acquired via anti-ADAMTS13 autoantibodies. It can be triggered by bone marrow or solid organ transplantation, cardiothoracic-, abdominal-, and orthopedic surgeries, infections including very rarely Helicobacter pylori infection...
January 31, 2019: American Journal of Case Reports
https://read.qxmd.com/read/30692066/-high-performance-liquid-chromatography-mass-spectrometry-based-serum-metabolic-profiling-in-patients-with-hbv-related-hepatocellular-carcinoma
#13
Lei Zhang, Zhijuan Fan, Hua Kang, Yufan Wang, Shuye Liu, Zhongqiang Shan
OBJECTIVE: To explore the diagnostic value of the serum metabolites identified by high-performance liquid chromatography-mass spectrometry (HPLC/MS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: A total of 126 patients admitted to Tianjin Third Central Hospital were enrolled, including 27 patients with HBV-related hepatitis with negative viral DNA (DNA-N), 24 with HBV-related hepatitis with positive viral DNA, 24 with HBV-related liver cirrhosis, 27 with HBV-related HCC undergoing surgeries or radiofrequency ablation, and 24 with HBV-related HCC receiving interventional therapy, with 25 healthy volunteers as the normal control group...
January 30, 2019: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/30691427/recurrent-tertiary-hyperparathyroidism-due-to-supernumerary-parathyroid-glands-in-a-patient-receiving-long-term-hemodialysis-a-case-report
#14
Tsai-Sung Tai, Yueh-Han Hsu, Jia Ming Chang, Chien-Chin Chen
BACKGROUND: Renal hyperparathyroidism is a common complication of chronic kidney disease (CKD) or end-stage renal disease (ESRD) characterized by elevated parathyroid hormone levels secondary to derangements in the homeostasis of calcium, phosphate, and vitamin D. Rapid correction of severe and prolonged hyperparathyroidism by surgical parathyroidectomy in long-term hemodialysis patients occasionally causes hungry bone syndrome. These patients then exhibit severe and long-lasting secondary or tertiary hyperparathyroidism with high bone turnover...
January 28, 2019: BMC Endocrine Disorders
https://read.qxmd.com/read/30686831/pattern-and-risk-factors-of-congenital-anomalies-in-a-pediatric-university-hospital-alexandria-egypt
#15
Marwa Shawky Mohammed Abdou, Aida Ali Reda Sherif, Iman Mohamed Helmy Wahdan, Khaled Saad El Din Ashour
Background: Congenital anomalies (CAs) are structural, functional, or metabolic anomalies that originate during intrauterine life and can interfere with the body functions. In Egypt, the prevalence of CAs is increasing. The study aimed to estimate the frequency, describe the types, and identify the possible risk factors of CAs among infants attending the Pediatric University Hospital, Alexandria, Egypt. Methods: A retrospective case series and a case-control study were conducted...
2019: Journal of the Egyptian Public Health Association
https://read.qxmd.com/read/30684617/open-repair-of-a-ruptured-abdominal-aortic-aneurysm-on-a-patient-under-rivaroxaban-and-clopidogrel
#16
Poulou Aikaterini, Alexiou Evangelos, Geroulakos George, Lazaris M Andreas
INTRODUCTION: Direct oral anticoagulants are commonly used instead of vitamin K antagonists, in patients needing long-term anticoagulant treatment. As their use has become more popular, there is an increase possibility to perform a major surgery on an urgent or emergency basis on patients under non vitamin K antagonists oral anticoagulants. CASE REPORT: We report a case of a ruptured abdominal aortic aneurysm on a male patient under rivaroxaban and clopidogrel. Emergency open repair of the aneurysm was performed...
January 23, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30683325/vitamin-d-deficiency-in-cancer-patients-and-predictors-for-screening-d-onc-study
#17
Ali Alkan, Elif Berna Köksoy
INTRODUCTION: Vitamin D is a prohormone that is vital for calcium/phosphate balance, bone structure, and physiological functioning. Vitamin D deficiency (VDD) is an important clinical problem worldwide. However, there are no standardized protocols for screening of patients with a diagnosis of cancer. The purpose of this study is to define the prevalence of VDD in cancer patients and establish the predictors of VDD to address a specific group of patient for screening. MATERIAL/METHODS: The study was designed as a retrospective case-control study...
January 17, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30670251/pediatric-perioperative-measures-of-sleep-pain-anxiety-and-anesthesia-emergence-a-healing-touch-proof-of-concept-randomized-clinical-trial
#18
Laura E James, Michele M Gottschlich, Judith K Nelson, Lois C Cone, John E McCall
BACKGROUND AND PURPOSE: The purpose of this study was to determine the impact of healing touch (HT) on sleep, anxiety, anesthesia emergence and pain. METHODS: HT, sham HT, control with an aide (CP) and control groups without the presence of an aide (CNP), underwent polysomnography (PSG) preoperatively. The Yale Preoperative Anxiety Scale (YPAS) score was obtained preoperatively before medications were given and in the preoperative surgery area. Sedation score, anesthesia emergence score and vital signs were recorded...
February 2019: Complementary Therapies in Medicine
https://read.qxmd.com/read/30668264/relationship-of-vitamin-d-deficiency-and-intraoperative-parathyroid-hormone-elevation-in-completion-and-total-thyroidectomy
#19
Bradley R Lawson, Andrew M Hinson, Jacob C Lucas, Donald L Bodenner, Brendan C Stack
OBJECTIVE: To quantify how frequently intraoperative parathyroid hormone levels increase during thyroid surgery and to explore a possible relationship between secondary hyperparathyroidism due to vitamin D deficiency and elevation in intraoperative parathyroid hormone. STUDY DESIGN: Case series with chart review. SETTING: Tertiary academic center. SUBJECTS AND METHODS: A total of 428 consecutive patients undergoing completion and total thyroidectomy by the senior author over a 7-year period were included for analysis...
January 22, 2019: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/30665549/non-surgical-management-of-primary-hyperparathyroidism
#20
REVIEW
Filomena Cetani, Federica Saponaro, Claudio Marcocci
The purpose of this chapter is to discuss the options available for patients with primary hyperparathyrodism (PHPT) not undergoing parathyroidectomy (PTx). Adequate hydration should be recommended in all patients. Calcium intake should not be restricted and vitamin D deficiency should be corrected aiming at a serum concentration of 25OHD of >20 ng/mL or even higher (>30 ng/mL according to some opinion leaders). Pharmacologic therapy is not an alternative to PTx and could be considered in patients who meet the surgical criteria but unwilling to undergo PTx, as well as in patients with an increased risk of surgery or failed surgery...
December 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
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