keyword
https://read.qxmd.com/read/38495953/bert-based-medical-chatbot-enhancing-healthcare-communication-through-natural-language-understanding
#21
JOURNAL ARTICLE
Arun Babu, Sekhar Babu Boddu
The advent of modern technologies like Artificial Intelligence(AI), Internet of Things(IoT) and Deep Learning(DL) has ushered in a transformative era in healthcare, offering innovative solutions towards personalized healthcare by enhancing the quality of various medical services. Our proposed methodology involves the development of a BERT-based medical chatbot, leveraging cutting-edge deep learning technology to significantly enhance healthcare communication and accessibility. The traditional challenges faced by medical chatbots, such as imprecise understanding of medical conversations, inaccurate responses to jargon, and the inability to offer personalized feedback, are addressed through the utilization of Bidirectional Encoder Representations from Transformers (BERT)...
March 2024: Explor Res Clin Soc Pharm
https://read.qxmd.com/read/38491544/generative-ai-in-healthcare-an-implementation-science-informed-translational-path-on-application-integration-and-governance
#22
REVIEW
Sandeep Reddy
BACKGROUND: Artificial intelligence (AI), particularly generative AI, has emerged as a transformative tool in healthcare, with the potential to revolutionize clinical decision-making and improve health outcomes. Generative AI, capable of generating new data such as text and images, holds promise in enhancing patient care, revolutionizing disease diagnosis and expanding treatment options. However, the utility and impact of generative AI in healthcare remain poorly understood, with concerns around ethical and medico-legal implications, integration into healthcare service delivery and workforce utilisation...
March 15, 2024: Implementation Science: IS
https://read.qxmd.com/read/38484967/assessing-the-accessibility-engagement-and-value-of-the-virtual-global-spine-conference-as-an-educational-platform-for-spine-a-three-year-review
#23
JOURNAL ARTICLE
Amna Hussein, Khoi Than, Wende Gibbs, Jonathan Rasouli, Nader S Dahdaleh, Michael Selby, Michael Galgano, Alexander Mameghani, Matthew L Goodwin, John Shin, Alfredo Guiroy, Ali Baaj
INTRODUCTION: The COVID-19 pandemic ushered a paradigm shift in medical education, accelerating the transition to virtual learning in select cases. The Virtual Global Spine Conference (VGSC), launched at the height of the pandemic, is a testament to this evolution, providing an independent educational series for spine care professionals worldwide. This study assesses VGSC's three-year performance, focusing on accessibility, engagement, and educational value. METHODOLOGY: Through retrospective data analysis from April 2020 to August 2023, we examined our social media metrics to measure VGSC's reach and impact...
March 12, 2024: World Neurosurgery
https://read.qxmd.com/read/38483739/fragment-based-drug-design-of-novel-inhibitors-targeting-lipoprotein-a-kringle-domain-kiv-10-mediated-cardiovascular-disease
#24
JOURNAL ARTICLE
Mohammed Alsieni, Ahmed Esmat, Mohammed A Bazuhair, Hisham N Altayb
Cardiovascular diseases (CVDs) are the leading cause of death globally, attributed to a complex etiology involving metabolic, genetic, and protein-related factors. Lipoprotein(a) (Lp(a)), identified as a genetic risk factor, exhibits elevated levels linked to an increased risk of cardiovascular diseases. The lipoprotein(a) kringle domains have recently been identified as a potential target for the treatment of CVDs, in this study we utilized a fragment-based drug design approach to design a novel, potent, and safe inhibitor for lipoprotein(a) kringle domain...
March 14, 2024: Journal of Bioenergetics and Biomembranes
https://read.qxmd.com/read/38480799/a-platform-independent-ai-tumor-lineage-and-site-atlas-classifier
#25
JOURNAL ARTICLE
Nicholas R Rydzewski, Yue Shi, Chenxuan Li, Matthew R Chrostek, Hamza Bakhtiar, Kyle T Helzer, Matthew L Bootsma, Tracy J Berg, Paul M Harari, John M Floberg, Grace C Blitzer, David Kosoff, Amy K Taylor, Marina N Sharifi, Menggang Yu, Joshua M Lang, Krishnan R Patel, Deborah E Citrin, Kaitlin E Sundling, Shuang G Zhao
Histopathologic diagnosis and classification of cancer plays a critical role in guiding treatment. Advances in next-generation sequencing have ushered in new complementary molecular frameworks. However, existing approaches do not independently assess both site-of-origin (e.g. prostate) and lineage (e.g. adenocarcinoma) and have minimal validation in metastatic disease, where classification is more difficult. Utilizing gradient-boosted machine learning, we developed ATLAS, a pair of separate AI Tumor Lineage and Site-of-origin models from RNA expression data on 8249 tumor samples...
