Kiruthiga Chandramohan, Devasahayam Jaya Balan, Kasi Pandima Devi, Seyed Fazel Nabavi, Sara Reshadat, Maryam Khayatkashani, Sepideh Mahmoodifar, Rosanna Filosa, Nilofar Amirkhalili, Soroush Pishvaei, Omolbanin Sargazi Aval, Seyed Mohammad Nabavi
Colorectal cancer (CRC) is the third most common cancer and the leading cause of gastrointestinal cancer death. 90% of people diagnosed with colorectal cancer are over the age of 50; nevertheless, the illness is more aggressive among those detected at a younger age. Chemotherapy-based treatment has several adverse effects on both normal and malignant cells. The primary signaling pathways implicated in the advancement of CRC include hedgehog (Hh), janus kinase and signal transducer and activator of transcription (JAK/STAT), Wingless-related integration site (Wnt)/β-catenin, transforming growth factor-β (TNF-β), epidermal growth factor receptor (EGFR)/Mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), nuclear factor kappa B (NF-κB), and Notch...
April 1, 2023: European Journal of Pharmacology