Jeong-Han Lee, Cristina Perez-Flores, Seojin Park, Hyo J Kim, Yingying Chen, Mincheol Kang, Jennifer Kersigo, Jinsil Choi, Phung Thai, Ryan Woltz, Guy Perkins, Choong-Ryoul Sihn, Bernd Fritzsch, Pauline Trinh, Xiao-Dong Zhang, Nipavan Chiamvimonvat, Dolores Perez-Flores, Padmini Sirish, Yao Dong, Isaac Pessah, Feng Wei, Rose Dixon, Bernd Sokolowski, Ebenezer Yamoah
The inner ear is the hub where hair cells transduce sound, gravity, and head acceleration stimuli carried by neural codes to the brain. Of all the senses, hearing and balance, which rely on mechanosensation, are the fastest sensory signals transmitted to the central nervous system. The mechanoelectrical transducer (MET) channel in hair cells is the entryway for the sound-balance-brain interface, but the channel's composition has eluded biologists due to its complexity. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as central components of the MET complex...
July 12, 2023: Research Square