March 13, 2024: Communications Biology
https://read.qxmd.com/read/38474678/catalysts-of-healing-a-symphony-of-synthesis-and-clinical-artistry-in-small-molecule-agents-for-breast-cancer-alleviation
#26
REVIEW
Jing Hu, Bi-Yue Zhu, Zhen-Xi Niu
Breast cancer, characterized by its molecular intricacy, has witnessed a surge in targeted therapeutics owing to the rise of small-molecule drugs. These entities, derived from cutting-edge synthetic routes, often encompassing multistage reactions and chiral synthesis, target a spectrum of oncogenic pathways. Their mechanisms of action range from modulating hormone receptor signaling and inhibiting kinase activity, to impeding DNA damage repair mechanisms. Clinical applications of these drugs have resulted in enhanced patient survival rates, reduction in disease recurrence, and improved overall therapeutic indices...
March 5, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38470933/co-occurring-usher-syndrome-type-1-and-renal-failure
#27
JOURNAL ARTICLE
Hong Le, Helen Anderson, Glydel Lopez, Julie Bayer-Vile, Hind Al-Saif, Natario Couser
PURPOSE: To describe a patient with a rare co-occurrence of Usher syndrome type 1C (USH1C) and renal disease, suspected to be secondary to Alport syndrome. METHOD: Case report and literature review of cases with Usher syndrome and renal failure. Clinical examination, color fundus photography, visual field tests, electroretinography and whole exome sequencing were used to diagnose and document the patient's clinical presentation. RESULTS: An 18-year-old female with known history of congenital hearing loss and chronic renal failure, presents with progressive night and peripheral visual impairment suspicious for an inherited retinal disease...
March 8, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38465142/expanding-the-genotype-phenotype-correlations-and-mutational-spectrum-in-inherited-retinal-diseases-novel-and-recurrent-mutations
#28
JOURNAL ARTICLE
Ibrahim Sahin, Haktan B Erdem, Taha Bahsi, Hanife Saat
Background Inherited retinal diseases (IRD) represent a prominent etiology of visual impairment on a global scale. The lack of a clear definition of the etiology and genotypic spectrum of IRD is attributed to the significant genetic variability seen. Additionally, there is a scarcity of available data about the correlations between genotypes and phenotypes in this context. This study aimed to clarify the range of mutations and the associations between genotypes and phenotypes in IRD. Methods This cohort consists of 223 patients who have been diagnosed with a range of retinal illnesses, such as retinitis pigmentosa (RP), Stargardt (STGD)/STGD-like disease, Usher syndrome, and Leber congenital amaurosis (LCA)...
February 2024: Curēus
https://read.qxmd.com/read/38464015/the-ush3a-causative-gene-clarin1-functions-in-m%C3%A3-ller-glia-to-maintain-retinal-photoreceptors
#29
Hannah J T Nonarath, Samantha L Simpson, Tricia L Slobodianuk, Ross F Collery, Astra Dinculescu, Brian A Link
UNLABELLED: Mutations in CLRN1 cause Usher syndrome type IIIA (USH3A), an autosomal recessive disorder characterized by hearing and vision loss, and often accompanied by vestibular balance issues. The identity of the cell types responsible for the pathology and mechanisms leading to vision loss in USH3A remains elusive. To address this, we employed CRISPR/Cas9 technology to delete a large region in the coding and untranslated (UTR) region of zebrafish clrn1 . Retina of clrn1 mutant larvae exhibited sensitivity to cell stress, along with age-dependent loss of function and degeneration in the photoreceptor layer...
March 1, 2024: bioRxiv
https://read.qxmd.com/read/38462281/opportunities-and-challenges-of-artificial-intelligence-and-distributed-systems-to-improve-the-quality-of-healthcare-service
#30
REVIEW
Sarina Aminizadeh, Arash Heidari, Mahshid Dehghan, Shiva Toumaj, Mahsa Rezaei, Nima Jafari Navimipour, Fabio Stroppa, Mehmet Unal
The healthcare sector, characterized by vast datasets and many diseases, is pivotal in shaping community health and overall quality of life. Traditional healthcare methods, often characterized by limitations in disease prevention, predominantly react to illnesses after their onset rather than proactively averting them. The advent of Artificial Intelligence (AI) has ushered in a wave of transformative applications designed to enhance healthcare services, with Machine Learning (ML) as a noteworthy subset of AI...
March 2024: Artificial Intelligence in Medicine
https://read.qxmd.com/read/38461367/full-length-single-protein-molecules-tracking-and-counting-in-thin-silicon-channels
#31
JOURNAL ARTICLE
Shilo Ohayon, Liran Taib, Navneet C Verma, Marzia Iarossi, Ivy Bhattacharya, Barak Marom, Diana Huttner, Amit Meller
Emerging single-molecule protein sensing techniques are ushering in a transformative era in biomedical research. Nevertheless, challenges persist in realizing ultra-fast full-length protein sensing, including loss of molecular integrity due to protein fragmentation, biases introduced by antibodies affinity, identification of proteoforms and low throughputs. Here, we introduce a single-molecule method for parallel protein separation and tracking, yielding multi-dimensional and are electrophoretically separated by their mass/charge in custom-designed thin silicon channel with subwavelength height...
March 9, 2024: Advanced Materials
https://read.qxmd.com/read/38460947/molecular-characteristics-and-prognostic-significances-of-lysosomal-dependent-cell-death-in-kidney-renal-clear-cell-carcinoma
#32
JOURNAL ARTICLE
Shunliang He, Jiaao Sun, Hewen Guan, Ji Su, Xu Chen, Zhijun Hong, Jianbo Wang
Lysosomal-dependent cell death (LDCD) has an excellent therapeutic effect on apoptosis-resistant and drug-resistant tumors; however, the important role of LDCD-related genes (LDCD-RGs) in kidney renal clear cell carcinoma (KIRC) has not been reported. Initially, single-cell atlas of LDCD signal in KIRC was comprehensively depicted. We also emphasized the molecular characteristics of LDCD-RGs in various human neoplasms. Predicated upon the expressive quotients of LDCD-RGs, we stratified KIRC patients into tripartite cohorts denoted as C1, C2, and C3...
March 7, 2024: Aging
https://read.qxmd.com/read/38460428/are-monoclonals-the-only-panacea-for-treatment-of-aquaporin-4-positive-nmosd-experience-from-a-low-middle-income-lmic-region
#33
JOURNAL ARTICLE
Kamakshi Dhamija, Mandara Ganganakudige Manjappaiah, Thennarasu Kandavel, A Mahadevan, M Netravathi
OBJECTIVE: A plethora of monoclonals have ushered up for NMOSD treatment. However, their limited availability and cost concerns poses a challenge for usage in developing nations. We compared relapse rates and disabilities among aquaporin-4 positive(AQP4+ve) patients on conventional immunosuppressants and rituximab in a tertiary referral center in southern India. METHODS: This was a chart review of AQP4+ve patients registered under national demyelination registry maintained at institute...
March 2, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38460012/insights-into-taxadiene-synthase-catalysis-and-promiscuity-facilitated-by-mutability-landscape-and-molecular-dynamics
#34
JOURNAL ARTICLE
Siqi He, Ingy I Abdallah, Ronald van Merkerk, Wim J Quax
Protein modeling, carbocation docking, and molecular dynamics along with structure-based mutability landscapes provided insight into taxadiene synthase catalysis (first step of the anticancer Taxol biosynthesis), protein structure-function correlations, and promiscuity. Plant terpenes belong to one of the largest and most diverse classes of natural products. This diversity is driven by the terpene synthase enzyme family which comprises numerous different synthases, several of which are promiscuous. Taxadiene synthase (TXS) is a class I diterpene synthase that catalyzes the first step in the biosynthesis pathway of the diterpene Taxol, an anticancer natural product produced by the Taxus plant...
March 9, 2024: Planta
https://read.qxmd.com/read/38459060/machine-learning-predictor-pspire-screens-for-phase-separating-proteins-lacking-intrinsically-disordered-regions
#35
JOURNAL ARTICLE
Shuang Hou, Jiaojiao Hu, Zhaowei Yu, Dan Li, Cong Liu, Yong Zhang
The burgeoning comprehension of protein phase separation (PS) has ushered in a wealth of bioinformatics tools for the prediction of phase-separating proteins (PSPs). These tools often skew towards PSPs with a high content of intrinsically disordered regions (IDRs), thus frequently undervaluing potential PSPs without IDRs. Nonetheless, PS is not only steered by IDRs but also by the structured modular domains and interactions that aren't necessarily reflected in amino acid sequences. In this work, we introduce PSPire, a machine learning predictor that incorporates both residue-level and structure-level features for the precise prediction of PSPs...
March 8, 2024: Nature Communications
https://read.qxmd.com/read/38457203/decreasing-opioid-addiction-and-diversion-using-behavioral-economics-applied-through-a-digital-engagement-solution-protocol-for-a-randomized-controlled-trial
#36
JOURNAL ARTICLE
Rubina Fatima Rizvi, Jamee Ann Schoephoerster, Sagar Satish Desphande, Michael Usher, Andy Elaine Oien, Maya Marie Peters, Matthew Scott Loth, Matthew William Bahr, Steffen Ventz, Joseph Stephen Koopmeiners, Genevieve B Melton
BACKGROUND: Despite strong and growing interest in ending the ongoing opioid health crisis, there has been limited success in reducing the prevalence of opioid addiction and the number of deaths associated with opioid overdoses. Further, 1 explanation for this is that existing interventions target those who are opiate-dependent but do not prevent opioid-naïve patients from becoming addicted. OBJECTIVE: Leveraging behavioral economics at the patient level could help patients successfully use, discontinue, and dispose of their opioid medications in an acute pain setting...
March 8, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38456470/safety-of-biologic-agents-for-the-management-of-rheumatic-diseases-during-pregnancy
#37
JOURNAL ARTICLE
Jonathan D D'Gama, Bonnie L Bermas
PURPOSE OF REVIEW: To discuss the current understanding regarding the use of biologic therapeutics in pregnancy. RECENT FINDINGS: Our understanding of the mechanisms underlying the potential fetal and infant exposure to biologics as well as a growing body of empirical evidence from real world use of biologics in pregnancy have demonstrated that biologics are generally compatible preconception and during pregnancy. Long-term effects of exposure to biologic agents in utero are not known, but will be uncovered in time...
March 11, 2024: Current Opinion in Rheumatology
https://read.qxmd.com/read/38455514/hypoxia-induced-stabilization-of-hif2a-promotes-cardiomyocyte-proliferation-by-attenuating-dna-damage
#38
JOURNAL ARTICLE
Shah R Ali, Ngoc Uyen Nhi Nguyen, Ivan Menendez-Montes, Ching-Cheng Hsu, Waleed Elhelaly, Nicholas T Lam, Shujuan Li, Abdallah Elnwasany, Yuji Nakada, Suwannee Thet, Roger S Y Foo, Hesham A Sadek
INTRODUCTION: Gradual exposure to a chronic hypoxic environment leads to cardiomyocyte proliferation and improved cardiac function in mouse models through a reduction in oxidative DNA damage. However, the upstream transcriptional events that link chronic hypoxia to DNA damage have remained obscure. AIM: We sought to determine whether hypoxia signaling mediated by the hypoxia-inducible factor 1 or 2 (HIF1A or HIF2A) underlies the proliferation phenotype that is induced by chronic hypoxia...
January 2024: The journal of cardiovascular aging
https://read.qxmd.com/read/38455136/unlocking-the-potential-vitamin-d-in-prostate-cancer-prevention
#39
EDITORIAL
Ayun Cassell, Solomane Konneh
Prostate cancer poses a significant health challenge globally, demanding proactive prevention strategies. This editorial explores the emerging role of vitamin D in prostate cancer prevention. While traditionally associated with bone health, vitamin D is increasingly recognized for its broader impact on immune function, cellular signaling, and cancer prevention. Epidemiological studies suggest an intriguing link between vitamin D deficiency and elevated prostate cancer risk, particularly in regions with limited sunlight exposure...
February 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38455131/updates-on-management-of-gliomas-in-the-molecular-age
#40
REVIEW
Ali Ahmed Mohamed, Rakan Alshaibi, Steven Faragalla, Youssef Mohamed, Brandon Lucke-Wold
Gliomas are primary brain tumors derived from glial cells of the central nervous system, afflicting both adults and children with distinct characteristics and therapeutic challenges. Recent developments have ushered in novel clinical and molecular prognostic factors, reshaping treatment paradigms based on classification and grading, determined by histological attributes and cellular lineage. This review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year 2023...
February 24, 2024: World Journal of Clinical Oncology
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